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Select item 108582511.

Mechanistic characterization of a Drosophila model of paraneoplastic nephrotic syndrome

Jun Xu, Ying Liu, Fangying Yang, Yurou Cao, Weihang Chen, Joshua Shing Shun Li, Shuai Zhang, Aram Comjean, Yanhui Hu, Norbert Perrimon

Nat Commun. 2024; 15: 1241. Published online 2024 Feb 9. doi: 10.1038/s41467-024-45493-8

PMCID:: PMC10858251

Abstract Article PDF–3.8M

Select item 101057362.

Next-generation large-scale binary protein interaction network for Drosophila melanogaster

Hong-Wen Tang, Kerstin Spirohn, Yanhui Hu, Tong Hao, István A. Kovács, Yue Gao, Richard Binari, Donghui Yang-Zhou, Kenneth H. Wan, Joel S. Bader, Dawit Balcha, Wenting Bian, Benjamin W. Booth, Atina G. Coté, Steffi de Rouck, Alice Desbuleux, Kah Yong Goh, Dae-Kyum Kim, Jennifer J. Knapp, Wen Xing Lee, Irma Lemmens, Cathleen Li, Mian Li, Roujia Li, Hyobin Julianne Lim, Yifang Liu, Katja Luck, Dylan Markey, Carl Pollis, Sudharshan Rangarajan, Jonathan Rodiger, Sadie Schlabach, Yun Shen, Dayag Sheykhkarimli, Bridget TeeKing, Frederick P. Roth, Jan Tavernier, Michael A. Calderwood, David E. Hill, Susan E. Celniker, Marc Vidal, Norbert Perrimon, Stephanie E. Mohr

Nat Commun. 2023; 14: 2162. Published online 2023 Apr 15. doi: 10.1038/s41467-023-37876-0

PMCID:: PMC10105736

Abstract Article PDF–3.2M

Select item 97067023.

Uric acid metabolism modulates diet-dependent responses to intraspecific competition in Drosophila larvae

Juliano Morimoto

iScience. 2022 Dec 22; 25(12): 105598. Published online 2022 Nov 15. doi: 10.1016/j.isci.2022.105598

PMCID:: PMC9706702

Abstract Article PDF–2.3M

Select item 96169994.

A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response

Tyler A. U. Hilsabeck, Ru Liu-Bryan, Tracy Guo, Kenneth A. Wilson, Neelanjan Bose, Daniel Raftery, Jennifer N. Beck, Sven Lang, Kelly Jin, Christopher S. Nelson, Tal Oron, Marshall Stoller, Daniel Promislow, Rachel B. Brem, Robert Terkeltaub, Pankaj Kapahi

GeroScience. 2022 Aug; 44(4): 2195–2211. Published online 2022 Apr 6. doi: 10.1007/s11357-022-00557-9

PMCID:: PMC9616999

Abstract Article PDF–3.9M

Select item 92316075.

Transcriptional and functional motifs defining renal function revealed by single-nucleus RNA sequencing

Jun Xu, Yifang Liu, Hongjie Li, Alexander J. Tarashansky, Colin H. Kalicki, Ruei-Jiun Hung, Yanhui Hu, Aram Comjean, Sai Saroja Kolluru, Bo Wang, Stephen R. Quake, Liqun Luo, Andrew P. McMahon, Julian A. T. Dow, Norbert Perrimon

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2203179119. Published online 2022 Jun 13. doi: 10.1073/pnas.2203179119

PMCID:: PMC9231607

Abstract Article PDF–2.7M

Select item 84058806.

Activation of innate immunity during development induces unresolved dysbiotic inflammatory gut and shortens lifespan

Kyoko Yamashita, Ayano Oi, Hina Kosakamoto, Toshitaka Yamauchi, Hibiki Kadoguchi, Takayuki Kuraishi, Masayuki Miura, Fumiaki Obata

Dis Model Mech. 2021 Sep 1; 14(9): dmm049103. Published online 2021 Aug 27. doi: 10.1242/dmm.049103

PMCID:: PMC8405880

Abstract Article

Select item 81481857.

The Impact of Microbiome and Microbiota-Derived Sodium Butyrate on Drosophila Transcriptome and Metabolome Revealed by Multi-Omics Analysis

Fan Zhou, Biaodi Liu, Xin Liu, Yan Li, Luoluo Wang, Jia Huang, Guanzheng Luo, Xiaoyun Wang

Metabolites. 2021 May; 11(5): 298. Published online 2021 May 6. doi: 10.3390/metabo11050298

PMCID:: PMC8148185

Abstract Article PDF–28M

Select item 80437528.

Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose

Zhejun Ji, Jacky Chuen, Marianthi Kiparaki, Nicholas Baker

eLife. 2021; 10: e61172. Published online 2021 Apr 13. doi: 10.7554/eLife.61172

PMCID:: PMC8043752

Abstract Article PDF–10M

Select item 78851209.

Wolbachia and Virus Alter the Host Transcriptome at the Interface of Nucleotide Metabolism Pathways

Amelia R. I. Lindsey, Tamanash Bhattacharya, Richard W. Hardy, Irene L. G. Newton

mBio. 2021 Jan-Feb; 12(1): e03472-20. Published online 2021 Feb 9. doi: 10.1128/mBio.03472-20

PMCID:: PMC7885120

Abstract Article PDF–3.5M

Select item 747729610.

Rosy Beginnings: Studying Peroxisomes in Drosophila

C. Pridie, Kazuki Ueda, Andrew J. Simmonds

Front Cell Dev Biol. 2020; 8: 835. Published online 2020 Aug 25. doi: 10.3389/fcell.2020.00835

PMCID:: PMC7477296

Abstract Article PDF–1.1M

Select item 741401411.

Genome-wide transcriptional effects of deletions of sulphur metabolism genes in Drosophila melanogaster

O. Zatsepina, D. Karpov, L. Chuvakova, A. Rezvykh, S. Funikov, S. Sorokina, A. Zakluta, D. Garbuz, V. Shilova, M. Evgen'ev

Redox Biol. 2020 Sep; 36: 101654. Published online 2020 Jul 25. doi: 10.1016/j.redox.2020.101654

Correction in:: Redox Biol. 2024 Dec; 78: 103431.

PMCID:: PMC7414014

Abstract Article PDF–12M

Select item 709315212.

An abundant quiescent stem cell population in Drosophila Malpighian tubules protects principal cells from kidney stones

Chenhui Wang, Allan C Spradling

eLife. 2020; 9: e54096. Published online 2020 Mar 16. doi: 10.7554/eLife.54096

PMCID:: PMC7093152

Abstract Article PDF–10M

Select item 701701013.

Physiology, Development, and Disease Modeling in the Drosophila Excretory System

Erez Cohen, Jessica K. Sawyer, Nora G. Peterson, Julian A. T. Dow, Donald T. Fox

Genetics. 2020 Feb; 214(2): 235–264. Published online 2020 Feb 3. doi: 10.1534/genetics.119.302289

PMCID:: PMC7017010

Abstract Article PDF–1.7M

Select item 683458014.

Divergence in Transcriptional and Regulatory Responses to Mating in Male and Female Fruitflies

Emily K. Fowler, Thomas Bradley, Simon Moxon, Tracey Chapman

Sci Rep. 2019; 9: 16100. Published online 2019 Nov 6. doi: 10.1038/s41598-019-51141-9

PMCID:: PMC6834580

Abstract Article PDF–1.4M

Select item 669509415.

A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster

Sven Lang, Tyler A. Hilsabeck, Kenneth A. Wilson, Amit Sharma, Neelanjan Bose, Deanna J. Brackman, Jennifer N. Beck, Ling Chen, Mark A. Watson, David W. Killilea, Sunita Ho, Arnold Kahn, Kathleen Giacomini, Marshall L. Stoller, Thomas Chi, Pankaj Kapahi

PLoS Genet. 2019 Aug; 15(8): e1008318. Published online 2019 Aug 15. doi: 10.1371/journal.pgen.1008318

PMCID:: PMC6695094

Abstract Article PDF–4.1M

Select item 632378016.

Chronic circadian misalignment results in reduced longevity and large-scale changes in gene expression in Drosophila

Alex C. Boomgarden, Gabriel D. Sagewalker, Aashaka C. Shah, Sarah D. Haider, Pramathini Patel, Heather E. Wheeler, Christine M. Dubowy, Daniel J. Cavanaugh

BMC Genomics. 2019; 20: 14. Published online 2019 Jan 7. doi: 10.1186/s12864-018-5401-7