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Items: 1 to 20 of 208

1.
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity
Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yi-Chun Lin, Song-Bai Liu, Huafeng Wang, Le Xuan Truong Nguyen, Min Li, Yinghui Zhu, Dandan Zhao, Lucy Ghoda, Jonathan Serody, Benjamin Vincent, Leo Luznik, Ivana Gojo, Joshua Zeidner, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Lyna Luo, Ling Li
Nat Cancer. 2024; 5(4): 601–624. Published online 2024 Feb 27. doi: 10.1038/s43018-024-00736-x
PMCID:
PMC11056319
ArticlePDF–33M
2.
HLA-DQ8 Supports Development of Insulitis Mediated By Insulin-Reactive Human TCR-Transgenic T-cells In NOD Mice
Jeremy J. Racine, Adel Misherghi, Jennifer R. Dwyer, Richard Maser, Elvira Forte, Olivia Bedard, Susanne Sattler, Alberto Pugliese, Laurie Landry, Colleen Elso, Maki Nakayama, Stuart Mannering, Nadia Rosenthal, David V. Serreze
J Immunol. Author manuscript; available in PMC 2024 Dec 15.
Published in final edited form as: J Immunol. 2023 Dec 15; 211(12): 1792–1805. doi: 10.4049/jimmunol.2300303
PMCID:
PMC10939972
ArticlePDF–1.6M
3.
NLGN4X TCR transgenic T cells to treat gliomas
Christoper Krämer, Michael Kilian, Yu-Chan Chih, Alexandros Kourtesakis, Dirk C Hoffmann, Tamara Boschert, Philipp Koopmann, Khwab Sanghvi, Alice De Roia, Stefanie Jung, Kristine Jähne, Bryan Day, Lenny D Shultz, Miriam Ratliff, Richard Harbottle, Edward W Green, Rainer Will, Wolfgang Wick, Michael Platten, Lukas Bunse
Neuro Oncol. 2024 Feb; 26(2): 266–278. Published online 2023 Sep 16. doi: 10.1093/neuonc/noad172
PMCID:
PMC10836769
ArticlePDF–3.4M
4.
A narrow T cell receptor repertoire instructs thymic differentiation of MHC class Ib–restricted CD8+ regulatory T cells
Hye-Jung Kim, Hidetoshi Nakagawa, John Y. Choi, Xuchun Che, Andrew Divris, Qingshi Liu, Andrew E. Wight, Hengcheng Zhang, Anis Saad, Zhabiz Solhjou, Christa Deban, Jamil R. Azzi, Harvey Cantor
J Clin Invest. 2024 Jan 2; 134(1): e170512. Published online 2024 Jan 2. doi: 10.1172/JCI170512
PMCID:
PMC10760956
ArticlePDF–2.1M
5.
Antitumor activity of AZD0754, a dnTGFβRII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer
Peter Zanvit, Dewald van Dyk, Christine Fazenbaker, Kelly McGlinchey, Weichuan Luo, Jessica M. Pezold, John Meekin, Chien-ying Chang, Rosa A. Carrasco, Shannon Breen, Crystal Sao-Fong Cheung, Ariel Endlich-Frazier, Benjamin Clark, Nina J. Chu, Alessio Vantellini, Philip L. Martin, Clare E. Hoover, Kenesha Riley, Steve M. Sweet, David Chain, Yeoun Jin Kim, Eric Tu, Nathalie Harder, Sandrina Phipps, Melissa Damschroder, Ryan N. Gilbreth, Mark Cobbold, Gordon Moody, Emily E. Bosco
J Clin Invest. 2023 Nov 15; 133(22): e169655. Published online 2023 Nov 15. doi: 10.1172/JCI169655
PMCID:
PMC10645390
ArticlePDF–2.6M
6.
The promiscuous development of an unconventional Qa1b-restricted T cell population
Michael Manoharan Valerio, Kathya Arana, Jian Guan, Shiao Wei Chan, Xiaokun Yang, Nadia Kurd, Angus Lee, Nilabh Shastri, Laurent Coscoy, Ellen A. Robey
Front Immunol. 2023; 14: 1250316. Published online 2023 Oct 31. doi: 10.3389/fimmu.2023.1250316
PMCID:
PMC10644506
ArticlePDF–2.8M
7.
Ring1a protects against colitis through regulating mucosal immune system and colonic microbial ecology
Yashu Wang, Qianru Li, Jiayu Zhang, Pingping Liu, Huaixin Zheng, Lijuan Chen, Zhen Wang, Chen Tan, Min Zhang, Hongxia Zhang, Wenqing Miao, Yuke Wang, Xiaoyan Xuan, Guoqiang Yi, Peng Wang
Gut Microbes. 2023; 15(2): 2251646. Published online 2023 Sep 1. doi: 10.1080/19490976.2023.2251646
PMCID:
PMC10478745
ArticlePDF–5.1M
8.
PRC1 suppresses a female gene regulatory network to ensure testicular differentiation
So Maezawa, Masashi Yukawa, Kazuteru Hasegawa, Ryo Sugiyama, Mizuho Iizuka, Mengwen Hu, Akihiko Sakashita, Miguel Vidal, Haruhiko Koseki, Artem Barski, Tony DeFalco, Satoshi H. Namekawa
Cell Death Dis. 2023 Aug; 14(8): 501. Published online 2023 Aug 4. doi: 10.1038/s41419-023-05996-6
PMCID:
PMC10403552
ArticlePDF–3.8M
9.
Polycomb group protein CBX7 represses cardiomyocyte proliferation via modulation of the TARDBP/RBM38 axis
Kyu-Won Cho, Mark Andrade, Seongho Bae, Sangsung Kim, Jin Eyun Kim, Er Yearn Jang, Sangho Lee, Ahsan Husain, Roy L. Sutliff, John W. Calvert, Changwon Park, Young-sup Yoon
Circulation. Author manuscript; available in PMC 2024 Jun 13.
Published in final edited form as: Circulation. 2023 Jun 13; 147(24): 1823–1842. Published online 2023 May 9. doi: 10.1161/CIRCULATIONAHA.122.061131
PMCID:
PMC10330362
ArticlePDF–1.6M
10.
USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice
Xingguo Li, Jun Zhang, Bing Wang, Chao Chen, Enyu Zhang, Zhengpin Lv, Qicong He, Yaoquan Hu, Xuenan Wang, Fan Zhang
Biol Direct. 2023; 18: 37. Published online 2023 Jul 6. doi: 10.1186/s13062-023-00395-5
PMCID:
PMC10324278
ArticlePDF–2.7M
11.
Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model
Jiwon Yang, Jing Jiao, Kyle M. Draheim, Guoxiang Yang, Hongyuan Yang, Li-Chin Yao, Leonard D. Shultz, Dale L. Greiner, Deepa Rajagopal, Sandrine Vessillier, Curtis C. Maier, Sunish Mohanan, Danying Cai, Mingshan Cheng, Michael A. Brehm, James G. Keck
FASEB J. Author manuscript; available in PMC 2024 Jun 1.
Published in final edited form as: FASEB J. 2023 Jun; 37(6): e22995. doi: 10.1096/fj.202300040R
PMCID:
PMC10242584
ArticlePDF–1.6M
12.
Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome
Brianna K. Unda, Leon Chalil, Sehyoun Yoon, Savannah Kilpatrick, Courtney Irwin, Sansi Xing, Nadeem Murtaza, Anran Cheng, Chad Brown, Alexandria Afonso, Elizabeth McCready, Gabriel M. Ronen, Jennifer Howe, Aurélie Caye-Eude, Alain Verloes, Brad W. Doble, Laurence Faivre, Antonio Vitobello, Stephen W. Scherer, Yu Lu, Peter Penzes, Karun K. Singh
Mol Psychiatry. 2023; 28(4): 1747–1769. Published online 2023 Jan 6. doi: 10.1038/s41380-022-01937-5
PMCID:
PMC10208958
ArticlePDF–7.0M
13.
Deciphering the immunopeptidome in vivo reveals novel tumor antigens
Alex M. Jaeger, Lauren E. Stopfer, Ryuhjin Ahn, Emma A. Sanders, Demi A. Sandel, William A. Freed-Pastor, William M. Rideout, III, Santiago Naranjo, Tim Fessenden, Kim B. Nguyen, Peter S. Winter, Ryan E. Kohn, Peter M. K. Westcott, Jason Schenkel, Sean-Luc Shanahan, Alex K. Shalek, Stefani Spranger, Forest M. White, Tyler Jacks
Nature. Author manuscript; available in PMC 2023 Feb 22.
Published in final edited form as: Nature. 2022 Jul; 607(7917): 149–155. Published online 2022 Jun 15. doi: 10.1038/s41586-022-04839-2
PMCID:
PMC9945857
ArticlePDF–2.7M
14.
Mechanisms of CD40-dependent cDC1 licensing beyond costimulation
Renee Wu, Ray A. Ohara, Suin Jo, Tian-Tian Liu, Stephen T. Ferris, Feiya Ou, Sunkyung Kim, Derek J. Theisen, David A. Anderson, III, Brian W. Wong, Timothy Gershon, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy
Nat Immunol. Author manuscript; available in PMC 2023 Feb 3.
Published in final edited form as: Nat Immunol. 2022 Nov; 23(11): 1536–1550. Published online 2022 Oct 21. doi: 10.1038/s41590-022-01324-w
PMCID:
PMC9896965
ArticlePDF–2.6M
15.
Dendritic cells can prime anti-tumor CD8+ T cell responses through major histocompatibility complex cross-dressing
Brendan W. MacNabb, Sravya Tumuluru, Xiufen Chen, James Godfrey, Darshan N. Kasal, Jovian Yu, Marlieke L. M. Jongsma, Robbert M. Spaapen, Douglas E. Kline, Justin Kline
Immunity. Author manuscript; available in PMC 2023 Jun 14.
Published in final edited form as: Immunity. 2022 Jun 14; 55(6): 982–997.e8. Published online 2022 May 25. doi: 10.1016/j.immuni.2022.04.016
Correction in:
Immunity. 2022 Nov 8; 55(11): 2206–2208.
PMCID:
PMC9883788
ArticlePDF–3.2M
16.
PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment
Junichiro Takano, Shinsuke Ito, Yixing Dong, Jafar Sharif, Yaeko Nakajima-Takagi, Taichi Umeyama, Yong-Woon Han, Kyoichi Isono, Takashi Kondo, Yusuke Iizuka, Tomohiro Miyai, Yoko Koseki, Mika Ikegaya, Mizuki Sakihara, Manabu Nakayama, Osamu Ohara, Yoshinori Hasegawa, Kosuke Hashimoto, Erik Arner, Robert J. Klose, Atsushi Iwama, Haruhiko Koseki, Tomokatsu Ikawa
Nat Commun. 2022; 13: 7159. Published online 2022 Nov 28. doi: 10.1038/s41467-022-34856-8
PMCID:
PMC9705430
ArticlePDF–4.0M
17.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
ArticlePDF–3.5M
18.
Programme of Self-Reactive Innate-Like T Cell-Mediated Cancer Immunity
Chun Chou, Xian Zhang, Chirag Krishna, Briana G. Nixon, Saida Dadi, Kristelle J. Capistrano, Emily R. Kansler, Miranda Steele, Jian Han, Amy Shyu, Jing Zhang, Efstathios G. Stamatiades, Ming Liu, Shun Li, Mytrang H. Do, Davina S. Kang, Chin-Tung Chen, Iris H. Wei, Emmanouil P Pappou, Martin R. Weiser, J. Garcia-Aguilar, J. Joshua Smith, Christina S. Leslie, Ming O. Li
Nature. Author manuscript; available in PMC 2022 Jul 2.
Published in final edited form as: Nature. 2022 May; 605(7908): 139–145. Published online 2022 Apr 20. doi: 10.1038/s41586-022-04632-1
PMCID:
PMC9250102
ArticlePDF–7.2M
19.
PRC1 sustains the integrity of neural fate in the absence of PRC2 function
Ayana Sawai, Sarah Pfennig, Milica Bulajić, Alexander Miller, Alireza Khodadadi-Jamayran, Esteban O Mazzoni, Jeremy S Dasen
eLife. 2022; 11: e72769. Published online 2022 Jan 7. doi: 10.7554/eLife.72769
PMCID:
PMC8765755
ArticlePDF–7.5M
20.
Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice
Jamilah Abusarah, Fatemeh Khodayarian, Nehme El-Hachem, Natasha Salame, Martin Olivier, Mohammad Balood, Katiane Roversi, Sebastien Talbot, Jean-Pierre Bikorimana, Jingkui Chen, Mario Jolicoeur, Louis-Eric Trudeau, Samaneh Kamyabiazar, Borhane Annabi, Francis Robert, Jerry Pelletier, Abed-El-Hakim El-Kadiry, Riam Shammaa, Moutih Rafei
Cell Rep Med. 2021 Dec 21; 2(12): 100455. Published online 2021 Dec 21. doi: 10.1016/j.xcrm.2021.100455
PMCID:
PMC8714858
ArticlePDF–5.8M

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