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Select item 113691741.

Proteome-scale characterisation of motif-based interactome rewiring by disease mutations

Johanna Kliche, Leandro Simonetti, Izabella Krystkowiak, Hanna Kuss, Marcel Diallo, Emma Rask, Jakob Nilsson, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2024 Sep; 20(9): 1025–1048. Published online 2024 Jul 15. doi: 10.1038/s44320-024-00055-4

PMCID:: PMC11369174

Abstract Article PDF–2.7M

Select item 112099352.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111865773.

The Role of Ubiquitination and the E3 Ligase Nedd4 in Regulating Corneal Epithelial Wound Healing

Xuemei Ling, Weiwei Xu, Jingjing Tang, Qiongjie Cao, Guangying Luo, Xiaoyan Chen, Shuai Yang, Peter Sol Reinach, Dongsheng Yan

Invest Ophthalmol Vis Sci. 2024 Jun; 65(6): 29. Published online 2024 Jun 18. doi: 10.1167/iovs.65.6.29

PMCID:: PMC11186577

Abstract Article PDF–9.4M

Select item 111510504.

Thrombospondin‐1 Regulates Trophoblast Necroptosis via NEDD4‐Mediated Ubiquitination of TAK1 in Preeclampsia

Haoyue Hu, Jing Ma, You Peng, Rixuan Feng, Chenling Luo, Minyi Zhang, Zixin Tao, Lu Chen, Tao Zhang, Wenqian Chen, Qian Yin, Jinguo Zhai, Jun Chen, Ailan Yin, Chi Chiu Wang, Mei Zhong

Adv Sci (Weinh) 2024 Jun; 11(21): 2309002. Published online 2024 Apr 3. doi: 10.1002/advs.202309002

PMCID:: PMC11151050

Abstract Article PDF–15M

Select item 111181085.

ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis

Jiancheng He, Jianfeng Yi, Li Ji, Lingchen Dai, Yu Chen, Wanjiang Xue

Mol Med. 2024; 30: 69. Published online 2024 May 23. doi: 10.1186/s10020-024-00832-9

PMCID:: PMC11118108

Abstract Article PDF–3.6M

Select item 110246846.

DMT1 ubiquitination by Nedd4 protects against ferroptosis after intracerebral hemorrhage

Bingchen Lv, Ping Fu, Miao Wang, Likun Cui, Lei Bao, Xingzhi Wang, Lu Yu, Chao Zhou, Mengxin Zhu, Fei Wang, Ye Pang, Suhua Qi, Zuohui Zhang, Guiyun Cui

CNS Neurosci Ther. 2024 Apr; 30(4): e14685. Published online 2024 Apr 18. doi: 10.1111/cns.14685

PMCID:: PMC11024684

Abstract Article PDF–20M

Select item 109457077.

Comparative interactome analysis of α-arrestin families in human and Drosophila

Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam

eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328

PMCID:: PMC10945707

Abstract Article PDF–2.8M

Select item 108263278.

Ubiquitin ligase NEDD4 promotes the proliferation of hepatocellular carcinoma cells through targeting PCDH17 protein for ubiquitination and degradation

Zhiyi Liu, Qinghe Hu, Bin Hu, Kuan Cao, Tao Xu, Tianqi Hou, Tong Cao, Renhao Wang, Hengliang Shi, Bin Zhang

J Biol Chem. 2024 Jan; 300(1): 105593. Published online 2023 Dec 23. doi: 10.1016/j.jbc.2023.105593

PMCID:: PMC10826327

Abstract Article PDF–4.7M

Select item 107826159.

PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer

Liang Xu, Wanying Xiang, Jiezhen Yang, Jing Gao, Xinyue Wang, Li Meng, Kaihong Ye, Xiao Hong Zhao, Xu Dong Zhang, Lei Jin, Yan Ye

J Exp Clin Cancer Res. 2024; 43: 17. Published online 2024 Jan 11. doi: 10.1186/s13046-023-02937-1

PMCID:: PMC10782615

Abstract Article PDF–3.4M

Select item 1058927210.

Primate-specific isoform of Nedd4-1 regulates substrate binding via Ser/Thr phosphorylation and 14-3-3 binding

George Kefalas, Daniela Rotin

Sci Rep. 2023; 13: 17903. Published online 2023 Oct 20. doi: 10.1038/s41598-023-44761-9

PMCID:: PMC10589272

Abstract Article PDF–1.9M

Select item 1033388411.

Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions

Johanna Kliche, Dimitriya Hristoforova Garvanska, Leandro Simonetti, Dilip Badgujar, Doreen Dobritzsch, Jakob Nilsson, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2023 Jul; 19(7): e11164. Published online 2023 May 23. doi: 10.15252/msb.202211164

PMCID:: PMC10333884

Abstract Article PDF–5.0M

Select item 1026673012.

Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation

Dmitry Zenko, Jade Marsh, Andrew R. Castle, Rahel Lewin, Roman Fischer, George K. Tofaris

Sci Adv. 2023 Jun; 9(24): eadd8910. Published online 2023 Jun 14. doi: 10.1126/sciadv.add8910

PMCID:: PMC10266730

Abstract Article PDF–2.9M

Select item 1023742213.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1020954014.

Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation

Chengming Zhang, Zhiyi Liu, Xiaotian Wang, Bin Zhang, Licheng Cui, Qinghe Hu, Bin Hu, Kuan Cao, Wengang Shan, Hengliang Shi, Renhao Wang

iScience. 2023 Jun 16; 26(6): 106852. Published online 2023 May 9. doi: 10.1016/j.isci.2023.106852

PMCID:: PMC10209540

Abstract Article PDF–5.8M

Select item 1017409115.

Cytoplasmic YAP1‐mediated ESCRT‐III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer

Yan Guo, Yuqing Cui, Yangyang Li, Xiaoying Jin, Dandan Wang, Mengxia Lei, Fengzhi Chen, Yali Liu, Jinwen Xu, Guanyu Yao, Guangchun Zeng, Xuesong Chen

Cancer Commun (Lond) 2023 May; 43(5): 582–612. Published online 2023 Apr 2. doi: 10.1002/cac2.12417

PMCID:: PMC10174091

Abstract Article PDF–22M

Select item 1016736516.

GATA4-activated lncRNA MALAT1 promotes osteogenic differentiation through inhibiting NEDD4-mediated RUNX1 degradation

Xianzhe Huang, Shuo Jie, Wenzhao Li, Chan Liu

Cell Death Discov. 2023; 9: 150. Published online 2023 May 8. doi: 10.1038/s41420-023-01422-0

PMCID:: PMC10167365

Abstract Article PDF–4.4M

Select item 1016734417.

Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice

Lang Jiang, Jing Zhao, Qin Yang, Mei Li, Hao Liu, Xiaoyue Xiao, Song Tian, Sha Hu, Zhen Liu, Peiwen Yang, Manhua Chen, Ping Ye, Jiahong Xia

Nat Commun. 2023; 14: 2654. Published online 2023 May 8. doi: 10.1038/s41467-023-37908-9

PMCID:: PMC10167344

Abstract Article PDF–5.7M

Select item 1015611318.

Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell–specific β-arrestin 2 knockout mice

Stavroula Bitsi, Liliane El Eid, Yusman Manchanda, Affiong I. Oqua, Nimco Mohamed, Ben Hansen, Kinga Suba, Guy A. Rutter, Victoria Salem, Ben Jones, Alejandra Tomas

Sci Adv. 2023 May; 9(18): eadf7737. Published online 2023 May 3. doi: 10.1126/sciadv.adf7737

PMCID:: PMC10156113

Abstract Article PDF–3.0M

Select item 1013280519.

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

Filip Mihalič, Leandro Simonetti, Girolamo Giudice, Marie Rubin Sander, Richard Lindqvist, Marie Berit Akpiroro Peters, Caroline Benz, Eszter Kassa, Dilip Badgujar, Raviteja Inturi, Muhammad Ali, Izabella Krystkowiak, Ahmed Sayadi, Eva Andersson, Hanna Aronsson, Ola Söderberg, Doreen Dobritzsch, Evangelia Petsalaki, Anna K. Överby, Per Jemth, Norman E. Davey, Ylva Ivarsson

Nat Commun. 2023; 14: 2409. Published online 2023 Apr 26. doi: 10.1038/s41467-023-38015-5

PMCID:: PMC10132805

Abstract Article PDF–4.2M

Select item 1007150020.

A Semisynthetic Approach to the Analysis of Tumor Suppressor PTEN Ubiquitination

Reina Iwase, Daniel R. Dempsey, Samuel D. Whedon, Hanjie Jiang, Brad A. Palanski, Bedphiny Deng, Philip A. Cole

J Am Chem Soc. Author manuscript; available in PMC 2024 Mar 22.

Published in final edited form as: J Am Chem Soc. 2023 Mar 22; 145(11): 6039–6044. Published online 2023 Mar 10. doi: 10.1021/jacs.2c13871

PMCID:: PMC10071500

Abstract Article PDF–1.2M

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