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Select item 77015711.

Changes in the expression and function of the PDE5 pathway in the obstructed urinary bladder

Weixiang He, Han Xiang, Daoquan Liu, Jianmin Liu, Mingzhou Li, Qian Wang, Qiaofeng Qian, Yan Li, Xun Fu, Ping Chen, Yuming Guo, Guang Zeng, Zhonghua Wu, Daxing Zhan, Xinghuan Wang, Michael E. DiSanto, Xinhua Zhang

J Cell Mol Med. 2020 Nov; 24(22): 13181–13195. Published online 2020 Oct 3. doi: 10.1111/jcmm.15926

PMCID:: PMC7701571

Abstract Article PDF–3.2M

Select item 53365772.

Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats

Gemma Sangüesa, Sonali Shaligram, Farjana Akther, Núria Roglans, Juan C. Laguna, Roshanak Rahimian, Marta Alegret

Am J Physiol Heart Circ Physiol. 2017 Feb 1; 312(2): H289–H304. Published online 2016 Dec 6. doi: 10.1152/ajpheart.00339.2016

PMCID:: PMC5336577

Abstract Article

Select item 46747413.

Upregulation of Phosphodiesterase type 5 in the Hyperplastic Prostate

Wenhao Zhang, Ning Zang, Yaoming Jiang, Ping Chen, Xinghuan Wang, Xinhua Zhang

Sci Rep. 2015; 5: 17888. Published online 2015 Dec 10. doi: 10.1038/srep17888

PMCID:: PMC4674741

Abstract Article PDF–1.5M

Select item 41444014.

Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: A mechanism by which angiotensin II antagonizes cGMP signaling

Dongsoo Kim, Toru Aizawa, Heng Wei, Xinchun Pi, Sergei D. Rybalkin, Bradford C. Berk, Chen Yan

J Mol Cell Cardiol. Author manuscript; available in PMC 2014 Aug 26.

Published in final edited form as: J Mol Cell Cardiol. 2005 Jan; 38(1): 175–184. Published online 2004 Dec 8. doi: 10.1016/j.yjmcc.2004.10.013

PMCID:: PMC4144401

Abstract Article PDF–973K

Select item 38418005.

Chronic vasodilation increases renal medullary PDE5A and α-ENaC through independent renin-angiotensin-aldosterone system pathways

Crystal A. West, Stefan Shaw, Jennifer M. Sasser, Andrea Fekete, Tyler Alexander, Mark W. Cunningham, Jr., Shyama M. E. Masilamani, Chris Baylis

Am J Physiol Regul Integr Comp Physiol. 2013 Nov 15; 305(10): R1133–R1140. Published online 2013 Sep 25. doi: 10.1152/ajpregu.00003.2013

PMCID:: PMC3841800

Abstract Article

Select item 31780596.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 29388477.

The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model

Weiguo Hu, Richard Jin, Jinyan Zhang, Tao You, Zhihai Peng, Xiaowen Ge, Roderick T. Bronson, Jose A. Halperin, Joseph Loscalzo, Xuebin Qin

Blood. 2010 Sep 2; 116(9): 1613–1622. Prepublished online 2010 May 28. doi: 10.1182/blood-2010-01-267112

PMCID:: PMC2938847

Abstract Article

Select item 28570618.

Phosphorylation of TRPC6 Channels at Thr⁶⁹ Is Required for Anti-hypertrophic Effects of Phosphodiesterase 5 Inhibition

Motohiro Nishida, Kenta Watanabe, Yoji Sato, Michio Nakaya, Naoyuki Kitajima, Tomomi Ide, Ryuji Inoue, Hitoshi Kurose

J Biol Chem. 2010 Apr 23; 285(17): 13244–13253. Published online 2010 Feb 22. doi: 10.1074/jbc.M109.074104

PMCID:: PMC2857061

Abstract Article PDF–1.7M

Select item 28377629.

Cyclic GMP/PKG-Dependent Inhibition of TRPC6 Channel Activity and Expression Negatively Regulates Cardiomyocyte NFAT Activation: Novel Mechanism of Cardiac Stress Modulation by PDE5 Inhibition

Norimichi Koitabashi, Takeshi Aiba, Geoffrey G. Hesketh, Janelle Rowell, Manling Zhang, Eiki Takimoto, Gordon F. Tomaselli, David A. Kass

J Mol Cell Cardiol. Author manuscript; available in PMC 2011 Apr 1.

Published in final edited form as: J Mol Cell Cardiol. 2010 Apr; 48(4): 713–724. Published online 2009 Dec 1. doi: 10.1016/j.yjmcc.2009.11.015

PMCID:: PMC2837762

Abstract Article PDF–2.2M

Select item 275679710.

Increased Activity of cGMP-Specific Phosphodiesterase (PDE5) Contributes to Resistance to Atrial Natriuretic Peptide Natriuresis in the Pregnant Rat

XI-PING NI, MASSY SAFAI, RAHUL RISHI, CHRIS BAYLIS, MICHAEL H. HUMPHREYS

J Am Soc Nephrol. Author manuscript; available in PMC 2009 Oct 5.

Published in final edited form as: J Am Soc Nephrol. 2004 May; 15(5): 1254–1260. doi: 10.1097/01.asn.0000125613.96927.38

PMCID:: PMC2756797

Abstract Article PDF–210K

Select item 273198111.

Cyclic GMP Signaling Is Involved in the Luteinizing Hormone-Dependent Meiotic Maturation of Mouse Oocytes

Sergio Vaccari, James L. Weeks, II, Minnie Hsieh, Frank S. Menniti, Marco Conti

Biol Reprod. 2009 Sep; 81(3): 595–604. Published online 2009 May 27. doi: 10.1095/biolreprod.109.077768

PMCID:: PMC2731981

Abstract Article PDF–439K

Select item 268017912.

Lack of Direct Androgen Regulation of PDE5 Expression

Rong Yang, Yun-Ching Huang, Guiting Lin, Guifang Wang, Steven Hung, Yu-Tian Dai, Ze-Yu Sun, Tom F. Lue, Ching-Shwun Lin

Biochem Biophys Res Commun. Author manuscript; available in PMC 2010 Mar 20.

Published in final edited form as: Biochem Biophys Res Commun. 2009 Mar 20; 380(4): 758–762. Published online 2009 Jan 29. doi: 10.1016/j.bbrc.2009.01.144

PMCID:: PMC2680179

Abstract Article PDF–1.8M

Select item 263129213.

Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice

Eiki Takimoto, Norimichi Koitabashi, Steven Hsu, Elizabeth A. Ketner, Manling Zhang, Takahiro Nagayama, Djahida Bedja, Kathleen L. Gabrielson, Robert Blanton, David P. Siderovski, Michael E. Mendelsohn, David A. Kass

J Clin Invest. 2009 Feb 2; 119(2): 408–420. Published online 2009 Jan 5. doi: 10.1172/JCI35620

PMCID:: PMC2631292

Abstract Article PDF–3.8M

Select item 260162814.

Expression, Activity, and Pro-Hypertrophic Effects of PDE5A in Cardiac Myocytes

Manling Zhang, Norimichi Koitabashi, Takahiro Nagayama, Ryan Rambaran, Ning Feng, Eiki Takimoto, Trisha Koenke, Brian O'Rourke, Hunter C. Champion, Michael T. Crow, David A. Kass

Cell Signal. Author manuscript; available in PMC 2009 Dec 1.

Published in final edited form as: Cell Signal. 2008 Dec; 20(12): 2231–2236. Published online 2008 Aug 26. doi: 10.1016/j.cellsig.2008.08.012