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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Article PDF–4.8M

Select item 102509172.

Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation

Leonid A. Parunov, Yideng Liang, Qijin Lu, Alexey M. Shibeko, Erik I. Tucker, Timothy K. Lee, Fazoil I. Ataullakhanov, Dorothy E. Scott, Mikhail V. Ovanesov

Blood Adv. 2023 Jun 13; 7(11): 2622–2631. Published online 2023 Feb 3. doi: 10.1182/bloodadvances.2022008743

PMCID:: PMC10250917

Article PDF–1.2M

Select item 67684083.

A non-circulating pool of factor XI associated with glycosaminoglycans in mice

Bassem M. Mohammed, Qiufang Cheng, Anton Matafonov, Ingrid M. Verhamme, Jonas Emsley, Keith R. McCrae, Owen J. T. McCarty, Andras Gruber, David Gailani

J Thromb Haemost. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: J Thromb Haemost. 2019 Sep; 17(9): 1449–1460. Published online 2019 Jun 17. doi: 10.1111/jth.14494

PMCID:: PMC6768408

Article PDF–850K

Select item 64053354.

A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain

Ivan Ivanov, Anton Matafonov, Mao-fu Sun, Bassem M. Mohammed, Qiufang Cheng, S. Kent Dickeson, Suman Kundu, Ingrid M. Verhamme, Andras Gruber, Keith McCrae, David Gailani

Blood. 2019 Mar 7; 133(10): 1152–1163. Prepublished online 2018 Dec 27. doi: 10.1182/blood-2018-06-860270

PMCID:: PMC6405335

Article

Select item 57878675.

Factor XI contributes to myocardial ischemia-reperfusion injury in mice

Christina U. Lorentz, Norah G. Verbout, Zhiping Cao, Lijuan Liu, Monica T. Hinds, Owen J. T. McCarty, Ivan Ivanov, Erik I. Tucker, David Gailani, András Gruber

Blood Adv. 2018 Jan 23; 2(2): 85–88. Published online 2018 Jan 10. doi: 10.1182/bloodadvances.2017004879

PMCID:: PMC5787867

Article PDF–753K

Select item 50258626.

Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection

Linda Labberton, Ellinor Kenne, Andy T. Long, Katrin F. Nickel, Antonio Di Gennaro, Rachel A. Rigg, James S. Hernandez, Lynn Butler, Coen Maas, Evi X. Stavrou, Thomas Renné

Nat Commun. 2016; 7: 12616. Published online 2016 Sep 6. doi: 10.1038/ncomms12616

PMCID:: PMC5025862

Article PDF–3.4M

Select item 48739827.

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells

Kerstin Göbel, Susann Pankratz, Chloi-Magdalini Asaridou, Alexander M. Herrmann, Stefan Bittner, Monika Merker, Tobias Ruck, Sarah Glumm, Friederike Langhauser, Peter Kraft, Thorsten F. Krug, Johanna Breuer, Martin Herold, Catharina C. Gross, Denise Beckmann, Adelheid Korb-Pap, Michael K. Schuhmann, Stefanie Kuerten, Ioannis Mitroulis, Clemens Ruppert, Marc W. Nolte, Con Panousis, Luisa Klotz, Beate Kehrel, Thomas Korn, Harald F. Langer, Thomas Pap, Bernhard Nieswandt, Heinz Wiendl, Triantafyllos Chavakis, Christoph Kleinschnitz, Sven G. Meuth

Nat Commun. 2016; 7: 11626. Published online 2016 May 18. doi: 10.1038/ncomms11626

PMCID:: PMC4873982

Article PDF–1.5M

Select item 48216168.

Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice

Charles E. Bane, Jr, Ivan Ivanov, Anton Matafonov, Kelli L. Boyd, Qiufang Cheng, Edward R. Sherwood, Erik I. Tucker, Stephen T. Smiley, Owen J. T. McCarty, Andras Gruber, David Gailani

PLoS One. 2016; 11(4): e0152968. Published online 2016 Apr 5. doi: 10.1371/journal.pone.0152968

PMCID:: PMC4821616

Article PDF–1.7M

Select item 47868439.

Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease

Erica M. Sparkenbaugh, Pichika Chantrathammachart, Kasemsiri Chandarajoti, Nigel Mackman, Nigel S. Key, Rafal Pawlinski

Blood. 2016 Mar 10; 127(10): 1371–1373. doi: 10.1182/blood-2015-11-681114

PMCID:: PMC4786843

Article

Select item 478589310.

Factor XI Deficiency Protects Against Atherogenesis in Apolipoprotein E/Factor XI Double Knockout Mice

Reut Shnerb Ganor, Dror Harats, Ginette Schiby, David Gailani, Hanna Levkovitz, Camila Avivi, Ilia Tamarin, Aviv Shaish, Ophira Salomon

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2016 Sep 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3): 475–481. Published online 2016 Jan 21. doi: 10.1161/ATVBAHA.115.306954

PMCID:: PMC4785893

Article PDF–2.0M

Select item 456681211.

The polyphosphate–factor XII pathway drives coagulation in prostate cancer-associated thrombosis

Katrin F. Nickel, Göran Ronquist, Florian Langer, Linda Labberton, Tobias A. Fuchs, Carsten Bokemeyer, Guido Sauter, Markus Graefen, Nigel Mackman, Evi X. Stavrou, Gunnar Ronquist, Thomas Renné

Blood. 2015 Sep 10; 126(11): 1379–1389. Prepublished online 2015 Jul 7. doi: 10.1182/blood-2015-01-622811

PMCID:: PMC4566812

Article

Select item 386576412.

Factor XI Anion-Binding Sites are required for Productive Interactions with Polyphosphate

Yipeng Geng, Ingrid M. Verhamme, Stephanie A. Smith, Qiufang Cheng, Mao-fu Sun, John P. Sheehan, James H. Morrissey, David Gailani

J Thromb Haemost. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: J Thromb Haemost. 2013 Nov; 11(11): 10.1111/jth.12414. doi: 10.1111/jth.12414

PMCID:: PMC3865764

Article PDF–841K

Select item 377473913.

Regulation of the F11, Klkb1, Cyp4v3 Gene Cluster in Livers of Metabolically Challenged Mice

Huma Safdar, Audrey C. A. Cleuren, Ka Lei Cheung, Frank J. Gonzalez, Hans L. Vos, Yusuke Inoue, Pieter H. Reitsma, Bart J. M. van Vlijmen

PLoS One. 2013; 8(9): e74637. Published online 2013 Sep 16. doi: 10.1371/journal.pone.0074637

PMCID:: PMC3774739

Article PDF–571K

Select item 365070714.

The dimeric structure of factor XI and zymogen activation

Yipeng Geng, Ingrid M. Verhamme, Stephen B. Smith, Mao-fu Sun, Anton Matafonov, Qiufang Cheng, Stephanie A. Smith, James H. Morrissey, David Gailani

Blood. 2013 May 9; 121(19): 3962–3969. Prepublished online 2013 Mar 20. doi: 10.1182/blood-2012-12-473629

PMCID:: PMC3650707

Article

Select item 362212415.

Fibrin facilitates both innate and T cell-mediated defense against Yersinia pestis.

Deyan Luo, Shiuan Lin, Jr, Michelle A. Parent, Isis Mullarky Kanevsky, Frank M. Szaba, Lawrence W. Kummer, Debra K. Duso, Michael Tighe, Jim Hill, Andras Gruber, Nigel Mackman, David Gailani, Stephen T. Smiley

J Immunol. Author manuscript; available in PMC 2014 Apr 15.

Published in final edited form as: J Immunol. 2013 Apr 15; 190(8): 4149–4161. Published online 2013 Mar 13. doi: 10.4049/jimmunol.1203253

PMCID:: PMC3622124

Article PDF–4.4M

Select item 359184916.

A CpG Mutational Hotspot in a ONECUT Binding Site Accounts for the Prevalent Variant of Hemophilia B Leyden

Alister P.W. Funnell, Michael D. Wilson, Benoit Ballester, Ka Sin Mak, Jon Burdach, Natisha Magan, Richard C.M. Pearson, Frederic P. Lemaigre, Kathryn M. Stowell, Duncan T. Odom, Paul Flicek, Merlin Crossley

Am J Hum Genet. 2013 Mar 7; 92(3): 460–467. doi: 10.1016/j.ajhg.2013.02.003

PMCID:: PMC3591849

Article PDF–737K

Select item 357241017.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Article PDF–1.1M

Select item 325568118.

Factor XI-Deficient Mice Display Reduced Inflammation, Coagulopathy, and Bacterial Growth during Listeriosis

Deyan Luo, Frank M. Szaba, Lawrence W. Kummer, Lawrence L. Johnson, Erik I. Tucker, Andras Gruber, David Gailani, Stephen T. Smiley

Infect Immun. 2012 Jan; 80(1): 91–99. doi: 10.1128/IAI.05568-11

PMCID:: PMC3255681

Article PDF–1.9M

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Article PDF–1.0M

Select item 315034020.

Protective roles for fibrin, tissue factor, PAI-1, and TAFI, but not FXI, during defense against the gram-negative bacterium Yersinia enterocolitica

Deyan Luo, Frank M. Szaba, Lawrence W. Kummer, Edward F. Plow, Nigel Mackman, David Gailani, Stephen T. Smiley

J Immunol. Author manuscript; available in PMC 2012 Aug 15.

Published in final edited form as: J Immunol. 2011 Aug 15; 187(4): 1866–1876. Published online 2011 Jul 1. doi: 10.4049/jimmunol.1101094

PMCID:: PMC3150340

Article PDF–1.6M

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