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Items: 1 to 20 of 68

1.
Effects of glucokinase haploinsufficiency on the pancreatic β‐cell mass and function of long‐term high‐fat, high‐sucrose diet‐fed mice
Ikumi Shigesawa, Akinobu Nakamura, Yuki Yamauchi, Shinichiro Kawata, Asuka Miyazaki, Hiroshi Nomoto, Hiraku Kameda, Yasuo Terauchi, Tatsuya Atsumi
J Diabetes Investig. 2024 Dec; 15(12): 1732–1742. Published online 2024 Sep 21. doi: 10.1111/jdi.14307
PMCID:
PMC11615693
AbstractArticlePDF–6.5M
2.
Mice with deficiency in Pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature
Daisuke Mori, Chihiro Inami, Ryosuke Ikeda, Masahito Sawahata, Shinji Urata, Sho T. Yamaguchi, Yohei Kobayashi, Kosuke Fujita, Yuko Arioka, Hiroki Okumura, Itaru Kushima, Akiko Kodama, Toshiaki Suzuki, Takashi Hirao, Akira Yoshimi, Akira Sobue, Takahiro Ito, Yukikiro Noda, Hiroyuki Mizoguchi, Taku Nagai, Kozo Kaibuchi, Shigeo Okabe, Koji Nishiguchi, Kazuhiko Kume, Kiyofumi Yamada, Norio Ozaki
Transl Psychiatry. 2024; 14: 216. Published online 2024 May 28. doi: 10.1038/s41398-024-02952-6
PMCID:
PMC11133426
AbstractArticlePDF–3.4M
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell
Jeong Han Lee, Maria C. Perez-Flores, Seojin Park, Hyo Jeong Kim, Yingying Chen, Mincheol Kang, Jennifer Kersigo, Jinsil Choi, Phung N. Thai, Ryan L. Woltz, Dolores Columba Perez-Flores, Guy Perkins, Choong-Ryoul Sihn, Pauline Trinh, Xiao-Dong Zhang, Padmini Sirish, Yao Dong, Wayne Wei Feng, Isaac N. Pessah, Rose E. Dixon, Bernd Sokolowski, Bernd Fritzsch, Nipavan Chiamvimonvat, Ebenezer N. Yamoah
Nat Commun. 2024; 15: 526. Published online 2024 Jan 16. doi: 10.1038/s41467-023-44230-x
PMCID:
PMC10791687
AbstractArticlePDF–5.3M
5.
Control of stereocilia length during development of hair bundles
Jocelyn F. Krey, Paroma Chatterjee, Julia Halford, Christopher L. Cunningham, Benjamin J. Perrin, Peter G. Barr-Gillespie
PLoS Biol. 2023 Apr; 21(4): e3001964. Published online 2023 Apr 3. doi: 10.1371/journal.pbio.3001964
PMCID:
PMC10101650
AbstractArticlePDF–13M
6.
Ca2+ entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips
Julia Halford, Michael Bateschell, Peter G. Barr-Gillespie
Mol Biol Cell. 2022 Apr 1; 33(4): br6. Published online 2022 Mar 29. doi: 10.1091/mbc.E21-10-0491
PMCID:
PMC9250357
AbstractArticlePDF–14M
7.
Protocadherin 15 suppresses oligodendrocyte progenitor cell proliferation and promotes motility through distinct signalling pathways
Yilan Zhen, Carlie L. Cullen, Raphael Ricci, Benjamin S. Summers, Sakina Rehman, Zubair M. Ahmed, Antoinette Y. Foster, Ben Emery, Robert Gasperini, Kaylene M. Young
Commun Biol. 2022; 5: 511. Published online 2022 May 30. doi: 10.1038/s42003-022-03470-1
PMCID:
PMC9151716
AbstractArticlePDF–13M
8.
Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme
Morag A. Lewis, Neil J. Ingham, Jing Chen, Selina Pearson, Francesca Di Domenico, Sohinder Rekhi, Rochelle Allen, Matthew Drake, Annelore Willaert, Victoria Rook, Johanna Pass, Thomas Keane, David J. Adams, Abigail S. Tucker, Jacqueline K. White, Karen P. Steel
BMC Biol. 2022; 20: 67. Published online 2022 Mar 17. doi: 10.1186/s12915-022-01257-8
PMCID:
PMC8928630
AbstractArticlePDF–27M
9.
Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography
Johannes Elferich, Sarah Clark, Jingpeng Ge, April Goehring, Aya Matsui, Eric Gouaux
eLife. 2021; 10: e74512. Published online 2021 Dec 29. doi: 10.7554/eLife.74512
PMCID:
PMC8776254
AbstractArticlePDF–8.3M
10.
Proposed therapy, developed in a Pcdh15-deficient mouse, for progressive loss of vision in human Usher syndrome
Saumil Sethna, Wadih M Zein, Sehar Riaz, Arnaud PJ Giese, Julie M Schultz, Todd Duncan, Robert B Hufnagel, Carmen C Brewer, Andrew J Griffith, T Michael Redmond, Saima Riazuddin, Thomas B Friedman, Zubair M Ahmed
eLife. 2021; 10: e67361. Published online 2021 Nov 9. doi: 10.7554/eLife.67361
PMCID:
PMC8577840
AbstractArticlePDF–9.7M
11.
Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells
Vincent Michel, Elise Pepermans, Jacques Boutet de Monvel, Patrick England, Sylvie Nouaille, Alain Aghaie, Florent Delhommel, Nicolas Wolff, Isabelle Perfettini, Jean-Pierre Hardelin, Christine Petit, Amel Bahloul
Sci Rep. 2020; 10: 16430. Published online 2020 Oct 2. doi: 10.1038/s41598-020-73158-1
PMCID:
PMC7532178
AbstractArticlePDF–1.8M
12.
Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane
Paul Avan, Sébastien Le Gal, Vincent Michel, Typhaine Dupont, Jean-Pierre Hardelin, Christine Petit, Elisabeth Verpy
Proc Natl Acad Sci U S A. 2019 Dec 17; 116(51): 25948–25957. Published online 2019 Nov 27. doi: 10.1073/pnas.1902781116
PMCID:
PMC6926040
AbstractArticlePDF–3.3M
13.
The Tip-Link Antigen, a Protein Associated with the Transduction Complex of Sensory Hair Cells, Is Protocadherin-15
Zubair M. Ahmed, Richard Goodyear, Saima Riazuddin, Ayala Lagziel, P. Kevin Legan, Martine Behra, Shawn M. Burgess, Kathryn S. Lilley, Edward R. Wilcox, Sheikh Riazuddin, Andrew J. Griffith, Gregory I. Frolenkov, Inna A. Belyantseva, Guy P. Richardson, Thomas B. Friedman
J Neurosci. 2006 Jun 28; 26(26): 7022–7034. doi: 10.1523/JNEUROSCI.1163-06.2006
PMCID:
PMC6673907
AbstractArticlePDF–1.0M
14.
Hair Cell Mechanotransduction Regulates Spontaneous Activity and Spiral Ganglion Subtype Specification in the Auditory System
Shuohao Sun, Travis Babola, Gabriela Pregernig, Kathy So, Matthew Nguyen, Michael Su, Adam Palermo, Dwight E. Bergles, Joseph C. Burns, Ulrich Müller
Cell. Author manuscript; available in PMC 2019 Aug 23.
Published in final edited form as: Cell. 2018 Aug 23; 174(5): 1247–1263.e15. Published online 2018 Aug 2. doi: 10.1016/j.cell.2018.07.008
PMCID:
PMC6429032
AbstractArticlePDF–1.7M
15.
A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15
Pedro De-la-Torre, Deepanshu Choudhary, Raul Araya-Secchi, Yoshie Narui, Marcos Sotomayor
Biophys J. 2018 Dec 18; 115(12): 2368–2385. Published online 2018 Nov 16. doi: 10.1016/j.bpj.2018.11.010
PMCID:
PMC6302040
AbstractArticlePDF–4.4M
16.
Mechanotransduction by Pcdh15 relies on a novel cis-dimeric architecture
Gilman Dionne, Xufeng Qiu, Micah Rapp, Xiaoping Liang, Bo Zhao, Guihong Peng, Phinikoula S. Katsamba, Goran Ahlsen, Rotem Rubinstein, Clinton S. Potter, Bridget Carragher, Barry Honig, Ulrich Müller, Lawrence Shapiro
Neuron. Author manuscript; available in PMC 2018 Oct 2.
Published in final edited form as: Neuron. 2018 Aug 8; 99(3): 480–492.e5. Published online 2018 Jul 26. doi: 10.1016/j.neuron.2018.07.006
PMCID:
PMC6168201
AbstractArticlePDF–1.5M
17.
Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation
Laura F. Corns, Stuart L. Johnson, Terri Roberts, Kishani M. Ranatunga, Aenea Hendry, Federico Ceriani, Saaid Safieddine, Karen P. Steel, Andy Forge, Christine Petit, David N. Furness, Corné J. Kros, Walter Marcotti
Nat Commun. 2018; 9: 4015. Published online 2018 Oct 1. doi: 10.1038/s41467-018-06307-w
PMCID:
PMC6167318
AbstractArticlePDF–3.9M
18.
FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia
Akira Honda, Tomoko Kita, Shri Vidhya Seshadri, Kazuyo Misaki, Zamal Ahmed, John E. Ladbury, Guy P. Richardson, Shigenobu Yonemura, Raj K. Ladher
Proc Natl Acad Sci U S A. 2018 Aug 14; 115(33): 8388–8393. Published online 2018 Jul 30. doi: 10.1073/pnas.1719861115
PMCID:
PMC6099903
AbstractArticlePDF–1.6M
19.
Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5
Jingpeng Ge, Johannes Elferich, April Goehring, Huaying Zhao, Peter Schuck, Eric Gouaux
eLife. 2018; 7: e38770. Published online 2018 Aug 2. doi: 10.7554/eLife.38770
PMCID:
PMC6092121
AbstractArticlePDF–5.4M
20.
Tuning Inner-Ear Tip-Link Affinity Through Alternatively Spliced Variants of Protocadherin-15
Yoshie Narui, Marcos Sotomayor
Biochemistry. Author manuscript; available in PMC 2019 Mar 20.
Published in final edited form as: Biochemistry. 2018 Mar 20; 57(11): 1702–1710. Published online 2018 Mar 6. doi: 10.1021/acs.biochem.7b01075
PMCID:
PMC5892193
AbstractArticlePDF–798K

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