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Select item 105254031.

SHP-1 alleviates atrial fibrosis in atrial fibrillation by modulating STAT3 activation

Xiaobiao Zang, Zhihan Zhao, Ke Chen, Weifeng Song, Jifang Ma, Haixia Fu, Xianqing Wang, Yonghui Zhao

Exp Biol Med (Maywood) 2023 Jun; 248(11): 979–990. Published online 2023 May 25. doi: 10.1177/15353702231165717

PMCID:: PMC10525403

Abstract Article PDF–3.7M

Select item 98204602.

The Hippocampal Response to Acute Corticosterone Elevation Is Altered in a Mouse Model for Angelman Syndrome

Eva M. G. Viho, A. Mattijs Punt, Ben Distel, René Houtman, Jan Kroon, Ype Elgersma, Onno C. Meijer

Int J Mol Sci. 2023 Jan; 24(1): 303. Published online 2022 Dec 24. doi: 10.3390/ijms24010303

PMCID:: PMC9820460

Abstract Article PDF–3.4M

Select item 91063033.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80876445.

The Long and the Small Collide: LncRNAs and Small Heterodimer Partner (SHP) in Liver Disease

Jianguo Wu, Laura E. Nagy, Li Wang

Mol Cell Endocrinol. Author manuscript; available in PMC 2022 May 15.

Published in final edited form as: Mol Cell Endocrinol. 2021 May 15; 528: 111262. Published online 2021 Mar 26. doi: 10.1016/j.mce.2021.111262

PMCID:: PMC8087644

Abstract Article PDF–725K

Select item 80560466.

The Nuclear Farnesoid X Receptor Reduces p53 Ubiquitination and Inhibits Cervical Cancer Cell Proliferation

Xiaohua Huang, Bin Wang, Runji Chen, Shuping Zhong, Fenfei Gao, Yanmei Zhang, Yongdong Niu, Congzhu Li, Ganggang Shi

Front Cell Dev Biol. 2021; 9: 583146. Published online 2021 Apr 6. doi: 10.3389/fcell.2021.583146

PMCID:: PMC8056046

Abstract Article PDF–5.1M

Select item 71699837.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 69277548.

Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong

eLife. 2019; 8: e50223. Published online 2019 Nov 19. doi: 10.7554/eLife.50223

PMCID:: PMC6927754

Abstract Article PDF–5.1M

Select item 66720489.

The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation

Shengyi Sun, Sherwin Kelekar, Steven A. Kliewer, David J. Mangelsdorf

Genes Dev. 2019 Aug 1; 33(15-16): 1083–1094. doi: 10.1101/gad.326868.119

PMCID:: PMC6672048

Abstract Article PDF–7.3M

Select item 598620610.

Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis

An Zou, Nancy Magee, Fengyan Deng, Sarah Lehn, Cuncong Zhong, Yuxia Zhang

J Biol Chem. 2018 Jun 1; 293(22): 8656–8671. Published online 2018 Apr 17. doi: 10.1074/jbc.RA117.001653

PMCID:: PMC5986206

Abstract Article PDF–4.2M

Select item 559914211.

CIRCADIAN RHYTHMICITY: A FUNCTIONAL CONNECTION BETWEEN DIFFERENTIATED EMBRYONIC CHONDROCYTE-1 (DEC1) AND SMALL HETERODIMER PARTNER (SHP)

Marek M Marczak, Bingfang Yan

Arch Biochem Biophys. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: Arch Biochem Biophys. 2017 Oct 1; 631: 11–18. Published online 2017 Aug 8. doi: 10.1016/j.abb.2017.08.004

PMCID:: PMC5599142

Abstract Article PDF–951K

Select item 553161112.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 545205613.

Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner

Emily R. Weikum, C. Denise Okafor, Emma H. D’Agostino, Jennifer K. Colucci, Eric A. Ortlund

Mol Pharmacol. 2017 Jul; 92(1): 12–21. Published online 2017 Jul. doi: 10.1124/mol.117.108506

PMCID:: PMC5452056

Abstract Article PDF–1.5M

Select item 535668214.

Small heterodimer partner 1 directly interacts with NS5A viral protein and has a key role in HCV related liver cell transformation

Beatrice Conti, Cristiana Porcu, Carmela Viscomi, Antonella Minutolo, Susan Costantini, Marco Corazzari, Gino Iannucci, Barbara Barbaro, Clara Balsano

Oncotarget. 2016 Dec 20; 7(51): 84575–84586. Published online 2016 Sep 20. doi: 10.18632/oncotarget.12144

PMCID:: PMC5356682

Abstract Article PDF–3.0M

Select item 526973315.

RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP

Tsung-Yuan Tsai, Wei-Ting Wang, Hao-Kang Li, Wei-Ju Chen, Yu-Hong Tsai, Chi-Hong Chao, Yan-Hwa Wu Lee

Sci Rep. 2017; 7: 41452. Published online 2017 Jan 27. doi: 10.1038/srep41452

PMCID:: PMC5269733

Abstract Article PDF–2.2M

Select item 514127616.

Proteome-scale Binary Interactomics in Human Cells

Sam Lievens, José Van der Heyden, Delphine Masschaele, Leentje De Ceuninck, Ioanna Petta, Surya Gupta, Veronic De Puysseleyr, Virginie Vauthier, Irma Lemmens, Dries J. H. De Clercq, Dieter Defever, Nele Vanderroost, Anne-Sophie De Smet, Sven Eyckerman, Serge Van Calenbergh, Lennart Martens, Karolien De Bosscher, Claude Libert, David E. Hill, Marc Vidal, Jan Tavernier

Mol Cell Proteomics. 2016 Dec; 15(12): 3624–3639. Published online 2016 Nov 1. doi: 10.1074/mcp.M116.061994