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Select item 114938911.

Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans

Elizabeth M. L. Duxbury, Hanne Carlsson, Annabel Kimberley, Yvonne Ridge, Katie Johnson, Alexei A. Maklakov

GeroScience. 2024 Dec; 46(6): 5767–5780. Published online 2024 Apr 8. doi: 10.1007/s11357-024-01147-7

PMCID:: PMC11493891

Abstract Article PDF–1.0M

Select item 112584802.

Combinatorial transcriptomic and genetic dissection of insulin/IGF‐1 signaling‐regulated longevity in Caenorhabditis elegans

Seokjin Ham, Sieun S. Kim, Sangsoon Park, Hyunwoo C. Kwon, Seokjun G. Ha, Yunkyu Bae, Gee‐Yoon Lee, Seung‐Jae V. Lee

Aging Cell. 2024 Jul; 23(7): e14151. Published online 2024 Mar 26. doi: 10.1111/acel.14151

PMCID:: PMC11258480

Abstract Article PDF–1.4M

Select item 112094573.

Transgenerational Response of Germline Nuclear Hormone Receptor Genes to Nanoplastics at Predicted Environmental Doses in Caenorhabditis elegans

Zhengying Liu, Yuxing Wang, Qian Bian, Dayong Wang

Toxics. 2024 Jun; 12(6): 420. Published online 2024 Jun 7. doi: 10.3390/toxics12060420

PMCID:: PMC11209457

Abstract Article PDF–2.4M

Select item 112080494.

The neuron-specific IIS/FOXO transcriptome in aged animals reveals regulatory mechanisms of cognitive aging

Yifei Weng, Shiyi Zhou, Katherine Morillo, Rachel Kaletsky, Sarah Lin, Coleen T Murphy

eLife. 2024; 13: RP95621. Published online 2024 Jun 26. doi: 10.7554/eLife.95621

PMCID:: PMC11208049

Abstract Article PDF–4.7M

Select item 110199325.

LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans

Taruna Pandey, Bingying Wang, Changnan Wang, Jenny Zu, Huichao Deng, Kang Shen, Goncalo Dias do Vale, Jeffrey G. McDonald, Dengke K. Ma

Cell Rep. Author manuscript; available in PMC 2024 Apr 16.

Published in final edited form as: Cell Rep. 2024 Mar 26; 43(3): 113899. Published online 2024 Mar 5. doi: 10.1016/j.celrep.2024.113899

PMCID:: PMC11019932

Abstract Article PDF–1.8M

Select item 109180636.

Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans

Nadia Suryawinata, Rikuou Yokosawa, Ke Hui Cassandra Tan, Alison Lok Lai, Ryusei Sone, Ikue Mori, Kentaro Noma

Sci Rep. 2024; 14: 5529. Published online 2024 Mar 6. doi: 10.1038/s41598-024-52272-4

PMCID:: PMC10918063

Abstract Article PDF–2.3M

Select item 109147817.

Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B

Misaki Okahata, Natsumi Sawada, Kenji Nakao, Akane Ohta, Atsushi Kuhara

Sci Rep. 2024; 14: 5401. Published online 2024 Mar 5. doi: 10.1038/s41598-024-55794-z

PMCID:: PMC10914781

Abstract Article PDF–2.1M

Select item 108762128.

Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity

Yong Yu, Shihong M Gao, Youchen Guan, Pei-Wen Hu, Qinghao Zhang, Jiaming Liu, Bentian Jing, Qian Zhao, David M Sabatini, Monther Abu-Remaileh, Sung Yun Jung, Meng C Wang

eLife. 2024; 13: e85214. Published online 2024 Jan 19. doi: 10.7554/eLife.85214

PMCID:: PMC10876212

Abstract Article PDF–5.9M

Select item 108547219.

Considering Caenorhabditis elegans Aging on a Temporal and Tissue Scale: The Case of Insulin/IGF-1 Signaling

Paola Fabrizio, Allan Alcolei, Florence Solari

Cells. 2024 Feb; 13(3): 288. Published online 2024 Feb 5. doi: 10.3390/cells13030288

PMCID:: PMC10854721

Abstract Article PDF–4.4M

Select item 1085048810.

Magnolol extends lifespan and improves age-related neurodegeneration in Caenorhabditis elegans via increase of stress resistance

Jing Yu, Xiaoyan Gao, Lijun Zhang, Hang Shi, Yingxuan Yan, Yongli Han, Chengyuan Wu, Ying Liu, Minglv Fang, Cheng Huang, Shengjie Fan

Sci Rep. 2024; 14: 3158. Published online 2024 Feb 7. doi: 10.1038/s41598-024-53374-9

PMCID:: PMC10850488

Abstract Article PDF–6.3M

Select item 1070282311.

Metabolic plasticity sustains the robustness of Caenorhabditis elegans embryogenesis

Siyu Chen, Xing Su, Jinglin Zhu, Long Xiao, Yulin Cong, Leilei Yang, Zhuo Du, Xun Huang

EMBO Rep. 2023 Dec; 24(12): e57440. Published online 2023 Oct 27. doi: 10.15252/embr.202357440

PMCID:: PMC10702823

Abstract Article PDF–9.5M

Select item 1066501312.

Specific sensory neurons and insulin-like peptides modulate food type-dependent oogenesis and fertilization in Caenorhabditis elegans

Shashwat Mishra, Mohamed Dabaja, Asra Akhlaq, Bianca Pereira, Kelsey Marbach, Mediha Rovcanin, Rashmi Chandra, Antonio Caballero, Diana Fernandes de Abreu, QueeLim Ch'ng, Joy Alcedo

eLife. 2023; 12: e83224. Published online 2023 Nov 17. doi: 10.7554/eLife.83224

PMCID:: PMC10665013

Abstract Article PDF–1.4M

Select item 1058938113.

Automation of Caenorhabditis elegans lifespan assay using a simplified domain synthetic image-based neural network training strategy

Antonio García-Garví, Pablo E. Layana-Castro, Joan Carles Puchalt, Antonio-José Sánchez-Salmerón

Comput Struct Biotechnol J. 2023; 21: 5049–5065. Published online 2023 Oct 10. doi: 10.1016/j.csbj.2023.10.007

PMCID:: PMC10589381

Abstract Article PDF–3.5M

Select item 1057386514.

N⁶-Methyladenine Progressively Accumulates in Mitochondrial DNA during Aging

Ádám Sturm, Himani Sharma, Ferenc Bodnár, Maryam Aslam, Tibor Kovács, Ákos Németh, Bernadette Hotzi, Viktor Billes, Tímea Sigmond, Kitti Tátrai, Balázs Egyed, Blanka Téglás-Huszár, Gitta Schlosser, Nikolaos Charmpilas, Christina Ploumi, András Perczel, Nektarios Tavernarakis, Tibor Vellai

Int J Mol Sci. 2023 Oct; 24(19): 14858. Published online 2023 Oct 3. doi: 10.3390/ijms241914858

PMCID:: PMC10573865

Abstract Article PDF–3.6M

Select item 1055381915.

ADAR-mediated regulation of PQM-1 expression in neurons impacts gene expression throughout C. elegans and regulates survival from hypoxia

Ananya Mahapatra, Alfa Dhakal, Aika Noguchi, Pranathi Vadlamani, Heather A. Hundley

PLoS Biol. 2023 Sep; 21(9): e3002150. Published online 2023 Sep 25. doi: 10.1371/journal.pbio.3002150

PMCID:: PMC10553819

Abstract Article PDF–1.7M

Select item 1055190216.

Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans

Anita V. Kumar, Joslyn Mills, Wesley M. Parker, Joshua A. Leitão, Diego I. Rodriguez, Sandrine E. Daigle, Celeste Ng, Rishi Patel, Joseph L. Aguilera, Joseph R. Johnson, Shi Quan Wong, Louis R. Lapierre

iScience. 2023 Oct 20; 26(10): 107960. Published online 2023 Sep 16. doi: 10.1016/j.isci.2023.107960

PMCID:: PMC10551902

Abstract Article PDF–4.6M

Select item 1055091717.

Lactobacillus paracasei HII01 enhances lifespan and promotes neuroprotection in Caenorhabditis elegans

Kishoree K. Kumaree, Mani Iyer Prasanth, Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Tewin Tencomnao, Chaiyavat Chaiyasut, Anchalee Prasansuklab

Sci Rep. 2023; 13: 16707. Published online 2023 Oct 4. doi: 10.1038/s41598-023-43846-9