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Items: 1 to 20 of 38

1.
Ablating N-Acetylaspartate Prevents Leukodystrophy in a Canavan Disease Model
Fuzheng Guo, Peter Bannerman, Emily Mills Ko, Laird Miers, Jie Xu, Travis Burns, Shuo Li, Ernest Freeman, Jennifer A. McDonough, David Pleasure
Ann Neurol. Author manuscript; available in PMC 2024 May 28.
Published in final edited form as: Ann Neurol. 2015 May; 77(5): 884–888. Published online 2015 Mar 27. doi: 10.1002/ana.24392
PMCID:
PMC11131957
AbstractArticlePDF–1.8M
2.
Astroglial conditional Slc13a3 knockout is therapeutic in murine Canavan leukodystrophy
Vanessa L. Hull, Yan Wang, Jennifer McDonough, Meina Zhu, Travis Burns, Najmah Al Ramel, Ali Dehghani, Fuzheng Guo, David Pleasure
Ann Clin Transl Neurol. 2024 Apr; 11(4): 1059–1062. Published online 2024 Jan 28. doi: 10.1002/acn3.52010
PMCID:
PMC11021635
AbstractArticlePDF–513K
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
Pathological Bergmann glia alterations and disrupted calcium dynamics in ataxic Canavan disease mice
Vanessa L. Hull, Yan Wang, Travis Burns, Sarah Sternbach, Shuaishuai Gong, Jennifer McDonough, Fuzheng Guo, Laura N. Borodinsky, David Pleasure
Glia. Author manuscript; available in PMC 2023 Dec 1.
Published in final edited form as: Glia. 2023 Dec; 71(12): 2832–2849. Published online 2023 Aug 23. doi: 10.1002/glia.24454
PMCID:
PMC10591969
AbstractArticlePDF–6.4M
5.
Aspartoacylase suppresses prostate cancer progression by blocking LYN activation
Hong Weng, Kang-Ping Xiong, Wang Wang, Kai-Yu Qian, Shuai Yuan, Gang Wang, Fang Yu, Jun Luo, Meng-Xin Lu, Zhong-Hua Yang, Tao Liu, Xing Huang, Hang Zheng, Xing-Huan Wang
Mil Med Res. 2023; 10: 25. Published online 2023 Jun 5. doi: 10.1186/s40779-023-00460-0
PMCID:
PMC10240701
AbstractArticlePDF–18M
6.
Ablating the Transporter Sodium-Dependent Dicarboxylate Transporter 3 Prevents Leukodystrophy in Canavan Disease Mice
Yan Wang, Vanessa Hull, Sarah Sternbach, Brad Popovich, Travis Burns, Jennifer McDonough, Fuzheng Guo, David Pleasure
Ann Neurol. Author manuscript; available in PMC 2022 Oct 10.
Published in final edited form as: Ann Neurol. 2021 Nov; 90(5): 845–850. Published online 2021 Sep 24. doi: 10.1002/ana.26211
PMCID:
PMC9549923
AbstractArticlePDF–2.2M
7.
Therapeutic development for Canavan disease using patient iPSCs introduced with the wild-type ASPA gene
Jianfei Chao, Lizhao Feng, Peng Ye, Xianwei Chen, Qi Cui, Guihua Sun, Tao Zhou, E Tian, Wendong Li, Weidong Hu, Arthur D. Riggs, Reuben Matalon, Yanhong Shi
iScience. 2022 Jun 17; 25(6): 104391. Published online 2022 May 11. doi: 10.1016/j.isci.2022.104391
PMCID:
PMC9142666
AbstractArticlePDF–4.4M
8.
Antisense Oligonucleotide Reverses Leukodystrophy in Canavan Disease Mice
Vanessa Hull, Yan Wang, Travis Burns, Sheng Zhang, Sarah Sternbach, Jennifer McDonough, Fuzheng Guo, David Pleasure
Ann Neurol. Author manuscript; available in PMC 2021 Oct 18.
Published in final edited form as: Ann Neurol. 2020 Mar; 87(3): 480–485. Published online 2020 Jan 22. doi: 10.1002/ana.25674
PMCID:
PMC8523037
AbstractArticlePDF–1.1M
9.
S100B is selectively expressed by gray matter protoplasmic astrocytes and myelinating oligodendrocytes in the developing CNS
Junqing Du, Min Yi, Fang Zhou, Wanjun He, Aifen Yang, Mengsheng Qiu, Hao Huang
Mol Brain. 2021; 14: 154. Published online 2021 Oct 6. doi: 10.1186/s13041-021-00865-9
PMCID:
PMC8496084
AbstractArticlePDF–9.0M
10.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
11.
N-Acetylaspartate Synthase Deficiency Corrects the Myelin Phenotype in a Canavan Disease Mouse Model But Does Not Affect Survival Time
Helena Maier, Lihua Wang-Eckhardt, Dieter Hartmann, Volkmar Gieselmann, Matthias Eckhardt
J Neurosci. 2015 Oct 28; 35(43): 14501–14516. doi: 10.1523/JNEUROSCI.1056-15.2015
PMCID:
PMC6605458
AbstractArticlePDF–9.1M
12.
Brain Nat8l Knockdown Suppresses Spongiform Leukodystrophy in an Aspartoacylase-Deficient Canavan Disease Mouse Model
Peter Bannerman, Fuzheng Guo, Olga Chechneva, Travis Burns, Xiaoqing Zhu, Yan Wang, Bokyung Kim, Naveen K. Singhal, Jennifer A. McDonough, David Pleasure
Mol Ther. 2018 Mar 7; 26(3): 793–800. Published online 2018 Jan 10. doi: 10.1016/j.ymthe.2018.01.002
PMCID:
PMC5910673
AbstractArticlePDF–3.5M
13.
Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy
Georg von Jonquieres, Ziggy H. T. Spencer, Benjamin D. Rowlands, Claudia B. Klugmann, Andre Bongers, Anne E. Harasta, Kristina E. Parley, Jennie Cederholm, Orla Teahan, Russell Pickford, Fabien Delerue, Lars M. Ittner, Dominik Fröhlich, Catriona A. McLean, Anthony S. Don, Miriam Schneider, Gary D. Housley, Caroline D. Rae, Matthias Klugmann
Acta Neuropathol. 2018; 135(1): 95–113. Published online 2017 Nov 7. doi: 10.1007/s00401-017-1784-9
PMCID:
PMC5756261
AbstractArticlePDF–12M
14.
Behavioral impairment in SHATI/NAT8L knockout mice via dysfunction of myelination development
Kazuyuki Sumi, Kyosuke Uno, Hiroshi Noike, Takenori Tomohiro, Yasumaru Hatanaka, Yoko Furukawa-Hibi, Toshitaka Nabeshima, Yoshiaki Miyamoto, Atsumi Nitta
Sci Rep. 2017; 7: 16872. Published online 2017 Dec 4. doi: 10.1038/s41598-017-17151-1
PMCID:
PMC5715020
AbstractArticlePDF–3.1M
15.
Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function
Andrew J. Kennedy, Elizabeth J. Rahn, Brynna S. Paulukaitis, Katherine E. Savell, Holly B. Kordasiewicz, Jing Wang, John W. Lewis, Jessica Posey, Sarah K. Strange, Mikael C. Guzman-Karlsson, Scott E. Phillips, Kyle Decker, S. Timothy Motley, Eric E. Swayze, David J. Ecker, Todd P. Michael, Jeremy J. Day, J. David Sweatt
Cell Rep. Author manuscript; available in PMC 2017 Dec 1.
Published in final edited form as: Cell Rep. 2016 Sep 6; 16(10): 2666–2685. Published online 2016 Aug 25. doi: 10.1016/j.celrep.2016.08.004
PMCID:
PMC5710002
AbstractArticlePDF–1.4M
16.
Redirecting N-acetylaspartate metabolism in the central nervous system normalizes myelination and rescues Canavan disease
Dominic J. Gessler, Danning Li, Hongxia Xu, Qin Su, Julio Sanmiguel, Serafettin Tuncer, Constance Moore, Jean King, Reuben Matalon, Guangping Gao
JCI Insight. 2017 Feb 9; 2(3): e90807. Published online 2017 Feb 9. doi: 10.1172/jci.insight.90807
PMCID:
PMC5291725
AbstractArticlePDF–1.2M
17.
Suppressing N-Acetyl-l-Aspartate Synthesis Prevents Loss of Neurons in a Murine Model of Canavan Leukodystrophy
Jiho Sohn, Peter Bannerman, Fuzheng Guo, Travis Burns, Laird Miers, Christopher Croteau, Naveen K. Singhal, Jennifer A. McDonough, David Pleasure
J Neurosci. 2017 Jan 11; 37(2): 413–421. doi: 10.1523/JNEUROSCI.2013-16.2016
PMCID:
PMC5242397
AbstractArticlePDF–5.6M
18.
N-acetylaspartate Supports the Energetic Demands of Developmental Myelination via Oligodendroglial Aspartoacylase
Jeremy S. Francis, Ireneusz Wojtas, Vladimir Markov, Steven J. Gray, Thomas J. McCown, R. Jude Samulski, Larissa T. Bilaniuk, Dah-Jyuu Wang, Darryl C. De Vivo, Christopher G. Janson, Paola Leone
Neurobiol Dis. Author manuscript; available in PMC 2017 Dec 1.
Published in final edited form as: Neurobiol Dis. 2016 Dec; 96: 323–334. Published online 2016 Oct 4. doi: 10.1016/j.nbd.2016.10.001
PMCID:
PMC5102763
AbstractArticlePDF–1.8M
19.
Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival
Emmanuel L. Gautier, Stoyan Ivanov, Jesse W. Williams, Stanley Ching-Cheng Huang, Genevieve Marcelin, Keke Fairfax, Peter L. Wang, Jeremy S. Francis, Paola Leone, David B. Wilson, Maxim N. Artyomov, Edward J. Pearce, Gwendalyn J. Randolph
J Exp Med. 2014 Jul 28; 211(8): 1525–1531. doi: 10.1084/jem.20140570
PMCID:
PMC4113942
AbstractArticlePDF–2.0M
20.
A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination
Marina R. Carpinelli, Anne K. Voss, Michael G. Manning, Ashwyn A. Perera, Anne A. Cooray, Benjamin T. Kile, Rachel A. Burt
Dis Model Mech. 2014 Jun; 7(6): 649–657. Published online 2014 Mar 28. doi: 10.1242/dmm.014605
PMCID:
PMC4036472
AbstractArticle

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