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Items: 1 to 20 of 276

1.
Itaconate is a metabolic regulator of bone formation in homeostasis and arthritis
Markus Kieler, Leona Sophia Prammer, Gerwin Heller, Melanie Hofmann, Simon Sperger, Dominik Hanetseder, Birgit Niederreiter, Andrea Komljenovic, Kristaps Klavins, Thomas Köcher, Julia Stefanie Brunner, Irena Stanic, Laura Oberbichler, Ana Korosec, Andrea Vogel, Martina Kerndl, Dominika Hromadová, Laszlo Musiejovsky, Alexander Hajto, Anja Dobrijevic, Tina Piwonka, Arvand Haschemi, Anne Miller, Philippe Georgel, Darja Marolt Presen, Johannes Grillari, Silvia Hayer, Jean-Philippe Auger, Gerhard Krönke, Omar Sharif, Daniel Aletaha, Gernot Schabbauer, Stephan Blüml
Ann Rheum Dis. 2024 Jul; 83(11): e224898. Published online 2024 Jul 10. doi: 10.1136/ard-2023-224898
PMCID:
PMC11503170
AbstractArticlePDF–6.6M
2.
Batf3+ DCs and the 4–1BB/4–1BBL axis are required at the effector phase in the tumor microenvironment for PD-1/PD-L1 blockade efficacy
Andrea Ziblat, Brendan L. Horton, Emily F. Higgs, Ken Hatogai, Anna Martinez, Jason W. Shapiro, Danny E.C. Kim, YuanYuan Zha, Randy F. Sweis, Thomas F. Gajewski
Cell Rep. Author manuscript; available in PMC 2024 Jul 8.
Published in final edited form as: Cell Rep. 2024 May 28; 43(5): 114141. Published online 2024 Apr 23. doi: 10.1016/j.celrep.2024.114141
PMCID:
PMC11229087
AbstractArticlePDF–3.0M
3.
A synthetic cationic helical polypeptide as a multipotent innate immune activator for cancer immunotherapy
DaeYong Lee, Kristin Huntoon, Yifan Wang, Minjeong Kang, Yifei Lu, Seong Dong Jeong, Todd M. Link, Thomas D. Gallup, Yaqing Qie, Xuefeng Li, Yifan Ma, Shiyan Dong, Benjamin R. Schrank, Adam Grippin, Abin Antony, Jonghoon Ha, Mengyu Chang, Yi An, Liang Wang, Dadi Jiang, Jing Li, Albert C. Koong, John A. Tainer, Wen Jiang, Betty Y.S. Kim
Nat Biomed Eng. Author manuscript; available in PMC 2024 Jun 9.
Published in final edited form as: Nat Biomed Eng. 2024 May; 8(5): 593–610. Published online 2024 Apr 19. doi: 10.1038/s41551-024-01194-7
PMCID:
PMC11162332
AbstractArticlePDF–7.0M
4.
Mast cells help organize the Peyer’s patch niche for induction of IgA resonses
Marco De Giovanni, Vivasvan S. Vykunta, Adi Biram, Kevin Y. Chen, Hanna Taglinao, Jinping An, Dean Sheppard, Helena Paidassi, Jason G. Cyster
Sci Immunol. Author manuscript; available in PMC 2024 Apr 11.
Published in final edited form as: Sci Immunol. 2024 Mar; 9(93): eadj7363. Published online 2024 Mar 1. doi: 10.1126/sciimmunol.adj7363
PMCID:
PMC11008922
AbstractArticlePDF–2.4M
5.
Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity
Ellen Duong, Tim B. Fessenden, Emi Lutz, Teresa Dinter, Leon Yim, Sarah Blatt, Arjun Bhutkar, Karl Dane Wittrup, Stefani Spranger
Immunity. Author manuscript; available in PMC 2024 Jan 30.
Published in final edited form as: Immunity. 2022 Feb 8; 55(2): 308–323.e9. Published online 2021 Nov 19. doi: 10.1016/j.immuni.2021.10.020
PMCID:
PMC10827482
AbstractArticlePDF–2.4M
6.
The gut microbiota reprograms intestinal lipid metabolism through long non-coding RNA Snhg9
Yuhao Wang, Meng Wang, Jiaxin Chen, Yun Li, Zheng Kuang, Chaitanya Dende, Prithvi Raj, Gabriella Quinn, Zehan Hu, Tarun Srinivasan, Brian Hassell, Kelly Ruhn, Cassie L. Behrendt, Tingbo Liang, Xiaobing Dou, Zhangfa Song, Lora V. Hooper
Science. Author manuscript; available in PMC 2023 Nov 30.
Published in final edited form as: Science. 2023 Aug 25; 381(6660): 851–857. Published online 2023 Aug 24. doi: 10.1126/science.ade0522
PMCID:
PMC10688608
AbstractArticlePDF–1.7M
7.
Parabiosis reveals the correlation between the recruitment of circulating antigen presenting cells to the retina and the induction of spontaneous autoimmune uveoretinitis
Scott W. McPherson, Neal D. Heuss, Md. Abedin, Heidi Roehrich, Mark J. Pierson, Dale S. Gregerson
J Neuroinflammation. 2022; 19: 295. Published online 2022 Dec 9. doi: 10.1186/s12974-022-02660-2
PMCID:
PMC9733026
AbstractArticlePDF–3.5M
8.
Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice
Alexandre G. Maganin, Guilherme R. Souza, Miriam D. Fonseca, Alexandre H. Lopes, Rafaela M. Guimarães, André Dagostin, Nerry T. Cecilio, Atlante S. Mendes, William A. Gonçalves, Conceição E.A. Silva, Francisco Isaac Fernandes Gomes, Lucas M. Mauriz Marques, Rangel L. Silva, Letícia M. Arruda, Denis A. Santana, Henrique Lemos, Lei Huang, Marcela Davoli-Ferreira, Danielle Santana-Coelho, Morena B. Sant’Anna, Ricardo Kusuda, Jhimmy Talbot, Gabriela Pacholczyk, Gabriela A. Buqui, Norberto P. Lopes, Jose C. Alves-Filho, Ricardo M. Leão, Jason C. O’Connor, Fernando Q. Cunha, Andrew Mellor, Thiago M. Cunha
J Clin Invest. 2022 Dec 1; 132(23): e153805. Published online 2022 Dec 1. doi: 10.1172/JCI153805
PMCID:
PMC9711882
AbstractArticlePDF–12M
9.
Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
Jessica K. Mandula, Shiun Chang, Eslam Mohamed, Rachel Jimenez, Rosa A. Sierra-Mondragon, Darwin C. Chang, Alyssa N. Obermayer, Carlos M. Moran-Segura, Satyajit Das, Julio A. Vazquez-Martinez, Karol Prieto, Ann Chen, Keiran S.M. Smalley, Brian Czerniecki, Peter Forsyth, Richard C. Koya, Brian Ruffell, Juan R. Cubillos-Ruiz, David H. Munn, Timothy I. Shaw, Jose R. Conejo-Garcia, Paulo C. Rodriguez
Cancer Cell. Author manuscript; available in PMC 2023 Oct 10.
Published in final edited form as: Cancer Cell. 2022 Oct 10; 40(10): 1145–1160.e9. Published online 2022 Sep 22. doi: 10.1016/j.ccell.2022.08.016
PMCID:
PMC9561067
AbstractArticlePDF–1.7M
10.
Identification of Adipose Tissue as a Reservoir of Macrophages after Acute Myocardial Infarction
Ingrid Gomez, Virginie Robert, Paul Alayrac, Adèle Arlat, Vincent Duval, Marie-Laure Renoud, José Vilar, Mathilde Lemitre, Jean-Sébastien Silvestre, Béatrice Cousin
Int J Mol Sci. 2022 Sep; 23(18): 10498. Published online 2022 Sep 10. doi: 10.3390/ijms231810498
PMCID:
PMC9499676
AbstractArticlePDF–3.0M
11.
Indoleamine 2,3-dioxygenase 1 is Essential for Sustaining Durable Antibody Responses
Shivana M. Lightman, Jennifer L. Peresie, Louise M. Carlson, G. Aaron Holling, Mackenzie M. Honikel, Colin A. Chavel, Michael J Nemeth, Scott H. Olejniczak, Kelvin P. Lee
Immunity. Author manuscript; available in PMC 2022 Dec 14.
Published in final edited form as: Immunity. 2021 Dec 14; 54(12): 2772–2783.e5. Published online 2021 Nov 16. doi: 10.1016/j.immuni.2021.10.005
PMCID:
PMC9323746
AbstractArticlePDF–2.2M
12.
T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling
Shu Shien Chin, Erik Guillen, Laurent Chorro, Sooraj Achar, Karina Ng, Susanne Oberle, Francesca Alfei, Dietmar Zehn, Grégoire Altan-Bonnet, Fabien Delahaye, Grégoire Lauvau
Nat Commun. 2022; 13: 2240. Published online 2022 Apr 26. doi: 10.1038/s41467-022-29718-2
PMCID:
PMC9042912
AbstractArticlePDF–2.9M
13.
Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers
Wenzhi Song, Olivia Q. Antao, Emily Condiff, Gina M. Sanchez, Irene Chernova, Krzysztof Zembrzuski, Holly Steach, Kira Rubtsova, Davide Angeletti, Alexander Lemenze, Brian J. Laidlaw, Joe Craft, Jason S. Weinstein
Immunity. Author manuscript; available in PMC 2022 Mar 30.
Published in final edited form as: Immunity. 2022 Feb 8; 55(2): 290–307.e5. Published online 2022 Jan 31. doi: 10.1016/j.immuni.2022.01.002
PMCID:
PMC8965751
AbstractArticlePDF–2.8M
14.
An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity
Francesco Borriello, Valentina Poli, Ellen Shrock, Roberto Spreafico, Xin Liu, Novalia Pishesha, Claire Carpenet, Janet Chou, Marco Di Gioia, Marisa E. McGrath, Carly A. Dillen, Nora A. Barrett, Lucrezia Lacanfora, Marcella E. Franco, Laura Marongiu, Yoichiro Iwakura, Ferdinando Pucci, Michael D. Kruppa, Zuchao Ma, Douglas W. Lowman, Harry E. Ensley, Etsuro Nanishi, Yoshine Saito, Timothy R. O’Meara, Hyuk-Soo Seo, Sirano Dhe-Paganon, David J. Dowling, Matthew Frieman, Stephen J. Elledge, Ofer Levy, Darrell J. Irvine, Hidde L. Ploegh, David L. Wiliams, Ivan Zanoni
Cell. Author manuscript; available in PMC 2023 Feb 17.
Published in final edited form as: Cell. 2022 Feb 17; 185(4): 614–629.e21. Published online 2022 Feb 10. doi: 10.1016/j.cell.2022.01.009
PMCID:
PMC8857056
AbstractArticlePDF–2.1M
15.
Apolipoprotein E derived from CD11c+ cells ameliorates atherosclerosis
Manuela Sauter, Reinhard J. Sauter, Henry Nording, Chaolan Lin, Marcus Olbrich, Stella Autenrieth, Christian Gleissner, Martin Thunemann, Nadia Otero, Esther Lutgens, Zouhair Aherrahrou, Dennis Wolf, Lars Zender, Sven Meuth, Robert Feil, Harald F. Langer
iScience. 2022 Jan 21; 25(1): 103677. Published online 2021 Dec 25. doi: 10.1016/j.isci.2021.103677
PMCID:
PMC8749187
AbstractArticlePDF–2.8M
16.
Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria
Mitchell N. Lefebvre, Fionna A. Surette, Scott M. Anthony, Rahul Vijay, Isaac J. Jensen, Lecia L. Pewe, Lisa S. Hancox, Natalija Van Braeckel-Budimir, Stephanie van de Wall, Stina L. Urban, Madison R. Mix, Samarchith P. Kurup, Vladimir P. Badovinac, Noah S. Butler, John T. Harty
Cell Rep. Author manuscript; available in PMC 2021 Nov 29.
Published in final edited form as: Cell Rep. 2021 Nov 2; 37(5): 109956. doi: 10.1016/j.celrep.2021.109956
PMCID:
PMC8628427
AbstractArticlePDF–1.3M
17.
Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF
Annika Hausmann, Boas Felmy, Leo Kunz, Sanne Kroon, Dorothée Lisa Berthold, Giverny Ganz, Ioana Sandu, Toshihiro Nakamura, Nathan Sébastien Zangger, Yang Zhang, Tamas Dolowschiak, Stefan Alexander Fattinger, Markus Furter, Anna Angelika Müller-Hauser, Manja Barthel, Katerina Vlantis, Laurens Wachsmuth, Jan Kisielow, Luigi Tortola, Danijela Heide, Mathias Heikenwälder, Annette Oxenius, Manfred Kopf, Timm Schroeder, Manolis Pasparakis, Mikael Erik Sellin, Wolf-Dietrich Hardt
J Exp Med. 2021 Nov 1; 218(11): e20210862. Published online 2021 Sep 16. doi: 10.1084/jem.20210862
PMCID:
PMC8480669
AbstractArticlePDF–7.9M
18.
Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming
Giorgia De Simone, Francesco Andreata, Camille Bleriot, Valeria Fumagalli, Chiara Laura, José M. Garcia-Manteiga, Pietro Di Lucia, Stefano Gilotto, Xenia Ficht, Federico F. De Ponti, Elisa B. Bono, Leonardo Giustini, Gioia Ambrosi, Marta Mainetti, Paola Zordan, Alexandre P. Bénéchet, Micol Ravà, Svetoslav Chakarov, Federica Moalli, Marc Bajenoff, Luca G. Guidotti, Florent Ginhoux, Matteo Iannacone
Immunity. 2021 Sep 14; 54(9): 2089–2100.e8. doi: 10.1016/j.immuni.2021.05.005
PMCID:
PMC8459394
AbstractArticle
19.
A mechanism of cooling hot tumors: Lactate attenuates inflammation in dendritic cells
Hisashi Kanemaru, Yukari Mizukami, Akira Kaneko, Hidemi Tagawa, Toshihiro Kimura, Haruka Kuriyama, Soichiro Sawamura, Ikko Kajihara, Katsunari Makino, Azusa Miyashita, Jun Aoi, Takamitsu Makino, Shinichi Masuguchi, Satoshi Fukushima, Hironobu Ihn
iScience. 2021 Sep 24; 24(9): 103067. Published online 2021 Aug 30. doi: 10.1016/j.isci.2021.103067
PMCID:
PMC8441070
AbstractArticlePDF–3.8M
20.
MERTK on mononuclear phagocytes regulates T cell antigen recognition at autoimmune and tumor sites
Robin S. Lindsay, Jennifer C. Whitesell, Kristen E. Dew, Erika Rodriguez, Adam M. Sandor, Dayna Tracy, Seth F. Yannacone, Brittany N. Basta, Jordan Jacobelli, Rachel S. Friedman
J Exp Med. 2021 Oct 4; 218(10): e20200464. Published online 2021 Aug 20. doi: 10.1084/jem.20200464
PMCID:
PMC8383814
AbstractArticlePDF–5.3M

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