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Select item 110154971.

Y chromosome damage underlies testicular abnormalities in ATR-X syndrome

Nayla Y. León, Thanh Nha Uyen Le, Andrew Garvie, Lee H. Wong, Stefan Bagheri-Fam, Vincent R. Harley

iScience. 2024 May 17; 27(5): 109629. Published online 2024 Mar 28. doi: 10.1016/j.isci.2024.109629

PMCID:: PMC11015497

Abstract Article PDF–4.6M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108053943.

RIPK3 activation promotes DAXX‐dependent neuronal necroptosis after intracerebral hemorrhage in mice

Qingqing Bai, Shuoyang Wang, Dongmei Rao, Zhiming Zhou, Jianfei Wang, Qi Wang, Yu Qin, Zhaohu Chu, Shoucai Zhao, Dijing Yu, Yang Xu

CNS Neurosci Ther. 2024 Jan; 30(1): e14397. Published online 2023 Aug 8. doi: 10.1111/cns.14397

PMCID:: PMC10805394

Abstract Article PDF–9.5M

Select item 104604294.

The histone chaperone function of Daxx is dispensable for embryonic development

Chang Sun, Yuan Qi, Natalie Fowlkes, Nina Lazic, Xiaoping Su, Guillermina Lozano, Amanda R. Wasylishen

Cell Death Dis. 2023 Aug; 14(8): 565. Published online 2023 Aug 26. doi: 10.1038/s41419-023-06089-0

PMCID:: PMC10460429

Abstract Article PDF–2.9M

Select item 100977045.

DAXX drives de novo lipogenesis and contributes to tumorigenesis

Iqbal Mahmud, Guimei Tian, Jia Wang, Tarun E. Hutchinson, Brandon J. Kim, Nikee Awasthee, Seth Hale, Chengcheng Meng, Allison Moore, Liming Zhao, Jessica E. Lewis, Aaron Waddell, Shangtao Wu, Julia M. Steger, McKenzie L. Lydon, Aaron Chait, Lisa Y. Zhao, Haocheng Ding, Jian-Liang Li, Hamsa Thayele Purayil, Zhiguang Huo, Yehia Daaka, Timothy J. Garrett, Daiqing Liao

Nat Commun. 2023; 14: 1927. Published online 2023 Apr 12. doi: 10.1038/s41467-023-37501-0

PMCID:: PMC10097704

Abstract Article PDF–5.3M

Select item 94389296.

Context matters – Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas

Chang Sun, Jeannelyn S. Estrella, Elizabeth M. Whitley, Gilda P. Chau, Guillermina Lozano, Amanda R. Wasylishen

Dis Model Mech. 2022 Aug 1; 15(8): dmm049552. Published online 2022 Aug 26. doi: 10.1242/dmm.049552

PMCID:: PMC9438929

Abstract Article

Select item 86833767.

Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation

Julia P. Gerber, Jenny Russ, Vijay Chandrasekar, Nina Offermann, Hang-Mao Lee, Sarah Spear, Nicola Guzzi, Simona Maida, Sundararaghavan Pattabiraman, Ruoyu Zhang, Amir H. Kayvanjoo, Preeta Datta, Jagath Kasturiarachchi, Teresa Sposito, Natalia Izotova, Kristian Händler, Peter D. Adams, Teresa Marafioti, Tariq Enver, Jörg Wenzel, Marc Beyer, Elvira Mass, Cristian Bellodi, Joachim L. Schultze, Melania Capasso, Rachael Nimmo, Paolo Salomoni

Nat Cell Biol. 2021; 23(12): 1224–1239. Published online 2021 Dec 7. doi: 10.1038/s41556-021-00774-y

Correction in:: Nat Cell Biol. 2022; 24(1): 123.

PMCID:: PMC8683376

Abstract Article PDF–24M

Select item 83050948.

Death-Associated Protein 6 (Daxx) Alleviates Liver Fibrosis by Modulating Smad2 Acetylation

Sung-Min Kim, Won-Hee Hur, Byung-Yoon Kang, Sung-Won Lee, Pu-Reun Roh, Dong-Jun Park, Pil-Soo Sung, Seung-Kew Yoon

Cells. 2021 Jul; 10(7): 1742. Published online 2021 Jul 9. doi: 10.3390/cells10071742

PMCID:: PMC8305094

Abstract Article PDF–3.5M

Select item 82222569.

ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress

Yu-Ching Teng, Aishwarya Sundaresan, Ryan O’Hara, Vincent U. Gant, Minhua Li, Sara Martire, Jane N. Warshaw, Amrita Basu, Laura A. Banaszynski

Nat Commun. 2021; 12: 3887. Published online 2021 Jun 23. doi: 10.1038/s41467-021-24206-5

PMCID:: PMC8222256

Abstract Article PDF–2.5M

Select item 740636710.

Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo

Amanda R. Wasylishen, Chang Sun, Sydney M. Moyer, Yuan Qi, Gilda P. Chau, Neeraj K. Aryal, Florencia McAllister, Michael P. Kim, Michelle C. Barton, Jeannelyn S. Estrella, Xiaoping Su, Guillermina Lozano

Sci Adv. 2020 Aug; 6(32): eaba8415. Published online 2020 Aug 5. doi: 10.1126/sciadv.aba8415

PMCID:: PMC7406367

Abstract Article PDF–5.0M

Select item 732750111.

SUMOylated PRC1 controls histone H3.3 deposition and genome integrity of embryonic heterochromatin

Zichuan Liu, Mathieu Tardat, Mark E Gill, Helene Royo, Raphael Thierry, Evgeniy A Ozonov, Antoine HFM Peters

EMBO J. 2020 Jul 1; 39(13): e103697. Published online 2020 May 12. doi: 10.15252/embj.2019103697

PMCID:: PMC7327501

Abstract Article PDF–3.2M

Select item 695961012.

ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity

Courtney A. Lovejoy, Kaori Takai, Michael S. Huh, David J. Picketts, Titia de Lange

PLoS Biol. 2020 Jan; 18(1): e3000594. Published online 2020 Jan 2. doi: 10.1371/journal.pbio.3000594

PMCID:: PMC6959610

Abstract Article PDF–5.0M

Select item 680266513.

High levels of Daxx due to low cellular levels of HSP25 in murine cancer cells result in inefficient adenovirus replication

Zhezhu Han, Yeonsoo Joo, Jihyun Lee, Suwan Ko, Rong Xu, Geun-Hyeok Oh, Soojin Choi, Jeong A. Hong, Hye Jin Choi, Jae J. Song

Exp Mol Med. 2019 Oct; 51(10): 122. Published online 2019 Oct 15. doi: 10.1038/s12276-019-0321-4

PMCID:: PMC6802665

Abstract Article PDF–4.5M

Select item 670414714.

Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response

Yi Yang, Thea L. Willis, Robert W. Button, Conor J. Strang, Yuhua Fu, Xue Wen, Portia R. C. Grayson, Tracey Evans, Rebecca J. Sipthorpe, Sheridan L. Roberts, Bing Hu, Jianke Zhang, Boxun Lu, Shouqing Luo

Nat Commun. 2019; 10: 3759. Published online 2019 Aug 21. doi: 10.1038/s41467-019-11671-2

PMCID:: PMC6704147

Abstract Article PDF–5.3M

Select item 629449915.

Long non-coding RNA ChRO1 facilitates ATRX/DAXX-dependent H3.3 deposition for transcription-associated heterochromatin reorganization

Jinyoung Park, Hongmin Lee, Namshik Han, Sojung Kwak, Han-Teo Lee, Jae-Hwan Kim, Keonjin Kang, Byoung Ha Youn, Jae-Hyun Yang, Hyeon-Ju Jeong, Jong-Sun Kang, Seon-Young Kim, Jeung-Whan Han, Hong-Duk Youn, Eun-Jung Cho

Nucleic Acids Res. 2018 Dec 14; 46(22): 11759–11775. Published online 2018 Oct 18. doi: 10.1093/nar/gky923

PMCID:: PMC6294499

Abstract Article PDF–5.5M

Select item 623372316.

Daxx Functions are p53-independent In Vivo

Amanda R. Wasylishen, Jeannelyn S. Estrella, Vinod Pant, Gilda P. Chau, Guillermina Lozano

Mol Cancer Res. Author manuscript; available in PMC 2019 Oct 1.

Published in final edited form as: Mol Cancer Res. 2018 Oct; 16(10): 1523–1529. Published online 2018 Jun 14. doi: 10.1158/1541-7786.MCR-18-0281

PMCID:: PMC6233723

Abstract Article PDF–752K

Select item 619335517.

DAXX promotes ovarian cancer ascites cell proliferation and migration by activating the ERK signaling pathway

Sheng-Bing Liu, Xue-Ping Lin, Ying Xu, Zhong-Fei Shen, Wei-Wei Pan

J Ovarian Res. 2018; 11: 90. Published online 2018 Oct 18. doi: 10.1186/s13048-018-0462-4

PMCID:: PMC6193355

Abstract Article PDF–11M

Select item 566273718.

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

Dominik Hoelper, Hongda Huang, Aayushi Y. Jain, Dinshaw J. Patel, Peter W. Lewis

Nat Commun. 2017; 8: 1193. Published online 2017 Oct 30. doi: 10.1038/s41467-017-01206-y

PMCID:: PMC5662737

Abstract Article PDF–2.0M

Select item 545332519.

PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX

Erwan Delbarre, Kristina Ivanauskiene, Jane Spirkoski, Akshay Shah, Kristin Vekterud, Jan Øivind Moskaug, Stig Ove Bøe, Lee H. Wong, Thomas Küntziger, Philippe Collas

Genome Res. 2017 Jun; 27(6): 913–921. doi: 10.1101/gr.215830.116

PMCID:: PMC5453325

Abstract Article PDF–1.0M

Select item 538654620.

Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres

Jayme Salsman, Lindsy M Rapkin, Nandini N Margam, Roy Duncan, David P Bazett-Jones, Graham Dellaire

Cell Death Dis. 2017 Mar; 8(3): e2724. Published online 2017 Mar 30. doi: 10.1038/cddis.2017.151

PMCID:: PMC5386546

Abstract Article PDF–4.3M

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