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Items: 1 to 20 of 38

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes
Amanda J. Stock, Ross A. McDevitt, Chandrakala Puligilla, Yajun Wang, Yongqing Zhang, Kun Wang, Chongkui Sun, Kevin G. Becker, Elin Lehrmann, William H. Wood, 3rd, Yi Gong, Mohammad Aqdas, Myong-Hee Sung, Victoria Hoffmann, Chengyu Liu, Myriam Gorospe, Lea Harrington, Luigi Ferrucci, Yie Liu
PLoS Genet. 2022 Nov; 18(11): e1010506. Published online 2022 Nov 28. doi: 10.1371/journal.pgen.1010506
PMCID:
PMC9704629
AbstractArticlePDF–4.2M
3.
Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states
Raymond Mario Barry, Olivia Sacco, Amel Mameri, Martin Stojaspal, William Kartsonis, Pooja Shah, Pablo De Ioannes, Ctirad Hofr, Jacques Côté, Agnel Sfeir
Genes Dev. 2022 Mar 1; 36(5-6): 313–330. doi: 10.1101/gad.349039.121
PMCID:
PMC8973845
AbstractArticlePDF–7.0M
4.
Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice via p53/PPARα signaling
Yin Cai, Hao Liu, Erfei Song, Lin Wang, Jindong Xu, Yi He, Dengwen Zhang, Liyan Zhang, Kenneth King-yip Cheng, Leigang Jin, Min Wu, Shiming Liu, Dake Qi, Liangqing Zhang, Gary D. Lopaschuk, Sheng Wang, Aimin Xu, Zhengyuan Xia
Theranostics. 2021; 11(10): 4710–4727. Published online 2021 Mar 4. doi: 10.7150/thno.51739
PMCID:
PMC7978321
AbstractArticlePDF–2.3M
5.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
6.
Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2–interacting protein
Sivareddy Kotla, Hang Thi Vu, Kyung Ae Ko, Yin Wang, Masaki Imanishi, Kyung-Sun Heo, Yuka Fujii, Tamlyn N. Thomas, Young Jin Gi, Hira Mazhar, Jesus Paez-Mayorga, Ji-Hyun Shin, Yunting Tao, Carolyn J. Giancursio, Jan L.M. Medina, Jack Taunton, Aldos J. Lusis, John P. Cooke, Keigi Fujiwara, Nhat-Tu Le, Jun-ichi Abe
JCI Insight. 2019 May 2; 4(9): e124867. Published online 2019 May 2. doi: 10.1172/jci.insight.124867
PMCID:
PMC6538340
AbstractArticlePDF–49M
7.
TBC1D21 Potentially Interacts with and Regulates Rap1 during Murine Spermatogenesis
Chih-Chun Ke, Ying-Hung Lin, Ya-Yun Wang, Ying-Yu Wu, Mei-Feng Chen, Wei-Chi Ku, Han-Sun Chiang, Tsung-Hsuan Lai
Int J Mol Sci. 2018 Nov; 19(11): 3292. Published online 2018 Oct 23. doi: 10.3390/ijms19113292
PMCID:
PMC6274753
AbstractArticlePDF–2.2M
8.
Mice lacking RAP1 show early onset and higher rates of DEN-induced hepatocellular carcinomas in female mice
Iole Ferrara-Romeo, Paula Martínez, Maria A. Blasco
PLoS One. 2018; 13(10): e0204909. Published online 2018 Oct 11. doi: 10.1371/journal.pone.0204909
PMCID:
PMC6187989
AbstractArticlePDF–10M
9.
RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression
Paula Martínez, Gonzalo Gómez-López, Fernando García, Evi Mercken, Sarah Mitchell, Juana M. Flores, Rafael de Cabo, Maria A. Blasco
Cell Rep. Author manuscript; available in PMC 2018 Apr 7.
Published in final edited form as: Cell Rep. 2013 Jun 27; 3(6): 2059–2074. Published online 2013 Jun 20. doi: 10.1016/j.celrep.2013.05.030
PMCID:
PMC5889507
AbstractArticlePDF–3.0M
10.
Nontelomeric Role for Rap1 in Regulating Metabolism and Protecting against Obesity
Frank Yeung, Cristina M. Ramírez, Pedro A. Mateos-Gomez, Alexandra Pinzaru, Giovanni Ceccarini, Shaheen Kabir, Carlos Fernández-Hernando, Agnel Sfeir
Cell Rep. Author manuscript; available in PMC 2017 Jul 24.
Published in final edited form as: Cell Rep. 2013 Jun 27; 3(6): 1847–1856. Published online 2013 Jun 20. doi: 10.1016/j.celrep.2013.05.032
PMCID:
PMC5523811
AbstractArticlePDF–860K
11.
The differential spatiotemporal expression pattern of shelterin genes throughout lifespan
Kay-Dietrich Wagner, Yilin Ying, Waiian Leong, Jie Jiang, Xuefei Hu, Yi Chen, Jean-François Michiels, Yiming Lu, Eric Gilson, Nicole Wagner, Jing Ye
Aging (Albany NY) 2017 Apr; 9(4): 1219–1228. Published online 2017 Apr 17. doi: 10.18632/aging.101223
PMCID:
PMC5425123
AbstractArticlePDF–4.4M
12.
A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance
Paula Martínez, Gonzalo Gómez‐López, David G. Pisano, Juana M. Flores, Maria A. Blasco
Aging Cell. 2016 Dec; 15(6): 1113–1125. Published online 2016 Sep 1. doi: 10.1111/acel.12517
PMCID:
PMC5114719
AbstractArticlePDF–2.3M
13.
Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP
Yanping Li, Tara J. Dillon, Maho Takahashi, Keith T. Earley, Philip J. S. Stork
J Biol Chem. 2016 Oct 7; 291(41): 21584–21595. Published online 2016 Aug 16. doi: 10.1074/jbc.M116.730978
PMCID:
PMC5076829
AbstractArticlePDF–1.7M
14.
Repressor and activator protein accelerates hepatic ischemia reperfusion injury by promoting neutrophil inflammatory response
Chang Xian Li, Chung Mau Lo, Qizhou Lian, Kevin Tak-Pan Ng, Xiao Bing Liu, Yuen Yuen Ma, Xiang Qi, Oscar Wai Ho Yeung, Vinay Tergaonkar, Xin Xiang Yang, Hui Liu, Jiang Liu, Yan Shao, Kwan Man
Oncotarget. 2016 May 10; 7(19): 27711–27723. Published online 2016 Mar 30. doi: 10.18632/oncotarget.8509
PMCID:
PMC5053682
AbstractArticlePDF–13M
15.
TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
Rekha Rai, Yong Chen, Ming Lei, Sandy Chang
Nat Commun. 2016; 7: 10881. Published online 2016 Mar 4. doi: 10.1038/ncomms10881
PMCID:
PMC4785230
AbstractArticlePDF–2.9M
16.
Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis
Rupalatha Maddala, Tharkika Nagendran, Richard A. Lang, Alexei Morozov, Ponugoti V. Rao
Dev Biol. Author manuscript; available in PMC 2016 Oct 1.
Published in final edited form as: Dev Biol. 2015 Oct 1; 406(1): 74–91. Published online 2015 Jul 23. doi: 10.1016/j.ydbio.2015.06.022
PMCID:
PMC4587029
AbstractArticlePDF–1.6M
17.
RASA3 is a critical inhibitor of RAP1-dependent platelet activation
Lucia Stefanini, David S. Paul, Raymond F. Robledo, E. Ricky Chan, Todd M. Getz, Robert A. Campbell, Daniel O. Kechele, Caterina Casari, Raymond Piatt, Kathleen M. Caron, Nigel Mackman, Andrew S. Weyrich, Matthew C. Parrott, Yacine Boulaftali, Mark D. Adams, Luanne L. Peters, Wolfgang Bergmeier
J Clin Invest. 2015 Apr 1; 125(4): 1419–1432. Published online 2015 Feb 23. doi: 10.1172/JCI77993
PMCID:
PMC4396462
AbstractArticlePDF–3.5M
18.
TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling
Michal Zimmermann, Tatsuya Kibe, Shaheen Kabir, Titia de Lange
Genes Dev. 2014 Nov 15; 28(22): 2477–2491. doi: 10.1101/gad.251611.114
PMCID:
PMC4233241
AbstractArticlePDF–1.6M
19.
Rasa3 Controls Megakaryocyte Rap1 Activation, Integrin Signaling and Differentiation into Proplatelet
Patricia Molina-Ortiz, Séléna Polizzi, Eve Ramery, Stéphanie Gayral, Céline Delierneux, Cécile Oury, Shintaro Iwashita, Stéphane Schurmans
PLoS Genet. 2014 Jun; 10(6): e1004420. Published online 2014 Jun 26. doi: 10.1371/journal.pgen.1004420
PMCID:
PMC4072513
AbstractArticlePDF–7.8M
20.
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent t-loop formation
Ylli Doksani, John Y. Wu, Titia de Lange, Xiaowei Zhuang
Cell. Author manuscript; available in PMC 2014 Oct 10.
Published in final edited form as: Cell. 2013 Oct 10; 155(2): 345–356. doi: 10.1016/j.cell.2013.09.048
PMCID:
PMC4062873
AbstractArticlePDF–438K

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