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Select item 104561921.

Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic β cells resulting in neonatal lethality

Gurvinder Kaur, Rebecca A. Helmer, Dalia Martinez-Marin, Souad R. Sennoune, Rachel L. Washburn, Raul Martinez-Zaguilan, Jannette M. Dufour, Beverly S. Chilton

PLoS One. 2023; 18(8): e0286109. Published online 2023 Aug 25. doi: 10.1371/journal.pone.0286109

PMCID:: PMC10456192

Abstract Article PDF–3.7M

Select item 103671472.

Granzyme-A deficiency attenuates experimental osteoarthritis in mice, but perforin deficiency does not

Jorge Calvo, Llipsy Santiago, Maykel Arias, Julián Pardo, Jorge Albareda, Luis Martínez-Lostao, Felícito García-Alvarez

Jt Dis Relat Surg. 2023 Aug; 34(2): 271–278. Published online 2023 Apr 27. doi: 10.52312/jdrs.2023.892

PMCID:: PMC10367147

Abstract Article PDF–810K

Select item 93600163.

Limits to in vivo fate changes of epithelia in thymus and parathyroid by ectopic expression of transcription factors Gcm2 and Foxn1

Daisuke Nagakubo, Mayumi Hirakawa, Norimasa Iwanami, Thomas Boehm

Sci Rep. 2022; 12: 13554. Published online 2022 Aug 8. doi: 10.1038/s41598-022-17844-2

PMCID:: PMC9360016

Abstract Article PDF–4.8M

Select item 92209394.

EBAG9 controls CD8⁺ T cell memory formation responding to tumor challenge in mice

Armin Rehm, Anthea Wirges, Dana Hoser, Cornelius Fischer, Stefanie Herda, Kerstin Gerlach, Sascha Sauer, Gerald Willimsky, Uta E. Höpken

JCI Insight. 2022 Jun 8; 7(11): e155534. Published online 2022 Jun 8. doi: 10.1172/jci.insight.155534

PMCID:: PMC9220939

Abstract Article PDF–6.3M

Select item 89019125.

Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma

Yuxue Gao, Qingguo Xu, Xinqiang Li, Yuan Guo, Bowen Zhang, Yan Jin, Cunle zhu, Yuntai Shen, Pengxiang Yang, Ying Shi, Rifeng Jin, Daojie Liu, Yabo Ouyang, Xiaoni Liu, Wenjing Wang, Dexi Chen, Tongwang Yang

Cell Death Dis. 2022 Mar; 13(3): 213. Published online 2022 Mar 7. doi: 10.1038/s41419-022-04654-7

PMCID:: PMC8901912

Abstract Article PDF–7.9M

Select item 88813486.

γδ intraepithelial lymphocytes facilitate pathological epithelial cell shedding via CD103-mediated granzyme release

Madeleine D. Hu, Natasha B. Golovchenko, Grace L. Burns, Prema M. Nair, Thomas J. Kelly, IV, Jonathan Agos, Mudar Zand Irani, Wai Sinn Soh, Matthew R. Zeglinski, Alexander Lemenze, Edward M. Bonder, Inga Sandrock, Immo Prinz, David J. Granville, Simon Keely, Alastair J.M. Watson, Karen L. Edelblum

Gastroenterology. Author manuscript; available in PMC 2023 Mar 1.

Published in final edited form as: Gastroenterology. 2022 Mar; 162(3): 877–889.e7. Published online 2021 Dec 1. doi: 10.1053/j.gastro.2021.11.028

PMCID:: PMC8881348

Abstract Article PDF–1.3M

Select item 88163807.

Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies

Daniel J Rawle, Thuy T Le, Troy Dumenil, Cameron Bishop, Kexin Yan, Eri Nakayama, Phillip I Bird, Andreas Suhrbier

eLife. 2022; 11: e70207. Published online 2022 Feb 4. doi: 10.7554/eLife.70207

PMCID:: PMC8816380

Abstract Article PDF–7.7M

Select item 85814358.

Biological relevance of Granzymes A and K during E. coli sepsis

Iratxe Uranga-Murillo, Elena Tapia, Marcela Garzón-Tituaña, Ariel Ramirez-Labrada, Llipsy Santiago, Cecilia Pesini, Patricia Esteban, Francisco J Roig, Eva M Galvez, Phillip I Bird, Julián Pardo, Maykel Arias

Theranostics. 2021; 11(20): 9873–9883. Published online 2021 Oct 17. doi: 10.7150/thno.59418

PMCID:: PMC8581435

Abstract Article PDF–1.2M

Select item 79143449.

Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis

Marcela Garzón-Tituaña, José L Sierra-Monzón, Laura Comas, Llipsy Santiago, Tatiana Khaliulina-Ushakova, Iratxe Uranga-Murillo, Ariel Ramirez-Labrada, Elena Tapia, Elena Morte-Romea, Sonia Algarate, Ludovic Couty, Eric Camerer, Phillip I Bird, Cristina Seral, Pilar Luque, José R Paño-Pardo, Eva M Galvez, Julián Pardo, Maykel Arias

Theranostics. 2021; 11(8): 3781–3795. Published online 2021 Jan 30. doi: 10.7150/thno.49288

PMCID:: PMC7914344

Abstract Article PDF–1.7M

Select item 752654410.

Granzyme A–producing T helper cells are critical for acute graft-versus-host disease

Sungtae Park, Brad Griesenauer, Hua Jiang, Djamilatou Adom, Pegah Mehrpouya-Bahrami, Srishti Chakravorty, Majid Kazemian, Tanbeena Imam, Rajneesh Srivastava, Tristan A. Hayes, Julian Pardo, Sarath Chandra Janga, Sophie Paczesny, Mark H. Kaplan, Matthew R. Olson

JCI Insight. 2020 Sep 17; 5(18): e124465. Published online 2020 Sep 17. doi: 10.1172/jci.insight.124465

PMCID:: PMC7526544

Abstract Article PDF–28M

Select item 741599111.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 697105412.

Granzyme A in Chikungunya and Other Arboviral Infections

Alessandra S. Schanoski, Thuy T. Le, Dion Kaiserman, Caitlin Rowe, Natalie A. Prow, Diego D. Barboza, Cliomar A. Santos, Paolo M. A. Zanotto, Kelly G. Magalhães, Luigi Aurelio, David Muller, Paul Young, Peishen Zhao, Phillip I. Bird, Andreas Suhrbier

Front Immunol. 2019; 10: 3083. Published online 2020 Jan 14. doi: 10.3389/fimmu.2019.03083

PMCID:: PMC6971054

Abstract Article PDF–4.1M

Select item 673882113.

Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia

M. Isabel García-Laorden, Ingrid Stroo, Dana C. Blok, Sandrine Florquin, Jan Paul Medema, Alex F. de Vos, Tom van der Poll

J Innate Immun. 2016 Apr; 8(3): 258–268. Published online 2016 Feb 20. doi: 10.1159/000443401

PMCID:: PMC6738821

Abstract Article PDF–707K

Select item 660670914.

Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN

Kanako Shimizu, Satoru Yamasaki, Maki Sakurai, Noriko Yumoto, Mariko Ikeda, Chiemi Mishima-Tsumagari, Mutsuko Kukimoto-Niino, Takashi Watanabe, Masami Kawamura, Mikako Shirouzu, Shin-ichiro Fujii

Front Immunol. 2019; 10: 1450. Published online 2019 Jun 26. doi: 10.3389/fimmu.2019.01450

PMCID:: PMC6606709

Abstract Article PDF–2.2M

Select item 617747215.

Murine transcription factor Math6 is a regulator of placenta development

Marion Böing, Beate Brand-Saberi, Markus Napirei

Sci Rep. 2018; 8: 14997. Published online 2018 Oct 9. doi: 10.1038/s41598-018-33387-x

PMCID:: PMC6177472

Abstract Article PDF–2.8M

Select item 614351416.

Antigen-specific primed cytotoxic T cells eliminate tumour cells in vivo and prevent tumour development, regardless of the presence of anti-apoptotic mutations conferring drug resistance

Paula Jaime-Sánchez, Elena Catalán, Iratxe Uranga-Murillo, Nacho Aguiló, Llipsy Santiago, Pilar M Lanuza, Diego de Miguel, Maykel A Arias, Julián Pardo

Cell Death Differ. 2018 Sep; 25(9): 1536–1548. Published online 2018 May 9. doi: 10.1038/s41418-018-0112-9

PMCID:: PMC6143514

Abstract Article PDF–2.7M

Select item 610558717.

MAIT cells protect against pulmonary Legionella longbeachae infection

Huimeng Wang, Criselle D’Souza, Xin Yi Lim, Lyudmila Kostenko, Troi J. Pediongco, Sidonia B. G. Eckle, Bronwyn S. Meehan, Mai Shi, Nancy Wang, Shihan Li, Ligong Liu, Jeffrey Y. W. Mak, David P. Fairlie, Yoichiro Iwakura, Jennifer M. Gunnersen, Andrew W. Stent, Dale I. Godfrey, Jamie Rossjohn, Glen P. Westall, Lars Kjer-Nielsen, Richard A. Strugnell, James McCluskey, Alexandra J. Corbett, Timothy S. C. Hinks, Zhenjun Chen

Nat Commun. 2018; 9: 3350. Published online 2018 Aug 22. doi: 10.1038/s41467-018-05202-8

PMCID:: PMC6105587

Abstract Article PDF–3.1M

Select item 548533418.

Expression and Function of Granzymes A and B in Escherichia coli Peritonitis and Sepsis

M. Isabel García-Laorden, Ingrid Stroo, Sanne Terpstra, Sandrine Florquin, Jan Paul Medema, Cornelis van´t Veer, Alex F. de Vos, Tom van der Poll

Mediators Inflamm. 2017; 2017: 4137563. Published online 2017 Jun 12. doi: 10.1155/2017/4137563

PMCID:: PMC5485334

Abstract Article PDF–2.2M

Select item 531292819.

RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation

Jane A. C. Wilson, Natalie A. Prow, Wayne A. Schroder, Jonathan J. Ellis, Helen E. Cumming, Linden J. Gearing, Yee Suan Poo, Adam Taylor, Paul J. Hertzog, Francesca Di Giallonardo, Linda Hueston, Roger Le Grand, Bing Tang, Thuy T. Le, Joy Gardner, Suresh Mahalingam, Pierre Roques, Phillip I. Bird, Andreas Suhrbier

PLoS Pathog. 2017 Feb; 13(2): e1006155. Published online 2017 Feb 16. doi: 10.1371/journal.ppat.1006155

PMCID:: PMC5312928

Abstract Article PDF–6.0M

Select item 482439520.

Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo

Santiago Uranga, Dessislava Marinova, Carlos Martin, Julián Pardo, Nacho Aguilo

PLoS One. 2016; 11(4): e0153028. Published online 2016 Apr 7. doi: 10.1371/journal.pone.0153028

PMCID:: PMC4824395

Abstract Article PDF–517K

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