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Select item 111370781.

Conditional disruption of Nr5a1 directed by Sox9-Cre impairs adrenal development

Ayako Tagami, Yayoi Ikeda, Kyoko Ishizuka, Mamiko Maekawa

Sci Rep. 2024; 14: 12297. Published online 2024 May 29. doi: 10.1038/s41598-024-63264-9

PMCID:: PMC11137078

Abstract Article PDF–9.6M

Select item 107535872.

Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis

Sirine Souali-Crespo, Diana Condrea, Nadège Vernet, Betty Féret, Muriel Klopfenstein, Erwan Grandgirard, Violaine Alunni, Marie Cerciat, Matthieu Jung, Chloé Mayere, Serge Nef, Manuel Mark, Frédéric Chalmel, Norbert B. Ghyselinck

Development. 2023 Dec 15; 150(24): dev201710. Published online 2023 Dec 11. doi: 10.1242/dev.201710

PMCID:: PMC10753587

Abstract Article

Select item 104107173.

Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve

Camilla H. K. Hughes, Olivia E. Smith, Marie-Charlotte Meinsohn, Mylène Brunelle, Nicolas Gévry, Bruce D. Murphy

Proc Natl Acad Sci U S A. 2023 Aug 8; 120(32): e2220849120. Published online 2023 Jul 26. doi: 10.1073/pnas.2220849120

PMCID:: PMC10410717

Abstract Article PDF–3.9M

Select item 101939374.

CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice

Naoki Okashita, Ryo Maeda, Makoto Tachibana

Proc Natl Acad Sci U S A. 2023 May 16; 120(20): e2221499120. Published online 2023 May 8. doi: 10.1073/pnas.2221499120

PMCID:: PMC10193937

Abstract Article PDF–1.9M

Select item 101128985.

Biased precursor ingression underlies the center-to-pole pattern of male sex determination in mouse

Corey Bunce, Lindsey Barske, Gloria Zhang, Blanche Capel

Development. 2023 Mar 1; 150(5): dev201060. Published online 2023 Mar 13. doi: 10.1242/dev.201060

PMCID:: PMC10112898

Abstract Article

Select item 100685566.

Steroidogenic factor 1 protects mice from obesity-induced glucose intolerance via improving glucose-stimulated insulin secretion by beta cells

Yan Guo, Liehua Liu, Yanglei Cheng, Hai Li, Xuesi Wan, Jiajing Ma, Juan Liu, Weiwei Liang, Pengyuan Zhang, Jie Chen, Xiaopei Cao, Hongyu Guan, Haipeng Xiao, Yanbing Li

iScience. 2023 Apr 21; 26(4): 106451. Published online 2023 Mar 20. doi: 10.1016/j.isci.2023.106451

PMCID:: PMC10068556

Abstract Article PDF–7.2M

Select item 100177037.

Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions

Xiaowei Gu, Anna Heinrich, Shu-Yun Li, Tony DeFalco

Nat Commun. 2023; 14: 1439. Published online 2023 Mar 15. doi: 10.1038/s41467-023-37199-0

PMCID:: PMC10017703

Abstract Article PDF–16M

Select item 98202288.

Intronic Enhancer Is Essential for Nr5a1 Expression in the Pituitary Gonadotrope and for Postnatal Development of Male Reproductive Organs in a Mouse Model

Yuichi Shima, Kanako Miyabayashi, Takami Mori, Koji Ono, Mizuki Kajimoto, Hae Lim Cho, Hitomi Tsuchida, Yoshihisa Uenoyama, Hiroko Tsukamura, Kentaro Suzuki, Man Ho Choi, Kazunori Toida

Int J Mol Sci. 2023 Jan; 24(1): 192. Published online 2022 Dec 22. doi: 10.3390/ijms24010192

PMCID:: PMC9820228

Abstract Article PDF–8.2M

Select item 97615719.

Steroidogenic Factor 1 Regulates Transcription of the Inhibin B Coreceptor in Pituitary Gonadotrope Cells

Yeu-Farn Lin, Gauthier Schang, Evan R S Buddle, Hailey Schultz, Thea L Willis, Frederique Ruf-Zamojski, Michel Zamojski, Natalia Mendelev, Ulrich Boehm, Stuart C Sealfon, Cynthia L Andoniadou, Daniel J Bernard

Endocrinology. 2022 Nov; 163(11): bqac131. Published online 2022 Aug 12. doi: 10.1210/endocr/bqac131

PMCID:: PMC9761571

Abstract Article

Select item 965531310.

Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate

Nour Abou Nader, Amélie Ménard, Adrien Levasseur, Guillaume St-Jean, Derek Boerboom, Gustavo Zamberlam, Alexandre Boyer

Int J Mol Sci. 2022 Nov; 23(21): 13585. Published online 2022 Nov 5. doi: 10.3390/ijms232113585

PMCID:: PMC9655313

Abstract Article PDF–4.1M

Select item 920030711.

Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice

Alejo Torres-Cano, Rosa Portella-Fortuny, Claudia Müller-Sánchez, Sonia Porras-Marfil, Marina Ramiro-Pareta, You-Ying Chau, Manuel Reina, Francesc X. Soriano, Ofelia M. Martínez-Estrada

PLoS Genet. 2022 Jun; 18(6): e1010240. Published online 2022 Jun 15. doi: 10.1371/journal.pgen.1010240

PMCID:: PMC9200307

Abstract Article PDF–4.3M

Select item 897482912.

Steroidogenic Factor 1 Regulation of the Hypothalamic-Pituitary-Ovarian Axis of Adult Female Mice

Olivia E Smith, Vickie Roussel, Fanny Morin, Luisina Ongaro, Xiang Zhou, Micka C Bertucci, Daniel J Bernard, Bruce D Murphy

Endocrinology. 2022 Apr; 163(4): bqac028. Published online 2022 Mar 5. doi: 10.1210/endocr/bqac028

PMCID:: PMC8974829

Abstract Article

Select item 884375313.

Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse

Vijay K. Yadav, Julian M. Berger, Parminder Singh, Perumal Nagarajan, Gerard Karsenty

J Clin Invest. 2022 Feb 15; 132(4): e153752. Published online 2022 Feb 15. doi: 10.1172/JCI153752

PMCID:: PMC8843753

Abstract Article PDF–4.9M

Select item 880618614.

Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes

Hui Yu, Marcelo Rubinstein, Malcolm J Low

eLife. 2022; 11: e72883. Published online 2022 Jan 19. doi: 10.7554/eLife.72883

PMCID:: PMC8806186

Abstract Article PDF–26M

Select item 878692915.

Loss of NEDD4 causes complete XY gonadal sex reversal in mice

Simon P. Windley, Chloé Mayère, Alice E. McGovern, Natasha L. Harvey, Serge Nef, Quenten Schwarz, Sharad Kumar, Dagmar Wilhelm

Cell Death Dis. 2022 Jan; 13(1): 75. Published online 2022 Jan 24. doi: 10.1038/s41419-022-04519-z

PMCID:: PMC8786929

Abstract Article PDF–16M

Select item 868252016.

Loss of CREB Coactivator CRTC1 in SF1 Cells Leads to Hyperphagia and Obesity by High-fat Diet But Not Normal Chow Diet

Shigenobu Matsumura, Fuka Ishikawa, Tsutomu Sasaki, Mike Krogh Terkelsen, Kim Ravnskjaer, Tomoki Jinno, Jin Tanaka, Tsuyoshi Goto, Kazuo Inoue

Endocrinology. 2021 Sep; 162(9): bqab076. Published online 2021 Apr 12. doi: 10.1210/endocr/bqab076

PMCID:: PMC8682520

Abstract Article

Select item 851165917.

Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis^†

Shu-Yun Li, Xiaowei Gu, Anna Heinrich, Emily G Hurley, Blanche Capel, Tony DeFalco

Biol Reprod. 2021 Oct; 105(4): 958–975. Published online 2021 May 18. doi: 10.1093/biolre/ioab098

PMCID:: PMC8511659

Abstract Article PDF–2.6M

Select item 846459518.

Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1

Qiong Zhang, Lei Zhang, Ying Huang, Pengcheng Ma, Bingyu Mao, Yu-Qiang Ding, Ning-Ning Song

Cell Death Dis. 2021 Oct; 12(10): 879. Published online 2021 Sep 25. doi: 10.1038/s41419-021-04175-9

PMCID:: PMC8464595

Abstract Article PDF–5.6M

Select item 829986619.

Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility and metabolic homeostasis in female mice

Emmi Rotgers, Barbara Nicol, Karina Rodriguez, Saniya Rattan, Jodi A. Flaws, Humphrey Hung-Chang Yao

FASEB J. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: FASEB J. 2021 Aug; 35(8): e21770. doi: 10.1096/fj.202100304R

PMCID:: PMC8299866

Abstract Article PDF–2.6M

Select item 804714220.

A Highly Conserved Shh Enhancer Coordinates Hypothalamic and Craniofacial Development

Zoe Crane-Smith, Jeffrey Schoenebeck, Katy A. Graham, Paul S. Devenney, Lorraine Rose, Mark Ditzell, Eve Anderson, Joseph I. Thomson, Natasha Klenin, Deborah M. Kurrasch, Laura A. Lettice, Robert E. Hill

Front Cell Dev Biol. 2021; 9: 595744. Published online 2021 Apr 1. doi: 10.3389/fcell.2021.595744