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Select item 84101091.

The inflammatory role of dysregulated IRS2 in pulmonary vascular remodeling under hypoxic conditions

Mayumi Nakahara, Homare Ito, John T. Skinner, Qing Lin, Rasa Tamosiuniene, Mark R. Nicolls, Achsah D. Keegan, Roger A. Johns, Kazuyo Yamaji-Kegan

Am J Physiol Lung Cell Mol Physiol. 2021 Aug 1; 321(2): L416–L428. Published online 2021 Jun 30. doi: 10.1152/ajplung.00068.2020

PMCID:: PMC8410109

Abstract Article

Select item 74501352.

Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats

Yuka Toyoshima, Katsuyuki Nakamura, Reiko Tokita, Naomi Teramoto, Hidetoshi Sugihara, Hisanori Kato, Keitaro Yamanouchi, Shiro Minami

J Biol Chem. 2020 Aug 14; 295(33): 11914–11927. Published online 2020 Jul 6. doi: 10.1074/jbc.RA120.013095

PMCID:: PMC7450135

Abstract Article PDF–2.8M

Select item 67406723.

Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation

Markus Schubert, Derek P. Brazil, Deborah J. Burks, Jake A. Kushner, Jing Ye, Carrie L. Flint, Janet Farhang-Fallah, Pieter Dikkes, Xavier M. Warot, Carlos Rio, Gabriel Corfas, Morris F. White

J Neurosci. 2003 Aug 6; 23(18): 7084–7092. doi: 10.1523/JNEUROSCI.23-18-07084.2003

PMCID:: PMC6740672

Abstract Article PDF–461K

Select item 48753454.

MicroRNAs: a new ray of hope for diabetes mellitus

Munish Kumar, Sayantan Nath, Himanshu K. Prasad, G. D. Sharma, Yong Li

Protein Cell. 2012 Oct; 3(10): 726–738. Published online 2012 Oct 11. doi: 10.1007/s13238-012-2055-0

PMCID:: PMC4875345

Abstract Article PDF–3.8M

Select item 47692235.

MiR-126 Suppresses the Glucose-Stimulated Proliferation via IRS-2 in INS-1 β Cells

Hong Tao, Meng-meng Wang, Man Zhang, Shao-ping Zhang, Chun-hui Wang, Wen-jun Yuan, Tao Sun, Lan-jie He, Qi-kuan Hu

PLoS One. 2016; 11(2): e0149954. Published online 2016 Feb 26. doi: 10.1371/journal.pone.0149954

PMCID:: PMC4769223

Abstract Article PDF–1.4M

Select item 40223176.

Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy

Michelle B. Hookham, Helen C. O’Donovan, Rachel H. Church, Annie Mercier-Zuber, Lucilla Luzi, Simon P. Curran, Rosemarie M. Carew, Alejandra Droguett, Sergio Mezzano, Markus Schubert, Morris F. White, John K. Crean, Derek P. Brazil

FEBS J. Author manuscript; available in PMC 2014 May 15.

Published in final edited form as: FEBS J. 2013 Jul; 280(14): 3232–3243. Published online 2013 May 29. doi: 10.1111/febs.12305

PMCID:: PMC4022317

Abstract Article PDF–2.9M

Select item 40110217.

Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development

Brandy M Heckman, Geetika Chakravarty, Tracy Vargo-Gogola, Maria Gonzales-Rimbau, Darryl L Hadsell, Adrian V Lee, Jeffrey Settleman, Jeffrey M Rosen

Dev Biol. Author manuscript; available in PMC 2014 May 6.

Published in final edited form as: Dev Biol. 2007 Sep 1; 309(1): 137–149. Published online 2007 Jul 10. doi: 10.1016/j.ydbio.2007.07.002

PMCID:: PMC4011021

Abstract Article PDF–1.7M

Select item 39648028.

P38 Plays an Important Role in Glucolipotoxicity-Induced Apoptosis in INS-1 Cells

Lingli Zhou, Xiaoling Cai, Xueyao Han, Linong Ji

J Diabetes Res. 2014; 2014: 834528. Published online 2014 Mar 5. doi: 10.1155/2014/834528

PMCID:: PMC3964802

Abstract Article PDF–2.4M

Select item 38742329.

SH2-B Promotes Insulin Receptor Substrate 1 (IRS1)- and IRS2-mediated Activation of the Phosphatidylinositol 3-Kinase Pathway in Response to Leptin

Chaojun Duan, Minghua Li, Liangyou Rui

J Biol Chem. Author manuscript; available in PMC 2013 Dec 28.

Published in final edited form as: J Biol Chem. 2004 Oct 15; 279(42): 10.1074/jbc.M408495200. Published online 2004 Aug 16. doi: 10.1074/jbc.M408495200

PMCID:: PMC3874232

Abstract Article PDF–801K

Select item 375390110.

Serine Phosphorylation Sites on IRS2 Activated by Angiotensin II and Protein Kinase C To Induce Selective Insulin Resistance in Endothelial Cells

Kyoungmin Park, Qian Li, Christian Rask-Madsen, Akira Mima, Koji Mizutani, Jonathon Winnay, Yasutaka Maeda, Katharine D'Aquino, Morris F. White, Edward P. Feener, George L. King

Mol Cell Biol. 2013 Aug; 33(16): 3227–3241. doi: 10.1128/MCB.00506-13

PMCID:: PMC3753901

Abstract Article PDF–4.2M

Select item 342223911.

Identification of the Amino Acids 300–600 of IRS-2 as 14-3-3 Binding Region with the Importance of IGF-1/Insulin-Regulated Phosphorylation of Ser-573

Sabine S. Neukamm, Rachel Toth, Nick Morrice, David G. Campbell, Carol MacKintosh, Rainer Lehmann, Hans-Ulrich Haering, Erwin D. Schleicher, Cora Weigert

PLoS One. 2012; 7(8): e43296. Published online 2012 Aug 17. doi: 10.1371/journal.pone.0043296

PMCID:: PMC3422239

Abstract Article PDF–3.2M

Select item 319810412.

Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca²⁺-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells

Damien Demozay, Shin Tsunekawa, Isabelle Briaud, Ramila Shah, Christopher J. Rhodes

Diabetes. 2011 Nov; 60(11): 2892–2902. Published online 2011 Oct 17. doi: 10.2337/db11-0341

PMCID:: PMC3198104

Abstract Article PDF–1.8M

Select item 319074413.

Inducible Nitric-oxide Synthase and Nitric Oxide Donor Decrease Insulin Receptor Substrate-2 Protein Expression by Promoting Proteasome-dependent Degradation in Pancreatic β-Cells: INVOLVEMENT OF GLYCOGEN SYNTHASE KINASE-3β

Toshihiro Tanioka, Yoshiaki Tamura, Makiko Fukaya, Shohei Shinozaki, Ji Mao, Minhye Kim, Nobuyuki Shimizu, Tadahiro Kitamura, Masao Kaneki

J Biol Chem. 2011 Aug 19; 286(33): 29388–29396. Published online 2011 Jun 23. doi: 10.1074/jbc.M110.192732

PMCID:: PMC3190744

Abstract Article PDF–2.0M

Select item 317805914.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 282283915.

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

Ying Li, Wei Xu, Michael W. McBurney, Valter D. Longo

Cell Metab. Author manuscript; available in PMC 2010 Feb 16.

Published in final edited form as: Cell Metab. 2008 Jul; 8(1): 38–48. doi: 10.1016/j.cmet.2008.05.004

PMCID:: PMC2822839

Abstract Article PDF–1.3M

Select item 278884016.

Silencing Mitogen-activated Protein 4 Kinase 4 (MAP4K4) Protects Beta Cells from Tumor Necrosis Factor-α-induced Decrease of IRS-2 and Inhibition of Glucose-stimulated Insulin Secretion

Karim Bouzakri, Pascale Ribaux, Philippe A. Halban

J Biol Chem. 2009 Oct 9; 284(41): 27892–27898. Published online 2009 Aug 18. doi: 10.1074/jbc.M109.048058

PMCID:: PMC2788840

Abstract Article PDF–1.2M

Select item 276745217.

Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: role of p38 MAPK

Tara L. Archuleta, Andrew M. Lemieux, Vitoon Saengsirisuwan, Mary K. Teachey, Katherine A. Lindborg, John S. Kim, Erik J. Henriksen

Free Radic Biol Med. Author manuscript; available in PMC 2010 Nov 15.

Published in final edited form as: Free Radic Biol Med. 2009 Nov 15; 47(10): 1486–1493. Published online 2009 Aug 22. doi: 10.1016/j.freeradbiomed.2009.08.014

PMCID:: PMC2767452

Abstract Article PDF–1.8M

Select item 272692118.

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

Richard Killick, Georgie Scales, Karelle Leroy, Mirsada Causevic, Claudie Hooper, Elaine E. Irvine, Agharul I Choudhury, Laura Drinkwater, Fiona Kerr, Hind Al-Qassab, John Stephenson, Zehra Yilmaz, K. Peter Giese, Jean-Pierre Brion, Dominic J. Withers, Simon Lovestone

Biochem Biophys Res Commun. 2009 Aug 14; 386(1): 257–262. doi: 10.1016/j.bbrc.2009.06.032

PMCID:: PMC2726921

Abstract Article

Select item 265805519.

Night/Day Changes in Pineal Expression of >600 Genes: CENTRAL ROLE OF ADRENERGIC/cAMP SIGNALING

Michael J. Bailey, Steven L. Coon, David A. Carter, Ann Humphries, Jong-so Kim, Qiong Shi, Pascaline Gaildrat, Fabrice Morin, Surajit Ganguly, John B. Hogenesch, Joan L. Weller, Martin F. Rath, Morten Møller, Ruben Baler, David Sugden, Zoila G. Rangel, Peter J. Munson, David C. Klein

J Biol Chem. 2009 Mar 20; 284(12): 7606–7622. doi: 10.1074/jbc.M808394200