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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 103627972.

Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1β-evoked signaling in vascular smooth muscle cells and vascular inflammation

Lisheng Zhang, Jiao-Hui Wu, Pierre-Yves Jean-Charles, Pavitra Murali, Wenli Zhang, Aeva Jazic, Suneet Kaur, Igor Nepliouev, Jonathan A. Stiber, Kamie Snow, Neil J. Freedman, Sudha K. Shenoy

J Biol Chem. 2023 Jul; 299(7): 104911. Published online 2023 Jun 11. doi: 10.1016/j.jbc.2023.104911

PMCID:: PMC10362797

Abstract Article PDF–4.9M

Select item 99184853.

IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis

Yuanyuan Wang, Shanshan Pei, Zhuhe Liu, Yuewen Ding, Tinglin Qian, Haixia Wen, Ssu-Wei Hsu, Zheyi Zhou, Jun Zhang, Honghao Wang

Cell Death Dis. 2023 Feb; 14(2): 103. Published online 2023 Feb 10. doi: 10.1038/s41419-023-05621-6

PMCID:: PMC9918485

Abstract Article PDF–4.4M

Select item 93105294.

Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants

Thomas Hoyler, Bettina Bannert, Cédric André, Damian Beck, Thomas Boulay, David Buffet, Nadja Caesar, Thomas Calzascia, Janet Dawson, Diego Kyburz, Robert Hennze, Christine Huppertz, Amanda Littlewood-Evans, Pius Loetscher, Kirsten D. Mertz, Satoru Niwa, Gautier Robert, James S. Rush, Giulia Ruzzante, Sophie Sarret, Thomas Stein, Ismahane Touil, Grazyna Wieczorek, Geraldine Zipfel, Stuart Hawtin, Tobias Junt

JCI Insight. 2022 Jul 8; 7(13): e149825. Published online 2022 Jul 8. doi: 10.1172/jci.insight.149825

PMCID:: PMC9310529

Abstract Article PDF–1.5M

Select item 90156995.

The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery

Kiren Baines, Kazuaki Yoshioka, Yoh Takuwa, Jon D. Lane

Autophagy Rep. 2022; 1(1): 88–118. Published online 2022 Apr 7. doi: 10.1080/27694127.2022.2042054

PMCID:: PMC9015699

Abstract Article PDF–3.3M

Select item 87557816.

Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors

Yosuke Tanaka, Reina Takeda, Tsuyoshi Fukushima, Keiko Mikami, Shun Tsuchiya, Moe Tamura, Keito Adachi, Terumasa Umemoto, Shuhei Asada, Naoki Watanabe, Soji Morishita, Misa Imai, Masayoshi Nagata, Marito Araki, Hitoshi Takizawa, Tomofusa Fukuyama, Chrystelle Lamagna, Esteban S. Masuda, Ryoji Ito, Susumu Goyama, Norio Komatsu, Tomoiku Takaku, Toshio Kitamura

Nat Commun. 2022; 13: 271. Published online 2022 Jan 12. doi: 10.1038/s41467-021-27928-8

PMCID:: PMC8755781

Abstract Article PDF–2.4M

Select item 85533387.

IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay

Kotaro Akaki, Kosuke Ogata, Yuhei Yamauchi, Noriki Iwai, Ka Man Tse, Fabian Hia, Atsushi Mochizuki, Yasushi Ishihama, Takashi Mino, Osamu Takeuchi

eLife. 2021; 10: e71966. Published online 2021 Oct 12. doi: 10.7554/eLife.71966

PMCID:: PMC8553338

Abstract Article PDF–1.8M

Select item 84759508.

UNC93B1 Is Widely Expressed in the Murine CNS and Is Required for Neuroinflammation and Neuronal Injury Induced by MicroRNA let-7b

Markus G. Klammer, Omar Dzaye, Thomas Wallach, Christina Krüger, Dorothea Gaessler, Alice Buonfiglioli, Katja Derkow, Helmut Kettenmann, Melanie M. Brinkmann, Seija Lehnardt

Front Immunol. 2021; 12: 715774. Published online 2021 Sep 13. doi: 10.3389/fimmu.2021.715774

PMCID:: PMC8475950

Abstract Article PDF–5.7M

Select item 83132399.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 810572510.

MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling

Rafael Deliz-Aguirre, Fakun Cao, Fenja H.U. Gerpott, Nichanok Auevechanichkul, Mariam Chupanova, YeVin Mun, Elke Ziska, Marcus J. Taylor

J Cell Biol. 2021 Jul 5; 220(7): e202012071. Published online 2021 May 6. doi: 10.1083/jcb.202012071

PMCID:: PMC8105725

Abstract Article PDF–8.7M

Select item 768211711.

Altered Inflammatory Pathway but Unaffected Liver Fibrosis in Mouse Models of Nonalcoholic Steatohepatitis Involving Interleukin-1 Receptor-Associated Kinase 1 Knockout

Ying Lei, Tianxiao Yang, Aijing Shan, Wei Di, Mengyao Dai, Jingminjie Nan, Dongxue Liu, Yanan Cao, Xiuli Jiang

Med Sci Monit. 2020; 26: e926187-1–e926187-14. Prepublished online 2020 Sep 23. Published online 2020 Nov 18. doi: 10.12659/MSM.926187

PMCID:: PMC7682117

Abstract Article PDF–6.7M

Select item 719587512.

Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins

Sirish K. Ippagunta, Julie A. Pollock, Naina Sharma, Wenwei Lin, Taosheng Chen, Kazuki Tawaratsumida, Anthony A. High, Jaeki Min, Yizhe Chen, R. Kiplin Guy, Vanessa Redecke, John A. Katzenellenbogen, Hans Häcker

Sci Signal. Author manuscript; available in PMC 2020 May 2.

Published in final edited form as: Sci Signal. 2018 Aug 14; 11(543): eaaq1077. Published online 2018 Aug 14. doi: 10.1126/scisignal.aaq1077

PMCID:: PMC7195875

Abstract Article PDF–1.7M

Select item 705466813.

RNF152 positively regulates TLR/IL‐1R signaling by enhancing MyD88 oligomerization

Mei‐Guang Xiong, Zhi‐Sheng Xu, Yu‐Hui Li, Su‐Yun Wang, Yan‐Yi Wang, Yong Ran

EMBO Rep. 2020 Mar 4; 21(3): e48860. Published online 2020 Jan 13. doi: 10.15252/embr.201948860

PMCID:: PMC7054668

Abstract Article PDF–1.2M

Select item 693520014.

BAP31 regulates IRAK1-dependent neuroinflammation in microglia

Xia Liu, Kun Jiao, Cong-cong Jia, Guo-xun Li, Qing Yuan, Ji-kai Xu, Yue Hou, Bing Wang

J Neuroinflammation. 2019; 16: 281. Published online 2019 Dec 28. doi: 10.1186/s12974-019-1661-7

PMCID:: PMC6935200

Abstract Article PDF–7.6M

Select item 645951015.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 612541816.

Globular Adiponectin Exerts a Pro-Inflammatory Effect via IκB/NF-κB Pathway Activation and Anti-Inflammatory Effect by IRAK-1 Downregulation

Kyoung-Hee Lee, Jiyeong Jeong, Jisu Woo, Chang-Hoon Lee, Chul-Gyu Yoo

Mol Cells. 2018 Aug 31; 41(8): 762–770. Published online 2018 Jul 30. doi: 10.14348/molcells.2018.0005

PMCID:: PMC6125418

Abstract Article PDF–830K

Select item 606948517.

Endotoxin Tolerant Dendritic Cells Suppress Inflammatory Responses in Splenocytes via Interleukin-1 Receptor Associated Kinase (IRAK)-M and Programmed Death-Ligand 1 (PDL-1)

Yuping Zhou, Qin Xia, Xi Wang, Shukun Fu

Med Sci Monit. 2018; 24: 4798–4806. Published online 2018 Jul 11. doi: 10.12659/MSM.908242

PMCID:: PMC6069485

Abstract Article PDF–780K

Select item 603306918.

Anti-inflammatory effects of a novel compound, MPQP, through the inhibition of IRAK1 signaling pathways in LPS-stimulated RAW 264.7 macrophages

Ba Reum Kim, Young-Chang Cho, Sayeon Cho

BMB Rep. 2018 Jun; 51(6): 308–313. Published online 2018 Jun 30. doi: 10.5483/BMBRep.2018.51.6.064

PMCID:: PMC6033069

Abstract Article PDF–1.7M

Select item 580335719.

miR-146a regulates inflammatory cytokine production in Porphyromonas gingivalis lipopolysaccharide-stimulated B cells by targeting IRAK1 but not TRAF6

Shaoyun Jiang, Yang Hu, Shu Deng, Jiayin Deng, Xinbo Yu, Grace Huang, Toshihisa Kawai, Xiaozhe Han

Biochim Biophys Acta. Author manuscript; available in PMC 2019 Mar 1.

Published in final edited form as: Biochim Biophys Acta. 2018 Mar; 1864(3): 925–933. Published online 2017 Dec 27. doi: 10.1016/j.bbadis.2017.12.035

PMCID:: PMC5803357

Abstract Article PDF–1.2M

Select item 567281720.

Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages

Fansheng Kong, Zhiwei Liu, Viral G. Jain, Kenjiro Shima, Takuji Suzuki, Louis J. Muglia, Daniel T. Starczynowski, Chandrashekhar Pasare, Sandip Bhattacharyya

J Immunol. 2017 Nov 15; 199(10): 3654–3667. Published online 2017 Oct 16. doi: 10.4049/jimmunol.1700443

PMCID:: PMC5672817

Abstract Article PDF–1.9M

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