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Select item 71257431.

Insulin Degrading Enzyme Is a Cellular Receptor Mediating Varicella-Zoster Virus Infection and Cell-to-Cell Spread

Qingxue Li, Mir A. Ali, Jeffrey I. Cohen

Cell. 2006 Oct 20; 127(2): 305–316. Published online 2006 Oct 19. doi: 10.1016/j.cell.2006.08.046

PMCID:: PMC7125743

Abstract Article PDF–897K

Select item 67729182.

Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme

Konstantinos Vekrellis, Zhen Ye, Wei Qiao Qiu, Dominic Walsh, Dean Hartley, Valérie Chesneau, Marsha Rich Rosner, Dennis J. Selkoe

J Neurosci. 2000 Mar 1; 20(5): 1657–1665. doi: 10.1523/JNEUROSCI.20-05-01657.2000

PMCID:: PMC6772918

Abstract Article PDF–257K

Select item 67302643.

Insulin-Degrading Enzyme as a Downstream Target of Insulin Receptor Signaling Cascade: Implications for Alzheimer's Disease Intervention

Lixia Zhao, Bruce Teter, Takashi Morihara, Giselle P. Lim, Surendra S. Ambegaokar, Oliver J. Ubeda, Sally A. Frautschy, Greg M. Cole

J Neurosci. 2004 Dec 8; 24(49): 11120–11126. doi: 10.1523/JNEUROSCI.2860-04.2004

PMCID:: PMC6730264

Abstract Article PDF–294K

Select item 62807954.

FMRP recruitment of β‐catenin to the translation pre‐initiation complex represses translation

Saviz Ehyai, Tetsuaki Miyake, Declan Williams, Jyotsna Vinayak, Mark A Bayfield, John C McDermott

EMBO Rep. 2018 Dec; 19(12): e45536. Published online 2018 Oct 25. doi: 10.15252/embr.201745536

PMCID:: PMC6280795

Abstract Article PDF–3.4M

Select item 60437195.

GLP-1 receptor regulates cell growth through regulating IDE expression level in Aβ1–42-treated PC12 cells

Huajie Li, Liping Cao, Yi Ren, Ying Jiang, Wei Xie, Dawen Li

Biosci Rep. 2018 Aug 31; 38(4): BSR20171284. Prepublished online 2017 Dec 20. Published online 2018 Jul 13. doi: 10.1042/BSR20171284

PMCID:: PMC6043719

Abstract Article PDF–940K

Select item 54363666.

Neuroprotective mechanism of Kai Xin San: upregulation of hippocampal insulin-degrading enzyme protein expression and acceleration of amyloid-beta degradation

Na Wang, Yong-ming Jia, Bo Zhang, Di Xue, Maharjan Reeju, Yan Li, Shu-ming Huang, Xue-wei Liu

Neural Regen Res. 2017 Apr; 12(4): 654–659. doi: 10.4103/1673-5374.205107

PMCID:: PMC5436366

Abstract Article PDF–828K

Select item 54289247.

Pioglitazone ameliorates Aβ42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3β activation

Sisi Yang, Zhe Chen, Ming Cao, Renjie Li, Zhigang Wang, Muxun Zhang

Mol Med Rep. 2017 May; 15(5): 2588–2594. Published online 2017 Mar 16. doi: 10.3892/mmr.2017.6342

PMCID:: PMC5428924

Abstract Article PDF–888K

Select item 48545588.

Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease

Sung Min Son, Moon-Yong Cha, Heesun Choi, Seokjo Kang, Hyunjung Choi, Myung-Shik Lee, Sun Ah Park, Inhee Mook-Jung

Autophagy. 2016 May; 12(5): 784–800. Published online 2016 Mar 10. doi: 10.1080/15548627.2016.1159375

PMCID:: PMC4854558

Abstract Article PDF–1.5M

Select item 46303889.

Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats

Doaa A. Ghareeb, Sofia Khalil, Hani S. Hafez, Jürgen Bajorath, Hany E. A. Ahmed, Eman Sarhan, Eiman Elwakeel, Maha A. El-Demellawy

Evid Based Complement Alternat Med. 2015; 2015: 361847. Published online 2015 Oct 20. doi: 10.1155/2015/361847

PMCID:: PMC4630388

Abstract Article PDF–1.7M

Select item 420085210.

Metabolism of Cryptic Peptides Derived from Neuropeptide FF Precursors: The Involvement of Insulin-Degrading Enzyme

Giuseppe Grasso, Przemyslaw Mielczarek, Magdalena Niedziolka, Jerzy Silberring

Int J Mol Sci. 2014 Sep; 15(9): 16787–16799. Published online 2014 Sep 22. doi: 10.3390/ijms150916787

PMCID:: PMC4200852

Abstract Article PDF–1.2M

Select item 414221311.

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

Juan Pablo Maianti, Amanda McFedries, Zachariah H. Foda, Ralph E. Kleiner, Xiu Quan Du, Malcolm A. Leissring, Wei-Jen Tang, Maureen J. Charron, Markus A. Seeliger, Alan Saghatelian, David R. Liu

Nature. Author manuscript; available in PMC 2015 Jan 3.

Published in final edited form as: Nature. 2014 Jul 3; 511(7507): 94–98. Published online 2014 May 21. doi: 10.1038/nature13297

PMCID:: PMC4142213

Abstract Article PDF–4.5M

Select item 367911312.

Genetic Associations of Type 2 Diabetes with Islet Amyloid Polypeptide Processing and Degrading Pathways in Asian Populations

Vincent Kwok Lim Lam, Ronald Ching Wan Ma, Heung Man Lee, Cheng Hu, Kyong Soo Park, Hiroto Furuta, Ying Wang, Claudia Ha Ting Tam, Xueling Sim, Daniel Peng-Keat Ng, Jianjun Liu, Tien-Yin Wong, E. Shyong Tai, Andrew P. Morris, DIAGRAM Consortium, Nelson Leung Sang Tang, Jean Woo, Ping Chung Leung, Alice Pik Shan Kong, Risa Ozaki, Wei Ping Jia, Hong Kyu Lee, Kishio Nanjo, Gang Xu, Maggie Chor Yin Ng, Wing-Yee So, Juliana Chung Ngor Chan

PLoS One. 2013; 8(6): e62378. Published online 2013 Jun 11. doi: 10.1371/journal.pone.0062378

PMCID:: PMC3679113

Abstract Article PDF–445K

Select item 364233513.

Transcriptional Regulation of Insulin-degrading Enzyme Modulates Mitochondrial Amyloid β (Aβ) Peptide Catabolism and Functionality

María C. Leal, Natalia Magnani, Sergio Villordo, Cristina Marino Buslje, Pablo Evelson, Eduardo M. Castaño, Laura Morelli

J Biol Chem. 2013 May 3; 288(18): 12920–12931. Published online 2013 Mar 22. doi: 10.1074/jbc.M112.424820

PMCID:: PMC3642335

Abstract Article PDF–2.7M

Select item 362390514.

Proteolytically Inactive Insulin-Degrading Enzyme Inhibits Amyloid Formation Yielding Non-Neurotoxic Aβ Peptide Aggregates

Matias B. de Tullio, Valeria Castelletto, Ian W. Hamley, Pamela V. Martino Adami, Laura Morelli, Eduardo M. Castaño

PLoS One. 2013; 8(4): e59113. Published online 2013 Apr 11. doi: 10.1371/journal.pone.0059113

PMCID:: PMC3623905

Abstract Article PDF–2.9M

Select item 359281315.

Ginsenoside Rg1 Decreases Aβ_1–42 Level by Upregulating PPARγ and IDE Expression in the Hippocampus of a Rat Model of Alzheimer's Disease

QianKun Quan, Jue Wang, Xi Li, Yi Wang

PLoS One. 2013; 8(3): e59155. Published online 2013 Mar 8. doi: 10.1371/journal.pone.0059155

PMCID:: PMC3592813

Abstract Article PDF–856K

Select item 347191816.

Cysteine 904 Is Required for Maximal Insulin Degrading Enzyme Activity and Polyanion Activation

Eun Suk Song, Manana Melikishvili, Michael G. Fried, Maria A. Juliano, Luiz Juliano, David W. Rodgers, Louis B. Hersh

PLoS One. 2012; 7(10): e46790. Published online 2012 Oct 15. doi: 10.1371/journal.pone.0046790

PMCID:: PMC3471918

Abstract Article PDF–425K

Select item 344340917.

Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis

Chan-Hyun Na, Drew R. Jones, Yanling Yang, Xusheng Wang, Yanji Xu, Junmin Peng

J Proteome Res. Author manuscript; available in PMC 2013 Sep 7.

Published in final edited form as: J Proteome Res. 2012 Sep 7; 11(9): 4722–4732. Published online 2012 Aug 15. doi: 10.1021/pr300536k

PMCID:: PMC3443409

Abstract Article PDF–4.2M

Select item 336650918.

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

Yuequan Shen, Andrzej Joachimiak, Marsha Rich Rosner, Wei-Jen Tang

Nature. Author manuscript; available in PMC 2012 Jun 4.

Published in final edited form as: Nature. 2006 Oct 19; 443(7113): 870–874. Published online 2006 Oct 11. doi: 10.1038/nature05143

PMCID:: PMC3366509

Abstract Article PDF–4.1M

Select item 331797519.

Somatostatin Modulates Insulin-Degrading-Enzyme Metabolism: Implications for the Regulation of Microglia Activity in AD

Grazia Tundo, Chiara Ciaccio, Diego Sbardella, Mariaserena Boraso, Barbara Viviani, Massimiliano Coletta, Stefano Marini

PLoS One. 2012; 7(4): e34376. Published online 2012 Apr 3. doi: 10.1371/journal.pone.0034376

PMCID:: PMC3317975

Abstract Article PDF–333K

Select item 324910120.

Anion Activation Site of Insulin-degrading Enzyme

Nicholas Noinaj, Eun Suk Song, Sonia Bhasin, Benjamin J. Alper, Walter K. Schmidt, Louis B. Hersh, David W. Rodgers

J Biol Chem. 2012 Jan 2; 287(1): 48–57. Published online 2011 Nov 2. doi: 10.1074/jbc.M111.264614

PMCID:: PMC3249101

Abstract Article PDF–2.8M

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