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Select item 103986601.

C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains

Julia Jülg, Dieter Edbauer, Christian Behrends

EMBO Rep. 2023 Aug; 24(8): e55895. Published online 2023 Jun 15. doi: 10.15252/embr.202255895

PMCID:: PMC10398660

Abstract Article PDF–2.4M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 92191963.

circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop

Xiaomin Li, Jianjun Wang, Weihao Lin, Qinzi Yuan, Yanxia Lu, Haowei Wang, Yujia Chen, Lixia Chen, Peiling Dai, Huaicheng Long, Xuenong Li

Mol Cancer. 2022; 21: 135. Published online 2022 Jun 23. doi: 10.1186/s12943-022-01600-1

PMCID:: PMC9219196

Abstract Article PDF–13M

Select item 88066504.

Jianjia Xiao, Qingqing Liu, Weijie Wu, Ying Yuan, Jie Zhou, Jieyu Shi, Shaorong Zhou

Bioengineered. 2021; 12(1): 4620–4632. Published online 2021 Jul 29. doi: 10.1080/21655979.2021.1956402

PMCID:: PMC8806650

Abstract Article PDF–5.3M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 61355696.

TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis

Wei Wang, Zhijie Xia, Jean-Claude Farré, Suresh Subramani

Autophagy. 2018; 14(9): 1574–1585. Published online 2018 Aug 21. doi: 10.1080/15548627.2018.1463120

PMCID:: PMC6135569

Abstract Article PDF–2.3M

Select item 58339337.

TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer

Jonathan M. Cooper, Yi-Hung Ou, Elizabeth A. McMillan, Rachel M. Vaden, Aubhishek Zaman, Brian O. Bodemann, Gurbani Makkar, Bruce A. Posner, Michael A. White

Cancer Res. Author manuscript; available in PMC 2018 Sep 15.

Published in final edited form as: Cancer Res. 2017 Sep 15; 77(18): 5077–5094. Published online 2017 Jul 17. doi: 10.1158/0008-5472.CAN-17-0829

PMCID:: PMC5833933

Abstract Article PDF–2.9M

Select item 56720318.

Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1)

Shusaku Shibutani, Hana Okazaki, Hiroyuki Iwata

J Biol Chem. 2017 Nov 3; 292(44): 18052–18061. Published online 2017 Aug 14. doi: 10.1074/jbc.M117.776443

PMCID:: PMC5672031

Abstract Article PDF–2.2M

Select item 55705949.

SZT2 Dictates GATOR Control of mTORC1 Signaling

Min Peng, Na Yin, Ming O. Li

Nature. Author manuscript; available in PMC 2017 Aug 24.

Published in final edited form as: Nature. 2017 Mar 16; 543(7645): 433–437. Published online 2017 Feb 15. doi: 10.1038/nature21378

Correction in:: Nature. 2018 May 16

PMCID:: PMC5570594

Abstract Article PDF–2.1M

Select item 553161110.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 510420111.

TRIMs and Galectins globally cooperate and TRIM16 and Galectin-3 co-direct autophagy in endomembrane damage homeostasis

Santosh Chauhan, Suresh Kumar, Ashish Jain, Marisa Ponpuak, Michal H. Mudd, Tomonori Kimura, Seong Won Choi, Ryan Peters, Michael Mandell, Jack-Ansgar Bruun, Terje Johansen, Vojo Deretic

Dev Cell. Author manuscript; available in PMC 2017 Oct 10.

Published in final edited form as: Dev Cell. 2016 Oct 10; 39(1): 13–27. Published online 2016 Sep 29. doi: 10.1016/j.devcel.2016.08.003

PMCID:: PMC5104201

Abstract Article PDF–2.0M

Select item 461721112.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 437666513.

SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1

Manuele Rebsamen, Lorena Pochini, Taras Stasyk, Mariana E. G. de Araújo, Michele Galluccio, Richard K. Kandasamy, Berend Snijder, Astrid Fauster, Elena L. Rudashevskaya, Manuela Bruckner, Stefania Scorzoni, Przemyslaw A. Filipek, Kilian V. M. Huber, Johannes Bigenzahn, Leonhard X. Heinz, Claudine Kraft, Keiryn L. Bennett, Cesare Indiveri, Lukas A. Huber, Giulio Superti-Furga

Nature. Author manuscript; available in PMC 2015 Sep 26.

Published in final edited form as: Nature. 2015 Mar 26; 519(7544): 477–481. Published online 2015 Jan 7. doi: 10.1038/nature14107

PMCID:: PMC4376665

Abstract Article PDF–2.4M

Select item 434620314.

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2

Constantinos Demetriades, Nikolaos Doumpas, Aurelio A. Teleman

Cell. Author manuscript; available in PMC 2015 Mar 2.

Published in final edited form as: Cell. 2014 Feb 13; 156(4): 786–799. doi: 10.1016/j.cell.2014.01.024

PMCID:: PMC4346203

Abstract Article PDF–2.7M

Select item 429582615.

The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1

Shuyu Wang, Zhi-Yang Tsun, Rachel Wolfson, Kuang Shen, Gregory A. Wyant, Molly E. Plovanich, Elizabeth D. Yuan, Tony D. Jones, Lynne Chantranupong, William Comb, Tim Wang, Liron Bar-Peled, Roberto Zoncu, Christoph Straub, Choah Kim, Jiwon Park, Bernardo L. Sabatini, David M. Sabatini

Science. Author manuscript; available in PMC 2015 Jan 15.

Published in final edited form as: Science. 2015 Jan 9; 347(6218): 188–194. Published online 2015 Jan 7. doi: 10.1126/science.1257132

PMCID:: PMC4295826

Abstract Article PDF–1.6M

Select item 418135216.

Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling

Min Peng, Na Yin, Ming O. Li

Cell. Author manuscript; available in PMC 2015 Sep 25.

Published in final edited form as: Cell. 2014 Sep 25; 159(1): 122–133. doi: 10.1016/j.cell.2014.08.038

PMCID:: PMC4181352

Abstract Article PDF–2.7M

Select item 412618917.

Genome-wide association study of smoking behaviors among Bangladeshi adults

Maria Argos, Lin Tong, Brandon L. Pierce, Muhammad Rakibuz-Zaman, Alauddin Ahmed, Tariqul Islam, Mahfuzar Rahman, Rachelle Paul-Brutus, Ronald Rahaman, Shantanu Roy, Farzana Jasmine, Muhammad G. Kibriya, Habibul Ahsan

J Med Genet. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: J Med Genet. 2014 May; 51(5): 327–333. Published online 2014 Mar 24. doi: 10.1136/jmedgenet-2013-102151

PMCID:: PMC4126189

Abstract Article PDF–672K

Select item 395408118.

A high-throughput approach for measuring temporal changes in the interactome

Anders R. Kristensen, Joerg Gsponer, Leonard J. Foster

Nat Methods. Author manuscript; available in PMC 2014 Mar 14.

Published in final edited form as: Nat Methods. 2012 Sep; 9(9): 907–909. Published online 2012 Aug 5. doi: 10.1038/nmeth.2131

PMCID:: PMC3954081

Abstract Article PDF–632K

Select item 390866719.

mTor Regulates Lysosomal ATP-sensitive Two-Pore Na⁺ Channel to Adapt to Metabolic State

Chunlei Cang, Yandong Zhou, Betsy Navarro, Young-jun Seo, Kimberly Aranda, Lucy Shi, Shyuefang Battaglia-Hsu, Itzhak Nissim, David E. Clapham, Dejian Ren

Cell. Author manuscript; available in PMC 2014 Feb 14.

Published in final edited form as: Cell. 2013 Feb 14; 152(4): 778–790. Published online 2013 Feb 7. doi: 10.1016/j.cell.2013.01.023

PMCID:: PMC3908667

Abstract Article PDF–3.6M

Select item 390840020.

Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging

Noriko Oshiro, Joseph Rapley, Joseph Avruch

J Biol Chem. 2014 Jan 31; 289(5): 2658–2674. Published online 2013 Dec 11. doi: 10.1074/jbc.M113.528505

PMCID:: PMC3908400

Abstract Article PDF–2.6M

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