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Select item 111468881.

The modular nature of apoptotic signaling proteins

K. Hofmann

Cell Mol Life Sci. 1999 Jul; 55(8-9): 1113–1128. doi: 10.1007/s000180050361

PMCID:: PMC11146888

Abstract Article PDF–923K

Select item 110939692.

ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1

Margaret Solon, Nianfeng Ge, Shannon Hambro, Susan Haller, Jian Jiang, Miriam Baca, Jessica Preston, Allie Maltzman, Katherine E. Wickliffe, Yuxin Liang, Rohit Reja, Dorothee Nickles, Kim Newton, Joshua D. Webster

Cell Death Differ. 2024 May; 31(5): 672–682. Published online 2024 Mar 28. doi: 10.1038/s41418-024-01286-6

PMCID:: PMC11093969

Abstract Article PDF–5.5M

Select item 110398373.

Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1

Shannon N. Loftus, Mehrnaz Gharaee-Kermani, Bin Xu, Tyson M. Moore, Andrew Hannoudi, Mischa J. Mallbris, Benjamin Klein, Johann E. Gudjonsson, J. Michelle Kahlenberg

Front Immunol. 2024; 15: 1384606. Published online 2024 Apr 10. doi: 10.3389/fimmu.2024.1384606

PMCID:: PMC11039837

Abstract Article PDF–4.1M

Select item 110265254.

Caspase 8 deletion causes infection/inflammation-induced bone marrow failure and MDS-like disease in mice

Shanhui Liu, Kanak Joshi, Lei Zhang, Wenyan Li, Ryan Mack, Austin Runde, Patrick A. Hagen, Kevin Barton, Peter Breslin, Hong-Long Ji, Ameet R. Kini, Zhiping Wang, Jiwang Zhang

Cell Death Dis. 2024 Apr; 15(4): 278. Published online 2024 Apr 18. doi: 10.1038/s41419-024-06660-3

PMCID:: PMC11026525

Abstract Article PDF–3.0M

Select item 108605485.

Study on pyroptosis-related genes Casp8, Gsdmd and Trem2 in mice with cerebral infarction

Shunli Liang, Linsheng Xu, Xilin Xin, Rongbo Zhang, You Wu

PeerJ. 2024; 12: e16818. Published online 2024 Feb 9. doi: 10.7717/peerj.16818

PMCID:: PMC10860548

Abstract Article PDF–6.5M

Select item 105492046.

Autophagy critically controls skin inflammation and apoptosis-induced stem cell activation

Lisette Van Hove, Annagiada Toniolo, Mohammad Ghiasloo, Kim Lecomte, Fleur Boone, Maarten Ciers, Kris Raaijmakers, Niels Vandamme, Jana Roels, Sophia Maschalidi, Kodi S Ravichandran, Maria Kasper, Geert van Loo, Esther Hoste

Autophagy. 2023; 19(11): 2958–2971. Published online 2023 Sep 1. doi: 10.1080/15548627.2023.2247742

PMCID:: PMC10549204

Abstract Article PDF–3.9M

Select item 105473007.

Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development

Bingruo Wu, Brian Wu, Sonia Benkaci, Lijie Shi, Pengfei Lu, Taeju Park, Bernice E. Morrow, Yidong Wang, Bin Zhou

J Am Heart Assoc. 2023 Sep 19; 12(18): e029683. Published online 2023 Sep 13. doi: 10.1161/JAHA.123.029683

PMCID:: PMC10547300

Abstract Article PDF–41M

Select item 104169848.

Differential Modulation of miR-122 Transcription by TGFβ1/BMP6: Implications for Nonresolving Inflammation and Hepatocarcinogenesis

Martha Paluschinski, Claus Kordes, Mihael Vucur, Veronika Buettner, Christoph Roderburg, Haifeng C. Xu, Prashant V. Shinte, Philipp A. Lang, Tom Luedde, Mirco Castoldi

Cells. 2023 Aug; 12(15): 1955. Published online 2023 Jul 27. doi: 10.3390/cells12151955

PMCID:: PMC10416984

Abstract Article PDF–4.8M

Select item 104098009.

SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development

Yurika Matsui, Mohamed Nadhir Djekidel, Katherine Lindsay, Parimal Samir, Nina Connolly, Gang Wu, Xiaoyang Yang, Yiping Fan, Beisi Xu, Jamy C. Peng

Nat Commun. 2023; 14: 4754. Published online 2023 Aug 8. doi: 10.1038/s41467-023-40487-4

PMCID:: PMC10409800

Abstract Article PDF–5.3M

Select item 1039417110.

Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation

Germana Lentini, Agata Famà, Giuseppe Valerio De Gaetano, Francesco Coppolino, Ahlem Khachroub Mahjoub, Liv Ryan, Egil Lien, Terje Espevik, Concetta Beninati, Giuseppe Teti

Cell Rep Med. 2023 Jul 18; 4(7): 101098. Published online 2023 Jun 29. doi: 10.1016/j.xcrm.2023.101098

PMCID:: PMC10394171

Abstract Article PDF–6.8M

Select item 1029412111.

Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma

Xiangjun Yang, Qun Zeng, Gülgün Tezel

Neurobiol Dis. Author manuscript; available in PMC 2023 Jun 27.

Published in final edited form as: Neurobiol Dis. 2021 Mar; 150: 105258. Published online 2021 Jan 9. doi: 10.1016/j.nbd.2021.105258

PMCID:: PMC10294121

Abstract Article PDF–3.1M

Select item 1026756312.

Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis

Stephanie M. Bozonet, Nicholas J. Magon, Abigail J. Schwartfeger, Andreas Konigstorfer, Sarah G. Heath, Margreet C.M. Vissers, Vanessa K. Morris, Christoph Göbl, James M. Murphy, Guy S. Salvesen, Mark B. Hampton

J Biol Chem. 2023 Jun; 299(6): 104792. Published online 2023 May 6. doi: 10.1016/j.jbc.2023.104792

PMCID:: PMC10267563

Abstract Article PDF–2.2M

Select item 1011932313.

Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection

Elien Eeckhout, Lisa Hamerlinck, Veronique Jonckheere, Petra Van Damme, Geert van Loo, Andy Wullaert

Cell Death Dis. 2023 Apr; 14(4): 282. Published online 2023 Apr 21. doi: 10.1038/s41419-023-05801-4

PMCID:: PMC10119323

Abstract Article PDF–7.1M

Select item 997742514.

Role of the caspase-8/RIPK3 axis in Alzheimer’s disease pathogenesis and Aβ-induced NLRP3 inflammasome activation

Sushanth Kumar, Sakar Budhathoki, Christopher B. Oliveira, August D. Kahle, O. Yipkin Calhan, John R. Lukens, Christopher D. Deppmann

JCI Insight. 2023 Feb 8; 8(3): e157433. Published online 2023 Feb 8. doi: 10.1172/jci.insight.157433

PMCID:: PMC9977425

Abstract Article PDF–11M

Select item 996425415.

Caspase Inhibition Modulates Monocyte-Derived Macrophage Polarization in Damaged Tissues

Stéphanie Solier, Michele Mondini, Lydia Meziani, Arnaud Jacquel, Catherine Lacout, Tom Vanden Berghe, Yvon Julé, Jean-Claude Martinou, Gérard Pierron, Julie Rivière, Marc Deloger, Corinne Dupuy, Anny Slama-Schwok, Nathalie Droin, Peter Vandenabeele, Patrick Auberger, Eric Deutsch, Jamel El-Benna, Pham My-Chan Dang, Eric Solary

Int J Mol Sci. 2023 Feb; 24(4): 4151. Published online 2023 Feb 19. doi: 10.3390/ijms24044151

PMCID:: PMC9964254

Abstract Article PDF–7.5M

Select item 992231916.

RIPK3 controls MAIT cell accumulation during development but not during infection

Timothy Patton, Zhe Zhao, Xin Yi Lim, Eleanor Eddy, Huimeng Wang, Adam G. Nelson, Bronte Ennis, Sidonia B. G. Eckle, Michael N. T. Souter, Troi J. Pediongco, Hui-Fern Koay, Jian-Guo Zhang, Tirta M. Djajawi, Cynthia Louis, Najoua Lalaoui, Nicolas Jacquelot, Andrew M. Lew, Daniel G. Pellicci, James McCluskey, Yifan Zhan, Zhenjun Chen, Kate E. Lawlor, Alexandra J. Corbett

Cell Death Dis. 2023 Feb; 14(2): 111. Published online 2023 Feb 11. doi: 10.1038/s41419-023-05619-0

PMCID:: PMC9922319

Abstract Article PDF–2.2M

Select item 988352317.

Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria

Stefanie M. Bader, Simon P. Preston, Katie Saliba, Adam Lipszyc, Zoe L. Grant, Liana Mackiewicz, Andrew Baldi, Anne Hempel, Michelle P. Clark, Thanushi Peiris, William Clow, Jan Bjelic, Michael D. Stutz, Philip Arandjelovic, Jack Teale, Fashuo Du, Leigh Coultas, James M. Murphy, Cody C. Allison, Marc Pellegrini, Andre L. Samson

Cell Death Differ. 2023 Jan; 30(1): 27–36. Published online 2022 Jul 23. doi: 10.1038/s41418-022-01042-8

PMCID:: PMC9883523

Abstract Article PDF–3.3M

Select item 973254718.

Caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating CD4⁺ effector memory T cells

Jian Hu, Zhen Huang, Min Yu, Pei Zhang, Zhengkun Xia, Chunlin Gao

Front Immunol. 2022; 13: 1038134. Published online 2022 Nov 25. doi: 10.3389/fimmu.2022.1038134

PMCID:: PMC9732547

Abstract Article PDF–14M

Select item 963092719.

Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation

Yaqiu Wang, Rajendra Karki, Raghvendra Mall, Bhesh Raj Sharma, Ravi C. Kalathur, SangJoon Lee, Balabhaskararao Kancharana, Matthew So, Katie L. Combs, Thirumala-Devi Kanneganti

Cell Rep. Author manuscript; available in PMC 2022 Nov 3.

Published in final edited form as: Cell Rep. 2022 Oct 4; 41(1): 111434. doi: 10.1016/j.celrep.2022.111434

PMCID:: PMC9630927

Abstract Article PDF–2.5M

Select item 956553220.

Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis

Diego A. Rodriguez, Giovanni Quarato, Swantje Liedmann, Bart Tummers, Ting Zhang, Cliff Guy, Jeremy Chase Crawford, Gustavo Palacios, Stephane Pelletier, Halime Kalkavan, Jeremy J. P. Shaw, Patrick Fitzgerald, Mark J. Chen, Siddharth Balachandran, Douglas R. Green

Proc Natl Acad Sci U S A. 2022 Oct 11; 119(41): e2207240119. Published online 2022 Oct 3. doi: 10.1073/pnas.2207240119