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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 101795742.

Inhibition of ITK Signaling Causes Amelioration in Sepsis-Associated Neuroinflammation and Depression-like State in Mice

Mohammad M. Algahtani, Samiyah Alshehri, Sana S. Alqarni, Sheikh F. Ahmad, Naif O. Al-Harbi, Saleh A. Alqarni, Ali S. Alfardan, Khalid E. Ibrahim, Sabry M. Attia, Ahmed Nadeem

Int J Mol Sci. 2023 May; 24(9): 8101. Published online 2023 Apr 30. doi: 10.3390/ijms24098101

PMCID:: PMC10179574

Abstract Article PDF–3.7M

Select item 88734793.

ITK independent development of Th17 responses during hypersensitivity pneumonitis driven lung inflammation

Jessica Elmore, Chavez Carter, Amie Redko, Nicholas Koylass, Amelia Bennett, Max Mead, Marinel Ocasio-Rivera, Weishan Huang, Ankur Singh, Avery August

Commun Biol. 2022; 5: 162. Published online 2022 Feb 24. doi: 10.1038/s42003-022-03109-1

PMCID:: PMC8873479

Abstract Article PDF–2.0M

Select item 85363614.

Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK

Michael P. Gallagher, James M. Conley, Pranitha Vangala, Manuel Garber, Andrea Reboldi, Leslie J. Berg

Proc Natl Acad Sci U S A. 2021 Aug 31; 118(35): e2025825118. Published online 2021 Aug 27. doi: 10.1073/pnas.2025825118

PMCID:: PMC8536361

Abstract Article PDF–5.1M

Select item 84923195.

Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancer

Aparna Padhye, Jessica M. Konen, B. Leticia Rodriguez, Jared J. Fradette, Joshua K. Ochieng, Lixia Diao, Jing Wang, Wei Lu, Luisa S. Solis, Harsh Batra, Maria G. Raso, Michael D. Peoples, Rosalba Minelli, Alessandro Carugo, Christopher A. Bristow, Don L. Gibbons

JCI Insight. 2021 Sep 8; 6(17): e148392. Published online 2021 Sep 8. doi: 10.1172/jci.insight.148392

PMCID:: PMC8492319

Abstract Article PDF–7.9M

Select item 84585606.

The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis

Flavian Thelen, Stefanie Wissmann, Nora Ruef, Jens V. Stein

Front Immunol. 2021; 12: 716405. Published online 2021 Sep 9. doi: 10.3389/fimmu.2021.716405

PMCID:: PMC8458560

Abstract Article PDF–1001K

Select item 81130887.

Itk promotes the integration of TCR and CD28 costimulation, through its direct substrates, SLP-76 and Gads

Enas Hallumi, Rose Shalah, Wan-Lin Lo, Jasmin Corso, Ilana Oz, Dvora Beach, Samuel Wittman, Amy Isenberg, Meirav Sela, Henning Urlaub, Arthur Weiss, Deborah Yablonski

J Immunol. Author manuscript; available in PMC 2022 May 15.

Published in final edited form as: J Immunol. 2021 May 15; 206(10): 2322–2337. Published online 2021 Apr 30. doi: 10.4049/jimmunol.2001053

PMCID:: PMC8113088

Abstract Article PDF–2.7M

Select item 77262608.

Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT

Mahinbanu Mammadli, Weishan Huang, Rebecca Harris, Aisha Sultana, Ying Cheng, Wei Tong, Jeffery Pu, Teresa Gentile, Shanti Dsouza, Qi Yang, Alaji Bah, Avery August, Mobin Karimi

Front Immunol. 2020; 11: 593863. Published online 2020 Nov 26. doi: 10.3389/fimmu.2020.593863

PMCID:: PMC7726260

Abstract Article PDF–2.8M

Select item 75210199.

CD8⁺ T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine

Hyoung-Soo Cho, Soyoung Ha, Hyun Mu Shin, Andrea Reboldi, Jason A. Hall, Jun R. Huh, Edward J. Usherwood, Leslie J. Berg

Immunohorizons. Author manuscript; available in PMC 2020 Sep 28.

Published in final edited form as: Immunohorizons. 2020 Feb 7; 4(2): 57–71. Published online 2020 Feb 7. doi: 10.4049/immunohorizons.1900093

PMCID:: PMC7521019

Abstract Article PDF–2.8M

Select item 734362310.

Activation of the Tec kinase ITK controls graded IRF4 expression in response to variations in TCR signal strength

James M. Conley, Michael P. Gallagher, Anjana Rao, Leslie J. Berg

J Immunol. Author manuscript; available in PMC 2021 Jul 15.

Published in final edited form as: J Immunol. 2020 Jul 15; 205(2): 335–345. Published online 2020 Jun 3. doi: 10.4049/jimmunol.1900853

PMCID:: PMC7343623

Abstract Article PDF–932K

Select item 699311711.

Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection Against Mycobacterium tuberculosis Infection

Lu Huang, Kaixiong Ye, Michael C. McGee, Natalie F. Nidetz, Jessica P. Elmore, Candice B. Limper, Teresa L. Southard, David G. Russell, Avery August, Weishan Huang

Front Immunol. 2019; 10: 3103. Published online 2020 Jan 24. doi: 10.3389/fimmu.2019.03103

PMCID:: PMC6993117

Abstract Article PDF–2.2M

Select item 692055112.

Th1 cells rolling on selectins trigger DAP12-dependent signals that activate integrin αLβ2

Bojing Shao, Tadayuki Yago, Sumith R. Panicker, Nan Zhang, Zhenghui Liu, Rodger P. McEver

J Immunol. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: J Immunol. 2020 Jan 1; 204(1): 37–48. Published online 2019 Nov 22. doi: 10.4049/jimmunol.1900680

PMCID:: PMC6920551

Abstract Article PDF–2.4M

Select item 685906613.

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

Guillaume Voisinne, Kristof Kersse, Karima Chaoui, Liaoxun Lu, Julie Chaix, Lichen Zhang, Marisa Goncalves Menoita, Laura Girard, Youcef Ounoughene, Hui Wang, Odile Burlet-Schiltz, Hervé Luche, Frédéric Fiore, Marie Malissen, Anne Gonzalez de Peredo, Yinming Liang, Romain Roncagalli, Bernard Malissen

Nat Immunol. Author manuscript; available in PMC 2020 Apr 7.

Published in final edited form as: Nat Immunol. 2019 Nov 1; 20(11): 1530–1541. Published online 2019 Oct 7. doi: 10.1038/s41590-019-0489-8

PMCID:: PMC6859066

Abstract Article PDF–2.9M

Select item 682149314.

Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

Danielle J Clark, Laura E McMillan, Sin Lih Tan, Gaia Bellomo, Clementine Massoue, Harry Thompson, Lidiya Mykhaylechko, Dominic Alibhai, Xiongtao Ruan, Kentner L Singleton, Minna Du, Alan Hedges, Pamela L Schwartzberg, Paul Verkade, Robert F Murphy, Christoph Wülfing

eLife. 2019; 8: e45789. Published online 2019 Oct 30. doi: 10.7554/eLife.45789