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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 108384482.

Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets

Hao Zheng, Yuexuan Liu, Yasi Deng, Yunzhe Li, Shiqi Liu, Yong Yang, Yun Qiu, Bin Li, Wenbing Sheng, Jinzhi Liu, Caiyun Peng, Wei Wang, Huanghe Yu

Mol Med. 2024; 30: 20. Published online 2024 Feb 3. doi: 10.1186/s10020-024-00788-w

PMCID:: PMC10838448

Abstract Article PDF–3.3M

Select item 106434363.

Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption

Jin-Gang Yang, Bao Sun, Zheng Wang, Xing Li, Jia-hui Gao, Jia-jun Qian, Jiang Li, Wen-jia Wei, Ping Zhang, Wei Wang

Cell Death Dis. 2023 Nov; 14(11): 738. Published online 2023 Nov 13. doi: 10.1038/s41419-023-06263-4

PMCID:: PMC10643436

Abstract Article PDF–8.2M

Select item 104650784.

Risk Variants in or Near ZBTB40 AND NFATC1 Increase the Risk of Both IBD and Adverse Bone Health Outcomes Highlighting Common Genetic Underpinnings Across Both Diseases

Kelly C Cushing, Yanhua Chen, Xiaomeng Du, Vincent Chen, Annapurna Kuppa, Peter Higgins, Elizabeth K Speliotes

Inflamm Bowel Dis. 2023 Jun; 29(6): 938–945. Published online 2023 Jan 21. doi: 10.1093/ibd/izac273

PMCID:: PMC10465078

Abstract Article PDF–1.1M

Select item 102280395.

Human bone marrow-derived mesenchymal stem overexpressing microRNA-124-3p inhibit DLBCL progression by downregulating the NFATc1/cMYC pathway

Xiaoxuan Zhao, Mingxi Xu, Xuemeng Hu, Xiaolei Ding, Xian Zhang, Liye Xu, Li Li, Xiuhua Sun, Jincheng Song

Stem Cell Res Ther. 2023; 14: 148. Published online 2023 May 29. doi: 10.1186/s13287-023-03373-w

PMCID:: PMC10228039

Abstract Article PDF–7.7M

Select item 99501836.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Abstract Article PDF–2.4M

Select item 99142407.

NFATc1 Regulation of Dexamethasone-Induced TGFB2 Expression Is Cell Cycle Dependent in Trabecular Meshwork Cells

Mark S. Filla, Jennifer A. Faralli, Caleigh R. Dunn, Haania Khan, Donna M. Peters

Cells. 2023 Feb; 12(3): 504. Published online 2023 Feb 3. doi: 10.3390/cells12030504

PMCID:: PMC9914240

Abstract Article PDF–46M

Select item 98692498.

The role of FOXO4/NFAT2 signaling pathway in dysfunction of human coronary endothelial cells and inflammatory infiltration of vasculitis in Kawasaki disease

Hongbiao Huang, Jinfeng Dong, Jiaqi Jiang, Fang Yang, Yiming Zheng, Shuhui Wang, Nana Wang, Jin Ma, Miao Hou, Yueyue Ding, Lijun Meng, Wenyu Zhuo, Daoping Yang, Weiguo Qian, Qiaobin Chen, Guoping You, Guanghui Qian, Lei Gu, Haitao Lv

Front Immunol. 2022; 13: 1090056. Published online 2023 Jan 9. doi: 10.3389/fimmu.2022.1090056

PMCID:: PMC9869249

Abstract Article PDF–17M

Select item 96536009.

Regulation of Cyclooxygenase-2 Expression in Human T Cells by Glucocorticoid Receptor-Mediated Transrepression of Nuclear Factor of Activated T Cells

Cristina Cacheiro-Llaguno, Elena Hernández-Subirá, Manuel D. Díaz-Muñoz, Manuel Fresno, Juan M. Serrador, Miguel A. Íñiguez

Int J Mol Sci. 2022 Nov; 23(21): 13275. Published online 2022 Oct 31. doi: 10.3390/ijms232113275

PMCID:: PMC9653600

Abstract Article PDF–2.0M

Select item 950004510.

Ca_v2.2-NFAT2-USP43 axis promotes invadopodia formation and breast cancer metastasis through cortactin stabilization

Ying Xue, Min Li, Jie Hu, Yuanlin Song, Wei Guo, Changhong Miao, Di Ge, Yingyong Hou, Xuefei Wang, Xingxu Huang, Tianshu Liu, Xiaoping Zhang, Qihong Huang

Cell Death Dis. 2022 Sep; 13(9): 812. Published online 2022 Sep 22. doi: 10.1038/s41419-022-05174-0

PMCID:: PMC9500045

Abstract Article PDF–4.3M

Select item 949171311.

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ

Hua Jiang, Weixiang Bian, Yue Sui, Huanle Li, Han Zhao, Wenqi Wang, Xu Li

Sci Adv. 2022 Sep; 8(38): eabq4831. Published online 2022 Sep 21. doi: 10.1126/sciadv.abq4831

PMCID:: PMC9491713

Abstract Article PDF–12M

Select item 926261412.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 901862313.

DNA methylation of Nuclear Factor of Activated T Cells 1 mediates the prospective relation between exposure to different traumatic event types and post-traumatic stress disorder

James R. Occean, Agaz H. Wani, Janelle Donglasan, Allison E. Aiello, Sandro Galea, Karestan C. Koenen, Annie Qu, Derek E. Wildman, Monica Uddin

Psychiatry Res. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: Psychiatry Res. 2022 May; 311: 114510. Published online 2022 Mar 19. doi: 10.1016/j.psychres.2022.114510

PMCID:: PMC9018623

Abstract Article PDF–605K

Select item 887549114.

The Osteogenesis Imperfecta Type V Mutant BRIL/IFITM5 Promotes Transcriptional Activation of MEF2, NFATc, and NR4A in Osteoblasts

Vincent Maranda, Marie-Hélène Gaumond, Pierre Moffatt

Int J Mol Sci. 2022 Feb; 23(4): 2148. Published online 2022 Feb 15. doi: 10.3390/ijms23042148

PMCID:: PMC8875491

Abstract Article PDF–4.1M

Select item 876420515.

Estrogen receptor alpha and NFATc1 bind to a bone mineral density-associated SNP to repress WNT5B in osteoblasts

Sarocha Suthon, Jianjian Lin, Rachel S. Perkins, John R. Crockarell, Jr., Gustavo A. Miranda-Carboni, Susan A. Krum

Am J Hum Genet. 2022 Jan 6; 109(1): 97–115. Published online 2021 Dec 31. doi: 10.1016/j.ajhg.2021.11.018

PMCID:: PMC8764205

Abstract Article PDF–2.7M

Select item 874895816.

EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation

Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing

Nat Commun. 2022; 13: 12. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27609-6

PMCID:: PMC8748958

Abstract Article PDF–3.0M

Select item 874047217.

Predicting the targets of IRF8 and NFATc1 during osteoclast differentiation using the machine learning method framework cTAP

Honglin Wang, Pujan Joshi, Seung-Hyun Hong, Peter F. Maye, David W. Rowe, Dong-Guk Shin

BMC Genomics. 2022; 23: 14. Published online 2022 Jan 7. doi: 10.1186/s12864-021-08159-z

PMCID:: PMC8740472

Abstract Article PDF–2.0M

Select item 859300518.

Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter?

Ondřej Vymazal, Kamila Bendíčková, Marco De Zuani, Marcela Vlková, Marcela Hortová-Kohoutková, Jan Frič

Front Immunol. 2021; 12: 770515. Published online 2021 Nov 2. doi: 10.3389/fimmu.2021.770515

PMCID:: PMC8593005

Abstract Article PDF–344K

Select item 857998719.

Increased Expression of the lncRNA NRON Along With NFATc1/PIM-1 in Labial Salivary Glands of Sjögren’s Syndrome Patients

Yoshiro Horai, Hideki Nakamura, Toshimasa Shimizu, Shinya Nishihata, Naoki Iwamoto, Tamotsu Kuroki, Shinji Okano, Atsushi Kawakami

Appl Immunohistochem Mol Morphol. 2021 Nov-Dec; 29(10): 734–740. Published online 2021 Jul 14. doi: 10.1097/PAI.0000000000000959

PMCID:: PMC8579987

Abstract Article PDF–642K

Select item 856549620.

Nuclear factor of activated T-cells (NFAT) regulation of IL-1β-induced retinal vascular inflammation

Meredith J. Giblin, Taylor E. Smith, Garrett Winkler, Hannah A. Pendergrass, Minjae J. Kim, Megan E. Capozzi, Rong Yang, Gary W. McCollum, John S. Penn

Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1; 1867(12): 166238. Published online 2021 Jul 31. doi: 10.1016/j.bbadis.2021.166238

PMCID:: PMC8565496

Abstract Article PDF–803K

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