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Select item 113864651.

Endogenous PGD₂ acting on DP2 receptor counter regulates Schistosoma mansoni infection-driven hepatic granulomatous fibrosis

Giovanna N. Pezzella-Ferreira, Camila R. R. Pão, Isaac Bellas, Tatiana Luna-Gomes, Valdirene S. Muniz, Ligia A. Paiva, Natalia R. T. Amorim, Claudio Canetti, Patricia T. Bozza, Bruno L. Diaz, Christianne Bandeira-Melo

PLoS Pathog. 2024 Aug; 20(8): e1011812. Published online 2024 Aug 22. doi: 10.1371/journal.ppat.1011812

PMCID:: PMC11386465

Abstract Article PDF–2.1M

Select item 105710292.

Roles of lipocalin-type and hematopoietic prostaglandin D synthases in mouse retinal angiogenesis

Daiki Horikami, Erika Sekihachi, Keisuke Omori, Yui Kobayashi, Koji Kobayashi, Nanae Nagata, Kaori Kurata, Akiyoshi Uemura, Takahisa Murata

J Lipid Res. 2023 Oct; 64(10): 100439. Published online 2023 Sep 4. doi: 10.1016/j.jlr.2023.100439

PMCID:: PMC10571029

Abstract Article PDF–4.0M

Select item 104280763.

Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells

Fenghua Qian, Shaneice K. Nettleford, Jiayan Zhou, Brooke E. Arner, Molly A. Hall, Arati Sharma, Charyguly Annageldiyev, Randy M. Rossi, Diwakar B. Tukaramrao, Deborpita Sarkar, Shailaja Hegde, Ujjawal H. Gandhi, Emily R. Finch, Laura Goodfield, Michael D. Quickel, David F. Claxton, Robert F. Paulson, K. Sandeep Prabhu

Cell Rep. Author manuscript; available in PMC 2023 Aug 16.

Published in final edited form as: Cell Rep. 2023 Jul 25; 42(7): 112794. Published online 2023 Jul 18. doi: 10.1016/j.celrep.2023.112794

PMCID:: PMC10428076

Abstract Article PDF–4.0M

Select item 88918154.

Role of prostaglandin D₂ receptors in the pathogenesis of abdominal aortic aneurysm formation

Neal L. Weintraub, Andra L. Blomkalns, Mourad Ogbi, Tetsuo Horimatsu, Tyler W. Benson, Yuqing Huo, David J. Fulton, Gautam Agarwal, Richard Lee, Michael A. Winkler, Lufei Young, Ken Fujise, Avirup Guha, Tohru Fukai, Masuko Ushio-Fukai, Xiaochun Long, Brian H. Annex, Ha Won Kim

Clin Sci (Lond) 2022 Mar; 136(5): 309–321. Published online 2022 Mar 2. doi: 10.1042/CS20220031

PMCID:: PMC8891815

Abstract Article PDF–3.3M

Select item 83652665.

ER‐anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6

Shengkai Zuo, Bei Wang, Jiao Liu, Deping Kong, Hui Cui, Yaonan Jia, Chenyao Wang, Xin Xu, Guilin Chen, Yuanyang Wang, Linlin Yang, Kai Zhang, Ding Ai, Jie Du, Yujun Shen, Ying Yu

EMBO J. 2021 Aug 16; 40(16): e107403. Published online 2021 Jul 5. doi: 10.15252/embj.2020107403

PMCID:: PMC8365266

Abstract Article PDF–5.6M

Select item 83636046.

In situ imaging reveals disparity between prostaglandin localization and abundance of prostaglandin synthases

Kyle D. Duncan, Xiaofei Sun, Erin S. Baker, Sudhansu K. Dey, Ingela Lanekoff

Commun Biol. 2021; 4: 966. Published online 2021 Aug 13. doi: 10.1038/s42003-021-02488-1

Correction in:: Commun Biol. 2021; 4: 1010.

PMCID:: PMC8363604

Abstract Article PDF–1.9M

Select item 82949497.

PGD₂ and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection

Oyebola O. Oyesola, Michael T. Shanahan, Matt Kanke, Bridget M. Mooney, Lauren M. Webb, Shuchi Smita, Macy K. Matheson, Pamela Campioli, Duc Pham, Simon P. Früh, John W. McGinty, Madeline J. Churchill, Jordan L. Cahoon, Pavithra Sundaravaradan, Becca A. Flitter, Karthik Mouli, Marija S. Nadjsombati, Elena Kamynina, Seth A. Peng, Rebecca L. Cubitt, Karsten Gronert, James D. Lord, Isabella Rauch, Jakob von Moltke, Praveen Sethupathy, Elia D. Tait Wojno

J Exp Med. 2021 Sep 6; 218(9): e20202178. Published online 2021 Jul 20. doi: 10.1084/jem.20202178

PMCID:: PMC8294949

Abstract Article PDF–6.6M

Select item 69948428.

The Prostaglandin D₂ Receptor CRTH2 Promotes IL-33–Induced ILC2 Accumulation in the Lung

Oyebola O. Oyesola, Carolina Duque, Linda C. Huang, Elisabeth M. Larson, Simon P. Früh, Lauren M. Webb, Seth A. Peng, Elia D. Tait Wojno

J Immunol. 2020 Feb 15; 204(4): 1001–1011. Published online 2020 Jan 3. doi: 10.4049/jimmunol.1900745

PMCID:: PMC6994842

Abstract Article PDF–3.2M

Select item 69888539.

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium

Bastihalli T. Diwakar, Ryan Yoast, Shaneice Nettleford, Fenghua Qian, Tai-Jung Lee, Svanjita Berry, Ian Huffnagle, Randall M. Rossi, Mohamed Trebak, Robert F. Paulson, K. Sandeep Prabhu

FASEB J. 2019 Nov; 33(11): 12838–12852. Published online 2019 Nov. doi: 10.1096/fj.201802608R

PMCID:: PMC6988853

Abstract Article

Select item 680275010.

Central CRTH2, a Second Prostaglandin D₂ Receptor, Mediates Emotional Impairment in the Lipopolysaccharide and Tumor-Induced Sickness Behavior Model

Ryota Haba, Norihito Shintani, Yusuke Onaka, Takuya Kanoh, Hyper Wang, Risa Takenaga, Atsuko Hayata, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Atsushi Kasai, Ryota Hashimoto, Kazuki Nagayasu, Takanobu Nakazawa, Hitoshi Hashimoto, Akemichi Baba

J Neurosci. 2014 Feb 12; 34(7): 2514–2523. doi: 10.1523/JNEUROSCI.1407-13.2014

PMCID:: PMC6802750

Abstract Article PDF–2.2M

Select item 663913511.

Thermoregulation via Temperature-dependent PGD₂ Production in Mouse Preoptic Area

Tongfei A. Wang, Chin Fen Teo, Malin Åkerblom, Chao Chen, Marena Tynan-La Fontaine, Vanille Juliette Greiner, Aaron Diaz, Michael T. McManus, Yuh Nung Jan, Lily Y. Jan

Neuron. Author manuscript; available in PMC 2020 Jul 17.

Published in final edited form as: Neuron. 2019 Jul 17; 103(2): 309–322.e7. Published online 2019 May 28. doi: 10.1016/j.neuron.2019.04.035

PMCID:: PMC6639135

Abstract Article PDF–3.1M

Select item 608090112.

Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice

Guilin Chen, Shengkai Zuo, Juan Tang, Caojian Zuo, Daile Jia, Qian Liu, Guizhu Liu, Qian Zhu, Yuanyang Wang, Jian Zhang, Yujun Shen, Dongrui Chen, Ping Yuan, Zhiqiang Qin, Chengchao Ruan, Jue Ye, Xiao-Jian Wang, Yuping Zhou, Pingjin Gao, Peng Zhang, Jinming Liu, Zhi-Cheng Jing, Ankang Lu, Ying Yu

J Exp Med. 2018 Aug 6; 215(8): 2175–2195. doi: 10.1084/jem.20171767

PMCID:: PMC6080901

Abstract Article PDF–4.5M

Select item 584054913.

CRTH2 promotes endoplasmic reticulum stress‐induced cardiomyocyte apoptosis through m‐calpain

Shengkai Zuo, Deping Kong, Chenyao Wang, Jiao Liu, Yuanyang Wang, Qiangyou Wan, Shuai Yan, Jian Zhang, Juan Tang, Qianqian Zhang, Luheng Lyu, Xin Li, Zhixin Shan, Li Qian, Yujun Shen, Ying Yu

EMBO Mol Med. 2018 Mar; 10(3): e8237. Published online 2018 Jan 15. doi: 10.15252/emmm.201708237

PMCID:: PMC5840549

Abstract Article PDF–3.9M

Select item 541279214.

Niacin ameliorates ulcerative colitis via prostaglandin D₂‐mediated D prostanoid receptor 1 activation

Juanjuan Li, Deping Kong, Qi Wang, Wei Wu, Yanping Tang, Tingting Bai, Liang Guo, Lumin Wei, Qianqian Zhang, Yu Yu, Yuting Qian, Shengkai Zuo, Guizhu Liu, Qian Liu, Sheng Wu, Yi Zang, Qian Zhu, Daile Jia, Yuanyang Wang, Weiyan Yao, Yong Ji, Huiyong Yin, Masataka Nakamura, Michael Lazarus, Richard M Breyer, Lifu Wang, Ying Yu

EMBO Mol Med. 2017 May; 9(5): 571–588. Published online 2017 Mar 27. doi: 10.15252/emmm.201606987

Correction in:: EMBO Mol Med. 2020 Dec 7; 12(12): e13487.

PMCID:: PMC5412792

Abstract Article PDF–2.4M

Select item 495460615.

Activated prostaglandin D₂ receptors on macrophages enhance neutrophil recruitment into the lung

Katharina Jandl, Elvira Stacher, Zoltán Bálint, Eva Maria Sturm, Jovana Maric, Miriam Peinhaupt, Petra Luschnig, Ida Aringer, Alexander Fauland, Viktoria Konya, Sven-Erik Dahlen, Craig E. Wheelock, Dagmar Kratky, Andrea Olschewski, Gunther Marsche, Rufina Schuligoi, Akos Heinemann

J Allergy Clin Immunol. Author manuscript; available in PMC 2016 Jul 20.

Published in final edited form as: J Allergy Clin Immunol. 2016 Mar; 137(3): 833–843. Published online 2016 Jan 12. doi: 10.1016/j.jaci.2015.11.012

PMCID:: PMC4954606

Abstract Article PDF–2.4M

Select item 489235416.

Eosinophils contribute to intestinal inflammation via chemoattractant receptor-homologous molecule expressed on Th2 cells, CRTH2, in experimental Crohn’s disease

Balázs Radnai, Eva M Sturm, Angela Stančić, Katharina Jandl, Sandra Labocha, Nerea Ferreirós, Magdalena Grill, Carina Hasenoehrl, Gregor Gorkiewicz, Gunther Marsche, Ákos Heinemann, Christoph Högenauer, Rudolf Schicho

J Crohns Colitis. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: J Crohns Colitis. 2016 Sep; 10(9): 1087–1095. Published online 2016 Feb 29. doi: 10.1093/ecco-jcc/jjw061

PMCID:: PMC4892354

Abstract Article PDF–1.7M

Select item 459824617.

The prostaglandin D₂ receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung

ED Tait Wojno, LA Monticelli, SV Tran, T Alenghat, LC Osborne, JJ Thome, C Willis, A Budelsky, DL Farber, D Artis

Mucosal Immunol. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Mucosal Immunol. 2015 Nov; 8(6): 1313–1323. Published online 2015 Apr 8. doi: 10.1038/mi.2015.21

PMCID:: PMC4598246

Abstract Article PDF–2.0M

Select item 406530718.

Mast cell maturation is driven via a group III phospholipase A₂-prostaglandin D₂–DP1 receptor paracrine axis

Yoshitaka Taketomi, Noriko Ueno, Takumi Kojima, Hiroyasu Sato, Remi Murase, Kei Yamamoto, Satoshi Tanaka, Mariko Sakanaka, Masanori Nakamura, Yasumasa Nishito, Momoko Kawana, Naotomo Kambe, Kazutaka Ikeda, Ryo Taguchi, Satoshi Nakamizo, Kenji Kabashima, Michael H. Gelb, Makoto Arita, Takehiko Yokomizo, Motonao Nakamura, Kikuko Watanabe, Hiroyuki Hirai, Masataka Nakamura, Yoshimichi Okayama, Chisei Ra, Kosuke Aritake, Yoshihiro Urade, Kazushi Morimoto, Yukihiko Sugimoto, Takao Shimizu, Shuh Narumiya, Shuntaro Hara, Makoto Murakami

Nat Immunol. Author manuscript; available in PMC 2014 Jun 21.

Published in final edited form as: Nat Immunol. 2013 Jun; 14(6): 554–563. Published online 2013 Apr 28. doi: 10.1038/ni.2586

PMCID:: PMC4065307

Abstract Article PDF–1.0M

Select item 370118219.

The CRTH2 agonist Pyl A prevents lipopolysaccharide-induced fetal death but induces preterm labour

Lynne Sykes, Bronwen R Herbert, David A MacIntyre, Emma Hunte, Sathana Ponnampalam, Mark R Johnson, Tiong G Teoh, Phillip R Bennett

Immunology. 2013 Jul; 139(3): 352–365. Published online 2013 Jun 13. doi: 10.1111/imm.12085

PMCID:: PMC3701182

Abstract Article PDF–664K

Select item 359376120.

Prostaglandin D₂ inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44

Amanda M. Nelson, Dorothy E. Loy, John A. Lawson, Adiya S. Katseff, Garret A. FitzGerald, Luis A. Garza

J Invest Dermatol. Author manuscript; available in PMC 2013 Oct 1.

Published in final edited form as: J Invest Dermatol. 2013 Apr; 133(4): 881–889. Published online 2012 Nov 29. doi: 10.1038/jid.2012.398

PMCID:: PMC3593761

Abstract Article PDF–1.2M

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