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Items: 1 to 20 of 42

1.
Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis
Yesheng Fu, Lei Li, Xin Zhang, Zhikang Deng, Ying Wu, Wenzhe Chen, Yuchen Liu, Shan He, Jian Wang, Yuping Xie, Zhiwei Tu, Yadi Lyu, Yange Wei, Shujie Wang, Chun-Ping Cui, Cui Hua Liu, Lingqiang Zhang
Nat Commun. 2024; 15: 2974. Published online 2024 Apr 6. doi: 10.1038/s41467-024-47289-2
PMCID:
PMC10998861
AbstractArticlePDF–4.5M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
A20 controls RANK‐dependent osteoclast formation and bone physiology
Arne Martens, Pieter Hertens, Dario Priem, Vagelis Rinotas, Theodore Meletakos, Meropi Gennadi, Lisette Van Hove, Els Louagie, Julie Coudenys, Amélie De Muynck, Djoere Gaublomme, Mozes Sze, Jolanda van Hengel, Leen Catrysse, Esther Hoste, Jeffrey D Zajac, Rachel A Davey, Luc Van Hoorebeke, Tino Hochepied, Mathieu J M Bertrand, Marietta Armaka, Dirk Elewaut, Geert van Loo
EMBO Rep. 2022 Dec; 23(12): e55233. Published online 2022 Oct 4. doi: 10.15252/embr.202255233
PMCID:
PMC9724664
AbstractArticlePDF–3.0M
4.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
5.
Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing
Nina Frey, Luigi Tortola, David Egli, Sharan Janjuha, Tanja Rothgangl, Kim Fabiano Marquart, Franziska Ampenberger, Manfred Kopf, Gerald Schwank
Nat Commun. 2022; 13: 1804. Published online 2022 Apr 4. doi: 10.1038/s41467-022-29412-3
PMCID:
PMC8980030
AbstractArticlePDF–3.3M
6.
The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains
Carlos Gomez-Diaz, Gustav Jonsson, Katrin Schodl, Luiza Deszcz, Annika Bestehorn, Kevin Eislmayr, Jorge Almagro, Anoop Kavirayani, Mayu Seida, Lilian M. Fennell, Astrid Hagelkruys, Pavel Kovarik, Josef M. Penninger, Fumiyo Ikeda
iScience. 2021 Nov 19; 24(11): 103241. Published online 2021 Oct 8. doi: 10.1016/j.isci.2021.103241
PMCID:
PMC8561004
AbstractArticlePDF–4.4M
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
Site‐specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling
Lilian M Fennell, Carlos Gomez Diaz, Luiza Deszcz, Anoop Kavirayani, David Hoffmann, Kota Yanagitani, Alexander Schleiffer, Karl Mechtler, Astrid Hagelkruys, Josef Penninger, Fumiyo Ikeda
EMBO J. 2020 Dec 15; 39(24): e103303. Published online 2020 Nov 20. doi: 10.15252/embj.2019103303
PMCID:
PMC7737615
AbstractArticlePDF–1.9M
9.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
10.
Linear ubiquitin assembly complex regulates lung epithelial–driven responses during influenza infection
Patricia L. Brazee, Luisa Morales-Nebreda, Natalia D. Magnani, Joe G.N. Garcia, Alexander V. Misharin, Karen M. Ridge, G.R. Scott Budinger, Kazuhiro Iwai, Laura A. Dada, Jacob I. Sznajder
J Clin Invest. 2020 Mar 2; 130(3): 1301–1314. Published online 2020 Jan 27. doi: 10.1172/JCI128368
PMCID:
PMC7269564
AbstractArticlePDF–1.9M
11.
Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling
Yibo Zuo, Qian Feng, Lincong Jin, Fan Huang, Ying Miao, Jin Liu, Ying Xu, Xiangjie Chen, Hongguang Zhang, Tingting Guo, Yukang Yuan, Liting Zhang, Jun Wang, Hui Zheng
Nat Commun. 2020; 11: 1146. Published online 2020 Mar 2. doi: 10.1038/s41467-020-14948-z
PMCID:
PMC7052135
AbstractArticlePDF–3.5M
12.
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
Katsuhiro Sasaki, Ai Himeno, Tomoko Nakagawa, Yoshiteru Sasaki, Hiroshi Kiyonari, Kazuhiro Iwai
Nat Commun. 2019; 10: 3878. Published online 2019 Aug 28. doi: 10.1038/s41467-019-11858-7
PMCID:
PMC6713751
AbstractArticlePDF–4.4M
13.
Tumour necrosis factor signalling in health and disease
Jonathan Holbrook, Samuel Lara-Reyna, Heledd Jarosz-Griffiths, Michael F. McDermott
Version 1. F1000Res. 2019; 8: F1000 Faculty Rev-111. Published online 2019 Jan 28. doi: 10.12688/f1000research.17023.1
PMCID:
PMC6352924
AbstractArticlePDF–1.8M
14.
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L
Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L. Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J. Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke, Henning Walczak
Nat Commun. 2018; 9: 3910. Published online 2018 Sep 25. doi: 10.1038/s41467-018-06155-8
PMCID:
PMC6156229
AbstractArticlePDF–3.3M
15.
Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization
Hiroaki Fujita, Akira Tokunaga, Satoshi Shimizu, Amanda L. Whiting, Francisco Aguilar-Alonso, Kenji Takagi, Erik Walinda, Yoshiteru Sasaki, Taketo Shimokawa, Tsunehiro Mizushima, Izuru Ohki, Mariko Ariyoshi, Hidehito Tochio, Federico Bernal, Masahiro Shirakawa, Kazuhiro Iwai
Cell Rep. Author manuscript; available in PMC 2019 Apr 24.
Published in final edited form as: Cell Rep. 2018 Apr 24; 23(4): 1192–1204. doi: 10.1016/j.celrep.2018.03.112
PMCID:
PMC6044281
AbstractArticlePDF–1.0M
16.
LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis
Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Amanda Fisher, Ciaran Hutchinson, Lucia Taraborrelli, Torsten Hartwig, Elodie Lafont, Tobias L. Haas, Yutaka Shimizu, Charlotta Böiers, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Michael T. Ashworth, Allison Beal, Tariq Enver, John Bertin, William Kaiser, Andreas Strasser, John Silke, Philippe Bouillet, Henning Walczak
Nature. Author manuscript; available in PMC 2018 Oct 25.
Published in final edited form as: Nature. 2018 May; 557(7703): 112–117. Published online 2018 Apr 25. doi: 10.1038/s41586-018-0064-8
PMCID:
PMC5947819
AbstractArticlePDF–5.6M
17.
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy
Gian-Luca McLelland, Thomas Goiran, Wei Yi, Geneviève Dorval, Carol X Chen, Nadine D Lauinger, Andrea I Krahn, Sepideh Valimehr, Aleksandar Rakovic, Isabelle Rouiller, Thomas M Durcan, Jean-François Trempe, Edward A Fon
eLife. 2018; 7: e32866. Published online 2018 Apr 20. doi: 10.7554/eLife.32866
PMCID:
PMC5927771
AbstractArticlePDF–9.1M
18.
ABIN-1 Regulates RIPK1 Activation by Bridging M1 ubiquitination with K63 Deubiquitination in TNF-RSC
Slawomir A. Dziedzic, Zhenyi Su, Vica Jean Barrett, Ayaz Najafov, Adnan K. Mookhitiar, Palak Amin, Heling Pan, Li Sun, Hong Zhu, Averil Ma, Derek W. Abbott, Junying Yuan
Nat Cell Biol. Author manuscript; available in PMC 2018 Jun 4.
Published in final edited form as: Nat Cell Biol. 2018 Jan; 20(1): 58–68. Published online 2017 Dec 4. doi: 10.1038/s41556-017-0003-1
PMCID:
PMC5741489
AbstractArticlePDF–2.6M
19.
The Linear ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis
Yutaka Shimizu, Nieves Peltzer, Alexandra Sevko, Elodie Lafont, Aida Sarr, Helena Draberova, Henning Walczak
Hepatology. 2017 Jun; 65(6): 1963–1978. Published online 2017 Apr 10. doi: 10.1002/hep.29074
PMCID:
PMC5485060
AbstractArticlePDF–1.1M
20.
­­LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation
Julia Zinngrebe, Eva Rieser, Lucia Taraborrelli, Nieves Peltzer, Torsten Hartwig, Hongwei Ren, Ildikó Kovács, Cornelia Endres, Peter Draber, Maurice Darding, Silvia von Karstedt, Johannes Lemke, Balazs Dome, Michael Bergmann, Brian J. Ferguson, Henning Walczak
J Exp Med. 2016 Nov 14; 213(12): 2671–2689. doi: 10.1084/jem.20160041
PMCID:
PMC5110014
AbstractArticlePDF–3.3M

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