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Select item 111666441.

Knockout of the longevity gene Klotho perturbs aging and Alzheimer’s disease-linked brain microRNAs and tRNA fragments

Serafima Dubnov, Estelle R. Bennett, Nadav Yayon, Or Yakov, David A. Bennett, Sudha Seshadri, Elliott Mufson, Yonat Tzur, David Greenberg, Makoto Kuro-o, Iddo Paldor, Carmela R. Abraham, Hermona Soreq

Commun Biol. 2024; 7: 720. Published online 2024 Jun 11. doi: 10.1038/s42003-024-06407-y

PMCID:: PMC11166644

Abstract Article PDF–2.8M

Select item 111471182.

Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases

R. Nagai*, Y. Saito, Y. Ohyama, H. Aizawa, T. Suga, T. Nakamura, M. Kurabayashi, M. Kuro-o

Cell Mol Life Sci. 2000 May; 57(5): 738–746. doi: 10.1007/s000180050038

PMCID:: PMC11147118

Abstract PDF–289K

Select item 111467843.

Cellular and molecular mechanism of low-turnover osteopenia in the klotho-deficient mouse

H. Kawaguchi*, N. Manabe, H. Chikuda, K. Nakamura, M. Kuro-o

Cell Mol Life Sci. 2000 May; 57(5): 731–737. doi: 10.1007/s000180050037

PMCID:: PMC11146784

Abstract PDF–1.6M

Select item 111346644.

ABI3BP promotes renal aging through Klotho-mediated ferroptosis

Ren Ji, Lin Wei, Yuxin Zan, Xiao Li, Shinan Ma, Liming Ma, Xiju He, Li Wang, Yan Ding

J Transl Med. 2024; 22: 514. Published online 2024 May 29. doi: 10.1186/s12967-024-05300-w

PMCID:: PMC11134664

Abstract Article PDF–2.2M

Select item 109681255.

Absence of the Klotho Function Causes Cornea Degeneration with Specific Features Resembling Fuchs Endothelial Corneal Dystrophy and Bullous Keratopathy

Chun-Yen Wu, Da-Fong Song, Zhi-Jia Chen, Chao-Sheng Hu, David Pei-Cheng Lin, Han-Hsin Chang

Biology (Basel) 2024 Mar; 13(3): 133. Published online 2024 Feb 20. doi: 10.3390/biology13030133

PMCID:: PMC10968125

Abstract Article PDF–12M

Select item 108617706.

Relationship of the bone phenotype of the Klotho mutant mouse model of accelerated aging to changes in skeletal architecture that occur with chronological aging

Lieve Verlinden, Shanshan Li, Vaishali Veldurthy, Geert Carmeliet, Sylvia Christakos

Front Endocrinol (Lausanne) 2024; 15: 1310466. Published online 2024 Jan 30. doi: 10.3389/fendo.2024.1310466

PMCID:: PMC10861770

Abstract Article PDF–1.9M

Select item 108412257.

Klotho regulates the myogenic response of muscle to mechanical loading and exercise

Eisuke Ochi, Alice Barrington, Michelle Wehling‐Henricks, Marcus Avila, Makoto Kuro‐o, James G. Tidball

Exp Physiol. 2023 Dec; 108(12): 1531–1547. Published online 2023 Oct 20. doi: 10.1113/EP091263

PMCID:: PMC10841225

Abstract Article PDF–1.8M

Select item 107951678.

Klotho-derived peptide KP1 ameliorates SARS-CoV-2-associated acute kidney injury

Jie Xu, Enqing Lin, Xue Hong, Li Li, Jun Gu, Jinghong Zhao, Youhua Liu

Front Pharmacol. 2023; 14: 1333389. Published online 2024 Jan 3. doi: 10.3389/fphar.2023.1333389

PMCID:: PMC10795167

Abstract Article PDF–5.1M

Select item 107502009.

Klotho-derived peptide 1 inhibits cellular senescence in the fibrotic kidney by restoring Klotho expression via posttranscriptional regulation

Xiaoyao Zhang, Li Li, Huishi Tan, Xue Hong, Qian Yuan, Fan Fan Hou, Lili Zhou, Youhua Liu

Theranostics. 2024; 14(1): 420–435. Published online 2024 Jan 1. doi: 10.7150/thno.89105

PMCID:: PMC10750200

Abstract Article PDF–11M

Select item 1061230210.

Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease

Wei Jiang, Chun Gan, Xindi Zhou, Qing Yang, Dan Chen, Han Xiao, Lujun Dai, Yaxi Chen, Mo Wang, Haiping Yang, Qiu Li

Cardiovasc Diabetol. 2023; 22: 293. Published online 2023 Oct 27. doi: 10.1186/s12933-023-02025-w

PMCID:: PMC10612302

Abstract Article PDF–6.4M

Select item 1060415511.

Klotho Null Mutation Indirectly Leads to Age-Related Lacrimal Gland Degeneration in Mutant Mice

Chun-Yen Wu, Da-Fong Song, Tsung-Han Lu, Zhi-Jia Chen, Su-Min Tsai, Ya-Jing Liu, Han-Hsin Chang, David Pei-Cheng Lin

Biology (Basel) 2023 Oct; 12(10): 1328. Published online 2023 Oct 11. doi: 10.3390/biology12101328

PMCID:: PMC10604155

Abstract Article PDF–4.2M

Select item 1052609312.

Decreased Klotho Expression Causes Accelerated Decline of Male Fecundity through Oxidative Injury in Murine Testis

Ya-Yun Wang, Ying-Hung Lin, Vin-Cent Wu, Yu-Hua Lin, Chia-Yen Huang, Wei-Chi Ku, Chiao-Yin Sun

Antioxidants (Basel) 2023 Sep; 12(9): 1671. Published online 2023 Aug 25. doi: 10.3390/antiox12091671

PMCID:: PMC10526093

Abstract Article PDF–8.9M

Select item 1050189913.

Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice

Cana Park, Oliver Hahn, Shweta Gupta, Arturo J. Moreno, Francesca Marino, Blen Kedir, Dan Wang, Saul A. Villeda, Tony Wyss-Coray, Dena B. Dubal

Nat Aging. 2023; 3(9): 1067–1078. Published online 2023 Aug 16. doi: 10.1038/s43587-023-00468-0

PMCID:: PMC10501899

Abstract Article PDF–9.2M

Select item 1049751614.

Klotho increases antioxidant defenses in astrocytes and ubiquitin–proteasome activity in neurons

Ana Maria Orellana, Caio Henrique Mazucanti, Leticia Pavan dos Anjos, Larissa de Sá Lima, Elisa Mitiko Kawamoto, Cristoforo Scavone

Sci Rep. 2023; 13: 15080. Published online 2023 Sep 12. doi: 10.1038/s41598-023-41166-6

PMCID:: PMC10497516

Abstract Article PDF–1.8M

Select item 1045417415.

Extracellular Vesicles in Young Serum Contribute to the Restoration of Age-Related Brain Transcriptomes and Cognition in Old Mice

Nicholas F. Fitz, Amrita Sahu, Yi Lu, Fabrisia Ambrosio, Iliya Lefterov, Radosveta Koldamova

Int J Mol Sci. 2023 Aug; 24(16): 12550. Published online 2023 Aug 8. doi: 10.3390/ijms241612550

PMCID:: PMC10454174

Abstract Article PDF–3.7M

Select item 1037289816.

Insulin-Like Growth Factor1 Preserves Gastric Pacemaker Cells and Motor Function in Aging via ERK1/2 Activation

Vy Truong Thuy Nguyen, Negar Taheri, Egan L. Choi, Todd A. Kellogg, David R. Linden, Yujiro Hayashi

Cell Mol Gastroenterol Hepatol. 2023; 16(3): 369–383. Published online 2023 Jun 8. doi: 10.1016/j.jcmgh.2023.06.002

PMCID:: PMC10372898

Abstract Article PDF–4.0M

Select item 1019991717.

Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium

Ha Young Jang, Soo-Jin Kim, Kyu-Sang Park, Jeong Hun Kim

Cell Death Dis. 2023 May; 14(5): 334. Published online 2023 May 20. doi: 10.1038/s41419-023-05851-8

PMCID:: PMC10199917

Abstract Article PDF–6.6M

Select item 1012934518.

Klotho protects chromosomal DNA from radiation-induced damage

Shinya Nakayama, Jiying Sun, Yasunori Horikoshi, Yoshitaka Kamimura, Takeshi Ike, Shu Fujino, Yasuha Kinugasa, Kensuke Sasaki, Ayumu Nakashima, Takao Masaki, Satoshi Tashiro

J Biochem. 2023 May; 173(5): 375–382. Published online 2023 Jan 12. doi: 10.1093/jb/mvad001

PMCID:: PMC10129345

Abstract Article PDF–1.0M

Select item 994709919.

Soluble Klotho protects against glomerular injury through regulation of ER stress response

Emmanuelle Charrin, Dina Dabaghie, Ilke Sen, David Unnersjö-Jess, Katja Möller-Hackbarth, Mikhail Burmakin, Rik Mencke, Sonia Zambrano, Jaakko Patrakka, Hannes Olauson

Commun Biol. 2023; 6: 208. Published online 2023 Feb 22. doi: 10.1038/s42003-023-04563-1