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Select item 112039541.

Cardiac-Specific Suppression of Valosin-Containing Protein Induces Progressive Heart Failure and Premature Mortality Correlating with Temporal Dysregulations in mTOR Complex 2 and Protein Phosphatase 1

Xiaonan Sun, Xicong Tang, Hongyu Qiu

Int J Mol Sci. 2024 Jun; 25(12): 6445. Published online 2024 Jun 11. doi: 10.3390/ijms25126445

PMCID:: PMC11203954

Abstract Article PDF–2.9M

Select item 110727402.

DUSP1 interacts with and dephosphorylates VCP to improve mitochondrial quality control against endotoxemia-induced myocardial dysfunction

Hang Zhu, Jin Wang, Ting Xin, Shanshan Chen, Ruiying Hu, Yukun Li, Mingming Zhang, Hao Zhou

Cell Mol Life Sci. 2023 Aug; 80(8): 213. Published online 2023 Jul 18. doi: 10.1007/s00018-023-04863-z

PMCID:: PMC11072740

Abstract Article PDF–16M

Select item 110617523.

Valosin-containing protein acts as a target and mediator of S-nitrosylation in the heart through distinct mechanisms

Xiaomeng Shi, Molly O'Connor, Hongyu Qiu

Redox Biol. 2024 Jun; 72: 103166. Published online 2024 Apr 26. doi: 10.1016/j.redox.2024.103166

PMCID:: PMC11061752

Abstract Article PDF–4.9M

Select item 107297294.

Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis

Jiaqing Hao, Jianyu Yu, Matthew S. Yorek, Chi-Li Yu, R. Marshall Pope, Michael S. Chimenti, Yiqin Xiong, Aloysius Klingelhutz, Ali Jabbari, Bing Li

Cell Rep. Author manuscript; available in PMC 2023 Dec 19.

Published in final edited form as: Cell Rep. 2023 Nov 28; 42(11): 113449. Published online 2023 Nov 15. doi: 10.1016/j.celrep.2023.113449

PMCID:: PMC10729729

Abstract Article PDF–2.9M

Select item 104970055.

Inhibition of VCP modulates NF-κB signaling pathway to suppress multiple myeloma cell proliferation and osteoclast differentiation

Rongfang Wei, Yuhao Cao, Hongjie Wu, Xin Liu, Mingmei Jiang, Xian Luo, Zhendong Deng, Ze Wang, Mengying Ke, Yongqiang Zhu, Siqing Chen, Chunyan Gu, Ye Yang

Aging (Albany NY) 2023 Aug 30; 15(16): 8220–8236. Published online 2023 Aug 21. doi: 10.18632/aging.204965

PMCID:: PMC10497005

Abstract Article PDF–1.5M

Select item 103284146.

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis

Gerald Coulis, Diego Jaime, Christian Guerrero-Juarez, Jenna M. Kastenschmidt, Philip K. Farahat, Quy Nguyen, Nicholas Pervolarakis, Katherine McLinden, Lauren Thurlow, Saba Movahedi, Brandon S. Hughes, Jorge Duarte, Andrew Sorn, Elizabeth Montoya, Izza Mozaffar, Morgan Dragan, Shivashankar Othy, Trupti Joshi, Chetan P. Hans, Virginia Kimonis, Adam L. MacLean, Qing Nie, Lindsay M. Wallace, Scott Q. Harper, Tahseen Mozaffar, Marshall W. Hogarth, Surajit Bhattacharya, Jyoti K. Jaiswal, David R. Golann, Qi Su, Kai Kessenbrock, Michael Stec, Melissa J. Spencer, Jesse R. Zamudio, S. Armando Villalta

Sci Adv. 2023 Jul; 9(27): eadd9984. Published online 2023 Jul 7. doi: 10.1126/sciadv.add9984

PMCID:: PMC10328414

Abstract Article PDF–2.2M

Select item 102409987.

PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805

Yunpeng Bai, Guimei Yu, Hong-Ming Zhou, Ovini Amarasinghe, Yuan Zhou, Peipei Zhu, Qinglin Li, Lujuan Zhang, Frederick Nguele Meke, Yiming Miao, Eli Chapman, W. Andy Tao, Zhong-Yin Zhang

Autophagy. 2023; 19(5): 1562–1581. Published online 2022 Nov 7. doi: 10.1080/15548627.2022.2140558

PMCID:: PMC10240998

Abstract Article PDF–4.4M

Select item 102089588.

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome

Brianna K. Unda, Leon Chalil, Sehyoun Yoon, Savannah Kilpatrick, Courtney Irwin, Sansi Xing, Nadeem Murtaza, Anran Cheng, Chad Brown, Alexandria Afonso, Elizabeth McCready, Gabriel M. Ronen, Jennifer Howe, Aurélie Caye-Eude, Alain Verloes, Brad W. Doble, Laurence Faivre, Antonio Vitobello, Stephen W. Scherer, Yu Lu, Peter Penzes, Karun K. Singh

Mol Psychiatry. 2023; 28(4): 1747–1769. Published online 2023 Jan 6. doi: 10.1038/s41380-022-01937-5

PMCID:: PMC10208958

Abstract Article PDF–7.0M

Select item 99382169.

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yi-Zhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Jr., Mark S. LeDoux, Jennifer A. Kearney, Jeffrey N. Savas, Peter Penzes

Nat Commun. 2023; 14: 825. Published online 2023 Feb 17. doi: 10.1038/s41467-023-36087-x

PMCID:: PMC9938216

Abstract Article PDF–5.3M

Select item 990249210.

The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition

Rakesh Ganji, Joao A. Paulo, Yuecheng Xi, Ian Kline, Jiang Zhu, Christoph S. Clemen, Conrad C. Weihl, John G. Purdy, Steve P. Gygi, Malavika Raman

Nat Commun. 2023; 14: 638. Published online 2023 Feb 6. doi: 10.1038/s41467-023-36298-2

PMCID:: PMC9902492

Abstract Article PDF–4.1M

Select item 971554911.

Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage

Marta del Rio Oliva, Michael Basler

Cell Death Dis. 2022 Dec; 13(12): 1015. Published online 2022 Dec 1. doi: 10.1038/s41419-022-05461-w

PMCID:: PMC9715549

Abstract Article PDF–2.3M

Select item 971543412.

DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosis

Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Christian JF Bertens, Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akatsu, Naoki Atsuta, Masahisa Katsuno, Katsutoshi Furukawa, Aiko Ishiki, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Takanori Yokota, Haruhisa Inoue, Hiroyuki Arai, Gen Sobue, Masaki Sone, Kyota Fujita, Hitoshi Okazawa

Life Sci Alliance. 2021 Jul; 4(7): e202101022. Published online 2021 Jun 15. doi: 10.26508/lsa.202101022

PMCID:: PMC9715434

Abstract Article PDF–4.7M

Select item 960386013.

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3

Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany

Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527

PMCID:: PMC9603860

Abstract Article PDF–3.4M

Select item 948193314.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 912737015.

AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4

Koji Shibuya, Ken Ebihara, Chihiro Ebihara, Nagisa Sawayama, Masayo Isoda, Daisuke Yamamuro, Manabu Takahashi, Shuichi Nagashima, Shun Ishibashi

J Biol Chem. 2022 Jun; 298(6): 101936. Published online 2022 Apr 14. doi: 10.1016/j.jbc.2022.101936

PMCID:: PMC9127370

Abstract Article PDF–2.0M

Select item 900408216.

VCP suppresses proteopathic seeding in neurons

Jiang Zhu, Sara Pittman, Dhruva Dhavale, Rachel French, Jessica N. Patterson, Mohamed Salman Kaleelurrrahuman, Yuanzi Sun, Jaime Vaquer-Alicea, Gianna Maggiore, Christoph S. Clemen, William J. Buscher, Jan Bieschke, Paul Kotzbauer, Yuna Ayala, Marc I. Diamond, Albert A. Davis, Conrad Weihl

Mol Neurodegener. 2022; 17: 30. Published online 2022 Apr 12. doi: 10.1186/s13024-022-00532-0

PMCID:: PMC9004082

Abstract Article PDF–7.0M

Select item 872666217.

Loss-of-function mutation in VCP mimics the characteristic pathology as in FTLD-TARDBP

Abubakar Wani, Conrad C. Weihl

Autophagy. 2021; 17(12): 4502–4503. Published online 2021 Oct 10. doi: 10.1080/15548627.2021.1985880

PMCID:: PMC8726662

Abstract Article PDF–195K

Select item 845651418.

A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6

Henri Leinonen, Cheng Cheng, Marja Pitkänen, Christopher L. Sander, Jianye Zhang, Sama Saeid, Teemu Turunen, Alyaa Shmara, Lan Weiss, Lac Ta, Timothy Ton, Ari Koskelainen, Jesse D. Vargas, Virginia Kimonis, Krzysztof Palczewski

J Pharmacol Exp Ther. 2021 Jul; 378(1): 31–41. Published online 2021 Jul. doi: 10.1124/jpet.120.000486

PMCID:: PMC8456514

Abstract Article PDF–1.5M

Select item 838334419.

Neuronal VCP loss of function recapitulates FTLD-TDP pathology

Abubakar Wani, Jiang Zhu, Jason D. Ulrich, Abdallah Eteleeb, Andrew D. Sauerbeck, Sydney J. Reitz, Khalid Arhzaouy, Chiseko Ikenaga, Carla M. Yuede, Sara K. Pittman, Feng Wang, Shan Li, Bruno A. Benitez, Carlos Cruchaga, Terrance T. Kummer, Oscar Harari, Tsui-Fen Chou, Rolf Schröder, Christoph S. Clemen, Conrad C. Weihl

Cell Rep. Author manuscript; available in PMC 2021 Aug 24.

Published in final edited form as: Cell Rep. 2021 Jul 20; 36(3): 109399. doi: 10.1016/j.celrep.2021.109399

PMCID:: PMC8383344

Abstract Article PDF–1.9M

Select item 836110120.

Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis

Meihua Jin, Xiaocen Jin, Hidenori Homma, Kyota Fujita, Hikari Tanaka, Shigeo Murayama, Hiroyasu Akatsu, Kazuhiko Tagawa, Hitoshi Okazawa

Commun Biol. 2021; 4: 961. Published online 2021 Aug 12. doi: 10.1038/s42003-021-02475-6

PMCID:: PMC8361101

Abstract Article PDF–3.0M

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