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Items: 1 to 20 of 187

1.
5′-tRNAGly(GCC) halves generated by IRE1α are linked to the ER stress response
Hanyong Jin, Ji-Hyun Yeom, Eunkyoung Shin, Yoonjie Ha, Haifeng Liu, Daeyoung Kim, Minju Joo, Yong-Hak Kim, Hak Kyun Kim, Minkyung Ryu, Hong-Man Kim, Jeongkyu Kim, Keun P. Kim, Yoonsoo Hahn, Jeehyeon Bae, Kangseok Lee
Nat Commun. 2024; 15: 9273. Published online 2024 Oct 28. doi: 10.1038/s41467-024-53624-4
PMCID:
PMC11519470
AbstractArticlePDF–2.3M
2.
Disordered regions in the IRE1α ER lumenal domain mediate its stress-induced clustering
Paulina Kettel, Laura Marosits, Elena Spinetti, Michael Rechberger, Caterina Giannini, Philipp Radler, Isabell Niedermoser, Irmgard Fischer, Gijs A Versteeg, Martin Loose, Roberto Covino, G Elif Karagöz
EMBO J. 2024 Oct; 43(20): 4668–4698. Published online 2024 Sep 4. doi: 10.1038/s44318-024-00207-0
PMCID:
PMC11480506
AbstractArticlePDF–9.7M
3.
IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis
Dadi Jiang, Youming Guo, Tianyu Wang, Liang Wang, Yuelong Yan, Ling Xia, Rakesh Bam, Zhifen Yang, Hyemin Lee, Takao Iwawaki, Boyi Gan, Albert C. Koong
Nat Commun. 2024; 15: 4114. Published online 2024 May 15. doi: 10.1038/s41467-024-48330-0
PMCID:
PMC11096184
AbstractArticlePDF–3.7M
4.
TurboID-Based IRE1 Interactome Reveals Participants of the Endoplasmic Reticulum-Associated Protein Degradation Machinery in the Human Mast Cell Leukemia Cell Line HMC-1.2
Nabil Ahmed, Christian Preisinger, Thomas Wilhelm, Michael Huber
Cells. 2024 May; 13(9): 747. Published online 2024 Apr 25. doi: 10.3390/cells13090747
PMCID:
PMC11082977
AbstractArticlePDF–3.0M
5.
IRE1α recognizes a structural motif in cholera toxin to activate an unfolded protein response
Mariska S. Simpson, Heidi De Luca, Sarah Cauthorn, Phi Luong, Namrata D. Udeshi, Tanya Svinkina, Stefanie S. Schmieder, Steven A. Carr, Michael J. Grey, Wayne I. Lencer
J Cell Biol. 2024 Jul 1; 223(7): e202402062. Published online 2024 Apr 5. doi: 10.1083/jcb.202402062
PMCID:
PMC10996581
AbstractArticlePDF–4.3M
6.
ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication
Guy J. Pearson, Harriet V. Mears, Malgorzata Broncel, Ambrosius P. Snijders, David L. V. Bauer, Jeremy G. Carlton
Sci Adv. 2024 Apr 5; 10(14): eadl5012. Published online 2024 Apr 3. doi: 10.1126/sciadv.adl5012
PMCID:
PMC10990277
AbstractArticlePDF–3.9M
7.
Development of a Rapid in vivo Assay to Evaluate the Efficacy of IRE1-specific Inhibitors of the Unfolded Protein Response Using Medaka Fish
Byungseok Jin, Tokiro Ishikawa, Mai Taniguchi, Satoshi Ninagawa, Tetsuya Okada, Shigehide Kagaya, Kazutoshi Mori
Cell Struct Funct. 2020; 45(1): 23–31. Published online 2019 Dec 26. doi: 10.1247/csf.19032
PMCID:
PMC10749220
AbstractArticlePDF–821K
8.
Valosin-Containing Protein (VCP/p97) is Prognostically Unfavorable in Pediatric AML, and Negatively Correlates with Unfolded Protein Response Proteins IRE1 and GRP78: a Report from the Children’s Oncology Group
Fieke W. Hoff, Yihua Qiu, Brandon D. Brown, Robert B. Gerbing, Amanda R. Leonti, Rhonda E. Ries, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Gaye N Jenkins, Terzah Horton, Steven M. Kornblau
Proteomics Clin Appl. Author manuscript; available in PMC 2024 Nov 1.
Published in final edited form as: Proteomics Clin Appl. 2023 Nov; 17(6): e2200109. Published online 2023 Jun 7. doi: 10.1002/prca.202200109
PMCID:
PMC10700663
AbstractArticlePDF–893K
9.
IRE1-mediated degradation of pre-miR-301a promotes apoptosis through upregulation of GADD45A
Magdalena Gebert, Sylwia Bartoszewska, Lukasz Opalinski, James F. Collawn, Rafał Bartoszewski
Cell Commun Signal. 2023; 21: 322. Published online 2023 Nov 9. doi: 10.1186/s12964-023-01349-0
PMCID:
PMC10634081
AbstractArticlePDF–8.1M
10.
Beyond UPR: Cell-specific Roles of ER Stress Sensor IRE1α in Kidney Ischemic Injury and Transplant Rejection
Longhui Qiu, Xin Zheng, Dinesh Jaishankar, Richard Green, Deyu Fang, Satish Nadig, Zheng Jenny Zhang
Kidney Int. Author manuscript; available in PMC 2024 Sep 1.
Published in final edited form as: Kidney Int. 2023 Sep; 104(3): 463–469. Published online 2023 Jun 28. doi: 10.1016/j.kint.2023.06.016
PMCID:
PMC10519186
AbstractArticlePDF–694K
11.
Novel XBP1s-independent function of IRE1 RNase in HIF-1α-mediated glycolysis upregulation in human macrophages upon stimulation with LPS or saturated fatty acid
Margaud Iovino, Megan Colonval, Chloé Wilkin, Laurent L’homme, Cédric Lassence, Manon Campas, Olivier Peulen, Pascal de Tullio, Jacques Piette, Sylvie Legrand-Poels
Front Immunol. 2023; 14: 1204126. Published online 2023 Aug 30. doi: 10.3389/fimmu.2023.1204126
PMCID:
PMC10498766
AbstractArticlePDF–3.8M
12.
The unfolded protein response components IRE1α and XBP1 promote human coronavirus infection
Jessica M. Oda, Andreas B. den Hartigh, Shoen M. Jackson, Ana R. Tronco, Susan L. Fink
mBio. 2023 Jul-Aug; 14(4): e00540-23. Published online 2023 Jun 12. doi: 10.1128/mbio.00540-23
PMCID:
PMC10470493
AbstractArticlePDF–832K
13.
IRE1a-Induced FilaminA Phosphorylation Enhances Migration of Mesenchymal Stem Cells Derived from Multiple Myeloma Patients
Francesco Da Ros, Kinga Kowal, Carla Vicinanza, Elisabetta Lombardi, Francesco Agostini, Rosanna Ciancia, Maurizio Rupolo, Cristina Durante, Mariagrazia Michieli, Mario Mazzucato
Cells. 2023 Aug; 12(15): 1935. Published online 2023 Jul 26. doi: 10.3390/cells12151935
PMCID:
PMC10417526
AbstractArticlePDF–1.9M
14.
Deubiquitylase OTUD3 Mediates Endoplasmic Reticulum Stress through Regulating Fortilin Stability to Restrain Dopaminergic Neurons Apoptosis
Ling Chen, Xuejie Huan, Fengju Jia, Zhen Zhang, Mingxia Bi, Lin Fu, Xixun Du, Xi Chen, Chunling Yan, Qian Jiao, Hong Jiang
Antioxidants (Basel) 2023 Apr; 12(4): 809. Published online 2023 Mar 26. doi: 10.3390/antiox12040809
PMCID:
PMC10135230
AbstractArticlePDF–3.4M
15.
Loss of ATF6α in a human carcinoma cell line is compensated not by its paralogue ATF6β but by sustained activation of the IRE1 and PERK arms for tumor growth in nude mice
Shengyu Jin, Byungseok Jin, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Sho Koyasu, Hiroshi Harada, Kazutoshi Mori
Mol Biol Cell. 2023 Mar 1; 34(3): ar20. Published online 2023 Feb 21. doi: 10.1091/mbc.E22-07-0292
PMCID:
PMC10011727
AbstractArticlePDF–11M
16.
Enhanced IRE1α Phosphorylation/Oligomerization-Triggered XBP1 Splicing Contributes to Parkin-Mediated Prevention of SH-SY5Y Cell Death under Nitrosative Stress
Tsung-Lang Chiu, Hsin-Yi Huang, Hui-Fen Chang, Hsin-Rong Wu, Mei-Jen Wang
Int J Mol Sci. 2023 Feb; 24(3): 2017. Published online 2023 Jan 19. doi: 10.3390/ijms24032017
PMCID:
PMC9917145
AbstractArticlePDF–2.7M
17.
Ebola Virus Activates IRE1α-Dependent XBP1u Splicing
Cornelius Rohde, Sebastian Pfeiffer, Sara Baumgart, Stephan Becker, Verena Krähling
Viruses. 2023 Jan; 15(1): 122. Published online 2022 Dec 30. doi: 10.3390/v15010122
PMCID:
PMC9863596
AbstractArticlePDF–2.9M
18.
Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer
Michael J. P. Crowley, Bhavneet Bhinder, Geoffrey J. Markowitz, Mitchell Martin, Akanksha Verma, Tito A. Sandoval, Chang-Suk Chae, Shira Yomtoubian, Yang Hu, Sahil Chopra, Diamile A. Tavarez, Paolo Giovanelli, Dingcheng Gao, Timothy E. McGraw, Nasser K. Altorki, Olivier Elemento, Juan R. Cubillos-Ruiz, Vivek Mittal
Nat Commun. 2023; 14: 120. Published online 2023 Jan 9. doi: 10.1038/s41467-022-35584-9
PMCID:
PMC9829901
AbstractArticlePDF–2.8M
19.
Regulation of Blos1 by IRE1 prevents the accumulation of Huntingtin protein aggregates
Donghwi Bae, Rachel Elizabeth Jones, Katherine M. Piscopo, Mitali Tyagi, Jason D. Shepherd, Julie Hollien
Mol Biol Cell. 2022 Nov 1; 33(13): ar125. Published online 2022 Nov 1. doi: 10.1091/mbc.E22-07-0281
PMCID:
PMC9634971
AbstractArticlePDF–5.3M
20.
SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells
Long C. Nguyen, David M. Renner, Diane Silva, Dongbo Yang, Nicholas A. Parenti, Kaeri M. Medina, Vlad Nicolaescu, Haley Gula, Nir Drayman, Andrea Valdespino, Adil Mohamed, Christopher Dann, Kristin Wannemo, Lydia Robinson-Mailman, Alan Gonzalez, Letícia Stock, Mengrui Cao, Zeyu Qiao, Raymond E. Moellering, Savas Tay, Glenn Randall, Michael F. Beers, Marsha Rich Rosner, Scott A. Oakes, Susan R. Weiss
mBio. 2022 Sep-Oct; 13(5): e02415-22. Published online 2022 Sep 20. doi: 10.1128/mbio.02415-22
PMCID:
PMC9600248
AbstractArticlePDF–3.8M

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