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Select item 113917291.

SYK promotes the formation of neutrophil extracellular traps by inducing PKM2 nuclear translocation and promoting STAT3 phosphorylation to exacerbate hepatic ischemia-reperfusion injury and tumor recurrence

Xuejiao Chen, Chuanwei Jiang, Minhao Chen, Xiangdong Li, Wenjie Yu, Aigang Qiu, Linfeng Sun, Liyong Pu, Yuhua Shi

Mol Med. 2024; 30: 146. Published online 2024 Sep 11. doi: 10.1186/s10020-024-00907-7

PMCID:: PMC11391729

Abstract Article PDF–2.7M

Select item 113023802.

Neutrophil-specific deletion of Syk results in recruitment-independent stabilization of the barrier and a long-term improvement in cognitive function after traumatic injury to the developing brain

Alpa Trivedi, Kayleen G. Tercovich, Amy Jo Casbon, Jacob Raber, Clifford Lowell, Linda J. Noble-Haeusslein

Neurobiol Dis. Author manuscript; available in PMC 2024 Aug 6.

Published in final edited form as: Neurobiol Dis. 2021 Sep; 157: 105430. Published online 2021 Jun 19. doi: 10.1016/j.nbd.2021.105430

PMCID:: PMC11302380

Abstract Article PDF–2.2M

Select item 111148383.

Migration inhibition of mammary epithelial cells by Syk is blocked in the presence of DDR1 receptors

Brit Neuhaus, Sebastian Bühren, Barbara Böck, Frauke Alves, Wolfgang F. Vogel, Friedemann Kiefer

Cell Mol Life Sci. 2011 Nov; 68(22): 3757–3770. Published online 2011 Apr 17. doi: 10.1007/s00018-011-0676-8

PMCID:: PMC11114838

Abstract Article PDF–2.2M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105803585.

Endothelial TREM‐1 receptor regulates the blood–brain barrier integrity after intracerebral hemorrhage in mice via SYK/β‐catenin signaling

Yonglin Xie, Wei He, Li Ma, Reng Ren, Shuxu Yang, Qin Lu

CNS Neurosci Ther. 2023 Nov; 29(11): 3228–3238. Published online 2023 May 11. doi: 10.1111/cns.14255

PMCID:: PMC10580358

Abstract Article PDF–12M

Select item 105029206.

Biochemical characterization of the Spleen tyrosine kinase (SYK) isoforms in platelets

Pankaj Kumar Singh, Carol A. Dangelmaier, Hymavathi Reddy Vari, Alexander Y. Tsygankov, Satya P. Kunapuli

Platelets. Author manuscript; available in PMC 2024 Dec 1.

Published in final edited form as: Platelets. 2023 Dec; 34(1): 2249549. doi: 10.1080/09537104.2023.2249549

PMCID:: PMC10502920

Abstract Article PDF–709K

Select item 103826757.

GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling promotes atherosclerosis

Daisuke Tsukui, Yoshitaka Kimura, Hajime Kono

iScience. 2023 Aug 18; 26(8): 107293. Published online 2023 Jul 11. doi: 10.1016/j.isci.2023.107293

PMCID:: PMC10382675

Abstract Article PDF–5.1M

Select item 103205158.

Phosphorylation of spleen tyrosine kinase at Y346 negatively regulates ITAM-mediated signaling and function in platelets

Carol A. Dangelmaier, Margaret Patchin, Dhruv N. Vajipayajula, Hymavathi Reddy Vari, Pankaj K. Singh, Monica N. Wright, John C. Kostyak, Alexander Y. Tsygankov, Satya P. Kunapuli

J Biol Chem. 2023 Jul; 299(7): 104865. Published online 2023 Jun 1. doi: 10.1016/j.jbc.2023.104865

PMCID:: PMC10320515

Abstract Article PDF–2.9M

Select item 102917419.

SSRI treatment modifies the effects of maternal inflammation on in utero physiology and offspring neurobiology

Kristine E. Zengeler, Daniel A. Shapiro, Katherine R. Bruch, Catherine R. Lammert, Hannah Ennerfelt, John R. Lukens

Brain Behav Immun. Author manuscript; available in PMC 2023 Jun 26.

Published in final edited form as: Brain Behav Immun. 2023 Feb; 108: 80–97. Published online 2022 Nov 4. doi: 10.1016/j.bbi.2022.10.024

PMCID:: PMC10291741

Abstract Article PDF–2.7M

Select item 1028307110.

Targeting macrophage Syk enhances responses to immune checkpoint blockade and radiotherapy in high-risk neuroblastoma

Deepak Rohila, In Hwan Park, Timothy V. Pham, Riley Jones, Elisabette Tapia, Kevin X. Liu, Pablo Tamayo, Alice Yu, Andrew B. Sharabi, Shweta Joshi

Front Immunol. 2023; 14: 1148317. Published online 2023 Jun 7. doi: 10.3389/fimmu.2023.1148317

PMCID:: PMC10283071

Abstract Article PDF–8.2M

Select item 999750911.

B cell receptor ligation induces IgE plasma cell elimination

Adam K. Wade-Vallance, Zhiyong Yang, Jeremy B. Libang, Marcus J. Robinson, David M. Tarlinton, Christopher D.C. Allen

J Exp Med. 2023 Apr 3; 220(4): e20220964. Published online 2023 Feb 28. doi: 10.1084/jem.20220964

PMCID:: PMC9997509

Abstract Article PDF–5.0M

Select item 987811112.

Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation

Ryunosuke Muro, Tomoya Narita, Takeshi Nitta, Hiroshi Takayanagi

Front Immunol. 2022; 13: 1045881. Published online 2023 Jan 12. doi: 10.3389/fimmu.2022.1045881

PMCID:: PMC9878111

Abstract Article PDF–3.6M

Select item 987232813.

B cell–intrinsic requirement for WNK1 kinase in antibody responses in mice

Darryl A. Hayward, Lesley Vanes, Stefanie Wissmann, Sujana Sivapatham, Harald Hartweger, Joshua Biggs O’May, Leonard L. de Boer, Richard Mitter, Robert Köchl, Jens V. Stein, Victor L.J. Tybulewicz

J Exp Med. 2023 Mar 6; 220(3): e20211827. Published online 2023 Jan 20. doi: 10.1084/jem.20211827

PMCID:: PMC9872328

Abstract Article PDF–6.8M

Select item 970948214.

Neutrophils inhibit γδ T cell functions in the imiquimod-induced mouse model of psoriasis

Sara Costa, Dalila Bevilacqua, Elena Caveggion, Sara Gasperini, Elena Zenaro, Francesca Pettinella, Marta Donini, Stefano Dusi, Gabriela Constantin, Silvia Lonardi, William Vermi, Francesco De Sanctis, Stefano Ugel, Tiziana Cestari, Clare L. Abram, Clifford A. Lowell, Pamela Rodegher, Franco Tagliaro, Giampiero Girolomoni, Marco A. Cassatella, Patrizia Scapini

Front Immunol. 2022; 13: 1049079. Published online 2022 Nov 15. doi: 10.3389/fimmu.2022.1049079

PMCID:: PMC9709482

Abstract Article PDF–11M

Select item 962508215.

TREM2 Drives Microglia Response to Amyloid-β via SYK-dependent and -independent Paths

Shoutang Wang, Raki Sudan, Vincent Peng, Yingyue Zhou, Siling Du, Carla M. Yuede, Tingting Lei, Jinchao Hou, Zhangying Cai, Marina Cella, Khai Nguyen, Pietro L. Poliani, Wandy L. Beatty, Yun Chen, Siyan Cao, Kent Lin, Cecilia Rodrigues, Ali H. Ellebedy, Susan Gilfillan, Gordon D. Brown, David M. Holtzman, Simone Brioschi, Marco Colonna

Cell. Author manuscript; available in PMC 2023 Oct 27.

Published in final edited form as: Cell. 2022 Oct 27; 185(22): 4153–4169.e19. doi: 10.1016/j.cell.2022.09.033

PMCID:: PMC9625082

Abstract Article PDF–4.1M

Select item 961778416.

SYK coordinates neuroprotective microglial responses in neurodegenerative disease

Hannah Ennerfelt, Elizabeth L. Frost, Daniel A. Shapiro, Coco Holliday, Kristine E. Zengeler, Gabrielle Voithofer, Ashley C. Bolte, Catherine R. Lammert, Joshua A. Kulas, Tyler K. Ulland, John R. Lukens

Cell. Author manuscript; available in PMC 2022 Oct 30.

Published in final edited form as: Cell. 2022 Oct 27; 185(22): 4135–4152.e22. Published online 2022 Oct 17. doi: 10.1016/j.cell.2022.09.030

PMCID:: PMC9617784

Abstract Article PDF–3.8M

Select item 928714817.

Phosphorylation on Syk Y342 is important for both ITAM and hemITAM signaling in platelets

John C. Kostyak, Benjamin Mauri, Carol Dangelmaier, Hymavathi Reddy Vari, Akruti Patel, Monica Wright, Haritha Reddy, Alexander Y. Tsygankov, Satya P. Kunapuli

J Biol Chem. 2022 Aug; 298(8): 102189. Published online 2022 Jun 24. doi: 10.1016/j.jbc.2022.102189

PMCID:: PMC9287148

Abstract Article PDF–1.8M

Select item 900691218.

Syk Facilitates Influenza A Virus Replication by Restraining Innate Immunity at the Late Stage of Viral Infection

Yingying Li, Shasha Liu, Yuhai Chen, Biao Chen, Meng Xiao, Bincai Yang, Kul Raj Rai, Mohamed Maarouf, Guijie Guo, Ji-Long Chen

J Virol. 2022 Apr; 96(7): e00200-22. Published online 2022 Mar 16. doi: 10.1128/jvi.00200-22

PMCID:: PMC9006912

Abstract Article PDF–4.6M

Select item 873319919.

Syk-MyD88 Axis Is a Critical Determinant of Inflammatory-Response in Activated Macrophages

Young-Su Yi, Han Gyung Kim, Ji Hye Kim, Woo Seok Yang, Eunji Kim, Deok Jeong, Jae Gwang Park, Nur Aziz, Suk Kim, Narayanan Parameswaran, Jae Youl Cho

Front Immunol. 2021; 12: 767366. Published online 2021 Dec 23. doi: 10.3389/fimmu.2021.767366

PMCID:: PMC8733199

Abstract Article PDF–6.0M

Select item 870517320.

Spleen tyrosine kinase facilitates neutrophil activation and worsens long-term neurologic deficits after spinal cord injury

Dylan A. McCreedy, Clare L. Abram, Yongmei Hu, Sun Won Min, Madison E. Platt, Megan A. Kirchhoff, Shelby K. Reid, Frank L. Jalufka, Clifford A. Lowell

J Neuroinflammation. 2021; 18: 302. Published online 2021 Dec 24. doi: 10.1186/s12974-021-02353-2

PMCID:: PMC8705173

Abstract Article PDF–4.3M

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