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Select item 109816221.

circFTO from M2 macrophage-derived small extracellular vesicles (sEV) enhances NSCLC malignancy by regulation miR-148a-3pPDK4 axis

Qingtao Liu, Pei Xu, Mingming Jin, Lei Wang, Fengqing Hu, Qi Yang, Rui Bi, Haibo Xiao, Lianyong Jiang, Fangbao Ding

Cancer Immunol Immunother. 2024 May; 73(5): 91. Published online 2024 Mar 30. doi: 10.1007/s00262-024-03634-4

PMCID:: PMC10981622

Abstract Article PDF–14M

Select item 106195902.

Identification of PDK4 as Hub Gene for Diabetic Nephropathy Using Co-Expression Network Analysis

Yuanyuan Han, Liangzi Jin, Liangzhi Wang, Lan Wei, Chao Tu

Kidney Blood Press Res. 2023 Jan-Dec; 48(1): 522–534. Published online 2023 Jun 29. doi: 10.1159/000531288

PMCID:: PMC10619590

Abstract Article

Select item 105893183.

High glucose promotes benign prostatic hyperplasia by downregulating PDK4 expression

Pengyu Wei, Dongxu Lin, Changcheng Luo, Mengyang Zhang, Bolang Deng, Kai Cui, Zhong Chen

Sci Rep. 2023; 13: 17910. Published online 2023 Oct 20. doi: 10.1038/s41598-023-44954-2

PMCID:: PMC10589318

Abstract Article PDF–4.9M

Select item 102513004.

Glucocorticoid Receptors Drive Breast Cancer Cell Migration and Metabolic Reprogramming via PDK4

Amy R Dwyer, Carlos Perez Kerkvliet, Thu H Truong, Kyla M Hagen, Raisa I Krutilina, Deanna N Parke, Robert H Oakley, Christopher Liddle, John A Cidlowski, Tiffany N Seagroves, Carol A Lange

Endocrinology. 2023 Jul; 164(7): bqad083. Published online 2023 May 24. doi: 10.1210/endocr/bqad083

Correction in:: Endocrinology. 2023 Aug; 164(8): bqad101.

PMCID:: PMC10251300

Abstract Article

Select item 100406205.

The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4

Min-Ji Kim, Ibotombi Singh Sinam, Zerwa Siddique, Jae-Han Jeon, In-Kyu Lee

Diabetes Metab J. 2023 Mar; 47(2): 153–163. Published online 2023 Jan 12. doi: 10.4093/dmj.2022.0305

PMCID:: PMC10040620

Abstract Article PDF–840K

Select item 97455606.

Pyruvate dehydrogenase kinase 4 promotes ubiquitin–proteasome system‐dependent muscle atrophy

Ibotombi Singh Sinam, Dipanjan Chanda, Themis Thoudam, Min‐Ji Kim, Byung‐Gyu Kim, Hyeon‐Ji Kang, Jung Yi Lee, Seung‐Hoon Baek, Shin‐Yoon Kim, Bum Jin Shim, Dongryeol Ryu, Jae‐Han Jeon, In‐Kyu Lee

J Cachexia Sarcopenia Muscle. 2022 Dec; 13(6): 3122–3136. Published online 2022 Oct 19. doi: 10.1002/jcsm.13100

Correction in:: J Cachexia Sarcopenia Muscle. 2023 Jun; 14(3): 1585.

Correction in:: J Cachexia Sarcopenia Muscle. 2023 Oct; 14(5): 2455.

PMCID:: PMC9745560

Abstract Article PDF–2.6M

Select item 84624567.

Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis

Yihong Huang, Shuo Zheng, Ying Lin, Liming Ke

Mol Cell Biol. 2021 Oct; 41(10): e00609-20. Prepublished online 2021 Aug 9. Published online 2021 Sep 24. doi: 10.1128/MCB.00609-20

PMCID:: PMC8462456

Abstract Article PDF–4.4M

Select item 84094068.

Pyruvate dehydrogenase kinase 4‐mediated metabolic reprogramming is involved in rituximab resistance in diffuse large B‐cell lymphoma by affecting the expression of MS4A1/CD20

Duanfeng Jiang, Qiuyu Mo, Xiaoying Sun, Xiaotao Wang, Min Dong, Guozhen Zhang, Fangping Chen, Qiangqiang Zhao

Cancer Sci. 2021 Sep; 112(9): 3585–3597. Published online 2021 Jul 28. doi: 10.1111/cas.15055

PMCID:: PMC8409406

Abstract Article PDF–1.7M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 802487010.

Identification of differentially expressed genes and the role of PDK4 in CD14⁺ monocytes of coronary artery disease

Pei Du, Ren Guo, Keqin Gao, Shuang Yang, Baige Yao, Haobo Cui, Ming Zhao, Sujie Jia

Biosci Rep. 2021 Apr 30; 41(4): BSR20204124. Published online 2021 Apr 6. doi: 10.1042/BSR20204124

PMCID:: PMC8024870

Abstract Article PDF–1.1M

Select item 797455211.

A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells

Poornima Bhat-Nakshatri, Hongyu Gao, Liu Sheng, Patrick C. McGuire, Xiaoling Xuei, Jun Wan, Yunlong Liu, Sandra K. Althouse, Austyn Colter, George Sandusky, Anna Maria Storniolo, Harikrishna Nakshatri

Cell Rep Med. 2021 Mar 16; 2(3): 100219. Published online 2021 Mar 16. doi: 10.1016/j.xcrm.2021.100219

PMCID:: PMC7974552

Abstract Article PDF–6.7M

Select item 742732712.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 737470513.

Ascites-derived ALDH+CD44+ tumour cell subsets endow stemness, metastasis and metabolic switch via PDK4-mediated STAT3/AKT/NF-κB/IL-8 signalling in ovarian cancer

Yu-Xin Jiang, Michelle Kwan-Yee Siu, Jing-Jing Wang, Xue-Tang Mo, Thomas Ho-Yin Leung, David Wai Chan, Annie Nga-Yin Cheung, Hextan Yuen-Sheung Ngan, Karen Kar-Loen Chan

Br J Cancer. 2020 Jul 21; 123(2): 275–287. Published online 2020 May 11. doi: 10.1038/s41416-020-0865-z

PMCID:: PMC7374705

Abstract Article PDF–2.1M

Select item 724454414.

N⁶-methyladenosine regulates glycolysis of cancer cells through PDK4

Zihan Li, Yanxi Peng, Jiexin Li, Zhuojia Chen, Feng Chen, Jian Tu, Shuibin Lin, Hongsheng Wang

Nat Commun. 2020; 11: 2578. Published online 2020 May 22. doi: 10.1038/s41467-020-16306-5

PMCID:: PMC7244544

Abstract Article PDF–2.7M

Select item 717845115.

STAT3‐dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer

Monika Oberhuber, Matteo Pecoraro, Mate Rusz, Georg Oberhuber, Maritta Wieselberg, Peter Haslinger, Elisabeth Gurnhofer, Michaela Schlederer, Tanja Limberger, Sabine Lagger, Jan Pencik, Petra Kodajova, Sandra Högler, Georg Stockmaier, Sandra Grund‐Gröschke, Fritz Aberger, Marco Bolis, Jean‐Philippe Theurillat, Robert Wiebringhaus, Theresa Weiss, Andrea Haitel, Marc Brehme, Wolfgang Wadsak, Johannes Griss, Thomas Mohr, Alexandra Hofer, Anton Jäger, Jürgen Pollheimer, Gerda Egger, Gunda Koellensperger, Matthias Mann, Brigitte Hantusch, Lukas Kenner

Mol Syst Biol. 2020 Apr; 16(4): e9247. Published online 2020 Apr 23. doi: 10.15252/msb.20199247

PMCID:: PMC7178451

Abstract Article PDF–4.4M

Select item 716998316.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x