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Items: 1 to 20 of 157

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes
Yuan Yao, Jiaming Shi, Chunlai Zhang, Wei Gao, Ning Huang, Yaobei Liu, Weiwen Yan, Yingguang Han, Wenjuan Zhou, Liang Kong
Cell Death Dis. 2023 Nov; 14(11): 722. Published online 2023 Nov 7. doi: 10.1038/s41419-023-06249-2
PMCID:
PMC10630521
AbstractArticlePDF–5.3M
3.
Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk
Maria J Forteza, Martin Berg, Andreas Edsfeldt, Jangming Sun, Roland Baumgartner, Ilona Kareinen, Felipe Beccaria Casagrande, Ulf Hedin, Song Zhang, Ivan Vuckovic, Petras P Dzeja, Konstantinos A Polyzos, Anton Gisterå, Mette Trauelsen, Thue W Schwartz, Lea Dib, Joerg Herrmann, Claudia Monaco, Ljubica Matic, Isabel Gonçalves, Daniel F J Ketelhuth
Cardiovasc Res. 2023 Jun; 119(7): 1524–1536. Published online 2023 Mar 2. doi: 10.1093/cvr/cvad038
PMCID:
PMC10318388
AbstractArticlePDF–83M
4.
Analysis of a genetic region affecting mouse body weight
Connie L. K. Leung, Subashini Karunakaran, Michael G. Atser, Leyla Innala, Xiaoke Hu, Victor Viau, James D. Johnson, Susanne M. Clee
Physiol Genomics. 2023 Mar 1; 55(3): 132–146. Published online 2023 Jan 30. doi: 10.1152/physiolgenomics.00137.2022
PMCID:
PMC10042608
AbstractArticle
5.
Extracellular vesicle-derived circCEBPZOS attenuates postmyocardial infarction remodeling by promoting angiogenesis via the miR-1178-3p/PDPK1 axis
Ling Yu, Yubin Liang, Minzhou Zhang, Phillip C. Yang, Aleksander Hinek, Shuai Mao
Commun Biol. 2023; 6: 133. Published online 2023 Feb 1. doi: 10.1038/s42003-023-04505-x
PMCID:
PMC9892031
AbstractArticlePDF–3.1M
6.
Activation of long-non-coding RNA NEAT1 sponging microRNA-147 inhibits radiation damage by targeting PDPK1 in troxerutin radioprotection
Yong-jian Hu, Gui-yuan Song, Fan Zhang, Nan Zhang, Fei Wang, Jing-long Wang, Xia Wang, Tao-yang Wang, Yu-feng Li, Yi-di Yan, Wen-tao Dou, Chen-yi Cheng, Ping Xu
iScience. 2023 Feb 17; 26(2): 105932. Published online 2023 Jan 5. doi: 10.1016/j.isci.2023.105932
PMCID:
PMC9868541
AbstractArticlePDF–4.4M
7.
MicroRNA-193b impairs muscle growth in mouse models of type 2 diabetes by targeting the PDK1/Akt signalling pathway
Shu Yang, Guangyan Yang, Han Wu, Lin Kang, Jiaqing Xiang, Peilin Zheng, Shanhu Qiu, Zhen Liang, Yan Lu, Lijing Jia
Diabetologia. 2022; 65(3): 563–581. Published online 2021 Dec 16. doi: 10.1007/s00125-021-05616-y
PMCID:
PMC8803817
AbstractArticlePDF–7.9M
8.
A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro
Henry Querfurth, John Marshall, Keykavous Parang, Mengia S. Rioult-Pedotti, Rakesh Tiwari, Bumsup Kwon, Steve Reisinger, Han-Kyu Lee
PLoS One. 2022; 17(1): e0261696. Published online 2022 Jan 21. doi: 10.1371/journal.pone.0261696
Correction in:
PLoS One. 2024; 19(5): e0304731.
PMCID:
PMC8782417
AbstractArticlePDF–2.0M
9.
TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway
Suhong Zhang, Haiting Dai, Wenya Li, Runming Wang, Hanyu Wu, Ming Shen, Ye Hu, Lixin Xie, Yiming Xing
Cell Death Dis. 2021 Dec; 12(12): 1086. Published online 2021 Nov 16. doi: 10.1038/s41419-021-04369-1
PMCID:
PMC8599864
AbstractArticlePDF–5.8M
10.
Adhesion G protein–coupled receptor Gpr126/Adgrg6 is essential for placental development
Rebeca Torregrosa-Carrión, Rebeca Piñeiro-Sabarís, Marcos Siguero-Álvarez, Joaquím Grego-Bessa, Luis Luna-Zurita, Vitor Samuel Fernandes, Donal MacGrogan, Didier Y. R. Stainier, José Luis de la Pompa
Sci Adv. 2021 Nov; 7(46): eabj5445. Published online 2021 Nov 12. doi: 10.1126/sciadv.abj5445
PMCID:
PMC8589310
AbstractArticlePDF–19M
11.
Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes
Hyeon-Ji Kang, Byong-Keol Min, Won-Il Choi, Jae-Han Jeon, Dong Wook Kim, Sungmi Park, Yun-Kyung Lee, Hwa-jin Kim, Ju-Eun Byeon, Younghoon Go, Hye Jin Ham, Yong Hyun Jeon, Mi-Jin Kim, Jung Yi Lee, Adam R. Wende, Sung Hee Choi, Robert A. Harris, In-Kyu Lee
Exp Mol Med. 2021 Sep; 53(9): 1390–1401. Published online 2021 Sep 22. doi: 10.1038/s12276-021-00672-1
PMCID:
PMC8492875
AbstractArticlePDF–5.5M
12.
The kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis
Peiran Feng, Quanli Yang, Liang Luo, Yadong Sun, Wenkai Lv, Shuo Wan, Zerong Guan, Zhiqiang Xiao, Feng Liu, Zehua Li, Zhongjun Dong, Meixiang Yang
Theranostics. 2021; 11(19): 9503–9518. Published online 2021 Sep 13. doi: 10.7150/thno.63992
PMCID:
PMC8490516
AbstractArticlePDF–3.9M
13.
Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns
Anouk M Olthof, Alisa K White, Stephen Mieruszynski, Karen Doggett, Madisen F Lee, Almahdi Chakroun, Alice K Abdel Aleem, Justine Rousseau, Cinzia Magnani, Chaim M Roifman, Philippe M Campeau, Joan K Heath, Rahul N Kanadia
Nucleic Acids Res. 2021 Apr 6; 49(6): 3524–3545. Published online 2021 Feb 28. doi: 10.1093/nar/gkab118
PMCID:
PMC8034651
AbstractArticlePDF–7.2M
14.
PDK1 is required for maintenance of CD4+ FoxP3+ regulatory T cell function
Hyunju Oh, Jingyao Zhao, Yenkel Grinberg-Bleyer, Thomas S. Postler, Pingzhang Wang, Sung-Gyoo Park, Raul Rabadan, Matthew S. Hayden, Sankar Ghosh
J Immunol. Author manuscript; available in PMC 2022 Apr 15.
Published in final edited form as: J Immunol. 2021 Apr 15; 206(8): 1776–1783. Published online 2021 Mar 31. doi: 10.4049/jimmunol.2000051
PMCID:
PMC8026672
AbstractArticlePDF–2.1M
15.
Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes
Ji Liao, Tie-Bo Zeng, Nicholas Pierce, Diana A. Tran, Purnima Singh, Jeffrey R. Mann, Piroska E. Szabó
Cell Rep. Author manuscript; available in PMC 2021 Mar 17.
Published in final edited form as: Cell Rep. 2021 Feb 9; 34(6): 108729. doi: 10.1016/j.celrep.2021.108729
PMCID:
PMC7968144
AbstractArticlePDF–1.7M
16.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
17.
Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice
Ivan Menendez-Montes, Beatriz Escobar, Manuel J. Gomez, Teresa Albendea-Gomez, Beatriz Palacios, Elena Bonzon-Kulichenko, Jose Luis Izquierdo-Garcia, Ana Vanessa Alonso, Alessia Ferrarini, Luis Jesus Jimenez-Borreguero, Jesus Ruiz-Cabello, Jesus Vázquez, Silvia Martin-Puig
iScience. 2021 Feb 19; 24(2): 102124. Published online 2021 Feb 3. doi: 10.1016/j.isci.2021.102124
PMCID:
PMC7900219
AbstractArticlePDF–6.0M
18.
The kinase PDK1 is critical for promoting T follicular helper cell differentiation
Zhen Sun, Yingpeng Yao, Menghao You, Jingjing Liu, Wenhui Guo, Zhihong Qi, Zhao Wang, Fang Wang, Weiping Yuan, Shuyang Yu
eLife. 2021; 10: e61406. Published online 2021 Feb 17. doi: 10.7554/eLife.61406
PMCID:
PMC7889074
AbstractArticlePDF–8.0M
19.
PDK1 is a negative regulator of axon regeneration
Hyemin Kim, Jinyoung Lee, Yongcheol Cho
Mol Brain. 2021; 14: 31. Published online 2021 Feb 12. doi: 10.1186/s13041-021-00748-z
PMCID:
PMC7881570
AbstractArticlePDF–3.7M
20.
Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load
Naoki Kuramoto, Kazuhiro Nomura, Daisuke Kohno, Tadahiro Kitamura, Gerard Karsenty, Tetsuya Hosooka, Wataru Ogawa
Sci Rep. 2021; 11: 3447. Published online 2021 Feb 10. doi: 10.1038/s41598-021-83098-z
PMCID:
PMC7876046
AbstractArticlePDF–4.1M

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