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Select item 112475481.

WTAP promotes proliferation of esophageal squamous cell carcinoma via m⁶A‐dependent epigenetic promoting of PTP4A1

Jiang Zou, Qiang Ma, Chuanli Gao, Miyuan Yang, Jilin Wen, Lei Xu, Xiaolan Guo, Xiaowu Zhong, Yixiang Duan

Cancer Sci. 2024 Jul; 115(7): 2254–2268. Published online 2024 May 15. doi: 10.1111/cas.15924

PMCID:: PMC11247548

Abstract Article PDF–18M

Select item 112451602.

Elevated WTAP promotes hyperinflammation by increasing m⁶A modification in inflammatory disease models

Yong Ge, Rong Chen, Tao Ling, Biaodi Liu, Jingrong Huang, Youxiang Cheng, Yi Lin, Hongxuan Chen, Xiongmei Xie, Guomeng Xia, Guanzheng Luo, Shaochun Yuan, Anlong Xu

J Clin Invest. 2024 Jul 15; 134(14): e177932. Published online 2024 May 16. doi: 10.1172/JCI177932

PMCID:: PMC11245160

Abstract Article PDF–4.6M

Select item 110064713.

WTAP regulates the production of reactive oxygen species, promotes malignant progression, and is closely related to the tumor microenvironment in glioblastoma

Qiankun Ji, Yazhou Guo, Zibo Li, Xiaoyang Zhang

Aging (Albany NY) 2024 Mar 31; 16(6): 5601–5617. Published online 2024 Mar 25. doi: 10.18632/aging.205666

PMCID:: PMC11006471

Abstract Article PDF–3.5M

Select item 109291814.

WTAP Mediated N6-methyladenosine RNA Modification of ELF3 Drives Cellular Senescence by Upregulating IRF8

Lei Zhou, Yun Zhong, Fan Wang, Yi Guo, Rui Mao, Hongfu Xie, Yiya Zhang, Ji Li

Int J Biol Sci. 2024; 20(5): 1763–1777. Published online 2024 Feb 25. doi: 10.7150/ijbs.90459

PMCID:: PMC10929181

Abstract Article PDF–6.5M

Select item 108349615.

WTAP-mediated m⁶A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis

Xueying An, Rongliang Wang, Zhongyang Lv, Wenshu Wu, Ziying Sun, Rui Wu, Wenjin Yan, Qing Jiang, Xingquan Xu

Exp Mol Med. 2024 Feb; 56(1): 156–167. Published online 2024 Jan 4. doi: 10.1038/s12276-023-01135-5

PMCID:: PMC10834961

Abstract Article PDF–8.9M

Select item 108247206.

Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancer

Jiao Wang, Fei Zheng, Dandan Wang, Qing Yang

Cell Death Dis. 2024 Jan; 15(1): 97. Published online 2024 Jan 29. doi: 10.1038/s41419-024-06477-0

PMCID:: PMC10824720

Abstract Article PDF–8.4M

Select item 107740947.

甲基化酶WTAP通过调控FOXO1的表达参与肾缺血再灌注损伤

赵刚刚, 李华锋, 张鸿毅, 肖克兵, 杨辉, 李子峰, 傅崇德

Nan Fang Yi Ke Da Xue Xue Bao. 2023 Dec 20; 43(12): 2035–2042. Chinese. doi: 10.12122/j.issn.1673-4254.2023.12.07

PMCID:: PMC10774094

Abstract Article PDF–1.6M

Select item 104352378.

A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression

Chaojun Yan, Jingjing Xiong, Zirui Zhou, Qifang Li, Chuan Gao, Mengyao Zhang, Liya Yu, Jinpeng Li, Ming-Ming Hu, Chen-Song Zhang, Cheguo Cai, Haojian Zhang, Jing Zhang

eLife. 2023; 12: RP87283. Published online 2023 Aug 17. doi: 10.7554/eLife.87283

PMCID:: PMC10435237

Abstract Article PDF–7.9M

Select item 104165109.

N6-methyladenosine (m6A) methyltransferase WTAP-mediated miR-92b-5p accelerates osteoarthritis progression

Zhaowei Lin, Tao Jiang, Wei Zheng, Jiayuan Zhang, Anan Li, Chao Lu, Wengang Liu

Cell Commun Signal. 2023; 21: 199. Published online 2023 Aug 10. doi: 10.1186/s12964-023-01228-8

PMCID:: PMC10416510

Abstract Article PDF–18M

Select item 1041264910.

PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS6

Yachun Jia, Xiao Yu, Rui Liu, Luyi Shi, Hua Jin, Dan Yang, Xiaofeng Zhang, Ying Shen, Yuandong Feng, Peihua Zhang, Yi Yang, Linlin Zhang, Pengyu Zhang, Zongfang Li, Aili He, Guangyao Kong

Cell Death Dis. 2023 Aug; 14(8): 512. Published online 2023 Aug 9. doi: 10.1038/s41419-023-06036-z

PMCID:: PMC10412649

Abstract Article PDF–5.5M

Select item 1023742211.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1018470312.

WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis

Jincheng Liu, Yunhao You, Zhenqian Sun, Lu Zhang, Xiang Li, Zihan Dai, Jinlong Ma, Yunzhen Chen, Guangjun Jiao

Stem Cells Transl Med. 2023 May; 12(5): 307–321. Published online 2023 Apr 3. doi: 10.1093/stcltm/szad020

PMCID:: PMC10184703

Abstract Article PDF–61M

Select item 997637813.

Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP

Yan Gao, Lingling Yuan, Changbin Ke, Zhijun Pei, Xiaobo Liu, Ruimin Wu, Xueyan Kui, Yanmin Zhang

J Transl Med. 2023; 21: 159. Published online 2023 Feb 28. doi: 10.1186/s12967-023-04001-0

PMCID:: PMC9976378

Abstract Article PDF–13M

Select item 995044714.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 984523915.

WTAP-mediated m⁶A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis

Yunhao You, Jincheng Liu, Lu Zhang, Xiang Li, Zhenqian Sun, Zihan Dai, Jinlong Ma, Guangjun Jiao, Yunzhen Chen

Cell Death Dis. 2023 Jan; 14(1): 33. Published online 2023 Jan 17. doi: 10.1038/s41419-023-05565-x

PMCID:: PMC9845239

Abstract Article PDF–7.2M

Select item 976847716.

Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis

Tian-Ping Zhang, Rui Li, Li-Jun Wang, Qian Huang, Hong-Miao Li

Front Immunol. 2022; 13: 992628. Published online 2022 Dec 7. doi: 10.3389/fimmu.2022.992628

PMCID:: PMC9768477

Abstract Article PDF–1.1M

Select item 968300817.

WTAP Targets the METTL3 m⁶A-Methyltransferase Complex to Cytoplasmic Hepatitis C Virus RNA to Regulate Infection

Matthew T. Sacco, Katherine M. Bland, Stacy M. Horner

J Virol. 2022 Nov; 96(22): e00997-22. Published online 2022 Oct 31. doi: 10.1128/jvi.00997-22

PMCID:: PMC9683008

Abstract Article PDF–1.7M

Select item 966619718.

Potential impact of WTAP and YTHDF2 on tumor immunity in lung adenocarcinoma

Xinyu Zhang, Xinsheng Cai

Medicine (Baltimore) 2022 Nov 11; 101(45): e31195. Published online 2022 Nov 11. doi: 10.1097/MD.0000000000031195

PMCID:: PMC9666197

Abstract Article PDF–3.3M

Select item 953348619.

Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop

Yongzhen Mo, Yumin Wang, Yian Wang, Xiangying Deng, Qijia Yan, Chunmei Fan, Shuai Zhang, Shanshan Zhang, Zhaojian Gong, Lei Shi, Qianjin Liao, Can Guo, Yong Li, Guiyuan Li, Zhaoyang Zeng, Weihong Jiang, Wei Xiong, Bo Xiang

Mol Cancer. 2022; 21: 192. Published online 2022 Oct 5. doi: 10.1186/s12943-022-01659-w