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Select item 112534051.

PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation

Frida Lind-Holm Mogensen, Carole Sousa, Corrado Ameli, Katja Badanjak, Sandro L. Pereira, Arnaud Muller, Tony Kaoma, Djalil Coowar, Andrea Scafidi, Suresh K. Poovathingal, Maria Tziortziou, Paul M. A. Antony, Nathalie Nicot, Aurélien Ginolhac, Daniela M. Vogt Weisenhorn, Wolfgang Wurst, Aurélie Poli, Petr V. Nazarov, Alexander Skupin, Anne Grünewald, Alessandro Michelucci

J Neuroinflammation. 2024; 21: 174. Published online 2024 Jul 16. doi: 10.1186/s12974-024-03164-x

PMCID:: PMC11253405

Abstract Article PDF–6.8M

Select item 111132542.

N‐homocysteinylation of DJ‐1 promotes neurodegeneration in Parkinson's disease

Tao Guo, Lingyan Zhou, Min Xiong, Jing Xiong, Juan Huang, Yiming Li, Guoxin Zhang, Guiqin Chen, Zhi‐Hao Wang, Tingting Xiao, Dan Hu, Anyu Bao, Zhentao Zhang

Aging Cell. 2024 May; 23(5): e14124. Published online 2024 Feb 21. doi: 10.1111/acel.14124

PMCID:: PMC11113254

Abstract Article PDF–7.2M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106363624.

Aberrant DJ-1 expression underlies L-type calcium channel hypoactivity in dendrites in tuberous sclerosis complex and Alzheimer’s disease

Farr Niere, Ayse Uneri, Colin J. McArdle, Zhiyong Deng, Hailey X. Egido-Betancourt, Luisa P. Cacheaux, Sanjeev V. Namjoshi, William C. Taylor, Xin Wang, Samuel H. Barth, Cameron Reynoldson, Juan Penaranda, Michael P. Stierer, Chelcie F. Heaney, Suzanne Craft, C. Dirk Keene, Tao Ma, Kimberly F. Raab-Graham

Proc Natl Acad Sci U S A. 2023 Nov 7; 120(45): e2301534120. Published online 2023 Oct 30. doi: 10.1073/pnas.2301534120

PMCID:: PMC10636362

Abstract Article PDF–7.7M

Select item 105457725.

Loss of DJ-1 function contributes to Parkinson’s disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation

Le-le Liu, Yu Han, Zi-jia Zhang, Yi-qi Wang, Yu-wei Hu, Elena Kaznacheyeva, Jian-qing Ding, Dong-kai Guo, Guang-hui Wang, Bin Li, Hai-gang Ren

Acta Pharmacol Sin. 2023 Oct; 44(10): 1948–1961. Published online 2023 May 25. doi: 10.1038/s41401-023-01104-8

PMCID:: PMC10545772

Abstract Article PDF–6.6M

Select item 103078526.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 96038607.

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3

Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany

Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527

PMCID:: PMC9603860

Abstract Article PDF–3.4M

Select item 95399848.

DJ‐1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons

Melissa Conti Mazza, Sarah C. Shuck, Jiusheng Lin, Michael A. Moxley, John Termini, Mark R. Cookson, Mark A. Wilson

J Neurochem. 2022 Aug; 162(3): 245–261. Published online 2022 Jul 2. doi: 10.1111/jnc.15656

PMCID:: PMC9539984

Abstract Article PDF–6.1M

Select item 95057559.

PARK7 deficiency inhibits fatty acid β‐oxidation via PTEN to delay liver regeneration after hepatectomy

Xiaoye Qu, Yankai Wen, Junzhe Jiao, Jie Zhao, Xuehua Sun, Fang Wang, Yueqiu Gao, Weifeng Tan, Qiang Xia, Hailong Wu, Xiaoni Kong

Clin Transl Med. 2022 Sep; 12(9): e1061. Published online 2022 Sep 23. doi: 10.1002/ctm2.1061

PMCID:: PMC9505755

Abstract Article PDF–4.3M

Select item 948193310.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 889234511.

DJ‐1 depletion prevents immunoaging in T‐cell compartments

Ni Zeng, Christophe M Capelle, Alexandre Baron, Takumi Kobayashi, Severine Cire, Vera Tslaf, Cathy Leonard, Djalil Coowar, Haruhiko Koseki, Astrid M Westendorf, Jan Buer, Dirk Brenner, Rejko Krüger, Rudi Balling, Markus Ollert, Feng Q Hefeng

EMBO Rep. 2022 Mar 3; 23(3): e53302. Published online 2022 Jan 17. doi: 10.15252/embr.202153302

PMCID:: PMC8892345

Abstract Article PDF–1.7M

Select item 879555512.

Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite

Isaac P. Heremans, Francesco Caligiore, Isabelle Gerin, Marina Bury, Marilena Lutz, Julie Graff, Vincent Stroobant, Didier Vertommen, Aurelio A. Teleman, Emile Van Schaftingen, Guido T. Bommer

Proc Natl Acad Sci U S A. 2022 Jan 25; 119(4): e2111338119. Published online 2022 Jan 19. doi: 10.1073/pnas.2111338119

PMCID:: PMC8795555

Abstract Article PDF–1.4M

Select item 874425713.

The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins

Mickaële Hémono, Alexandre Haller, Johana Chicher, Anne-Marie Duchêne, Richard Patryk Ngondo

BMC Biol. 2022; 20: 13. Published online 2022 Jan 10. doi: 10.1186/s12915-021-01213-y

PMCID:: PMC8744257

Abstract Article PDF–6.0M

Select item 848466214.

DJ-1 attenuates the glycation of mitochondrial complex I and complex III in the post-ischemic heart

Yvanna Pantner, Rohini Polavarapu, Lih-Shen Chin, Lian Li, Yuuki Shimizu, John W. Calvert

Sci Rep. 2021; 11: 19408. Published online 2021 Sep 30. doi: 10.1038/s41598-021-98722-1

PMCID:: PMC8484662

Abstract Article PDF–1.4M

Select item 839506615.

Red Light Irradiation In Vivo Upregulates DJ-1 in the Retinal Ganglion Cell Layer and Protects against Axotomy-Related Dendritic Pruning

Kathy Beirne, Thomas J. Freeman, Malgorzata Rozanowska, Marcela Votruba

Int J Mol Sci. 2021 Aug; 22(16): 8380. Published online 2021 Aug 4. doi: 10.3390/ijms22168380

PMCID:: PMC8395066

Abstract Article PDF–52M

Select item 828625616.

DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65

Zixuan Lin, Chen Chen, Dongqin Yang, Jianqing Ding, Guanghui Wang, Haigang Ren

Cell Death Dis. 2021 Aug; 12(8): 715. Published online 2021 Jul 17. doi: 10.1038/s41419-021-04002-1

PMCID:: PMC8286256

Abstract Article PDF–6.0M

Select item 825898317.

DJ-1 Deficiency in Hepatocytes Improves Liver Ischemia-Reperfusion Injury by Enhancing Mitophagy

Min Xu, Hualian Hang, Miao Huang, Jichang Li, Dongwei Xu, Junzhe Jiao, Fang Wang, Hailong Wu, Xuehua Sun, Jinyang Gu, Xiaoni Kong, Yueqiu Gao

Cell Mol Gastroenterol Hepatol. 2021; 12(2): 567–584. Published online 2021 Mar 23. doi: 10.1016/j.jcmgh.2021.03.007

PMCID:: PMC8258983

Abstract Article PDF–6.1M

Select item 820919418.

The C terminus of DJ-1 determines its homodimerization, MGO detoxification activity and suppression of ferroptosis

Li Jiang, Xiao-bing Chen, Qian Wu, Hai-ying Zhu, Cheng-yong Du, Mei-dan Ying, Qiao-jun He, Hong Zhu, Bo Yang, Ji Cao

Acta Pharmacol Sin. 2021 Jul; 42(7): 1150–1159. Published online 2020 Oct 6. doi: 10.1038/s41401-020-00531-1

PMCID:: PMC8209194

Abstract Article PDF–2.8M

Select item 817611419.

PARK7 Protects Against Chronic Kidney Injury and Renal Fibrosis by Inducing SOD2 to Reduce Oxidative Stress

Lijun Yin, Honglin Li, Zhiwen Liu, Wenwen Wu, Juan Cai, Chengyuan Tang, Zheng Dong

Front Immunol. 2021; 12: 690697. Published online 2021 May 21. doi: 10.3389/fimmu.2021.690697

PMCID:: PMC8176114

Abstract Article PDF–13M

Select item 813672720.

Extracellular DJ-1 induces sterile inflammation in the ischemic brain

Koutarou Nakamura, Seiichiro Sakai, Jun Tsuyama, Akari Nakamura, Kento Otani, Kumiko Kurabayashi, Yoshiko Yogiashi, Hisao Masai, Takashi Shichita

PLoS Biol. 2021 May; 19(5): e3000939. Published online 2021 May 20. doi: 10.1371/journal.pbio.3000939

PMCID:: PMC8136727

Abstract Article PDF–2.1M

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