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Select item 111094831.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 106976622.

A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body–like pathology

Juan A. Gerez, Natalia C. Prymaczok, Edward Rockenstein, Uli S. Herrmann, Petra Schwarz, Anthony Adame, Radoslav I. Enchev, Thibault Courtheoux, Paul J. Boersema, Roland Riek, Matthias Peter, Adriano Aguzzi, Eliezer Masliah, Paola Picotti

Sci Transl Med. Author manuscript; available in PMC 2023 Dec 5.

Published in final edited form as: Sci Transl Med. 2019 Jun 5; 11(495): eaau6722. doi: 10.1126/scitranslmed.aau6722

PMCID:: PMC10697662

Abstract Article PDF–2.4M

Select item 104695603.

Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development

Sarai T. Dean, Chiharu Ishikawa, Xiaoqin Zhu, Sean Walulik, Timothy Nixon, Jessica K. Jordan, Samantha Henderson, Michael Wyder, Nathan Salomonis, Mark Wunderlich, Kenneth D. Greis, Daniel T. Starczynowski, Andrew G. Volk

Blood Adv. 2023 Sep 12; 7(17): 4822–4837. Published online 2023 May 22. doi: 10.1182/bloodadvances.2022009438

PMCID:: PMC10469560

Abstract Article PDF–4.2M

Select item 102794724.

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

Julie K. Monda, Xuezhen Ge, Moritz Hunkeler, Katherine A. Donovan, Michelle W. Ma, Cyrus Y. Jin, Marilyn Leonard, Eric S. Fischer, Eric J. Bennett

Cell Rep. Author manuscript; available in PMC 2023 Jun 19.

Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112496. Published online 2023 May 9. doi: 10.1016/j.celrep.2023.112496

PMCID:: PMC10279472

Abstract Article PDF–2.9M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 94819336.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 93814787.

A context-dependent and disordered ubiquitin-binding motif

Jesper E. Dreier, Andreas Prestel, João M. Martins, Sebastian S. Brøndum, Olaf Nielsen, Anna E. Garbers, Hiroaki Suga, Wouter Boomsma, Joseph M. Rogers, Rasmus Hartmann-Petersen, Birthe B. Kragelund

Cell Mol Life Sci. 2022 Sep; 79(9): 484. Published online 2022 Aug 16. doi: 10.1007/s00018-022-04486-w

PMCID:: PMC9381478

Abstract Article PDF–8.1M

Select item 90341018.

Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates

Hanjie Jiang, Claire Y. Chiang, Zan Chen, Sara Nathan, Gabriel D’Agostino, Joao A. Paulo, Guang Song, Heng Zhu, Sandra B. Gabelli, Philip A. Cole

J Biol Chem. 2022 May; 298(5): 101854. Published online 2022 Mar 21. doi: 10.1016/j.jbc.2022.101854

PMCID:: PMC9034101

Abstract Article PDF–3.7M

Select item 90205179.

Structural and functional consequences of NEDD8 phosphorylation

Katrin Stuber, Tobias Schneider, Jill Werner, Michael Kovermann, Andreas Marx, Martin Scheffner

Nat Commun. 2021; 12: 5939. Published online 2021 Oct 12. doi: 10.1038/s41467-021-26189-9

PMCID:: PMC9020517

Abstract Article PDF–2.8M

Select item 896441310.

Structure of UBE2K–Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension

Mark A. Nakasone, Karolina A. Majorek, Mads Gabrielsen, Gary J. Sibbet, Brian O. Smith, Danny T. Huang

Nat Chem Biol. 2022; 18(4): 422–431. Published online 2022 Jan 13. doi: 10.1038/s41589-021-00952-x

PMCID:: PMC8964413

Abstract Article PDF–7.3M

Select item 889702211.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 881029112.

Structural basis and regulation of the reductive stress response

Andrew G. Manford, Elijah L. Mena, Karen Y. Shih, Christine L. Gee, Rachael McMinimy, Brenda Martínez-González, Rumi Sherriff, Brandon Lew, Madeline Zoltek, Fernando Rodríguez-Pérez, Makda Woldesenbet, John Kuriyan, Michael Rape

Cell. Author manuscript; available in PMC 2022 Oct 14.

Published in final edited form as: Cell. 2021 Oct 14; 184(21): 5375–5390.e16. Published online 2021 Sep 24. doi: 10.1016/j.cell.2021.09.002

PMCID:: PMC8810291

Abstract Article PDF–1.5M

Select item 866666513.

CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism

Jean-Philippe Guégan, Justine Pollet, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Marcus E. Peter, Patrick Legembre

iScience. 2021 Dec 17; 24(12): 103538. Published online 2021 Dec 1. doi: 10.1016/j.isci.2021.103538

PMCID:: PMC8666665

Abstract Article PDF–3.2M

Select item 850550914.

FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth

Mengmeng Niu, Jing Xu, Yang Liu, Yuhuang Li, Tao He, Liangping Ding, Yajun He, Yong Yi, Fengtian Li, Rongtian Guo, Ya Gao, Rui Li, Luping Li, Mengyuan Fu, Qingyong Hu, Yangkun Luo, Chunyan Zhang, Kewei Qin, Jianqiao Yi, Shuhan Yu, Jian Yang, Hu Chen, Liang Wang, Zhonghan Li, Biao Dong, Shiqian Qi, Liang Ouyang, Yujun Zhang, Yang Cao, Zhi-Xiong Jim Xiao

Nat Commun. 2021; 12: 5919. Published online 2021 Oct 11. doi: 10.1038/s41467-021-26222-x

PMCID:: PMC8505509

Abstract Article PDF–7.1M

Select item 833109215.

Reconstitution of human CMG helicase ubiquitylation by CUL2^LRR1 and multiple E2 enzymes

Thanh Thi Le, Johanna Ainsworth, Cristian Polo Rivera, Thomas Macartney, Karim P.M. Labib

Biochem J. 2021 Jul 30; 478(14): 2825–2842. Prepublished online 2021 Jun 29. Published online 2021 Jul 23. doi: 10.1042/BCJ20210315

PMCID:: PMC8331092

Abstract Article PDF–1.9M

Select item 816503016.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 795013217.

The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases

Ryan J. Lumpkin, Alla S. Ahmad, Rachel Blake, Christopher J. Condon, Elizabeth A. Komives

Mol Cell Proteomics. 2021; 20: 100019. Published online 2021 Jan 6. doi: 10.1074/mcp.RA120.002414

PMCID:: PMC7950132

Abstract Article PDF–3.1M

Select item 772578518.

TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation

Ke Li, Feng Wang, Zhao-na Yang, Ting-ting Zhang, Yu-fen Yuan, Chen-xi Zhao, Zaiwuli Yeerjiang, Bing Cui, Fang Hua, Xiao-xi Lv, Xiao-wei Zhang, Jiao-jiao Yu, Shan-shan Liu, Jin-mei Yu, Shuang Shang, Yang Xiao, Zhuo-wei Hu

Nat Commun. 2020; 11: 6316. Published online 2020 Dec 9. doi: 10.1038/s41467-020-20107-1

PMCID:: PMC7725785

Abstract Article PDF–3.4M

Select item 765713219.

FBXO15 regulates P‐glycoprotein/ABCB1 expression through the ubiquitin–proteasome pathway in cancer cells

Kazuhiro Katayama, Kohji Noguchi, Yoshikazu Sugimoto

Cancer Sci. 2013 Jun; 104(6): 694–702. Published online 2013 Apr 15. doi: 10.1111/cas.12145

PMCID:: PMC7657132

Abstract Article PDF–1.2M

Select item 765425220.

Identification of small molecule inhibitors of p27^Kip1 ubiquitination by high‐throughput screening

Li‐Ching Ooi, Nobumoto Watanabe, Yushi Futamura, Shaida Fariza Sulaiman, Ibrahim Darah, Hiroyuki Osada

Cancer Sci. 2013 Nov; 104(11): 1461–1467. Published online 2013 Sep 6. doi: 10.1111/cas.12246

PMCID:: PMC7654252

Abstract Article PDF–578K

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