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Select item 111366531.

LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11 axis

Nan Cao, Fangmei Zhang, Jiang Yin, Jianlei Zhang, Xiqing Bian, Guopei Zheng, Nan Li, Ying Lin, Liyun Luo

Oncogene. 2024; 43(22): 1714–1725. Published online 2024 Apr 11. doi: 10.1038/s41388-024-02996-4

PMCID:: PMC11136653

Abstract Article PDF–6.7M

Select item 110778432.

Implication of system x_c⁻ in neuroinflammation during the onset and maintenance of neuropathic pain

Pauline Beckers, Inês Belo Do Nascimento, Mathilde Charlier, Nathalie Desmet, Ann Massie, Emmanuel Hermans

J Neuroinflammation. 2024; 21: 117. Published online 2024 May 7. doi: 10.1186/s12974-024-03112-9

PMCID:: PMC11077843

Abstract Article PDF–4.0M

Select item 110773793.

Aberrant Expression of SLC7A11 Impairs the Antimicrobial Activities of Macrophages in Staphylococcus Aureus Osteomyelitis in Mice

Bingsheng Yang, Wen Shu, Jin Hu, Zhongwen Wang, Jichang Wu, Jianwen Su, Jianye Tan, Bin Yu, Xianrong Zhang

Int J Biol Sci. 2024; 20(7): 2555–2575. Published online 2024 Apr 22. doi: 10.7150/ijbs.93592

PMCID:: PMC11077379

Abstract Article PDF–19M

Select item 110477864.

SLC7A11-ROS/αKG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression

Tingting Lv, Xiude Fan, Chang He, Suwei Zhu, Xiaofeng Xiong, Wei Yan, Mei Liu, Hongwei Xu, Ruihua Shi, Qin He

Redox Biol. 2024 Jun; 72: 103159. Published online 2024 Apr 16. doi: 10.1016/j.redox.2024.103159

PMCID:: PMC11047786

Abstract Article PDF–22M

Select item 109506985.

IL-13 facilitates ferroptotic death in asthmatic epithelial cells via SOCS1-mediated ubiquitinated degradation of SLC7A11

Manli Miao, Min Pan, Xu Chen, Jiapan Shen, Ling Zhang, Xiaoxia Feng, Mengting Chen, Guofeng Cui, Huaiyuan Zong, Wen Zhang, Shuang Chang, Fangzhou Xu, Zixi Wang, Dapeng Li, Weiwei Liu, Zhao Ding, Shengquan Zhang, Biao Chen, Xiaojun Zha, Xiaoyun Fan

Redox Biol. 2024 May; 71: 103100. Published online 2024 Mar 8. doi: 10.1016/j.redox.2024.103100

PMCID:: PMC10950698

Abstract Article PDF–25M

Select item 109176606.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108670557.

LINC00942 inhibits ferroptosis and induces the immunosuppression of regulatory T cells by recruiting IGF2BP3/SLC7A11 in hepatocellular carcinoma

Dong Jin, Yongfeng Hui, Di Liu, Nan Li, Junzhi Leng, Genwang Wang, Qi Wang, Zhenhui Lu

Funct Integr Genomics. 2024; 24(1): 29. Published online 2024 Feb 14. doi: 10.1007/s10142-024-01292-4

PMCID:: PMC10867055

Abstract Article PDF–6.7M

Select item 105649098.

Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis

Qiong Wu, Zongwen Liang, Jing Jiang, Xiaoming Feng, Jinming Liu, Zongfeng Zhang, Honglin Wang, Ning Wang, Yanling Gou, Zhi Li, Yingying Cao

Cell Death Dis. 2023 Oct; 14(10): 668. Published online 2023 Oct 11. doi: 10.1038/s41419-023-06182-4

PMCID:: PMC10564909

Abstract Article PDF–7.5M

Select item 105418469.

Cystine/glutamate antiporter System x_c^- deficiency impairs insulin secretion in mice

Axel de Baat, Daniel T. Meier, Leila Rachid, Adriano Fontana, Marianne Böni-Schnetzler, Marc Y. Donath

Diabetologia. 2023; 66(11): 2062–2074. Published online 2023 Aug 31. doi: 10.1007/s00125-023-05993-6

PMCID:: PMC10541846

Abstract Article PDF–1.1M

Select item 1054031810.

Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models

Roberto Ruiu, Chiara Cossu, Antonella Iacoviello, Laura Conti, Elisabetta Bolli, Luca Ponzone, Jolanda Magri, Alekya Rumandla, Enzo Calautti, Federica Cavallo

J Exp Clin Cancer Res. 2023; 42: 254. Published online 2023 Sep 29. doi: 10.1186/s13046-023-02830-x

PMCID:: PMC10540318

Abstract Article PDF–5.2M

Select item 1046298211.

Sex- and age-dependent contribution of System x_c^– to cognitive, sensory, and social behaviors revealed by comprehensive behavioral analyses of System x_c^– null mice

Carla Frare, Shannon K. Pitt, Sandra J. Hewett

Front Behav Neurosci. 2023; 17: 1238349. Published online 2023 Aug 15. doi: 10.3389/fnbeh.2023.1238349

PMCID:: PMC10462982

Abstract Article PDF–5.5M

Select item 1028406712.

Cystine/Glutamate Xc^– Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis

Karina Orlowska, Russ R. Fling, Rance Nault, Anthony L. Schilmiller, Timothy R. Zacharewski

Chem Res Toxicol. 2023 Jun 19; 36(6): 900–915. Published online 2023 May 15. doi: 10.1021/acs.chemrestox.3c00017

PMCID:: PMC10284067

Abstract Article PDF–5.5M

Select item 1019956413.

CEBPG suppresses ferroptosis through transcriptional control of SLC7A11 in ovarian cancer

Xiaoqian Zhang, Xiaocui Zheng, Xiang Ying, Weiwei Xie, Yujia Yin, Xipeng Wang

J Transl Med. 2023; 21: 334. Published online 2023 May 20. doi: 10.1186/s12967-023-04136-0

PMCID:: PMC10199564

Abstract Article PDF–3.0M

Select item 1018405014.

NFATc1-mediated expression of SLC7A11 drives sensitivity to TXNRD1 inhibitors in osteoclast precursors

Zeyuan Zhong, Chongjing Zhang, Shuo Ni, Miao Ma, Xiaomeng Zhang, Weicong Sang, Tao Lv, Zhi Qian, Chengqing Yi, Baoqing Yu

Redox Biol. 2023 Jul; 63: 102711. Published online 2023 Apr 29. doi: 10.1016/j.redox.2023.102711

PMCID:: PMC10184050

Abstract Article PDF–13M

Select item 1008105515.

HRD1 functions as a tumor suppressor in ovarian cancer by facilitating ubiquitination-dependent SLC7A11 degradation

Yanyan Wang, Shanfeng Wang, Wenjuan Zhang

Cell Cycle. 2023; 22(9): 1116–1126. Published online 2023 Feb 21. doi: 10.1080/15384101.2023.2178102

PMCID:: PMC10081055

Abstract Article PDF–2.2M

Select item 975392916.

Loss of functional System x-c uncouples aberrant postnatal neurogenesis from epileptogenesis in the hippocampus of Kcna1-Ko mice

Macarena S. Aloi, Samantha J. Thompson, Nicholas Quartapella, Jeffrey L. Noebels

Cell Rep. Author manuscript; available in PMC 2022 Dec 15.

Published in final edited form as: Cell Rep. 2022 Nov 22; 41(8): 111696. doi: 10.1016/j.celrep.2022.111696

PMCID:: PMC9753929

Abstract Article PDF–1.8M

Select item 951173717.

AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation

Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang, Jinhong Chen

J Exp Clin Cancer Res. 2022; 41: 284. Published online 2022 Sep 26. doi: 10.1186/s13046-022-02493-0

Correction in:: J Exp Clin Cancer Res. 2022; 41: 313.

PMCID:: PMC9511737

Abstract Article PDF–9.2M

Select item 926278218.

CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11

Pan He, Feng Liu, Zhijun Wang, Haoli Gong, Meilan Zhang, Zhen Jia, Xiaohui Zhai

Mol Biol Rep. 2022; 49(6): 4525–4535. Published online 2022 May 17. doi: 10.1007/s11033-022-07296-2

PMCID:: PMC9262782

Abstract Article PDF–1.6M

Select item 925058919.

Disruption of Trip11 in cranial neural crest cells is associated with increased ER and Golgi stress contributing to skull defects in mice

Hiroyuki Yamaguchi, Matthew D. Meyer, Li He, Yoshihiro Komatsu

Dev Dyn. Author manuscript; available in PMC 2023 Jul 1.

Published in final edited form as: Dev Dyn. 2022 Jul; 251(7): 1209–1222. Published online 2022 Feb 18. doi: 10.1002/dvdy.461

PMCID:: PMC9250589

Abstract Article PDF–2.3M

Select item 920520220.

FTO Prevents Thyroid Cancer Progression by SLC7A11 m6A Methylation in a Ferroptosis-Dependent Manner

Fei-Hong Ji, Xing-Hao Fu, Guo-Quan Li, Qi He, Xin-Guang Qiu

Front Endocrinol (Lausanne) 2022; 13: 857765. Published online 2022 Jun 3. doi: 10.3389/fendo.2022.857765

PMCID:: PMC9205202

Abstract Article PDF–12M

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