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Select item 110770831.

Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development

Eleonora Cesari, Donatella Farini, Vanessa Medici, Ingrid Ehrmann, Marika Guerra, Erika Testa, Chiara Naro, Maria Concetta Geloso, Vittoria Pagliarini, Livia La Barbera, Marcello D’Amelio, Tiziana Orsini, Stefano Farioli Vecchioli, Luca Tamagnone, Philippe Fort, Maria Teresa Viscomi, David J Elliott, Claudio Sette

Nucleic Acids Res. 2024 May 8; 52(8): 4167–4184. Published online 2024 Feb 7. doi: 10.1093/nar/gkae071

PMCID:: PMC11077083

Article PDF–3.3M

Select item 109836672.

CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1

Guiyong Jiang, Yu Cai, Duo Cheng, Hao Wang, Geyang Deng, Dayong Xiang

J Orthop Surg Res. 2024; 19: 212. Published online 2024 Apr 1. doi: 10.1186/s13018-024-04675-2

PMCID:: PMC10983667

Article PDF–9.0M

Select item 107003563.

T cell migration requires ion and water influx to regulate actin polymerization

Leonard L. de Boer, Lesley Vanes, Serena Melgrati, Joshua Biggs O’May, Darryl Hayward, Paul C. Driscoll, Jason Day, Alexander Griffiths, Renata Magueta, Alexander Morrell, James I. MacRae, Robert Köchl, Victor L. J. Tybulewicz

Nat Commun. 2023; 14: 7844. Published online 2023 Dec 6. doi: 10.1038/s41467-023-43423-8

PMCID:: PMC10700356

Article PDF–2.8M

Select item 106998064.

Apoptotic signaling clears engineered Salmonella in an organ-specific manner

Taylor J Abele, Zachary P Billman, Lupeng Li, Carissa K Harvest, Alexia K Bryan, Gabrielle R Magalski, Joseph P Lopez, Heather N Larson, Xiao-Ming Yin, Edward A Miao

eLife. 2023; 12: RP89210. Published online 2023 Dec 6. doi: 10.7554/eLife.89210

PMCID:: PMC10699806

Article PDF–4.4M

Select item 105473005.

Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development

Bingruo Wu, Brian Wu, Sonia Benkaci, Lijie Shi, Pengfei Lu, Taeju Park, Bernice E. Morrow, Yidong Wang, Bin Zhou

J Am Heart Assoc. 2023 Sep 19; 12(18): e029683. Published online 2023 Sep 13. doi: 10.1161/JAHA.123.029683

PMCID:: PMC10547300

Article PDF–41M

Select item 104850396.

WNK1 is required during male pachynema to sustain fertility

Ru-pin Alicia Chi, Xiaojiang Xu, Jian-Liang Li, Xin Xu, Guang Hu, Paula Brown, Cynthia Willson, Oleksandr Kirsanov, Christopher Geyer, Chou-Long Huang, Marcos Morgan, Francesco DeMayo

iScience. 2023 Sep 15; 26(9): 107616. Published online 2023 Aug 12. doi: 10.1016/j.isci.2023.107616

PMCID:: PMC10485039

Article PDF–9.5M

Select item 102566137.

mTOR inhibition suppresses Myc-driven polyposis by inducing immunogenic cell death

Brian J. Leibowitz, Guangyi Zhao, Wenxin Xia, Yuhan Wang, Hang Ruan, Lin Zhang, Jian Yu

Oncogene. 2023; 42(24): 2007–2016. Published online 2023 May 3. doi: 10.1038/s41388-023-02706-6

PMCID:: PMC10256613

Article PDF–4.7M

Select item 102319918.

WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release

Xin Jin, Jian Xie, Chia-Wei Yeh, Jen-Chi Chen, Chih-Jen Cheng, Cheng-Chang Lien, Chou-Long Huang

J Clin Invest. 2023 Jun 1; 133(11): e164222. Published online 2023 Jun 1. doi: 10.1172/JCI164222

PMCID:: PMC10231991

Article PDF–2.3M

Select item 98723289.

B cell–intrinsic requirement for WNK1 kinase in antibody responses in mice

Darryl A. Hayward, Lesley Vanes, Stefanie Wissmann, Sujana Sivapatham, Harald Hartweger, Joshua Biggs O’May, Leonard L. de Boer, Richard Mitter, Robert Köchl, Jens V. Stein, Victor L.J. Tybulewicz

J Exp Med. 2023 Mar 6; 220(3): e20211827. Published online 2023 Jan 20. doi: 10.1084/jem.20211827

PMCID:: PMC9872328

Article PDF–6.8M

Select item 985150110.

A role for BCL2L13 and autophagy in germline purifying selection of mtDNA

Laura S. Kremer, Lyuba V. Bozhilova, Diana Rubalcava-Gracia, Roberta Filograna, Mamta Upadhyay, Camilla Koolmeister, Patrick F. Chinnery, Nils-Göran Larsson

PLoS Genet. 2023 Jan; 19(1): e1010573. Published online 2023 Jan 6. doi: 10.1371/journal.pgen.1010573

PMCID:: PMC9851501

Article PDF–1.4M

Select item 934048711.

The BCL‐2 family member BID plays a role during embryonic development in addition to its BH3‐only protein function by acting in parallel to BAX, BAK and BOK

Francine S Ke, Steven Holloway, Rachel T Uren, Agnes W Wong, Melissa H Little, Ruth M Kluck, Anne K Voss, Andreas Strasser

EMBO J. 2022 Aug; 41(15): e110300. Published online 2022 Jun 27. doi: 10.15252/embj.2021110300

PMCID:: PMC9340487

Article PDF–6.2M

Select item 933530612.

WNK1 collaborates with TGF-β in endothelial cell junction turnover and angiogenesis

Ankita B. Jaykumar, Sakina Plumber, David M. Barry, Derk Binns, Chonlarat Wichaidit, Magdalena Grzemska, Svetlana Earnest, Elizabeth J. Goldsmith, Ondine Cleaver, Melanie H. Cobb

Proc Natl Acad Sci U S A. 2022 Jul 26; 119(30): e2203743119. Published online 2022 Jul 22. doi: 10.1073/pnas.2203743119

PMCID:: PMC9335306

Article PDF–2.1M

Select item 901569913.

The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery

Kiren Baines, Kazuaki Yoshioka, Yoh Takuwa, Jon D. Lane

Autophagy Rep. 2022; 1(1): 88–118. Published online 2022 Apr 7. doi: 10.1080/27694127.2022.2042054

PMCID:: PMC9015699

Article PDF–3.3M

Select item 882262014.

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

Daniel S. Simpson, Jiyi Pang, Ashley Weir, Isabella Y. Kong, Melanie Fritsch, Maryam Rashidi, James P. Cooney, Kathryn C. Davidson, Mary Speir, Tirta M. Djajawi, Sebastian Hughes, Liana Mackiewicz, Merle Dayton, Holly Anderton, Marcel Doerflinger, Yexuan Deng, Allan Shuai Huang, Stephanie A. Conos, Hazel Tye, Seong H. Chow, Arfatur Rahman, Raymond S. Norton, Thomas Naderer, Sandra E. Nicholson, Gaetan Burgio, Si Ming Man, Joanna R. Groom, Marco J. Herold, Edwin D. Hawkins, Kate E. Lawlor, Andreas Strasser, John Silke, Marc Pellegrini, Hamid Kashkar, Rebecca Feltham, James E. Vince

Immunity. 2022 Mar 8; 55(3): 423–441.e9. Published online 2022 Feb 8. doi: 10.1016/j.immuni.2022.01.003

PMCID:: PMC8822620

Article PDF–6.5M

Select item 880634515.

By targeting apoptosis facilitator BCL2L13, microRNA miR-484 alleviates cerebral ischemia/reperfusion injury-induced neuronal apoptosis in mice

Xindong Liu, Xin Wang, Lijuan Zhang, Yi Zhou, Le Yang, Minghao Yang

Bioengineered. 2021; 12(1): 948–959. Published online 2021 Mar 16. doi: 10.1080/21655979.2021.1898134

PMCID:: PMC8806345

Article PDF–1.8M

Select item 880581016.

Long noncoding RNA Gm44593 attenuates oxidative stress from age-related hearing loss by regulating miR-29b/WNK1

Qian Li, Yanzi Zang, Zhanwei Sun, Wenqi Zhang, Hongjian Liu

Bioengineered. 2022; 13(1): 573–582. Published online 2021 Dec 30. doi: 10.1080/21655979.2021.2012062

PMCID:: PMC8805810

Article PDF–1.7M

Select item 842466417.

L-WNK1 is required for BK channel activation in intercalated cells

Evan C. Ray, Rolando Carrisoza-Gaytan, Mohammad Al-Bataineh, Allison L. Marciszyn, Lubika J. Nkashama, Jingxin Chen, Aaliyah Winfrey, Shawn Griffiths, Tracey R. Lam, Daniel Flores, Peng Wu, WenHui Wang, Chou-Long Huang, Arohan R. Subramanya, Thomas R. Kleyman, Lisa M. Satlin

Am J Physiol Renal Physiol. 2021 Aug 1; 321(2): F245–F254. Published online 2021 Jul 7. doi: 10.1152/ajprenal.00472.2020

PMCID:: PMC8424664

Article

Select item 831649118.

Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis

Lindsey Mayes-Hopfinger, Aura Enache, Jian Xie, Chou-Long Huang, Robert Köchl, Victor L. J. Tybulewicz, Teresa Fernandes-Alnemri, Emad S. Alnemri

Nat Commun. 2021; 12: 4546. Published online 2021 Jul 27. doi: 10.1038/s41467-021-24784-4

PMCID:: PMC8316491

Article PDF–2.6M

Select item 831323919.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Article PDF–1.6M

Select item 818499320.

Stepwise activation of the pro-apoptotic protein Bid at mitochondrial membranes

Chien-Lun Hung, Hsin-Ho Chang, Su Wei Lee, Yun-Wei Chiang

Cell Death Differ. 2021 Jun; 28(6): 1910–1925. Published online 2021 Jan 18. doi: 10.1038/s41418-020-00716-5

PMCID:: PMC8184993

Article PDF–4.5M

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