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Select item 111781591.

NGF effects promote the maturation of rat pancreatic beta cells by regulating GLUT2 levels and distribution, and glucokinase activity

Jazmín Samario-Román, Myrian Velasco, Carlos Larqué, René Cárdenas-Vázquez, Rosa Isela Ortiz-Huidobro, Marcia Hiriart

PLoS One. 2024; 19(6): e0303934. Published online 2024 Jun 14. doi: 10.1371/journal.pone.0303934

PMCID:: PMC11178159

Abstract Article PDF–1.6M

Select item 71494882.

Metabolic control analysis of hepatic glycogen synthesis in vivo

Yuichi Nozaki, Max C. Petersen, Dongyan Zhang, Daniel F. Vatner, Rachel J. Perry, Abudukadier Abulizi, Sofie Haedersdal, Xian-Man Zhang, Gina M. Butrico, Varman T. Samuel, Graeme F. Mason, Gary W. Cline, Kitt F. Petersen, Douglas L. Rothman, Gerald I. Shulman

Proc Natl Acad Sci U S A. 2020 Apr 7; 117(14): 8166–8176. Published online 2020 Mar 18. doi: 10.1073/pnas.1921694117

PMCID:: PMC7149488

Abstract Article PDF–1.1M

Select item 61977233.

Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes

Ali J. Chakera, Paul S. Hurst, Gill Spyer, Emmanuel O. Ogunnowo-Bada, William J. Marsh, Christine H. Riches, Chen-Yu Yueh, S. Pauliina Markkula, Jeffrey W. Dalley, Roger D. Cox, Ian A. Macdonald, Stephanie A. Amiel, Kenneth M. MacLeod, Lora K. Heisler, Andrew T. Hattersley, Mark L. Evans

Mol Metab. 2018 Nov; 17: 17–27. Published online 2018 Aug 13. doi: 10.1016/j.molmet.2018.08.001

PMCID:: PMC6197723

Abstract Article PDF–1.3M

Select item 43822284.

Glucokinase activity in the arcuate nucleus regulates glucose intake

Syed Hussain, Errol Richardson, Yue Ma, Christopher Holton, Ivan De Backer, Niki Buckley, Waljit Dhillo, Gavin Bewick, Shuai Zhang, David Carling, Steve Bloom, James Gardiner

J Clin Invest. 2015 Jan 2; 125(1): 337–349. Published online 2014 Dec 8. doi: 10.1172/JCI77172

PMCID:: PMC4382228

Abstract Article PDF–931K

Select item 41753445.

Chronic Ethanol Consumption Inhibits Glucokinase Transcriptional Activity by Atf3 and Triggers Metabolic Syndrome in Vivo

Ji Yeon Kim, Joo-Yeon Hwang, Dae Yeon Lee, Eun Hyun Song, Keon Jae Park, Gyu Hee Kim, Eun Ae Jeong, Yoo Jeong Lee, Min Jin Go, Dae Jin Kim, Seong Su Lee, Bong-Jo Kim, Jihyun Song, Gu Seob Roh, Bin Gao, Won-Ho Kim

J Biol Chem. 2014 Sep 26; 289(39): 27065–27079. Published online 2014 Jul 29. doi: 10.1074/jbc.M114.585653

PMCID:: PMC4175344

Abstract Article PDF–4.1M

Select item 39667456.

Chronic glucokinase activator treatment at clinically translatable exposures gives durable glucose lowering in two animal models of type 2 diabetes

D J Baker, G P Wilkinson, A M Atkinson, H B Jones, M Coghlan, A D Charles, B Leighton

Br J Pharmacol. 2014 Apr; 171(7): 1642–1654. Published online 2014 Mar 18. doi: 10.1111/bph.12504

PMCID:: PMC3966745

Abstract Article PDF–1.7M

Select item 38616337.

Identification of the Ubiquitin-like Domain of Midnolin as a New Glucokinase Interaction Partner

Anke Hofmeister-Brix, Katrin Kollmann, Sara Langer, Julia Schultz, Sigurd Lenzen, Simone Baltrusch

J Biol Chem. 2013 Dec 13; 288(50): 35824–35839. Published online 2013 Nov 1. doi: 10.1074/jbc.M113.526632

PMCID:: PMC3861633

Abstract Article PDF–5.3M

Select item 37892488.

Retinoids synergize with insulin to induce hepatic Gck expression

Guoxun Chen, Yan Zhang, Danhong Lu, Nan-qian Li, A. Catharine Ross

Biochem J. Author manuscript; available in PMC 2013 Oct 3.

Published in final edited form as: Biochem J. 2009 May 1; 419(3): 645–653. doi: 10.1042/BJ20082368

PMCID:: PMC3789248

Abstract Article PDF–2.0M

Select item 37293869.

Characterization of the gene expression profile of heterozygous liver-specific glucokinase knockout mice at a young age

Tingting Guo, Yiqing Mao, Hui Li, Xi Wang, Wei Xu, Rongjing Song, Jianwei Jia, Zhen Lei, David M. Irwin, Gang Niu, Huanran Tan

Biomed Pharmacother. Author manuscript; available in PMC 2013 Dec 1.

Published in final edited form as: Biomed Pharmacother. 2012 Dec; 66(8): 587–596. Published online 2012 Aug 25. doi: 10.1016/j.biopha.2012.07.002

PMCID:: PMC3729386

Abstract Article PDF–1.4M

Select item 357256110.

Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans

Frédéric De Ceuninck, Catherine Kargar, Catherine Ilic, Audrey Caliez, Jean-Olivier Rolin, Thierry Umbdenstock, Cédric Vinson, Murielle Combettes, Brant Fanti, Elizabeth Harley, Marjorie Sadlo, Anne-Laure Lefèvre, Olivier Broux, Michel Wierzbicki, Jean-Marie Fourquez, Françoise Perron-Sierra, András Kotschy, Alain Ktorza

Br J Pharmacol. 2013 Jan; 168(2): 339–353. Published online 2012 Dec 20. doi: 10.1111/j.1476-5381.2012.02184.x

PMCID:: PMC3572561

Abstract Article PDF–3.7M

Select item 337961211.

Insights Into the Pathogenicity of Rare Missense GCK Variants From the Identification and Functional Characterization of Compound Heterozygous and Double Mutations Inherited in Cis

Nicola L. Beer, Kara K. Osbak, Martijn van de Bunt, Nicholas D. Tribble, Anna M. Steele, Kirsty J. Wensley, Emma L. Edghill, Kevin Colcough, Amy Barrett, Lucia Valentínová, Jana K. Rundle, Anne Raimondo, Joseph Grimsby, Sian Ellard, Anna L. Gloyn

Diabetes Care. 2012 Jul; 35(7): 1482–1484. Published online 2012 Jun 12. doi: 10.2337/dc11-2420

PMCID:: PMC3379612

Abstract Article PDF–606K

Select item 317805912.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 290925813.

Effects of GCK, GCKR, G6PC2 and MTNR1B Variants on Glucose Metabolism and Insulin Secretion

Cheng Hu, Rong Zhang, Congrong Wang, Weihui Yu, Jingyi Lu, Xiaojing Ma, Jie Wang, Feng Jiang, Shanshan Tang, Yuqian Bao, Kunsan Xiang, Weiping Jia

PLoS One. 2010; 5(7): e11761. Published online 2010 Jul 23. doi: 10.1371/journal.pone.0011761

PMCID:: PMC2909258

Abstract Article PDF–209K

Select item 288153714.

Glial glucokinase expression in adult and post-natal development of the hypothalamic region

Carola Millán, Fernando Martínez, Christian Cortés-Campos, Isabel Lizama, Maria Jose Yañez, Paula Llanos, Karin Reinicke, Federico Rodríguez, Bruno Peruzzo, Francisco Nualart, Maria Angeles García

ASN Neuro. 2010; 2(3): e00035. Prepublished online 2010 Apr 30. Published online 2010 May 25. doi: 10.1042/AN20090059

PMCID:: PMC2881537

Abstract Article PDF–15M

Select item 268568915.

Interrelationship between Liver X Receptor α, Sterol Regulatory Element-binding Protein-1c, Peroxisome Proliferator-activated Receptor γ, and Small Heterodimer Partner in the Transcriptional Regulation of Glucokinase Gene Expression in Liver

Tae-Hyun Kim, Hail Kim, Joo-Man Park, Seung-Soon Im, Jin-Sik Bae, Mi-Young Kim, Ho-Geun Yoon, Ji-Young Cha, Kyung-Sup Kim, Yong-Ho Ahn

J Biol Chem. 2009 May 29; 284(22): 15071–15083. doi: 10.1074/jbc.M109.006742

PMCID:: PMC2685689

Abstract Article PDF–968K

Select item 249469016.

Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance

Michelle Goldsworthy, Alison Hugill, Helen Freeman, Emma Horner, Kenju Shimomura, Debora Bogani, Guido Pieles, Vesna Mijat, Ruth Arkell, Shoumo Bhattacharya, Frances M. Ashcroft, Roger D. Cox

Diabetes. 2008 Aug; 57(8): 2234–2244. doi: 10.2337/db07-0337

PMCID:: PMC2494690

Abstract Article PDF–1.0M

Select item 247854617.

Substrate-induced Nuclear Export and Peripheral Compartmentalization of Hepatic Glucokinase Correlates with Glycogen Deposition

Thomas L. Jetton, Masa Shiota, Susan M. Knobel, David W. Piston, Alan D. Cherrington, Mark A. Magnuson

Int J Exp Diabetes Res. 2001; 2(3): 173–186. doi: 10.1155/EDR.2001.173

PMCID:: PMC2478546

Summary PDF–1.7M

Select item 160991418.

Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor

Franck Hansmannel, Sylvie Mordier, Patrick B. Iynedjian

Biochem J. 2006 Oct 15; 399(Pt 2): 275–283. Prepublished online 2006 Jul 12. Published online 2006 Sep 27. doi: 10.1042/BJ20060811

Correction in:: Biochem J, volume 411 on page 697

PMCID:: PMC1609914

Abstract Article PDF–333K

Select item 138369819.

Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability

María Galán, Olivier Vincent, Isabel Roncero, Sharona Azriel, Pedro Boix-Pallares, Elías Delgado-Alvarez, Francisco Díaz-Cadórniga, Enrique Blázquez, María-Angeles Navas

Biochem J. 2006 Jan 1; 393(Pt 1): 389–396. Prepublished online 2005 Sep 21. Published online 2005 Dec 12. doi: 10.1042/BJ20051137

PMCID:: PMC1383698

Abstract Article PDF–424K

Select item 122397420.

Differences in regulatory properties between human and rat glucokinase regulatory protein.

Katy J Brocklehurst, Rick A Davies, Loranne Agius

Biochem J. 2004 Mar 1; 378(Pt 2): 693–697. doi: 10.1042/BJ20031414

PMCID:: PMC1223974

Summary PDF–105K

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