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Select item 108508181.

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord

Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537

PMCID:: PMC10850818

Abstract Article PDF–2.7M

Select item 107533692.

Preliminary exploration of SKA1 expression in lung adenocarcinoma and its clinical significance: SKA1 expression in lung adenocarcinoma

Wen Zeng, Yong Chen, Jun Liu, Zhen An, Hui Yan, Tao Sun

Acta Biochim Biophys Sin (Shanghai) 2023 Dec 25; 55(12): 2008–2012. Published online 2023 Oct 9. doi: 10.3724/abbs.2023243

PMCID:: PMC10753369

Article PDF–966K

Select item 105195083.

Integrated analysis of SKA1-related ceRNA network and SKA1 immunoassays in HCC: A study based on bioinformatic

Fanjing Zeng, Zhiqi Xu, Peng Zhuang

Medicine (Baltimore) 2023 Sep 22; 102(38): e34826. Published online 2023 Sep 22. doi: 10.1097/MD.0000000000034826

PMCID:: PMC10519508

Abstract Article PDF–4.7M

Select item 102841174.

Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry

Fenglong Jiao, Leah J. Salituro, Clinton Yu, Craig B. Gutierrez, Scott D. Rychnovsky, Lan Huang

Anal Chem. Author manuscript; available in PMC 2023 Jun 21.

Published in final edited form as: Anal Chem. 2023 Jan 31; 95(4): 2532–2539. Published online 2023 Jan 18. doi: 10.1021/acs.analchem.2c04986

PMCID:: PMC10284117

Abstract Article PDF–2.5M

Select item 100447195.

Hypoxia-induced lncRNA MRVI1-AS1 accelerates hepatocellular carcinoma progression by recruiting RNA-binding protein CELF2 to stabilize SKA1 mRNA

Hang Tuo, Runkun Liu, Yufeng Wang, Wei Yang, Qingguang Liu

World J Surg Oncol. 2023; 21: 111. Published online 2023 Mar 28. doi: 10.1186/s12957-023-02993-z

PMCID:: PMC10044719

Abstract Article PDF–7.8M

Select item 99805836.

SKA1 is overexpressed in laryngocarcinoma and modulates cell growth via P53 signaling pathway

Zheng Li, Jiali Liu, Haisen Peng, Chunhua Li, Yuehui Liu, Wen Xie

Cell Cycle. 2023; 22(6): 693–704. Published online 2022 Nov 17. doi: 10.1080/15384101.2022.2145817

PMCID:: PMC9980583

Abstract Article PDF–3.5M

Select item 99261227.

Kinetochore-microtubule attachment in human cells is regulated by the interaction of a conserved motif of Ska1 with EB1

Renjith M. Radhakrishnan, Safwa T. Kizhakkeduth, Vishnu M. Nair, Shine Ayyappan, R. Bhagya Lakshmi, Neethu Babu, Anjaly Prasannajith, Kenichi Umeda, Vinesh Vijayan, Noriyuki Kodera, Tapas K. Manna

J Biol Chem. 2023 Feb; 299(2): 102853. Published online 2022 Dec 31. doi: 10.1016/j.jbc.2022.102853

PMCID:: PMC9926122

Abstract Article PDF–3.8M

Select item 97921978.

SKA1 promotes tumor metastasis via SAFB-mediated transcription repression of DUSP6 in clear cell renal cell carcinoma

Yan Pu, Jing Han, Mengmeng Zhang, Mengxue Liu, Gulnazar Abdusamat, Huibin Liu

Aging (Albany NY) 2022 Dec 15; 14(23): 9679–9698. Published online 2022 Dec 2. doi: 10.18632/aging.204418

PMCID:: PMC9792197

Abstract Article PDF–2.1M

Select item 97696989.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 948193310.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 925437811.

ETV5 overexpression promotes progression of esophageal squamous cell carcinoma by upregulating SKA1 and TRPV2

Ming-Chuang Sun, Kang Fang, Zhao-Xing Li, Yuan Chu, Ai-Ping Xu, Zi-Ying Zhao, Zhu-Yun Leng, Yun-Wei Zhang, Ze-Hua Zhang, Li Zhang, Tao Chen, Mei-Dong Xu

Int J Med Sci. 2022; 19(6): 1072–1081. Published online 2022 Jun 21. doi: 10.7150/ijms.71892

PMCID:: PMC9254378

Abstract Article PDF–1.9M

Select item 880641512.

Circular RNA FAT atypical cadherin 1 (circFAT1)/microRNA-525-5p/spindle and kinetochore-associated complex subunit 1 (SKA1) axis regulates oxaliplatin resistance in breast cancer by activating the notch and Wnt signaling pathway

Ye Yao, Xiaoqin Li, Lihua Cheng, Xiuhua Wu, Bobo Wu

Bioengineered. 2021; 12(1): 4032–4043. Published online 2021 Jul 21. doi: 10.1080/21655979.2021.1951929

PMCID:: PMC8806415

Abstract Article PDF–2.3M

Select item 831454713.

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation

Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang

Cell Biosci. 2021; 11: 146. Published online 2021 Jul 27. doi: 10.1186/s13578-021-00659-5

PMCID:: PMC8314547

Abstract Article PDF–3.7M

Select item 816503014.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 816013115.

Transcript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma

De-Chen Yu, Xiang-Yi Chen, Xin Li, Hai-Yu Zhou, De-Quan Yu, Xiao-Lei Yu, Yi-Cun Hu, Rui-Hao Zhang, Xiao-Bo Zhang, Kun Zhang, Jiang-Dong An

Sci Rep. 2021; 11: 11165. Published online 2021 May 27. doi: 10.1038/s41598-021-89628-z

PMCID:: PMC8160131

Abstract Article PDF–7.0M

Select item 758952416.

Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1–AKT axis-mediated glycolysis

Wei Gao, Yuliang Zhang, Hongjie Luo, Min Niu, Xiwang Zheng, Wanglai Hu, Jiajia Cui, Xuting Xue, Yunfeng Bo, Fengsheng Dai, Yan Lu, Dongli Yang, Yujia Guo, Huina Guo, Huizheng Li, Yu Zhang, Tao Yang, Li Li, Linshi Zhang, Rui Hou, Shuxin Wen, Changming An, Teng Ma, Lei Jin, Wei Xu, Yongyan Wu

Cell Death Dis. 2020 Oct; 11(10): 919. Published online 2020 Oct 26. doi: 10.1038/s41419-020-03104-6

PMCID:: PMC7589524

Abstract Article PDF–5.2M

Select item 716998317.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 716280518.

SKA1 regulates actin cytoskeleton remodelling via activating Cdc42 and influences the migration of pancreatic ductal adenocarcinoma cells

Tong Li, Xu Liu, Bin Xu, Wei Wu, Yi Zang, Juanjuan Li, Lumin Wei, Yuting Qian, Hui Xu, Mingping Xie, Qi Wang, Lifu Wang

Cell Prolif. 2020 Apr; 53(4): e12799. Published online 2020 Mar 30. doi: 10.1111/cpr.12799

PMCID:: PMC7162805

Abstract Article PDF–3.3M

Select item 674264619.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 650456120.

MARK3-mediated phosphorylation of ARHGEF2 couples the actin and tubulin cytoskeletons to establish cell polarity

María-José Sandí, Christopher B. Marshall, Marc Balan, Étienne Coyaud, Ming Zhou, Daniel M. Monson, Noboru Ishiyama, Arun A. Chandrakumar, José La Rose, Amber L. Couzens, Anne-Claude Gingras, Brian Raught, Wei Xu, Mitsuhiko Ikura, Deborah K. Morrison, Robert Rottapel

Sci Signal. Author manuscript; available in PMC 2019 May 7.

Published in final edited form as: Sci Signal. 2017 Oct 31; 10(503): eaan3286. Published online 2017 Oct 31. doi: 10.1126/scisignal.aan3286

PMCID:: PMC6504561

Abstract Article PDF–3.6M

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