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Select item 112104481.

TXNRD1 drives innate immune response in senescent cells with implications in age-associated inflammation

Xue Hao, Bo Zhao, Martina Towers, Liping Liao, Edgar Luzete Monteiro, Xin Xu, Christina Freeman, Hongzhuang Peng, Hsin-Yao Tang, Aaron Havas, Andrew V. Kossenkov, Shelley L. Berger, Peter D. Adams, David W. Speicher, David Schultz, Ronen Marmorstein, Kenneth S. Zaret, Rugang Zhang

Nat Aging. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Nat Aging. 2024 Feb; 4(2): 185–197. Published online 2024 Jan 24. doi: 10.1038/s43587-023-00564-1

PMCID:: PMC11210448

Abstract Article PDF–4.9M

Select item 110759062.

Unraveling the genetics of arsenic toxicity with cellular morphology QTL

Callan O’Connor, Gregory R. Keele, Whitney Martin, Timothy Stodola, Daniel Gatti, Brian R. Hoffman, Ron Korstanje, Gary A. Churchill, Laura G. Reinholdt

PLoS Genet. 2024 Apr; 20(4): e1011248. Published online 2024 Apr 25. doi: 10.1371/journal.pgen.1011248

PMCID:: PMC11075906

Abstract Article PDF–3.2M

Select item 108379063.

Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development

Xiangyan Wang, Yan Zhang, Jianjie Yu, Yabo Ma, Yaxiu Xu, Jiaqi Shi, Zhipeng Qi, Xinfeng Liu

BMC Genomics. 2024; 25: 139. Published online 2024 Feb 3. doi: 10.1186/s12864-024-10058-y

PMCID:: PMC10837906

Abstract Article PDF–7.1M

Select item 107718654.

Thioredoxin reductase 1 (TR1) modulates pigmentation and photobiology of murine melanocytes in vivo

Evan L. Carpenter, Mark B. Wyant, Aaryan Indra, Shosuke Ito, Kazumasa Wakamatsu, Gary F. Merrill, Philip J. Moos, Pamela B. Cassidy, Sancy A. Leachman, Gitali Ganguli-Indra, Arup K. Indra

J Invest Dermatol. Author manuscript; available in PMC 2024 Jan 7.

Published in final edited form as: J Invest Dermatol. 2022 Jul; 142(7): 1903–1911.e5. Published online 2022 Jan 11. doi: 10.1016/j.jid.2021.11.030

PMCID:: PMC10771865

Abstract Article PDF–1.1M

Select item 98334505.

Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury

Colin T. Shearn, Aimee L. Anderson, Colin G. Miller, Reed C. Noyd, Michael W. Devereaux, Nata Balasubramaniyan, David J. Orlicky, Edward E. Schmidt, Ronald J. Sokol

Hepatol Commun. 2023 Jan; 7(1): e0020. Published online 2023 Jan 10. doi: 10.1097/HC9.0000000000000020

PMCID:: PMC9833450

Abstract Article PDF–1.7M

Select item 93013236.

Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function

Jennifer S Stancill, Polly A Hansen, Angela J Mathison, Edward E Schmidt, John A Corbett

Function (Oxf) 2022; 3(4): zqac034. Published online 2022 Jul 4. doi: 10.1093/function/zqac034

PMCID:: PMC9301323

Abstract Article PDF–6.3M

Select item 83132397.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 79387708.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 77088699.

Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice

Mary E. Robbins, Hye-Youn Cho, Jason M. Hansen, Joseph R. Luchsinger, Morgan L. Locy, Markus Velten, Steven R. Kleeberger, Lynette K. Rogers, Trent E. Tipple

Redox Biol. 2021 Jan; 38: 101797. Published online 2020 Nov 13. doi: 10.1016/j.redox.2020.101797

PMCID:: PMC7708869

Abstract Article PDF–8.6M

Select item 706247210.

Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

Jonathan Muri, Helen Thut, Qian Feng, Manfred Kopf

eLife. 2020; 9: e53627. Published online 2020 Feb 25. doi: 10.7554/eLife.53627

PMCID:: PMC7062472

Abstract Article PDF–1.7M

Select item 693870111.

Control of protein function through oxidation and reduction of persulfidated states

É. Dóka, T. Ida, M. Dagnell, Y. Abiko, N. C. Luong, N. Balog, T. Takata, B. Espinosa, A. Nishimura, Q. Cheng, Y. Funato, H. Miki, J. M. Fukuto, J. R. Prigge, E. E. Schmidt, E. S. J. Arnér, Y. Kumagai, T. Akaike, P. Nagy

Sci Adv. 2020 Jan; 6(1): eaax8358. Published online 2020 Jan 1. doi: 10.1126/sciadv.aax8358

PMCID:: PMC6938701

Abstract Article PDF–3.2M

Select item 656127812.

TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy

Michael R. McLoughlin, David J. Orlicky, Justin R. Prigge, Pushya Krishna, Emily A. Talago, Ian R. Cavigli, Sofi Eriksson, Colin G. Miller, Jean A. Kundert, Volkan I. Sayin, Rachel A. Sabol, Joshua Heinemann, Luke O. Brandenberger, Sonya V. Iverson, Brian Bothner, Thales Papagiannakopoulos, Colin T. Shearn, Elias S. J. Arnér, Edward E. Schmidt

Proc Natl Acad Sci U S A. 2019 Jun 4; 116(23): 11408–11417. Published online 2019 May 16. doi: 10.1073/pnas.1903244116

PMCID:: PMC6561278

Abstract Article PDF–3.2M

Select item 636054913.

Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia

Stephanie B. Wall, Rachael Wood, Katelyn Dunigan, Qian Li, Rui Li, Lynette K. Rogers, Trent E. Tipple

Oxid Med Cell Longev. 2019; 2019: 7945983. Published online 2019 Jan 21. doi: 10.1155/2019/7945983

PMCID:: PMC6360549

Abstract Article PDF–1.6M

Select item 633430014.

Disruption of Thioredoxin Reductase 1 Protects Mice from Acute Acetaminophen-Induced Hepatotoxicity through Enhanced NRF2 Activity

Andrew D. Patterson, Bradley A. Carlson, Fei Li, Jessica A. Bonzo, Min-Hyuk Yoo, Kristopher W. Krausz, Marcus Conrad, Chi Chen, Frank J. Gonzalez, Dolph L. Hatfield

Chem Res Toxicol. Author manuscript; available in PMC 2019 Jan 16.

Published in final edited form as: Chem Res Toxicol. 2013 Jul 15; 26(7): 1088–1096. Published online 2013 Jun 7. doi: 10.1021/tx4001013

PMCID:: PMC6334300

Abstract Article PDF–851K

Select item 594563715.

The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation

Jonathan Muri, Sebastian Heer, Mai Matsushita, Lea Pohlmeier, Luigi Tortola, Tobias Fuhrer, Marcus Conrad, Nicola Zamboni, Jan Kisielow, Manfred Kopf

Nat Commun. 2018; 9: 1851. Published online 2018 May 10. doi: 10.1038/s41467-018-04274-w

PMCID:: PMC5945637

Abstract Article PDF–1.6M

Select item 573009316.

Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase

Justin R. Prigge, Lucia Coppo, Sebastin S. Martin, Fernando Ogata, Colin G. Miller, Michael D. Bruschwein, David J. Orlicky, Colin T. Shearn, Jean A. Kundert, Julia Lytchier, Alix E. Herr, Åse Mattsson, Matthew P. Taylor, Tomas N. Gustafsson, Elias S.J. Arnér, Arne Holmgren, Edward E. Schmidt

Cell Rep. Author manuscript; available in PMC 2017 Dec 14.

Published in final edited form as: Cell Rep. 2017 Jun 27; 19(13): 2771–2781. doi: 10.1016/j.celrep.2017.06.019

PMCID:: PMC5730093

Abstract Article PDF–2.9M

Select item 554312117.

MiR-23-TrxR1 as a novel molecular axis in skeletal muscle differentiation

Neri Mercatelli, Simona Fittipaldi, Elisa De Paola, Ivan Dimauro, Maria Paola Paronetto, Malcolm J. Jackson, Daniela Caporossi

Sci Rep. 2017; 7: 7219. Published online 2017 Aug 3. doi: 10.1038/s41598-017-07575-0

PMCID:: PMC5543121

Abstract Article PDF–3.7M

Select item 550160618.

GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea: Possible role of the thioredoxin system as a functional backup for GSR

Chul Han, Mi-Jung Kim, Dalian Ding, Hyo-Jin Park, Karessa White, Logan Walker, Tongjun Gu, Masaru Tanokura, Tatsuya Yamasoba, Paul Linser, Richard Salvi, Shinichi Someya

PLoS One. 2017; 12(7): e0180817. Published online 2017 Jul 7. doi: 10.1371/journal.pone.0180817

PMCID:: PMC5501606

Abstract Article PDF–4.8M

Select item 502302419.

Thioredoxin Reductase Inhibition Attenuates Neonatal Hyperoxic Lung Injury and Enhances Nuclear Factor E2–Related Factor 2 Activation

Qian Li, Stephanie B. Wall, Changchun Ren, Markus Velten, Cynthia L. Hill, Morgan L. Locy, Lynette K. Rogers, Trent E. Tipple

Am J Respir Cell Mol Biol. 2016 Sep; 55(3): 419–428. doi: 10.1165/rcmb.2015-0228OC

PMCID:: PMC5023024

Abstract Article PDF–1.2M

Select item 492186120.

Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness

Xiaoxiao Peng, Alfredo Giménez-Cassina, Paul Petrus, Marcus Conrad, Mikael Rydén, Elias S. J. Arnér

Sci Rep. 2016; 6: 28080. Published online 2016 Jun 27. doi: 10.1038/srep28080

PMCID:: PMC4921861

Abstract Article PDF–2.5M

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