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Select item 110933531.

Whole genome profiling of short-term hypoxia induced genes and identification of HIF-1 binding sites provide insights into HIF-1 function in Caenorhabditis elegans

Dingxia Feng, Long Qu, Jo Anne Powell-Coffman

PLoS One. 2024; 19(5): e0295094. Published online 2024 May 14. doi: 10.1371/journal.pone.0295094

PMCID:: PMC11093353

Abstract Article PDF–2.3M

Select item 98135782.

One-day thermal regime extends the lifespan in Caenorhabditis elegans

Jichang Huang, Kai Wang, Mengqing Wang, Zhen Wu, Guangjie Xie, Yuling Peng, Yan Zhang, Xumin Zhang, Zhiyong Shao

Comput Struct Biotechnol J. 2023; 21: 495–505. Published online 2022 Dec 15. doi: 10.1016/j.csbj.2022.12.017

PMCID:: PMC9813578

Abstract Article PDF–6.8M

Select item 96915423.

Co-opted genes of algal origin protect C. elegans against cyanogenic toxins

Bingying Wang, Taruna Pandey, Yong Long, Sofia E. Delgado-Rodriguez, Matthew D. Daugherty, Dengke K. Ma

Curr Biol. Author manuscript; available in PMC 2023 Nov 21.

Published in final edited form as: Curr Biol. 2022 Nov 21; 32(22): 4941–4948.e3. Published online 2022 Oct 11. doi: 10.1016/j.cub.2022.09.041

PMCID:: PMC9691542

Abstract Article PDF–1.9M

Select item 96427804.

Cobalt chloride has beneficial effects across species through a hormetic mechanism

Alfonso Schiavi, Alessandra Runci, Teresa Maiorino, Francesco Davide Naso, Marta Barenys, Ellen Fritsche, Flavie Strappazzon, Natascia Ventura

Front Cell Dev Biol. 2022; 10: 986835. Published online 2022 Oct 25. doi: 10.3389/fcell.2022.986835

PMCID:: PMC9642780

Abstract Article PDF–1.7M

Select item 95791515.

The hypoxia response pathway promotes PEP carboxykinase and gluconeogenesis in C. elegans

Mehul Vora, Stephanie M. Pyonteck, Tatiana Popovitchenko, Tarmie L. Matlack, Aparna Prashar, Nanci S. Kane, John Favate, Premal Shah, Christopher Rongo

Nat Commun. 2022; 13: 6168. Published online 2022 Oct 18. doi: 10.1038/s41467-022-33849-x

PMCID:: PMC9579151

Abstract Article PDF–2.9M

Select item 95481816.

Dietary-derived vitamin B12 protects Caenorhabditis elegans from thiol-reducing agents

Alan D. Winter, Elissa Tjahjono, Leonardo J. Beltrán, Iain L. Johnstone, Neil J. Bulleid, Antony P. Page

BMC Biol. 2022; 20: 228. Published online 2022 Oct 8. doi: 10.1186/s12915-022-01415-y

PMCID:: PMC9548181

Abstract Article PDF–2.5M

Select item 94130917.

Galangin Exhibits Neuroprotective Effects in 6-OHDA-Induced Models of Parkinson’s Disease via the Nrf2/Keap1 Pathway

Qiu-Xu Chen, Ling Zhou, Tao Long, Da-Lian Qin, Yi-Ling Wang, Yun Ye, Xiao-Gang Zhou, Jian-Ming Wu, An-Guo Wu

Pharmaceuticals (Basel) 2022 Aug; 15(8): 1014. Published online 2022 Aug 17. doi: 10.3390/ph15081014

PMCID:: PMC9413091

Abstract Article PDF–5.9M

Select item 92492238.

ROS and cGMP signaling modulate persistent escape from hypoxia in Caenorhabditis elegans

Lina Zhao, Lorenz A. Fenk, Lars Nilsson, Niko Paresh Amin-Wetzel, Nelson Javier Ramirez-Suarez, Mario de Bono, Changchun Chen

PLoS Biol. 2022 Jun; 20(6): e3001684. Published online 2022 Jun 21. doi: 10.1371/journal.pbio.3001684

PMCID:: PMC9249223

Abstract Article PDF–3.5M

Select item 92431789.

Ingestion of single guide RNAs induces gene overexpression and extends lifespan in Caenorhabditis elegans via CRISPR activation

Fabian Fischer, Christoph Benner, Anita Goyala, Giovanna Grigolon, Davide Vitiello, JiaYee Wu, Kim Zarse, Collin Y. Ewald, Michael Ristow

J Biol Chem. 2022 Jul; 298(7): 102085. Published online 2022 May 27. doi: 10.1016/j.jbc.2022.102085

PMCID:: PMC9243178

Abstract Article PDF–984K

Select item 917078310.

SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells

Joshua Jackson, Lena Wischhof, Enzo Scifo, Anna Pellizzer, Yiru Wang, Antonia Piazzesi, Debora Gentile, Sana Siddig, Miriam Stork, Chris E. Hopkins, Kristian Händler, Joachim Weis, Andreas Roos, Joachim L. Schultze, Pierluigi Nicotera, Dan Ehninger, Daniele Bano

Mol Metab. 2022 Jul; 61: 101503. Published online 2022 Apr 19. doi: 10.1016/j.molmet.2022.101503

PMCID:: PMC9170783

Abstract Article PDF–3.7M

Select item 912776911.

Meta-Analysis of Caenorhabditis elegans Transcriptomics Implicates Hedgehog-Like Signaling in Host-Microbe Interactions

Alejandra Zárate-Potes, Irtiqa Ali, Margarida Ribeiro Camacho, Hayley Brownless, Alexandre Benedetto

Front Microbiol. 2022; 13: 853629. Published online 2022 May 10. doi: 10.3389/fmicb.2022.853629

PMCID:: PMC9127769

Abstract Article PDF–4.6M

Select item 895960212.

Nuclear hormone receptor NHR-49 acts in parallel with HIF-1 to promote hypoxia adaptation in Caenorhabditis elegans

Kelsie RS Doering, Xuanjin Cheng, Luke Milburn, Ramesh Ratnappan, Arjumand Ghazi, Dana L Miller, Stefan Taubert

eLife. 2022; 11: e67911. Published online 2022 Mar 14. doi: 10.7554/eLife.67911

PMCID:: PMC8959602

Abstract Article PDF–9.4M

Select item 881402613.

Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis

Eirini Lionaki, Ilias Gkikas, Ioanna Daskalaki, Maria-Konstantina Ioannidi, Maria I. Klapa, Nektarios Tavernarakis

Nat Commun. 2022; 13: 651. Published online 2022 Feb 3. doi: 10.1038/s41467-022-28272-1

PMCID:: PMC8814026

Abstract Article PDF–2.3M

Select item 827012614.

Crosstalk in oxygen homeostasis networks: SKN-1/NRF inhibits the HIF-1 hypoxia-inducible factor in Caenorhabditis elegans

Dingxia Feng, Zhiwei Zhai, Zhiyong Shao, Yi Zhang, Jo Anne Powell-Coffman

PLoS One. 2021; 16(7): e0249103. Published online 2021 Jul 9. doi: 10.1371/journal.pone.0249103

PMCID:: PMC8270126

Abstract Article PDF–1.6M

Select item 799517615.

EPIC: Software Toolkit for Elution Profile-Based Inference of Protein Complexes

Lucas ZhongMing Hu, Florian Goebels, June H. Tan, Eric Wolf, Uros Kuzmanov, Cuihong Wan, Sadhna Phanse, Changjiang Xu, Mike Schertzberg, Andrew G. Fraser, Gary D. Bader, Andrew Emili

Nat Methods. Author manuscript; available in PMC 2021 Mar 26.

Published in final edited form as: Nat Methods. 2019 Aug; 16(8): 737–742. Published online 2019 Jul 15. doi: 10.1038/s41592-019-0461-4

PMCID:: PMC7995176

Abstract Article PDF–1.0M

Select item 773292216.

Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response

Joseph C.P. Kruempel, Hillary A. Miller, Megan L. Schaller, Abrielle Fretz, Marshall Howington, Marjana Sarker, Shijiao Huang, Scott F. Leiser

GeroScience. 2020 Dec; 42(6): 1621–1633. Published online 2020 May 12. doi: 10.1007/s11357-020-00194-0

PMCID:: PMC7732922

Abstract Article PDF–1.2M

Select item 731368017.

Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways

Emily Machiela, Thomas Liontis, Dylan J. Dues, Paige D. Rudich, Annika Traa, Leslie Wyman, Corah Kaufman, Jason F. Cooper, Leira Lew, Saravanapriah Nadarajan, Megan M. Senchuk, Jeremy M. Van Raamsdonk

FASEB J. 2020 Jun; 34(6): 8475–8492. Published online 2020 May 8. doi: 10.1096/fj.201903235R

PMCID:: PMC7313680

Abstract Article PDF–2.4M

Select item 727478918.

Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans

Yanan Sun, Meijiao Li, Dongfeng Zhao, Xin Li, Chonglin Yang, Xiaochen Wang

eLife. 2020; 9: e55745. Published online 2020 Jun 2. doi: 10.7554/eLife.55745

PMCID:: PMC7274789

Abstract Article PDF–8.1M

Select item 726531119.

Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30

Yasmine J. Liu, Rebecca L. McIntyre, Georges E. Janssens, Evan G. Williams, Jiayi Lan, Michel van Weeghel, Bauke Schomakers, Henk van der Veen, Nicole N. van der Wel, Pallas Yao, William B. Mair, Ruedi Aebersold, Alyson W. MacInnes, Riekelt H. Houtkooper

J Cell Biol. 2020 Jun 1; 219(6): e201907067. Published online 2020 Apr 7. doi: 10.1083/jcb.201907067