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Items: 1 to 20 of 258

1.
MAVS signaling shapes microglia responses to neurotropic virus infection
Olivia Luise Gern, Andreas Pavlou, Felix Mulenge, Lena Mareike Busker, Luca Ghita, Angela Aringo, Bibiana Costa, Julia Spanier, Inken Waltl, Martin Stangel, Ulrich Kalinke
J Neuroinflammation. 2024; 21: 264. Published online 2024 Oct 18. doi: 10.1186/s12974-024-03258-6
PMCID:
PMC11490141
ArticlePDF–7.1M
2.
The Immunostimulatory RNA RN7SL1 Enables CAR-T Cells to Enhance Autonomous and Endogenous Immune Function
Lexus R. Johnson, Daniel Y. Lee, Jacqueline S. Eacret, Darwin Ye, Carl H. June, Andy J. Minn
Cell. Author manuscript; available in PMC 2024 Aug 21.
Published in final edited form as: Cell. 2021 Sep 16; 184(19): 4981–4995.e14. Published online 2021 Aug 30. doi: 10.1016/j.cell.2021.08.004
PMCID:
PMC11338632
ArticlePDF–3.5M
3.
Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua
Yael Alippe, Leran Wang, Reyan Coskun, Stéfanie P. Muraro, Fang R. Zhao, Michelle Elam-Noll, J. Michael White, Daiana M. Vota, Vanesa C. Hauk, Jeffrey I. Gordon, Scott A. Handley, Michael S. Diamond
J Exp Med. 2024 Sep 2; 221(9): e20240694. Published online 2024 Jul 23. doi: 10.1084/jem.20240694
PMCID:
PMC11270594
ArticlePDF–13M
4.
Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity
Xing Liu, Chunchun Zhu, Shuke Jia, Hongyan Deng, Jinhua Tang, Xueyi Sun, Xiaoli Zeng, Xiaoyun Chen, Zixuan Wang, Wen Liu, Qian Liao, Huangyuan Zha, Xiaolian Cai, Wuhan Xiao
Proc Natl Acad Sci U S A. 2024 Apr 23; 121(17): e2314201121. Published online 2024 Apr 18. doi: 10.1073/pnas.2314201121
PMCID:
PMC11047105
ArticlePDF–7.7M
5.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
ArticlePDF–4.8M
6.
Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity
Domnica Luca, Sumin Lee, Keiji Hirota, Yasutaka Okabe, Junji Uehori, Kazushi Izawa, Anna-Lisa Lanz, Verena Schütte, Burcu Sivri, Yuta Tsukamoto, Fabian Hauck, Rayk Behrendt, Axel Roers, Takashi Fujita, Ryuta Nishikomori, Min Ae Lee-Kirsch, Hiroki Kato
Sci Adv. 2024 Mar 1; 10(9): eadk0820. Published online 2024 Mar 1. doi: 10.1126/sciadv.adk0820
PMCID:
PMC10906915
ArticlePDF–4.5M
7.
3β-hydroxysteroid-Δ24 reductase dampens anti-viral innate immune responses by targeting K27 ubiquitination of MAVS and STING
Qian Liu, Shengwen Chen, Renyun Tian, Binbin Xue, Huiyi Li, Mengmeng Guo, Shun Liu, Ming Yan, Ruina You, Luoling Wang, Di Yang, Mengyu Wan, Haizhen Zhu
J Virol. 2023 Dec; 97(12): e01513-23. Published online 2023 Nov 30. doi: 10.1128/jvi.01513-23
PMCID:
PMC10734464
ArticlePDF–4.9M
8.
MAVS Positively Regulates Mitochondrial Integrity and Metabolic Fitness in B Cells
Hongsheng Wang, Wenxiang Sun, Javier Traba, Juan Wu, Chen-Feng Qi, Laura Amo, Hemanta K. Kole, Bethany Scott, Komudi Singh, Michael N. Sack, Silvia Bolland
Immunohorizons. 2023 Aug 1; 7(8): 587–599. Published online 2023 Aug 23. doi: 10.4049/immunohorizons.2300038
PMCID:
PMC10587501
ArticlePDF–2.3M
9.
MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade
Feng Liu, Wanxin Zhuang, Bin Song, Yuan Yang, Junqi Liu, Yi Zheng, Bingyu Liu, Jie Zheng, Wei Zhao, Chengjiang Gao
Cell Mol Immunol. 2023 Oct; 20(10): 1186–1202. Published online 2023 Aug 15. doi: 10.1038/s41423-023-01065-2
PMCID:
PMC10542333
ArticlePDF–6.3M
10.
IFN-λ derived from nonsusceptible enterocytes acts on tuft cells to limit persistent norovirus
Harshad Ingle, Heyde Makimaa, Somya Aggarwal, Hongju Deng, Lynne Foster, Yuhao Li, Elizabeth A. Kennedy, Stefan T. Peterson, Craig B. Wilen, Sanghyun Lee, Mehul S. Suthar, Megan T. Baldridge
Sci Adv. 2023 Sep; 9(37): eadi2562. Published online 2023 Sep 13. doi: 10.1126/sciadv.adi2562
PMCID:
PMC10499323
ArticlePDF–1.4M
11.
MAVS integrates glucose metabolism and RIG-I-like receptor signaling
Qiao-qiao He, Yu Huang, Longyu Nie, Sheng Ren, Gang Xu, Feiyan Deng, Zhikui Cheng, Qi Zuo, Lin Zhang, Huanhuan Cai, Qiming Wang, Fubing Wang, Hong Ren, Huan Yan, Ke Xu, Li Zhou, Mengji Lu, Zhibing Lu, Ying Zhu, Shi Liu
Nat Commun. 2023; 14: 5343. Published online 2023 Sep 2. doi: 10.1038/s41467-023-41028-9
PMCID:
PMC10475032
ArticlePDF–4.7M
12.
WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response
Jiaxin Li, Rui Zhang, Changwan Wang, Junyan Zhu, Miao Ren, Yingbo Jiang, Xianteng Hou, Yangting Du, Qing Wu, Shishi Qi, Lin Li, She Chen, Hui Yang, Fajian Hou
Nat Commun. 2023; 14: 4824. Published online 2023 Aug 10. doi: 10.1038/s41467-023-40567-5
Correction in:
Nat Commun. 2023; 14: 5960.
PMCID:
PMC10415273
ArticlePDF–3.6M
13.
MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation
Maria G. Noval, Sophie N. Spector, Eric Bartnicki, Franco Izzo, Navneet Narula, Stephen T. Yeung, Payal Damani-Yokota, M. Zahidunnabi Dewan, Valeria Mezzano, Bruno A. Rodriguez-Rodriguez, Cynthia Loomis, Kamal M. Khanna, Kenneth A. Stapleford
Nat Commun. 2023; 14: 4668. Published online 2023 Aug 3. doi: 10.1038/s41467-023-40047-w
PMCID:
PMC10400619
ArticlePDF–5.1M
14.
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
Yuanjiu Lei, Jordyn J. VanPortfliet, Yi-Fan Chen, Joshua D. Bryant, Ying Li, Danielle Fails, Sylvia Torres-Odio, Katherine B. Ragan, Jingti Deng, Armaan Mohan, Bing Wang, Olivia N. Brahms, Shawn D. Yates, Michael Spencer, Carl W. Tong, Marcus W. Bosenberg, Laura Ciaccia West, Gerald S. Shadel, Timothy E. Shutt, Jason W. Upton, Pingwei Li, A. Phillip West
Cell. Author manuscript; available in PMC 2024 Jul 6.
Published in final edited form as: Cell. 2023 Jul 6; 186(14): 3013–3032.e22. Published online 2023 Jun 22. doi: 10.1016/j.cell.2023.05.039
PMCID:
PMC10330843
ArticlePDF–4.7M
15.
Borrelia burgdorferi engages mammalian type I interferon responses via the cGAS-STING pathway
Lauren C. Farris, Sylvia Torres-Odio, L. Garry Adams, A. Phillip West, Jenny A. Hyde
J Immunol. Author manuscript; available in PMC 2024 Jun 1.
Published in final edited form as: J Immunol. 2023 Jun 1; 210(11): 1761–1770. doi: 10.4049/jimmunol.2200354
PMCID:
PMC10192154
ArticlePDF–982K
16.
USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities
Chao Liu, Lingang Sun, Yijun Tan, Qi Wang, Tao Luo, Chenlu Li, Nan Yao, Yuting Xie, Xiao Yi, Yi Zhu, Tiannan Guo, Junfeng Ji
Sci Adv. 2023 May; 9(20): eade3888. Published online 2023 May 17. doi: 10.1126/sciadv.ade3888
PMCID:
PMC10191441
ArticlePDF–2.4M
17.
Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling
Dhwani N. Rupani, Fredrik I. Thege, Vidhi Chandra, Hajar Rajaei, Robert W. Cowan, Sonja M. Wörmann, Olivereen Le Roux, Prerna Malaney, Sara L. Manning, Jack Hashem, Jennifer Bailey-Lundberg, Andrew D. Rhim, Florencia McAllister
Development. 2023 Jan 15; 150(2): dev201097. Published online 2023 Jan 16. doi: 10.1242/dev.201097
PMCID:
PMC10110501
Article
18.
Nucleic DHX9 cooperates with STAT1 to transcribe interferon-stimulated genes
Xingxing Ren, Decai Wang, Guorong Zhang, Tingyue Zhou, Zheng Wei, Yi Yang, Yunjiang Zheng, Xuqiu Lei, Wanyin Tao, Anmin Wang, Mingsong Li, Richard A. Flavell, Shu Zhu
Sci Adv. 2023 Feb; 9(5): eadd5005. Published online 2023 Feb 3. doi: 10.1126/sciadv.add5005
PMCID:
PMC9897671
ArticlePDF–1.8M
19.
Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis
Xu Wang, Chao Yang, Xuejie Wang, Jinmin Miao, Weitao Chen, Yiren Zhou, Ying Xu, Yongyan An, Aifang Cheng, Wenkang Ye, Mengxian Chen, Dong Song, Xue Yuan, Jiguang Wang, Peiyuan Qian, Angela Ruohao Wu, Zhong-Yin Zhang, Kai Liu
Neuron. Author manuscript; available in PMC 2023 Jan 20.
Published in final edited form as: Neuron. 2023 Jan 18; 111(2): 236–255.e7. Published online 2022 Nov 11. doi: 10.1016/j.neuron.2022.10.028
PMCID:
PMC9851977
ArticlePDF–3.6M
20.
Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies
Achraf Shamseddine, Suchit H. Patel, Valery Chavez, Zachary R. Moore, Mutayyaba Adnan, Melody Di Bona, Jun Li, Chau T. Dang, Lakshmi V. Ramanathan, Kevin C. Oeffinger, Jennifer E. Liu, Richard M. Steingart, Alessandra Piersigilli, Nicholas D. Socci, Angel T. Chan, Anthony F. Yu, Samuel F. Bakhoum, Adam M. Schmitt
J Exp Med. 2023 Mar 6; 220(3): e20220809. Published online 2022 Dec 19. doi: 10.1084/jem.20220809
PMCID:
PMC9767651
ArticlePDF–5.4M

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