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Select item 86734661.

Open State Structure and Pore Gating Mechanism of the Cardiac Sodium Channel

Daohua Jiang, Richard Banh, Tamer M. Gamal El-Din, Lige Tonggu, Michael Lenaeus, Régis Pomès, Ning Zheng, William A. Catterall

Cell. Author manuscript; available in PMC 2022 Sep 30.

Published in final edited form as: Cell. 2021 Sep 30; 184(20): 5151–5162.e11. Published online 2021 Sep 13. doi: 10.1016/j.cell.2021.08.021

PMCID:: PMC8673466

Abstract Article PDF–3.0M

Select item 79631912.

Epigenetic Changes Governing Scn5a Expression in Denervated Skeletal Muscle

David Carreras, Rebecca Martinez-Moreno, Mel·lina Pinsach-Abuin, Manel M. Santafe, Pol Gomà, Ramon Brugada, Fabiana S. Scornik, Guillermo J. Pérez, Sara Pagans

Int J Mol Sci. 2021 Mar; 22(5): 2755. Published online 2021 Mar 9. doi: 10.3390/ijms22052755

PMCID:: PMC7963191

Abstract Article PDF–2.5M

Select item 77827383.

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin

Daohua Jiang, Lige Tonggu, Tamer M. Gamal El-Din, Richard Banh, Régis Pomès, Ning Zheng, William A. Catterall

Nat Commun. 2021; 12: 128. Published online 2021 Jan 4. doi: 10.1038/s41467-020-20078-3

PMCID:: PMC7782738

Abstract Article PDF–5.5M

Select item 65882924.

Predicting Patient Response to the Antiarrhythmic Mexiletine Based on Genetic Variation: Personalized Medicine for Long QT Syndrome

Wandi Zhu, Andrea Mazzanti, Taylor L. Voelker, Panpan Hou, Jonathan D. Moreno, Paweorn Angsutararux, Kristen M. Naegle, Silvia G. Priori, Jonathan R. Silva

Circ Res. Author manuscript; available in PMC 2020 Feb 15.

Published in final edited form as: Circ Res. 2019 Feb 15; 124(4): 539–552. doi: 10.1161/CIRCRESAHA.118.314050

PMCID:: PMC6588292

Abstract Article PDF–2.4M

Select item 64868505.

UBC9 regulates cardiac sodium channel Na_v1.5 ubiquitination, degradation and sodium current density

Bo Tang, Yushuang Hu, Zhijie Wang, Chen Cheng, Pengyun Wang, Lina Liang, Hongbo Xiong, Chunyan Luo, Chengqi Xu, Qiuyun Chen, Qing Kenneth Wang

J Mol Cell Cardiol. Author manuscript; available in PMC 2020 Apr 1.

Published in final edited form as: J Mol Cell Cardiol. 2019 Apr; 129: 79–91. Published online 2019 Feb 14. doi: 10.1016/j.yjmcc.2019.02.007

PMCID:: PMC6486850

Abstract Article PDF–1.9M

Select item 63492016.

Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to regulate cardiac bioelectricity

Yi Guan, Xueting Gao, Qiuyu Tang, Lin Huang, Siyun Gao, Shuai Yu, Jiale Huang, Jun Li, Daizhan Zhou, Yangyang Zhang, Dan Shi, Dandan Liang, Yi Liu, Li Li, Yingyu Cui, Liang Xu, Yi‐Han Chen

J Cell Mol Med. 2019 Feb; 23(2): 1448–1457. Published online 2018 Dec 3. doi: 10.1111/jcmm.14051

PMCID:: PMC6349201

Abstract Article PDF–837K

Select item 59700517.

Cardiac Kir2.1 and Na_V1.5 Channels Traffic Together to the Sarcolemma to Control Excitability

Daniela Ponce-Balbuena, Guadalupe Guerrero-Serna, Carmen R. Valdivia, Ricardo Caballero, F. Javier Diez-Guerra, Eric N. Jiménez-Vázquez, Rafael J. Ramírez, André Monteiro da Rocha, Todd J. Herron, Katherine F. Campbell, B. Cicero Willis, Francisco J. Alvarado, Manuel Zarzoso, Kuljeet Kaur, Marta Pérez-Hernández, Marcos Matamoros, Héctor H. Valdivia, Eva Delpón, José Jalife

Circ Res. Author manuscript; available in PMC 2019 May 25.

Published in final edited form as: Circ Res. 2018 May 25; 122(11): 1501–1516. Published online 2018 Mar 7. doi: 10.1161/CIRCRESAHA.117.311872

PMCID:: PMC5970051

Abstract Article PDF–2.2M

Select item 58248528.

A common variant alters SCN5A–miR-24 interaction and associates with heart failure mortality

Xiaoming Zhang, Jin-Young Yoon, Michael Morley, Jared M. McLendon, Kranti A. Mapuskar, Rebecca Gutmann, Haider Mehdi, Heather L. Bloom, Samuel C. Dudley, Patrick T. Ellinor, Alaa A. Shalaby, Raul Weiss, W.H. Wilson Tang, Christine S. Moravec, Madhurmeet Singh, Anne L. Taylor, Clyde W. Yancy, Arthur M. Feldman, Dennis M. McNamara, Kaikobad Irani, Douglas R. Spitz, Patrick Breheny, Kenneth B. Margulies, Barry London, Ryan L. Boudreau

J Clin Invest. 2018 Mar 1; 128(3): 1154–1163. Published online 2018 Feb 19. doi: 10.1172/JCI95710

PMCID:: PMC5824852

Abstract Article PDF–3.4M

Select item 56945519.

Kir2.1-Nav1.5 Channel Complexes Are Differently Regulated than Kir2.1 and Nav1.5 Channels Alone

Raquel G. Utrilla, Paloma Nieto-Marín, Silvia Alfayate, David Tinaquero, Marcos Matamoros, Marta Pérez-Hernández, Sandra Sacristán, Lorena Ondo, Raquel de Andrés, F. Javier Díez-Guerra, Juan Tamargo, Eva Delpón, Ricardo Caballero

Front Physiol. 2017; 8: 903. Published online 2017 Nov 14. doi: 10.3389/fphys.2017.00903

PMCID:: PMC5694551

Abstract Article PDF–3.1M

Select item 531196210.

Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine

Jacob M. Hooker, Martin G. Strebl, Frederick A. Schroeder, Hsiao-Ying Wey, Amrut V. Ambardekar, Timothy A. McKinsey, Matthias Schoenberger

Sci Rep. 2017; 7: 42136. Published online 2017 Feb 16. doi: 10.1038/srep42136

PMCID:: PMC5311962

Abstract Article PDF–690K

Select item 483662511.

Nav1.5 N-terminal domain binding to α1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels

Marcos Matamoros, Marta Pérez-Hernández, Guadalupe Guerrero-Serna, Irene Amorós, Adriana Barana, Mercedes Núñez, Daniela Ponce-Balbuena, Sandra Sacristán, Ricardo Gómez, Juan Tamargo, Ricardo Caballero, José Jalife, Eva Delpón

Cardiovasc Res. 2016 May 15; 110(2): 279–290. Published online 2016 Jan 19. doi: 10.1093/cvr/cvw009

PMCID:: PMC4836625

Abstract Article PDF–1.0M

Select item 468807612.

Expression and Function of the Scn5a-Encoded Voltage-Gated Sodium Channel Na_V1.5 in the Rat Jejunum

Arthur Beyder, Simon J. Gibbons, Amelia Mazzone, Peter R. Strege, Siva Arumugam Saravanaperumal, Lei Sha, Suzanne Higgins, Seth T. Eisenman, Cheryl E. Bernard, Aron Geurts, Crystal F. Kline, Peter J. Mohler, Gianrico Farrugia

Neurogastroenterol Motil. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: Neurogastroenterol Motil. 2016 Jan; 28(1): 64–73. Published online 2015 Oct 13. doi: 10.1111/nmo.12697

PMCID:: PMC4688076

Abstract Article PDF–749K

Select item 460350213.

SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia

Hassan Musa, Crystal F. Kline, Amy C. Sturm, Nathaniel Murphy, Sara Adelman, Chaojian Wang, Haidun Yan, Benjamin L. Johnson, Thomas A. Csepe, Ahmet Kilic, Robert S. D. Higgins, Paul M. L. Janssen, Vadim V. Fedorov, Raul Weiss, Christina Salazar, Thomas J. Hund, Geoffrey S. Pitt, Peter J. Mohler

Proc Natl Acad Sci U S A. 2015 Oct 6; 112(40): 12528–12533. Published online 2015 Sep 21. doi: 10.1073/pnas.1516430112

PMCID:: PMC4603502

Abstract Article PDF–1.4M

Select item 456891914.

Cardiac Na_v1.5 is modulated by ubiquitin protein ligase E3 component n-recognin UBR3 and 6

Chunxia Zhao, Lijie Wang, Xiue Ma, Weidong Zhu, Lei Yao, Yingyu Cui, Yi Liu, Jun Li, Xingqun Liang, Yunfu Sun, Li Li, Yi-Han Chen

J Cell Mol Med. 2015 Sep; 19(9): 2143–2152. Published online 2015 Jun 7. doi: 10.1111/jcmm.12588

PMCID:: PMC4568919

Abstract Article PDF–669K

Select item 454358115.

Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function in vivo

Patric Glynn, Hassan Musa, Xiangqiong Wu, Sathya D. Unudurthi, Sean Little, Lan Qian, Patrick J. Wright, Przemyslaw B. Radwanski, Sandor Gyorke, Peter J. Mohler, Thomas J. Hund

Circulation. Author manuscript; available in PMC 2016 Aug 18.

Published in final edited form as: Circulation. 2015 Aug 18; 132(7): 567–577. Published online 2015 Jul 17. doi: 10.1161/CIRCULATIONAHA.114.015218

PMCID:: PMC4543581

Abstract Article PDF–2.6M

Select item 451081716.

Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts

S C Salvage, J H King, K H Chandrasekharan, D I G Jafferji, L Guzadhur, H R Matthews, C L-H Huang, J A Fraser

Acta Physiol (Oxf) 2015 Jul; 214(3): 361–375. Published online 2015 Apr 23. doi: 10.1111/apha.12505

PMCID:: PMC4510817

Abstract Article PDF–948K

Select item 427464417.

A Connexin 40 Mutation Associated with a Malignant Variant of Progressive Familial Heart Block Type-1

Naomasa Makita, Akiko Seki, Naokata Sumitomo, Halina Chkourko, Shigetomo Fukuhara, Hiroshi Watanabe, Wataru Shimizu, Connie R. Bezzina, Can Hasdemir, Hideo Mugishima, Takeru Makiyama, Alban Baruteau, Estelle Baron, Minoru Horie, Nobuhisa Hagiwara, Arthur A.M. Wilde, Vincent Probst, Hervé Le Marec, Dan M. Roden, Naoki Mochizuki, Jean-Jacques Schott, Mario Delmar

Circ Arrhythm Electrophysiol. Author manuscript; available in PMC 2014 Dec 23.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2012 Feb; 5(1): 163–172. Published online 2012 Jan 13. doi: 10.1161/CIRCEP.111.967604

PMCID:: PMC4274644

Abstract Article PDF–4.1M

Select item 411627618.

Mutations in SCN10A Responsible for a Large Fraction of Brugada Syndrome Cases

Dan Hu, Hector Barajas-Martínez, Ryan Pfeiffer, Fabio Dezi, Jenna Pfeiffer, Tapan Buch, Matthew J. Betzenhauser, Luiz Belardinelli, Kristopher M. Kahlig, Sridharan Rajamani, Harry J. DeAntonio, Robert J. Myerburg, Hiroyuki Ito, Pramod Deshmukh, Mark Marieb, Gi-Byoung Nam, Atul Bhatia, Can Hasdemir, Michel Haïssaguerre, Christian Veltmann, Rainer Schimpf, Martin Borggrefe, Sami Viskin, Charles Antzelevitch

J Am Coll Cardiol. Author manuscript; available in PMC 2015 Jul 8.

Published in final edited form as: J Am Coll Cardiol. 2014 Jul 8; 64(1): 66–79. doi: 10.1016/j.jacc.2014.04.032

PMCID:: PMC4116276

Abstract Article PDF–1.0M

Select item 408504519.

Cx43 Associates with Na_v1.5 in the Cardiomyocyte Perinexus

J. Matthew Rhett, Emily L. Ongstad, Jane Jourdan, Robert G. Gourdie

J Membr Biol. Author manuscript; available in PMC 2014 Jul 7.

Published in final edited form as: J Membr Biol. 2012 Jul; 245(7): 411–422. Published online 2012 Jul 19. doi: 10.1007/s00232-012-9465-z

PMCID:: PMC4085045

Abstract Article PDF–1.0M

Select item 363322320.

MOG1 Rescues Defective Trafficking of Na_v1.5 Mutations in Brugada Syndrome and Sick Sinus Syndrome

Susmita Chakrabarti, Xiaofen Wu, Zhaogang Yang, Ling Wu, Sandro L. Yong, Cuntai Zhang, Keli Hu, Qing K. Wang, Qiuyun Chen

Circ Arrhythm Electrophysiol. Author manuscript; available in PMC 2013 Apr 23.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2013 Apr 1; 6(2): 392–401. Published online 2013 Feb 18. doi: 10.1161/CIRCEP.111.000206

PMCID:: PMC3633223

Abstract Article PDF–2.5M

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