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Select item 112969141.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Article PDF–1.7M

Select item 111451172.

Tumor suppressive role of the epigenetic master regulator BRD3 in colorectal cancer

Masahiro Hashimoto, Takaaki Masuda, Yusuke Nakano, Taro Tobo, Hideyuki Saito, Kensuke Koike, Junichi Takahashi, Tadashi Abe, Yuki Ando, Yuki Ozato, Kiyotaka Hosoda, Satoshi Higuchi, Yuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Tsuyoshi Hata, Mamoru Uemura, Hidetoshi Eguchi, Yuichiro Doki, Masaki Mori, Koshi Mimori

Cancer Sci. 2024 Jun; 115(6): 1866–1880. Published online 2024 Mar 17. doi: 10.1111/cas.16129

PMCID:: PMC11145117

Article PDF–20M

Select item 108436843.

Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies

Jakub Chrustowicz, Dawafuti Sherpa, Jerry Li, Christine R. Langlois, Eleftheria C. Papadopoulou, D. Tung Vu, Laura A. Hehl, Özge Karayel, Viola Beier, Susanne von Gronau, Judith Müller, J. Rajan Prabu, Matthias Mann, Gary Kleiger, Arno F. Alpi, Brenda A. Schulman

Mol Cell. Author manuscript; available in PMC 2025 Jan 18.

Published in final edited form as: Mol Cell. 2024 Jan 18; 84(2): 293–308.e14. Published online 2023 Dec 18. doi: 10.1016/j.molcel.2023.11.027

PMCID:: PMC10843684

Article PDF–3.1M

Select item 106964674.

Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP

Nafiseh Sabri, Matthew J. Cuneo, Melissa R. Marzahn, Jihun Lee, Jill J. Bouchard, Ömer Güllülü, Sivaraja Vaithiyalingam, Madeleine B. Borgia, Jeremy Schmit, Tanja Mittag

J Biol Chem. 2023 Dec; 299(12): 105427. Published online 2023 Nov 4. doi: 10.1016/j.jbc.2023.105427

PMCID:: PMC10696467

Article PDF–5.1M

Select item 103532985.

Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair

Chen Wang, Doug W. Chan, Eric A. Hendrickson

DNA Repair (Amst) Author manuscript; available in PMC 2023 Jul 18.

Published in final edited form as: DNA Repair (Amst). 2023 Feb; 122: 103445. Published online 2022 Dec 24. doi: 10.1016/j.dnarep.2022.103445

PMCID:: PMC10353298

Article PDF–2.5M

Select item 100965876.

Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis

Pei-Ling Hsu, Chun-Wei Chien, Yen-An Tang, Bo-Wen Lin, Shih-Chieh Lin, Yi-Syuan Lin, Sih-Yu Chen, H. Sunny Sun, Shaw-Jenq Tsai

Sci Adv. 2023 Apr; 9(15): eade3422. Published online 2023 Apr 12. doi: 10.1126/sciadv.ade3422

Correction in:: Sci Adv. 2023 Nov 10; 9(45): eadl3229.

PMCID:: PMC10096587

Article PDF–3.9M

Select item 99923477.

Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation

Matthew J. Cuneo, Brian G. O’Flynn, Yu-Hua Lo, Nafiseh Sabri, Tanja Mittag

Mol Cell. Author manuscript; available in PMC 2024 Mar 2.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 731–745.e4. Published online 2023 Jan 23. doi: 10.1016/j.molcel.2022.12.033

PMCID:: PMC9992347

Article PDF–4.6M

Select item 99224688.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Article PDF–4.9M

Select item 95403459.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Article PDF–3.9M

Select item 929024110.

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer

Annamaria Salvati, Viola Melone, Assunta Sellitto, Francesca Rizzo, Roberta Tarallo, Tuula A. Nyman, Giorgio Giurato, Giovanni Nassa, Alessandro Weisz

Breast Cancer Res. 2022; 24: 52. Published online 2022 Jul 18. doi: 10.1186/s13058-022-01547-7

PMCID:: PMC9290241

Article PDF–8.2M

Select item 927928511.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Article PDF–2.5M

Select item 880735912.

Epigenetic readers and lung cancer: the rs2427964C>T variant of the bromodomain and extraterminal domain gene BRD3 is associated with poorer survival outcome in NSCLC

Jang Hyuck Lee, Seung Soo Yoo, Mi Jeong Hong, Jin Eun Choi, Hyo‐Gyoung Kang, Sook Kyung Do, Won Kee Lee, Sun Ha Choi, Yong Hoon Lee, Hyewon Seo, Jaehee Lee, Shin Yup Lee, Seung Ick Cha, Chang Ho Kim, Eung Bae Lee, Sukki Cho, Sanghoon Jheon, Jae Yong Park

Mol Oncol. 2022 Feb; 16(3): 750–763. Published online 2021 Oct 15. doi: 10.1002/1878-0261.13109

PMCID:: PMC8807359

Article PDF–5.3M

Select item 876007713.

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Dragomir B. Krastev, Shudong Li, Yilun Sun, Andrew J. Wicks, Gwendoline Hoslett, Daniel Weekes, Luned M. Badder, Eleanor G. Knight, Rebecca Marlow, Mercedes Calvo Pardo, Lu Yu, Tanaji T. Talele, Jiri Bartek, Jyoti S. Choudhary, Yves Pommier, Stephen J. Pettitt, Andrew N. J. Tutt, Kristijan Ramadan, Christopher J. Lord

Nat Cell Biol. 2022; 24(1): 62–73. Published online 2022 Jan 10. doi: 10.1038/s41556-021-00807-6

PMCID:: PMC8760077

Article PDF–12M

Select item 836418114.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Article PDF–3.0M

Select item 834977615.

A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins

Sriram Aiyer, G.V.T. Swapna, Li-Chung Ma, Gaohua Liu, Jingzhou Hao, Gordon Chalmers, Brian C. Jacobs, Gaetano T. Montelione, Monica J. Roth

Structure. Author manuscript; available in PMC 2021 Nov 5.

Published in final edited form as: Structure. 2021 Aug 5; 29(8): 886–898.e6. Published online 2021 Feb 15. doi: 10.1016/j.str.2021.01.010

PMCID:: PMC8349776

Article PDF–3.0M

Select item 831454716.

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation

Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang

Cell Biosci. 2021; 11: 146. Published online 2021 Jul 27. doi: 10.1186/s13578-021-00659-5

PMCID:: PMC8314547

Article PDF–3.7M

Select item 816503017.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Article PDF–2.2M

Select item 800824718.

lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation

Kaveh Daneshvar, M. Behfar Ardehali, Isaac A. Klein, Fu-Kai Hsieh, Arcadia J. Kratkiewicz, Amin Mahpour, Sabrina O.L. Cancelliere, Chan Zhou, Brett M. Cook, Wenyang Li, Joshua V. Pondick, Sweta K. Gupta, Sean P. Moran, Richard A. Young, Robert E. Kingston, Alan C. Mullen

Nat Cell Biol. Author manuscript; available in PMC 2021 Apr 1.

Published in final edited form as: Nat Cell Biol. 2020 Oct; 22(10): 1211–1222. Published online 2020 Sep 7. doi: 10.1038/s41556-020-0572-2

PMCID:: PMC8008247

Article PDF–5.8M

Select item 777336819.

BCL6 confers KRAS-mutant non–small-cell lung cancer resistance to BET inhibitors

Jiawei Guo, Yanan Liu, Jing Lv, Bin Zou, Zhi Chen, Kun Li, Juanjuan Feng, Zhenyu Cai, Lai Wei, Mingyao Liu, Xiufeng Pang

J Clin Invest. 2021 Jan 4; 131(1): e133090. Published online 2021 Jan 4. doi: 10.1172/JCI133090

PMCID:: PMC7773368

Article PDF–10M

Select item 743811220.

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency

Joana G Marques, Berkley E Gryder, Blaz Pavlovic, Yeonjoo Chung, Quy A Ngo, Fabian Frommelt, Matthias Gstaiger, Young Song, Katharina Benischke, Dominik Laubscher, Marco Wachtel, Javed Khan, Beat W Schäfer

eLife. 2020; 9: e54993. Published online 2020 Aug 3. doi: 10.7554/eLife.54993

PMCID:: PMC7438112

Article PDF–4.5M

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