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Select item 110445051.

Dysregulation of innate immune signaling in animal models of spinal muscular atrophy

Eric L. Garcia, Rebecca E. Steiner, Amanda C. Raimer, Laura E. Herring, A. Gregory Matera, Ashlyn M. Spring

BMC Biol. 2024; 22: 94. Published online 2024 Apr 25. doi: 10.1186/s12915-024-01888-z

PMCID:: PMC11044505

Abstract Article PDF–4.0M

Select item 109568542.

mTORC1 is required for differentiation of germline stem cells in the Drosophila melanogaster testis

Marie Clémot, Cecilia D’Alterio, Alexa C. Kwang, D. Leanne Jones

PLoS One. 2024; 19(3): e0300337. Published online 2024 Mar 21. doi: 10.1371/journal.pone.0300337

PMCID:: PMC10956854

Abstract Article PDF–3.0M

Select item 109457073.

Comparative interactome analysis of α-arrestin families in human and Drosophila

Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam

eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328

PMCID:: PMC10945707

Abstract Article PDF–2.8M

Select item 108693624.

The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy

Shannon Nicolson, Jantina A. Manning, Yoon Lim, Xin Jiang, Erica Kolze, Sonia Dayan, Ruchi Umargamwala, Tianqi Xu, Jarrod J. Sandow, Andrew I. Webb, Sharad Kumar, Donna Denton

Commun Biol. 2024; 7: 183. Published online 2024 Feb 15. doi: 10.1038/s42003-024-05834-1

PMCID:: PMC10869362

Abstract Article PDF–6.1M

Select item 108684245.

Glial control of sphingolipid levels sculpts diurnal remodeling of circadian circuits

John P. Vaughen, Emma Theisen, Irma Magaly Rivas-Serna, Andrew B. Berger, Prateek Kalakuntla, Ina Anreiter, Vera C. Mazurak, Tamy Portillo Rodriguez, Joshua D. Mast, Tom Hartl, Ethan O. Perlstein, Richard J. Reimer, M. Thomas Clandinin, Thomas R. Clandinin

Neuron. Author manuscript; available in PMC 2024 Feb 15.

Published in final edited form as: Neuron. 2022 Oct 5; 110(19): 3186–3205.e7. Published online 2022 Aug 11. doi: 10.1016/j.neuron.2022.07.016

PMCID:: PMC10868424

Abstract Article PDF–4.2M

Select item 108589106.

Nutrient-dependent regulation of a stable intron modulates germline mitochondrial quality control

Annabel Qi En Ng, Seow Neng Chan, Jun Wei Pek

Nat Commun. 2024; 15: 1252. Published online 2024 Feb 10. doi: 10.1038/s41467-024-45651-y

PMCID:: PMC10858910

Abstract Article PDF–8.6M

Select item 108118607.

Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models

Aitor Martinez, Alvaro Sanchez-Martinez, Jake T. Pickering, Madeleine J. Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alexander J. Whitworth

Mol Neurodegener. 2024; 19: 12. Published online 2024 Jan 25. doi: 10.1186/s13024-024-00701-3

PMCID:: PMC10811860

Abstract Article PDF–13M

Select item 107835128.

A conserved nutrient responsive axis mediates autophagic degradation of miRNA–mRNA hybrids in blood cell progenitors

Sushmit Ghosh, Sreemoyee Chakraborti, Devki Devi, Rajesh Sahu, Sudip Mandal, Lolitika Mandal

Nucleic Acids Res. 2024 Jan 11; 52(1): 385–403. Published online 2023 Nov 22. doi: 10.1093/nar/gkad1047

PMCID:: PMC10783512

Abstract Article PDF–3.1M

Select item 107433849.

The Drosophila NPY-like system protects against chronic stress–induced learning deficit by preventing the disruption of autophagic flux

Tianli Chen, Mengyu Zhang, Zhaowen Ding, Jiao Hu, Jie Yang, Lei He, Jia Jia, Jingjing Yang, Junfei Yang, Xiaoxu Song, Peng Chen, Zongzhao Zhai, Jing Huang, Yirong Wang, Hongtao Qin

Proc Natl Acad Sci U S A. 2023 Dec 19; 120(51): e2307632120. Published online 2023 Dec 11. doi: 10.1073/pnas.2307632120

PMCID:: PMC10743384

Abstract Article PDF–1.3M

Select item 1067636410.

ACO2 deficiency increases vulnerability to Parkinson’s disease via dysregulating mitochondrial function and histone acetylation-mediated transcription of autophagy genes

Junge Zhu, Fanxi Xu, Hong Lai, Huiyao Yuan, Xu-Ying Li, Junya Hu, Wei Li, Lei Liu, Chaodong Wang

Commun Biol. 2023; 6: 1201. Published online 2023 Nov 25. doi: 10.1038/s42003-023-05570-y

PMCID:: PMC10676364

Abstract Article PDF–4.0M

Select item 1064507911.

Structure and molecular basis of spermatid elongation in the Drosophila testis

Qiuru Huang, Xia Chen, Hao Yu, Li Ji, Yi Shi, Xinmeng Cheng, Hao Chen, Jun Yu

Open Biol. 2023 Nov; 13(11): 230136. Published online November 8, 2023. doi: 10.1098/rsob.230136

PMCID:: PMC10645079

Abstract Article PDF–1.0M

Select item 1056959212.

Genomes from historical Drosophila melanogaster specimens illuminate adaptive and demographic changes across more than 200 years of evolution

Max Shpak, Hamid R. Ghanavi, Jeremy D. Lange, John E. Pool, Marcus C. Stensmyr

PLoS Biol. 2023 Oct; 21(10): e3002333. Published online 2023 Oct 12. doi: 10.1371/journal.pbio.3002333

PMCID:: PMC10569592

Abstract Article PDF–3.5M

Select item 1056486313.

The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains

Sebastián Oyarce-Pezoa, Guilherme Gischkow Rucatti, Francisco Muñoz-Carvajal, Nicole Sanhueza, Wileidy Gomez, Sandra Espinoza, Mario Leiva, Nicolás García, Daniela P. Ponce, Carol D. SanMartín, Diego Rojas-Rivera, Natalia Salvadores, Maria I. Behrens, Ute Woehlbier, Melissa Calegaro-Nassif, Mario Sanhueza

Sci Rep. 2023; 13: 17137. Published online 2023 Oct 10. doi: 10.1038/s41598-023-44203-6

PMCID:: PMC10564863

Abstract Article PDF–2.6M

Select item 1054919214.

Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosis

Beatriz Pino-Jiménez, Panagiotis Giannios, Jordi Casanova

Autophagy. 2023; 19(11): 2972–2981. Published online 2023 Jul 9. doi: 10.1080/15548627.2023.2231828

PMCID:: PMC10549192

Abstract Article PDF–2.8M

Select item 1047287115.

PtdIns4P exchange at endoplasmic reticulum-autolysosome contacts is essential for autophagy and neuronal homeostasis

Hao Liu, Wenxia Shao, Wei Liu, Weina Shang, Jun-Ping Liu, Liquan Wang, Chao Tong

Autophagy. 2023; 19(10): 2682–2701. Published online 2023 Jun 13. doi: 10.1080/15548627.2023.2222556

PMCID:: PMC10472871

Abstract Article PDF–10M

Select item 1046377616.

Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity

Javier Morón-Oset, Lilly Katharina Sophie Fischer, Nathalie Jauré, Pingze Zhang, Annika Julia Jahn, Tessa Supèr, André Pahl, Adrian M. Isaacs, Sebastian Grönke, Linda Partridge

Acta Neuropathol Commun. 2023; 11: 140. Published online 2023 Aug 29. doi: 10.1186/s40478-023-01634-6

PMCID:: PMC10463776

Abstract Article PDF–10M

Select item 1044489017.

The deubiquitinase Leon/USP5 interacts with Atg1/ULK1 and antagonizes autophagy

Yueh-Ling Pai, Yuchieh Jay Lin, Wen-Hsin Peng, Li-Ting Huang, He-Yen Chou, Chien-Hsiang Wang, Cheng-Ting Chien, Guang-Chao Chen

Cell Death Dis. 2023 Aug; 14(8): 540. Published online 2023 Aug 22. doi: 10.1038/s41419-023-06062-x

PMCID:: PMC10444890

Abstract Article PDF–4.9M

Select item 1023277518.

Drosophila melanogaster as a model to study autophagy in neurodegenerative diseases induced by proteinopathies

Stefania Santarelli, Chiara Londero, Alessia Soldano, Carlotta Candelaresi, Leonardo Todeschini, Luisa Vernizzi, Paola Bellosta

Front Neurosci. 2023; 17: 1082047. Published online 2023 May 18. doi: 10.3389/fnins.2023.1082047

PMCID:: PMC10232775

Abstract Article PDF–2.4M

Select item 1022708019.

LC3-associated phagocytosis promotes glial degradation of axon debris after injury in Drosophila models

Áron Szabó, Virág Vincze, Aishwarya Sanjay Chhatre, András Jipa, Sarolta Bognár, Katalin Eszter Varga, Poulami Banik, Adél Harmatos-Ürmösi, Lukas J. Neukomm, Gábor Juhász

Nat Commun. 2023; 14: 3077. Published online 2023 May 29. doi: 10.1038/s41467-023-38755-4