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Items: 1 to 20 of 48

1.
Deleterious ZNRF3 germline variants cause neurodevelopmental disorders with mirror brain phenotypes via domain-specific effects on Wnt/β-catenin signaling
Paranchai Boonsawat, Reza Asadollahi, Dunja Niedrist, Katharina Steindl, Anaïs Begemann, Pascal Joset, Elizabeth J. Bhoj, Dong Li, Elaine Zackai, Annalisa Vetro, Carmen Barba, Renzo Guerrini, Sandra Whalen, Boris Keren, Amjad Khan, Duan Jing, María Palomares Bralo, Emi Rikeros Orozco, Qin Hao, Britta Schlott Kristiansen, Bixia Zheng, Deirdre Donnelly, Virginia Clowes, Markus Zweier, Michael Papik, Gabriele Siegel, Valeria Sabatino, Martina Mocera, Anselm H.C. Horn, Heinrich Sticht, Anita Rauch
Am J Hum Genet. 2024 Sep 5; 111(9): 1994–2011. Published online 2024 Aug 20. doi: 10.1016/j.ajhg.2024.07.016
PMCID:
PMC11393693
AbstractArticlePDF–5.9M
2.
E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors
Jeroen M Bugter, Peter van Kerkhof, Ingrid Jordens, Eline Janssen, Thi Tran Ngoc Minh, Daniel Iglesias van Montfort, Cara Jamieson, Madelon M Maurice
Life Sci Alliance. 2024 Sep; 7(9): e202402575. Published online 2024 Jul 8. doi: 10.26508/lsa.202402575
PMCID:
PMC11231576
AbstractArticlePDF–1.7M
3.
LGR4 and LGR5 form distinct homodimers that only LGR4 complexes with RNF43/ZNRF3 to provide high affinity binding of R-spondin ligands
Yukimatsu Toh, Ling Wu, Soohyun Park, Allison Wang, Jianghua Tu, Wangsheng Yu, Mingxin Zuo, Kendra S. Carmon, Qingyun J. Liu
Sci Rep. 2023; 13: 10796. Published online 2023 Jul 4. doi: 10.1038/s41598-023-37856-w
PMCID:
PMC10319729
AbstractArticlePDF–3.3M
4.
Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR): A Targeted Protein Degradation Toolbox
Dirk H. Siepe, Lora K. Picton, K. Christopher Garcia
ACS Synth Biol. 2023 Apr 21; 12(4): 1081–1093. Published online 2023 Apr 3. doi: 10.1021/acssynbio.2c00587
PMCID:
PMC10127277
AbstractArticlePDF–5.0M
5.
Additional evidence for the role of chromosomal imbalances and SOX8, ZNRF3 and HHAT gene variants in early human testis development
Khouloud Rjiba, Soumaya Mougou-Zerelli, Imen hadj Hamida, Ghada Saad, Bochra Khadija, Afef Jelloul, Wafa Slimani, Yosra Hasni, Sarra Dimassi, Hela Ben khelifa, Amira Sallem, Molka Kammoun, Hamza Hadj Abdallah, Moez Gribaa, Joelle Bignon-Topalovic, Sami Chelly, Hédi Khairi, Mohamed Bibi, Maha Kacem, Ali Saad, Anu Bashamboo, Kenneth McElreavey
Reprod Biol Endocrinol. 2023; 21: 2. Published online 2023 Jan 11. doi: 10.1186/s12958-022-01045-7
PMCID:
PMC9990451
AbstractArticlePDF–1.2M
6.
Antibody targeting of E3 ubiquitin ligases for receptor degradation
Hadir Marei, Wen-Ting K. Tsai, Yee-Seir Kee, Karen Ruiz, Jieyan He, Chris Cox, Tao Sun, Sai Penikalapati, Pankaj Dwivedi, Meena Choi, David Kan, Pablo Saenz-Lopez, Kristel Dorighi, Pamela Zhang, Yvonne T. Kschonsak, Noelyn Kljavin, Dhara Amin, Ingrid Kim, Andrew G. Mancini, Thao Nguyen, Chunling Wang, Eric Janezic, Alexander Doan, Elaine Mai, Hongkang Xi, Chen Gu, Melanie Heinlein, Brian Biehs, Jia Wu, Isabelle Lehoux, Seth Harris, Laetitia Comps-Agrar, Dhaya Seshasayee, Frederic J. de Sauvage, Matthew Grimmer, Jing Li, Nicholas J. Agard, Felipe de Sousa e Melo
Nature. 2022; 610(7930): 182–189. Published online 2022 Sep 21. doi: 10.1038/s41586-022-05235-6
PMCID:
PMC9534761
AbstractArticlePDF–18M
7.
A dual-activity topoisomerase complex regulates mRNA translation and turnover
Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang
Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538
PMCID:
PMC9262614
AbstractArticlePDF–3.6M
8.
RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state
Germán Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M. Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R. Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch
Nat Commun. 2022; 13: 334. Published online 2022 Jan 17. doi: 10.1038/s41467-021-27923-z
PMCID:
PMC8764073
AbstractArticlePDF–3.7M
9.
Somatic driver mutation prevalence in 1844 prostate cancers identifies ZNRF3 loss as a predictor of metastatic relapse
Michael Fraser, Julie Livingstone, Jeffrey L. Wrana, Antonio Finelli, Housheng Hansen He, Theodorus van der Kwast, Alexandre R. Zlotta, Robert G. Bristow, Paul C. Boutros
Nat Commun. 2021; 12: 6248. Published online 2021 Oct 29. doi: 10.1038/s41467-021-26489-0
PMCID:
PMC8556363
AbstractArticlePDF–2.6M
10.
A positive feedback loop of lncRNA-RMRP/ZNRF3 axis and Wnt/β-catenin signaling regulates the progression and temozolomide resistance in glioma
Tie Liu, Jie Hu, Bo Han, Shishan Tan, Wenqing Jia, Yu Xin
Cell Death Dis. 2021 Nov; 12(11): 952. Published online 2021 Oct 16. doi: 10.1038/s41419-021-04245-y
PMCID:
PMC8520527
AbstractArticlePDF–4.6M
11.
A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling
Minseong Kim, Carmen Reinhard, Christof Niehrs
eLife. 2021; 10: e70885. Published online 2021 Sep 30. doi: 10.7554/eLife.70885
PMCID:
PMC8516413
AbstractArticlePDF–10M
12.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
13.
USP42 protects ZNRF3/RNF43 from R‐spondin‐dependent clearance and inhibits Wnt signalling
Nicole Giebel, Anchel de Jaime‐Soguero, Ana García del Arco, Jonathan J M Landry, Marlene Tietje, Laura Villacorta, Vladimir Benes, Vanesa Fernández‐Sáiz, Sergio P Acebrón
EMBO Rep. 2021 May 5; 22(5): e51415. Published online 2021 Mar 30. doi: 10.15252/embr.202051415
PMCID:
PMC8097334
AbstractArticlePDF–2.3M
14.
A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition
Yahya Benslimane, María Sánchez‐Osuna, Jasmin Coulombe‐Huntington, Thierry Bertomeu, Danielle Henry, Caroline Huard, Éric Bonneil, Pierre Thibault, Mike Tyers, Lea Harrington
Aging Cell. 2021 Apr; 20(4): e13331. Published online 2021 Mar 4. doi: 10.1111/acel.13331
PMCID:
PMC8045932
AbstractArticlePDF–1.9M
15.
Unlike LGR4, LGR5 potentiates Wnt–β-catenin signaling without sequestering E3 ligases
Soohyun Park, Ling Wu, Jianghua Tu, Wangsheng Yu, Yukimatsu Toh, Kendra S. Carmon, Qingyun J. Liu
Sci Signal. Author manuscript; available in PMC 2021 Dec 1.
Published in final edited form as: Sci Signal. 2020 Dec 1; 13(660): eaaz4051. Published online 2020 Dec 1. doi: 10.1126/scisignal.aaz4051
PMCID:
PMC7905944
AbstractArticlePDF–2.3M
16.
Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma
Vania Balderrama Brondani, Amanda Meneses Ferreira Lacombe, Beatriz Marinho de Paula Mariani, Luciana Montenegro, Iberê Cauduro Soares, João Evangelista Bezerra-Neto, Fabio Yoshiaki Tanno, Victor Srougi, José Luis Chambo, Berenice Bilharinho Mendonca, Madson Q. Almeida, Maria Claudia Nogueira Zerbini, Maria Candida Barisson Villares Fragoso
Int J Mol Sci. 2021 Feb; 22(3): 1238. Published online 2021 Jan 27. doi: 10.3390/ijms22031238
PMCID:
PMC7866180
AbstractArticlePDF–7.1M
17.
ZNRF3 Inhibits the Invasion and Tumorigenesis in Nasopharyngeal Carcinoma Cells by Inactivating the Wnt/β-Catenin Pathway
Zhongwei Wang, Yali Wang, Hongtao Ren, Yingying Jin, Ya Guo
Oncol Res. 2017; 25(4): 571–577. Published online 2017 Apr 14. doi: 10.3727/97818823455816X14760478220149
PMCID:
PMC7841061
AbstractArticlePDF–3.5M
18.
MicroRNA-301a/ZNRF3/wnt/β-catenin signal regulatory crosstalk mediates glioma progression
Jikui Sun, Quanfeng Ma, Chang Shu, Jinbiao Xiong, Banban Li, Jingchao Wu, Shusheng Zhang, Jialin Li, Jun Liu, Jinhuan Wang
Int J Oncol. 2021 Jan; 58(1): 45–56. Published online 2020 Nov 10. doi: 10.3892/ijo.2020.5145
PMCID:
PMC7721082
AbstractArticlePDF–2.5M
19.
LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling
Jin Huk Choi, Xue Zhong, William McAlpine, Tzu-Chieh Liao, Duanwu Zhang, Beibei Fang, Jamie Russell, Sara Ludwig, Evan Nair-Gill, Zhao Zhang, Kuan-wen Wang, Takuma Misawa, Xiaoming Zhan, Mihwa Choi, Tao Wang, Xiaohong Li, Miao Tang, Qihua Sun, Liyang Yu, Anne R. Murray, Eva Marie Y. Moresco, Bruce Beutler
Science. Author manuscript; available in PMC 2020 May 8.
Published in final edited form as: Science. 2019 May 10; 364(6440): eaau0812. doi: 10.1126/science.aau0812
PMCID:
PMC7206793
AbstractArticlePDF–2.2M
20.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M

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