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Items: 1 to 20 of 37

1.
Knockout mice with pituitary malformations help identify human cases of hypopituitarism
Julian Martinez-Mayer, Michelle L. Brinkmeier, Sean P. O’Connell, Arnold Ukagwu, Marcelo A. Marti, Mirta Miras, Maria V. Forclaz, Maria G. Benzrihen, Leonard Y. M. Cheung, Sally A. Camper, Buffy S. Ellsworth, Lori T. Raetzman, Maria I. Pérez-Millán, Shannon W. Davis
Genome Med. 2024; 16: 75. Published online 2024 May 31. doi: 10.1186/s13073-024-01347-y
PMCID:
PMC11140907
AbstractArticlePDF–4.4M
2.
Primordial germ cell DNA demethylation and development require DNA translesion synthesis
Pranay Shah, Ross Hill, Camille Dion, Stephen J. Clark, Abdulkadir Abakir, Jeroen Willems, Mark J. Arends, Juan I. Garaycoechea, Harry G. Leitch, Wolf Reik, Gerry P. Crossan
Nat Commun. 2024; 15: 3734. Published online 2024 May 3. doi: 10.1038/s41467-024-47219-2
PMCID:
PMC11068800
AbstractArticlePDF–5.6M
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
REV7 Monomer Is Unable to Participate in Double Strand Break Repair and Translesion Synthesis but Suppresses Mitotic Errors
Faye M. Vassel, Daniel J. Laverty, Ke Bian, Cortt G. Piett, Michael T. Hemann, Graham C. Walker, Zachary D. Nagel
Int J Mol Sci. 2023 Nov; 24(21): 15799. Published online 2023 Oct 31. doi: 10.3390/ijms242115799
PMCID:
PMC10649693
AbstractArticlePDF–2.6M
5.
MAD2B Blunts Chronic Unpredictable Stress and Corticosterone Stimulation–Induced Depression-Like Behaviors in Mice
Xiao-Lan Wang, Cheng Miao, Yanfang Su, Chun Zhang, Xianfang Meng
Int J Neuropsychopharmacol. 2023 Feb; 26(2): 137–148. Published online 2022 Dec 27. doi: 10.1093/ijnp/pyac083
PMCID:
PMC9926055
AbstractArticlePDF–6.9M
6.
MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy
Meng-Ran Li, Chun-Tao Lei, Hui Tang, Xing-Jie Yin, Zhe Hao, Yang Qiu, Ya-Ru Xie, Jie-Yu Zeng, Hua Su, Chun Zhang
Int J Biol Sci. 2022; 18(5): 1896–1911. Published online 2022 Feb 21. doi: 10.7150/ijbs.68977
PMCID:
PMC8935242
AbstractArticlePDF–2.9M
7.
53BP1/shieldin-dependent DSB processing in BRCA1-deficient cells requires CST/Polα/primase fill-in synthesis
Zachary Mirman, Nanda Kumar Sasi, Ashleigh King, J. Ross Chapman, Titia de Lange
Nat Cell Biol. Author manuscript; available in PMC 2022 Jul 13.
Published in final edited form as: Nat Cell Biol. 2022 Jan; 24(1): 51–61. Published online 2022 Jan 13. doi: 10.1038/s41556-021-00812-9
PMCID:
PMC8849574
AbstractArticlePDF–6.1M
8.
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary
Cell. Author manuscript; available in PMC 2021 May 10.
Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050
PMCID:
PMC8108093
AbstractArticlePDF–3.5M
9.
Rev7 loss alters cisplatin response and increases drug efficacy in chemotherapy-resistant lung cancer
Faye-Marie Vassel, Ke Bian, Graham C. Walker, Michael T. Hemann
Proc Natl Acad Sci U S A. 2020 Nov 17; 117(46): 28922–28924. Published online 2020 Nov 3. doi: 10.1073/pnas.2016067117
PMCID:
PMC7682549
AbstractArticlePDF–976K
10.
REV7 is required for processing AID initiated DNA lesions in activated B cells
Dingpeng Yang, Ying Sun, Jingjing Chen, Ying Zhang, Shuangshuang Fan, Min Huang, Xia Xie, Yanni Cai, Yafang Shang, Tuantuan Gui, Liming Sun, Jiazhi Hu, Junchao Dong, Leng-Siew Yeap, Xiaoming Wang, Wei Xiao, Fei-Long Meng
Nat Commun. 2020; 11: 2812. Published online 2020 Jun 4. doi: 10.1038/s41467-020-16632-8
PMCID:
PMC7272641
AbstractArticlePDF–2.0M
11.
53BP1 cooperation with the REV7-Shieldin complex underpins DNA structure-specific NHEJ
Hind Ghezraoui, Catarina Oliveira, Jordan R. Becker, Kirstin Bilham, Daniela Moralli, Consuelo Anzilotti, Roman Fischer, Mukta Deobagkar-Lele, Maria Sanchiz-Calvo, Elena Fueyo-Marcos, Sarah Bonham, Benedikt M. Kessler, Sven Rottenberg, Richard J. Cornall, Catherine M. Green, J. Ross Chapman
Nature. Author manuscript; available in PMC 2020 Jan 29.
Published in final edited form as: Nature. 2018 Aug 1; 560(7716): 122–127. Published online 2018 Jul 25. doi: 10.1038/s41586-018-0362-1
PMCID:
PMC6989217
AbstractArticlePDF–4.2M
12.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
13.
MAD2L2 Promotes Open Chromatin in Embryonic Stem Cells and Derepresses the Dppa3 Locus
Ali Rahjouei, Mehdi Pirouz, Michela Di Virgilio, Dirk Kamin, Michael Kessel
Stem Cell Reports. 2017 Apr 11; 8(4): 813–821. Published online 2017 Mar 16. doi: 10.1016/j.stemcr.2017.02.011
PMCID:
PMC5390107
AbstractArticlePDF–2.4M
14.
REV7 counteracts DNA double-strand break resection and impacts PARP inhibition
Guotai Xu, J. Ross Chapman, Inger Brandsma, Jingsong Yuan, Martin Mistrik, Peter Bouwman, Jirina Bartkova, Ewa Gogola, Daniël Warmerdam, Marco Barazas, Janneke E. Jaspers, Kenji Watanabe, Mark Pieterse, Ariena Kersbergen, Wendy Sol, Patrick H. N. Celie, Philip C. Schouten, Bram van den Broek, Ahmed Salman, Marja Nieuwland, Iris de Rink, Jorma de Ronde, Kees Jalink, Simon J. Boulton, Junjie Chen, Dik C. van Gent, Jiri Bartek, Jos Jonkers, Piet Borst, Sven Rottenberg
Nature. Author manuscript; available in PMC 2015 Dec 7.
Published in final edited form as: Nature. 2015 May 28; 521(7553): 541–544. Published online 2015 Mar 23. doi: 10.1038/nature14328
PMCID:
PMC4671316
AbstractArticlePDF–4.4M
15.
Destabilization of pluripotency in the absence of Mad2l2
Mehdi Pirouz, Ali Rahjouei, Farnaz Shamsi, Kolja Neil Eckermann, Gabriela Salinas-Riester, Claudia Pommerenke, Michael Kessel
Cell Cycle. 2015 May 15; 14(10): 1596–1610. Published online 2015 Apr 30. doi: 10.1080/15384101.2015.1026485
PMCID:
PMC4614513
AbstractArticlePDF–1.1M
16.
Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells
Hong Seok Shim, Min Wei, Sebastian Brandhorst, Valter D. Longo
Cancer Res. Author manuscript; available in PMC 2016 Mar 15.
Published in final edited form as: Cancer Res. 2015 Mar 15; 75(6): 1056–1067. Published online 2015 Jan 22. doi: 10.1158/0008-5472.CAN-14-2249
PMCID:
PMC4359966
AbstractArticlePDF–1.5M
17.
Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen
Kifayathullah Liakath-Ali, Valerie E. Vancollie, Emma Heath, Damian P. Smedley, Jeanne Estabel, David Sunter, Tia DiTommaso, Jacqueline K. White, Ramiro Ramirez-Solis, Ian Smyth, Karen P. Steel, Fiona M. Watt
Nat Commun. 2014 Apr 11; 5: 3540. Published online 2014 Apr 11. doi: 10.1038/ncomms4540
PMCID:
PMC3996542
AbstractArticlePDF–4.0M
18.
A Missense Mutation in Rev7 Disrupts Formation of Polζ, Impairing Mouse Development and Repair of Genotoxic Agent-induced DNA Lesions
Maryam Khalaj, Abdolrahim Abbasi, Hiroshi Yamanishi, Kouyou Akiyama, Shuso Wakitani, Sotaro Kikuchi, Michiko Hirose, Misako Yuzuriha, Masaki Magari, Heba A. Degheidy, Kuniya Abe, Atsuo Ogura, Hiroshi Hashimoto, Tetsuo Kunieda
J Biol Chem. 2014 Feb 7; 289(6): 3811–3824. Published online 2013 Dec 19. doi: 10.1074/jbc.M113.514752
PMCID:
PMC3916577
AbstractArticlePDF–4.9M
19.
siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/− with susceptibility versus C57BL/6-Trp53+/− mice with resistance to mammary tumors
M Böhringer, K Obermeier, N Griner, D Waldraff, E Dickinson, K Eirich, D Schindler, M Hagen, D J Jerry, L Wiesmüller
Oncogene. 2013 Nov 28; 32(48): 5458–5470. Published online 2013 Feb 25. doi: 10.1038/onc.2013.38
PMCID:
PMC3898496
AbstractArticlePDF–1.6M
20.
Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset
Tamar Listovsky, Julian E. Sale
J Cell Biol. 2013 Oct 14; 203(1): 87–100. doi: 10.1083/jcb.201302060
PMCID:
PMC3798251
AbstractArticlePDF–3.0M

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