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Select item 86283611.

Multidrug resistance-associated protein 4 (Mrp4) is a novel genetic factor in the pathogenesis of obesity and diabetes

Ajay C Donepudi, Yoojin Lee, Ji-Young Lee, John D. Schuetz, José E Manautou

FASEB J. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: FASEB J. 2021 Feb; 35(2): e21304. doi: 10.1096/fj.202001299RR

PMCID:: PMC8628361

Abstract Article PDF–1.7M

Select item 74166972.

An ABC transporter drives the Sonic Hedgehog pathway contributing to medulloblastoma pathogenesis

Juwina Wijaya, BaoHan T Vo, Jingjing Liu, Beisi Xu, Gang Wu, Yao Wang, Junmin Peng, Jin Zhang, Laura J Janke, Brent A Orr, Jiyang Yu, Martine F Roussel, John D Schuetz

Cancer Res. Author manuscript; available in PMC 2020 Aug 10.

Published in final edited form as: Cancer Res. 2020 Apr 1; 80(7): 1524–1537. Published online 2020 Jan 16. doi: 10.1158/0008-5472.CAN-19-2054

PMCID:: PMC7416697

Abstract Article PDF–3.4M

Select item 68131383.

TNFα Induces Multidrug Resistance-Associated Protein 4 Expression through p38-E2F1-Nrf2 Signaling in Obstructive Cholestasis

Wei Lian, Xiaocong Liu, Wensheng Chen

Yonsei Med J. 2019 Nov 1; 60(11): 1045–1053. Published online 2019 Oct 17. doi: 10.3349/ymj.2019.60.11.1045

PMCID:: PMC6813138

Abstract Article PDF–575K

Select item 56119554.

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development

Elisabeth A. Rutledge, Jean-Denis Benazet, Andrew P. McMahon

Development. 2017 Sep 1; 144(17): 3177–3188. doi: 10.1242/dev.149112

PMCID:: PMC5611955

Abstract Article

Select item 49057205.

ABCC4 Is a Determinant of Cytarabine‐Induced Cytotoxicity and Myelosuppression

CD Drenberg, S Hu, L Li, DR Buelow, SJ Orwick, AA Gibson, JD Schuetz, A Sparreboom, SD Baker

Clin Transl Sci. 2016 Feb; 9(1): 51–59. Published online 2016 Feb 4. doi: 10.1111/cts.12366

PMCID:: PMC4905720

Abstract Article PDF–598K

Select item 47284216.

Blood–brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P‐glycoprotein on a novel verapamil influx carrier

Hélène Chapy, Bruno Saubaméa, Nicolas Tournier, Fanchon Bourasset, Francine Behar‐Cohen, Xavier Declèves, Jean‐Michel Scherrmann, Salvatore Cisternino

Br J Pharmacol. 2016 Feb; 173(3): 497–510. Published online 2016 Jan 15. doi: 10.1111/bph.13376

PMCID:: PMC4728421

Abstract Article PDF–1.3M

Select item 46430057.

The ABCC4 membrane transporter modulates platelet aggregation

Satish B. Cheepala, Aaron Pitre, Yu Fukuda, Kazumasa Takenaka, Yuanyuan Zhang, Yao Wang, Sharon Frase, Tamara Pestina, T. Kent Gartner, Carl Jackson, John D. Schuetz

Blood. 2015 Nov 12; 126(20): 2307–2319. Prepublished online 2015 Sep 24. doi: 10.1182/blood-2014-08-595942

PMCID:: PMC4643005

Abstract Article

Select item 46266638.

Impaired platelet activation and cAMP homeostasis in MRP4-deficient mice

Benoit Decouture, Elise Dreano, Tiphaine Belleville-Rolland, Orjeta Kuci, Blandine Dizier, Amine Bazaa, Bérard Coqueran, Anne-Marie Lompre, Cécile V. Denis, Jean-Sébastien Hulot, Christilla Bachelot-Loza, Pascale Gaussem

Blood. 2015 Oct 8; 126(15): 1823–1830. Prepublished online 2015 Aug 27. doi: 10.1182/blood-2015-02-631044

PMCID:: PMC4626663

Abstract Article

Select item 45983569.

Maternal bile acid transporter deficiency promotes neonatal demise

Yuanyuan Zhang, Fei Li, Yao Wang, Aaron Pitre, Zhong-ze Fang, Matthew W. Frank, Christopher Calabrese, Kristopher W. Krausz, Geoffrey Neale, Sharon Frase, Peter Vogel, Charles O. Rock, Frank J. Gonzalez, John D. Schuetz

Nat Commun. 2015; 6: 8186. Published online 2015 Sep 29. doi: 10.1038/ncomms9186

PMCID:: PMC4598356

Abstract Article PDF–1.5M

Select item 451912910.

Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis

Jun Hamazaki, Shoshiro Hirayama, Shigeo Murata

PLoS Genet. 2015 Jul; 11(7): e1005401. Published online 2015 Jul 29. doi: 10.1371/journal.pgen.1005401

PMCID:: PMC4519129

Abstract Article PDF–11M

Select item 449002811.

Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide is Dependent on Abcc2, Abcc3, and Oatp1a/1b

Aksana Vasilyeva, Selvi Durmus, Lie Li, Els Wagenaar, Shuiying Hu, Alice A. Gibson, John C. Panetta, Sridhar Mani, Alex Sparreboom, Sharyn D. Baker, Alfred H. Schinkel

Cancer Res. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Cancer Res. 2015 Jul 1; 75(13): 2729–2736. Published online 2015 May 7. doi: 10.1158/0008-5472.CAN-15-0280

PMCID:: PMC4490028

Abstract Article PDF–2.2M

Select item 448600412.

P-glycoprotein, but not Multidrug Resistance Protein 4, Plays a Role in the Systemic Clearance of Irinotecan and SN-38 in Mice

Michael Tagen, Yanli Zhuang, Fan Zhang, K. Elaine Harstead, Jun Shen, Paula Schaiquevich, Charles H. Fraga, John C. Panetta, Christopher M. Waters, Clinton F. Stewart

Drug Metab Lett. Author manuscript; available in PMC 2015 Jun 30.

Published in final edited form as: Drug Metab Lett. 2010 Dec; 4(4): 195–201. doi: 10.2174/187231210792928251

PMCID:: PMC4486004

Abstract Article PDF–321K

Select item 443785213.

PKA and Actin Play Critical Roles as Downstream Effectors in MRP4-Mediated Regulation of Fibroblast Migration

Chandrima Sinha, Aixia Ren, Kavisha Arora, Chang Suk Moon, Sunitha Yarlagadda, Koryse Woodrooffe, Songbai Lin, John D. Schuetz, Assem G. Ziady, Anjaparavanda P. Naren

Cell Signal. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Cell Signal. 2015 Jul; 27(7): 1345–1355. Published online 2015 Apr 2. doi: 10.1016/j.cellsig.2015.03.022

PMCID:: PMC4437852

Abstract Article PDF–2.9M

Select item 429720414.

Cardiac myocyte–secreted cAMP exerts paracrine action via adenosine receptor activation

Yassine Sassi, Andrea Ahles, Dong-Jiunn Jeffery Truong, Younis Baqi, Sang-Yong Lee, Britta Husse, Jean-Sébastien Hulot, Ariana Foinquinos, Thomas Thum, Christa E. Müller, Andreas Dendorfer, Bernhard Laggerbauer, Stefan Engelhardt

J Clin Invest. 2014 Dec 1; 124(12): 5385–5397. Published online 2014 Nov 17. doi: 10.1172/JCI74349

PMCID:: PMC4297204

Abstract Article PDF–3.0M

Select item 415431915.

Prostaglandin signaling regulates ciliogenesis by modulating intraflagellar transport

Daqing Jin, Terri T. Ni, Jianjian Sun, Haiyan Wan, Jeffrey D. Amack, Guangju Yu, Jonathan Fleming, Chin Chiang, Wenyan Li, Anna Papierniak, Satish Cheepala, Gwenaëlle Conseil, Susan P.C. Cole, Bin Zhou, Iain A. Drummond, John D. Schuetz, Jarema Malicki, Tao P. Zhong

Nat Cell Biol. Author manuscript; available in PMC 2015 Mar 1.

Published in final edited form as: Nat Cell Biol. 2014 Sep; 16(9): 841–851. Published online 2014 Aug 31. doi: 10.1038/ncb3029

PMCID:: PMC4154319

Abstract Article PDF–2.8M

Select item 396849516.

Na⁺/H⁺ Exchanger Regulatory Factor 3 Is Critical for Multidrug Resistance Protein 4–Mediated Drug Efflux in the Kidney

Joonhee Park, Jin-Oh Kwak, Brigitte Riederer, Ursula Seidler, Susan P.C. Cole, Hwa Jeong Lee, Min Goo Lee

J Am Soc Nephrol. 2014 Apr; 25(4): 726–736. Published online 2014 Jan 16. doi: 10.1681/ASN.2013040438

PMCID:: PMC3968495

Abstract Article

Select item 375290117.

Contribution of Abcc4-Mediated Gastric Transport to the Absorption and Efficacy of Dasatinib

Brian D. Furmanski, Shuiying Hu, Ken-ichi Fujita, Lie Li, Alice A. Gibson, Laura J. Janke, Richard T. Williams, John D. Schuetz, Alex Sparreboom, Sharyn D. Baker

Clin Cancer Res. Author manuscript; available in PMC 2014 Aug 15.

Published in final edited form as: Clin Cancer Res. 2013 Aug 15; 19(16): 4359–4370. Published online 2013 Jun 21. doi: 10.1158/1078-0432.CCR-13-0980

PMCID:: PMC3752901

Abstract Article PDF–1.1M

Select item 363255618.

The Absence of Mrp4 Has No Effect on the Recruitment of Neutrophils and Eosinophils into the Lung after LPS, Cigarette Smoke or Allergen Challenge

Jürgen Schymeinsky, Hannah Mayer, Christopher Tomsic, Cornelia Tilp, John D. Schuetz, Yunhai Cui, Lutz Wollin, Florian Gantner, Klaus J. Erb

PLoS One. 2013; 8(4): e61193. Published online 2013 Apr 22. doi: 10.1371/journal.pone.0061193

PMCID:: PMC3632556

Abstract Article PDF–902K

Select item 356763319.

Multi-drug Resistance Protein 4 (MRP4)-mediated Regulation of Fibroblast Cell Migration Reflects a Dichotomous Role of Intracellular Cyclic Nucleotides

Chandrima Sinha, Aixia Ren, Kavisha Arora, Chang-Suk Moon, Sunitha Yarlagadda, Weiqiang Zhang, Satish B. Cheepala, John D. Schuetz, Anjaparavanda P. Naren

J Biol Chem. 2013 Feb 8; 288(6): 3786–3794. Published online 2012 Dec 22. doi: 10.1074/jbc.M112.435925