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Items: 1 to 20 of 80

1.
Anti-CD137 monoclonal antibodies and adoptive T cell therapy: a perfect marriage?
Bettina Weigelin, Elixabet Bolaños, Maria E. Rodriguez-Ruiz, Ivan Martinez-Forero, Peter Friedl, Ignacio Melero
Cancer Immunol Immunother. 2016 May; 65(5): 493–497. Published online 2016 Mar 12. doi: 10.1007/s00262-016-1818-5
PMCID:
PMC11028781
AbstractArticlePDF–815K
2.
Epstein-Barr virus-induced ectopic CD137 expression helps nasopharyngeal carcinoma to escape immune surveillance and enables targeting by chimeric antigen receptors
Mukul Prasad, Sashigala Ponnalagu, Qun Zeng, Khang Luu, Si Min Lang, Hiu Yi Wong, Man Si Cheng, Meihui Wu, Karthik Mallilankaraman, Radoslaw Mikolaj Sobota, Yan Ting Lim, Loo Chien Wang, Chuan Keng Goh, Kai Xun Joshua Tay, Kwok Seng Loh, Cheng-I. Wang, Wen-Hsien Lee, Boon Cher Goh, Chwee Ming Lim, Herbert Schwarz
Cancer Immunol Immunother. 2022 Nov; 71(11): 2583–2596. Published online 2022 Mar 17. doi: 10.1007/s00262-022-03183-8
PMCID:
PMC10992239
AbstractArticlePDF–2.1M
3.
Soluble CD137: A Potential Prognostic Biomarker in Critically Ill Patients
Ulrich Räth, Patricia Mester, Herbert Schwarz, Stephan Schmid, Martina Müller, Christa Buechler, Vlad Pavel
Int J Mol Sci. 2023 Dec; 24(24): 17518. Published online 2023 Dec 15. doi: 10.3390/ijms242417518
PMCID:
PMC10744319
AbstractArticlePDF–1.9M
4.
Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB
Morten Aagaard Nielsen, Kristian Juul-Madsen, John Stegmayr, Chao Gao, Akul Y. Mehta, Stinne Ravn Greisen, Tue Wenzel Kragstrup, Malene Hvid, Thomas Vorup-Jensen, Richard D. Cummings, Hakon Leffler, Bent Winding Deleuran
Front Immunol. 2022; 13: 915890. Published online 2022 Jun 24. doi: 10.3389/fimmu.2022.915890
PMCID:
PMC9263355
AbstractArticlePDF–4.1M
5.
CD137 (4-1BB) stimulation leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity
A. Stoll, H. Bruns, M. Fuchs, S. Völkl, F. Nimmerjahn, M. Kunz, M. Peipp, A. Mackensen, D. Mougiakakos
Leukemia. 2021; 35(12): 3482–3496. Published online 2021 May 21. doi: 10.1038/s41375-021-01287-1
PMCID:
PMC8632678
AbstractArticlePDF–4.7M
6.
Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction
Baptiste Lamarthée, Armance Marchal, Soëli Charbonnier, Tifanie Blein, Juliette Leon, Emmanuel Martin, Lucas Rabaux, Katrin Vogt, Matthias Titeux, Marianne Delville, Hélène Vinçon, Emmanuelle Six, Nicolas Pallet, David Michonneau, Dany Anglicheau, Christophe Legendre, Jean-Luc Taupin, Ivan Nemazanyy, Birgit Sawitzki, Sylvain Latour, Marina Cavazzana, Isabelle André, Julien Zuber
Nat Commun. 2021; 12: 6446. Published online 2021 Nov 8. doi: 10.1038/s41467-021-26844-1
PMCID:
PMC8575891
AbstractArticlePDF–5.0M
7.
Early loss of T lymphocyte 4-1BB receptor expression is associated with higher short-term mortality in alcoholic hepatitis
Lotte Lindgreen Eriksen, Morten Aagaard Nielsen, Tea Lund Laursen, Bent Deleuran, Hendrik Vilstrup, Sidsel Støy
PLoS One. 2021; 16(8): e0255574. Published online 2021 Aug 5. doi: 10.1371/journal.pone.0255574
PMCID:
PMC8341529
AbstractArticlePDF–1.3M
8.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
9.
Role of ADAM10 and ADAM17 in Regulating CD137 Function
Jana Seidel, Sinje Leitzke, Björn Ahrens, Maria Sperrhacke, Sucharit Bhakdi, Karina Reiss
Int J Mol Sci. 2021 Mar; 22(5): 2730. Published online 2021 Mar 8. doi: 10.3390/ijms22052730
PMCID:
PMC7962946
AbstractArticlePDF–1.6M
10.
Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis
Khang Luu, Mugdha Vijay Patwardhan, Qun Zeng, Stina L. Wickström, Andreas Lundqvist, Herbert Schwarz
Cells. 2021 Feb; 10(2): 353. Published online 2021 Feb 9. doi: 10.3390/cells10020353
PMCID:
PMC7914903
AbstractArticlePDF–1.4M
11.
4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling
Benjamin I. Philipson, Roddy S. O’Connor, Michael J. May, Carl H. June, Steven M. Albelda, Michael C. Milone
Sci Signal. Author manuscript; available in PMC 2021 Feb 15.
Published in final edited form as: Sci Signal. 2020 Mar 31; 13(625): eaay8248. Published online 2020 Mar 31. doi: 10.1126/scisignal.aay8248
PMCID:
PMC7883633
AbstractArticlePDF–1.3M
12.
Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting
Kang Yi Lee, Hiu Yi Wong, Qun Zeng, Jia Le Lin, Man Si Cheng, Chik Hong Kuick, Kenneth Tou En Chang, Amos Hong Pheng Loh, Herbert Schwarz
Oncoimmunology. 2021; 10(1): 1877459. Published online 2021 Feb 4. doi: 10.1080/2162402X.2021.1877459
PMCID:
PMC7872024
AbstractArticlePDF–3.4M
13.
T cells expanded from renal cell carcinoma display tumor-specific CD137 expression but lack significant IFN-γ, TNF-α or IL-2 production
Saskia D. van Asten, Rosa de Groot, Marleen M. van Loenen, Suzanne M. Castenmiller, Jeroen de Jong, Kim Monkhorst, John B.A.G. Haanen, Derk Amsen, Axel Bex, Robbert M. Spaapen, Monika C. Wolkers
Oncoimmunology. 2021; 10(1): 1860482. Published online 2021 Jan 21. doi: 10.1080/2162402X.2020.1860482
PMCID:
PMC7833735
AbstractArticlePDF–1.9M
14.
4-1BB Signaling Boosts the Anti-Tumor Activity of CD28-Incorporated 2nd Generation Chimeric Antigen Receptor-Modified T Cells
Qiang Dai, Ping Han, Xinyue Qi, Fanlin Li, Min Li, Lilv Fan, Huihui Zhang, Xiaoqing Zhang, Xuanming Yang
Front Immunol. 2020; 11: 539654. Published online 2020 Nov 13. doi: 10.3389/fimmu.2020.539654
PMCID:
PMC7691374
AbstractArticlePDF–934K
15.
Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway
Bo Li, Yue Zhang, Runting Yin, Wei Zhong, Rui Chen, Jinchuan Yan
Mediators Inflamm. 2020; 2020: 1649453. Published online 2020 Oct 24. doi: 10.1155/2020/1649453
PMCID:
PMC7604604
AbstractArticlePDF–3.0M
16.
PD-1 abrogates the prolonged persistence of CD8+ CAR-T cells with 4-1BB co-stimulation
Feng Li, Zhen Zhang, Yujing Xuan, Daiqun Zhang, Jinyan Liu, Aitian Li, Shumin Wang, Ting Li, Xiaojuan Shi, Yi Zhang
Signal Transduct Target Ther. 2020; 5: 164. Published online 2020 Aug 25. doi: 10.1038/s41392-020-00277-6
PMCID:
PMC7447768
ArticlePDF–1.6M
17.
A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target
Zachary T. Freeman, Thomas R. Nirschl, Daniel H. Hovelson, Robert J. Johnston, John J. Engelhardt, Mark J. Selby, Christina M. Kochel, Ruth Y. Lan, Jingyi Zhai, Ali Ghasemzadeh, Anuj Gupta, Alyza M. Skaist, Sarah J. Wheelan, Hui Jiang, Alexander T. Pearson, Linda A. Snyder, Alan J. Korman, Scott A. Tomlins, Srinivasan Yegnasubramanian, Charles G. Drake
J Clin Invest. 2020 Mar 2; 130(3): 1405–1416. Published online 2020 Feb 4. doi: 10.1172/JCI128672
PMCID:
PMC7269585
AbstractArticlePDF–6.4M
18.
CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus
Yujun Pei, Kun Wen, Zheng Xiang, Chunyu Huang, Xiwei Wang, Xiaofeng Mu, Liyan Wen, Yinping Liu, Wenwei Tu
Signal Transduct Target Ther. 2020; 5: 74. Published online 2020 Jun 3. doi: 10.1038/s41392-020-0174-2
PMCID:
PMC7266814
AbstractArticlePDF–3.5M
19.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
20.
4‐1BB Delineates Distinct Activation Status of Exhausted Tumor‐Infiltrating CD8+ T Cells in Hepatocellular Carcinoma
Hyung‐Don Kim, Seongyeol Park, Seongju Jeong, Yong Joon Lee, Hoyoung Lee, Chang Gon Kim, Kyung Hwan Kim, Seung‐Mo Hong, Jung‐Yun Lee, Sunghoon Kim, Hong Kwan Kim, Byung Soh Min, Jong Hee Chang, Young Seok Ju, Eui‐Cheol Shin, Gi‐Won Song, Shin Hwang, Su‐Hyung Park
Hepatology. 2020 Mar; 71(3): 955–971. Published online 2019 Oct 18. doi: 10.1002/hep.30881
PMCID:
PMC7154753
AbstractArticlePDF–1.7M

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