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Select item 111596731.

Impact of alcohol consumption with polymorphisms in alcohol‐metabolizing enzymes on pancreatic cancer risk in Japanese

Junya Kanda, Keitaro Matsuo, Takeshi Suzuki, Takakazu Kawase, Akio Hiraki, Miki Watanabe, Nobumasa Mizuno, Akira Sawaki, Kenji Yamao, Kazuo Tajima, Hideo Tanaka

Cancer Sci. 2009 Feb; 100(2): 296–302. Published online 2008 Dec 5. doi: 10.1111/j.1349-7006.2008.01044.x

PMCID:: PMC11159673

Abstract Article PDF–123K

Select item 92013752.

Activation of aldehyde dehydrogenase 2 protects ethanol‐induced osteonecrosis of the femoral head in rat model

Xiaoyi Lin, Daoming Zhu, Kaiyang Wang, Pengbo Luo, Gang Rui, Youshui Gao, Fuan Liu, Hongping Yu

Cell Prolif. 2022 Jun; 55(6): e13252. Published online 2022 May 14. doi: 10.1111/cpr.13252

PMCID:: PMC9201375

Abstract Article PDF–3.7M

Select item 86641293.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

Marcel Morgenstern, Christian D. Peikert, Philipp Lübbert, Ida Suppanz, Cinzia Klemm, Oliver Alka, Conny Steiert, Nataliia Naumenko, Alexander Schendzielorz, Laura Melchionda, Wignand W.D. Mühlhäuser, Bettina Knapp, Jakob D. Busch, Sebastian B. Stiller, Stefan Dannenmaier, Caroline Lindau, Mariya Licheva, Christopher Eickhorst, Riccardo Galbusera, Ralf M. Zerbes, Michael T. Ryan, Claudine Kraft, Vera Kozjak-Pavlovic, Friedel Drepper, Sven Dennerlein, Silke Oeljeklaus, Nikolaus Pfanner, Nils Wiedemann, Bettina Warscheid

Cell Metab. 2021 Dec 7; 33(12): 2464–2483.e18. doi: 10.1016/j.cmet.2021.11.001

PMCID:: PMC8664129

Abstract Article

Select item 85570424.

ALDH2/SIRT1 Contributes to Type 1 and Type 2 Diabetes-Induced Retinopathy through Depressing Oxidative Stress

Mengshan He, Pan Long, Tao Chen, Kaifeng Li, Dongyu Wei, Yufei Zhang, Wenjun Wang, Yonghe Hu, Yi Ding, Aidong Wen

Oxid Med Cell Longev. 2021; 2021: 1641717. Published online 2021 Oct 23. doi: 10.1155/2021/1641717

PMCID:: PMC8557042

Abstract Article PDF–2.3M

Select item 82325965.

Cardioprotective Effects of PPARβ/δ Activation against Ischemia/Reperfusion Injury in Rat Heart Are Associated with ALDH2 Upregulation, Amelioration of Oxidative Stress and Preservation of Mitochondrial Energy Production

Ioanna Papatheodorou, Eleftheria Galatou, Georgios-Dimitrios Panagiotidis, Táňa Ravingerová, Antigone Lazou

Int J Mol Sci. 2021 Jun; 22(12): 6399. Published online 2021 Jun 15. doi: 10.3390/ijms22126399

PMCID:: PMC8232596

Abstract Article PDF–2.7M

Select item 67439346.

线粒体ALDH2对高糖处理的乳鼠心肌成纤维细胞中自噬相关蛋白影响

唐碧, 康品方, 郭建路, 朱磊, 徐庆梅, 高琴, 张恒, 王洪巨

Nan Fang Yi Ke Da Xue Xue Bao. 2019 May 20; 39(5): 523–527. Chinese. doi: 10.12122/j.issn.1673-4254.2019.05.04

PMCID:: PMC6743934

Abstract Article PDF–1.0M

Select item 65827477.

Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids

Yanhang Gao, Zhou Zhou, Tianyi Ren, Seung-Jin Kim, Yong He, Wonhyo Seo, Adrien Guillot, Yanhua Ding, Ruihong Wu, Shuang Shao, Xiaomei Wang, Hong Zhang, Wei Wang, Dechun Feng, Mingjiang Xu, Elaine Han, Wei Zhong, Zhanxiang Zhou, Pal Pacher, Junqi Niu, Bin Gao

Gut. 2019 Jul; 68(7): 1311–1322. Published online 2018 Aug 18. doi: 10.1136/gutjnl-2018-316221

PMCID:: PMC6582747

Abstract Article PDF–7.1M

Select item 64797078.

Vinyl chloride-induced interaction of nonalcoholic and toxicant-associated steatohepatitis: Protection by the ALDH2 activator Alda-1

Liya Chen, Anna L. Lang, Gavin D. Poff, Wen-Xing Ding, Juliane I. Beier

Redox Biol. 2019 Jun; 24: 101205. Published online 2019 Apr 19. doi: 10.1016/j.redox.2019.101205

PMCID:: PMC6479707

Abstract Article PDF–3.5M

Select item 63234949.

Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice

Meng Li, Min Xu, Jichang Li, Lili Chen, Dongwei Xu, Ying Tong, Jianjun Zhang, Hailong Wu, Xiaoni Kong, Qiang Xia

J Immunol Res. 2018; 2018: 9807139. Published online 2018 Dec 24. doi: 10.1155/2018/9807139

PMCID:: PMC6323494

Abstract Article PDF–12M

Select item 616439810.

Aldehyde Dehydrogenase 2 (ALDH2) in Rat Fatty Liver Cold Ischemia Injury

Arnau Panisello-Roselló, Norma Alva, Marta Flores, Alexandre Lopez, Carlos Castro Benítez, Emma Folch-Puy, Anabela Rolo, Carlos Palmeira, René Adam, Teresa Carbonell, Joan Roselló-Catafau

Int J Mol Sci. 2018 Sep; 19(9): 2479. Published online 2018 Aug 22. doi: 10.3390/ijms19092479

PMCID:: PMC6164398

Abstract Article PDF–3.0M

Select item 606376811.

Association between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease

Binxia Chang, Shuli Hao, Longyu Zhang, Miaomiao Gao, Ying Sun, Ang Huang, Guangju Teng, Baosen Li, David W. Crabb, Praveen Kusumanchi, Li Wang, Suthat Liangpunsakul, Zhengsheng Zou

Am J Med Sci. Author manuscript; available in PMC 2019 Jul 1.

Published in final edited form as: Am J Med Sci. 2018 Jul; 356(1): 10–14. Published online 2018 Mar 20. doi: 10.1016/j.amjms.2018.03.012

PMCID:: PMC6063768

Abstract Article PDF–317K

Select item 594239212.

Genetic variants of ALDH2-rs671 and CYP2E1-rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population

Xinping Ye, Xiangkun Wang, Liming Shang, Guangzhi Zhu, Hao Su, Chuangye Han, Wei Qin, Guanghui Li, Tao Peng

Cancer Manag Res. 2018; 10: 1037–1050. Published online 2018 May 4. doi: 10.2147/CMAR.S162105

PMCID:: PMC5942392

Abstract Article PDF–2.8M

Select item 570083113.

Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease

Liuyi Hao, Qian Sun, Wei Zhong, Wenliang Zhang, Xinguo Sun, Zhanxiang Zhou

Redox Biol. 2018 Apr; 14: 626–636. Published online 2017 Nov 11. doi: 10.1016/j.redox.2017.11.005

PMCID:: PMC5700831

Abstract Article PDF–2.3M

Select item 565425414.

Effect of ALDH2 on High Glucose-Induced Cardiac Fibroblast Oxidative Stress, Apoptosis, and Fibrosis

Xiaoyu Gu, Tingting Fang, Pinfang Kang, Junfeng Hu, Ying Yu, Zhenghong Li, Xiangyang Cheng, Qin Gao

Oxid Med Cell Longev. 2017; 2017: 9257967. Published online 2017 Oct 9. doi: 10.1155/2017/9257967

PMCID:: PMC5654254

Abstract Article PDF–4.9M

Select item 538669415.

Inhibition of ALDH2 by O-GlcNAcylation contributes to the hyperglycemic exacerbation of myocardial ischemia/reperfusion injury

Baoshan Liu, Jiali Wang, Minghua Li, Qiuhuan Yuan, Mengyang Xue, Feng Xu, Yuguo Chen

Oncotarget. 2017 Mar 21; 8(12): 19413–19426. Published online 2016 Dec 27. doi: 10.18632/oncotarget.14297

PMCID:: PMC5386694

Abstract Article PDF–7.1M

Select item 506332816.

Cardiac Mitochondrial Respiratory Dysfunction and Tissue Damage in Chronic Hyperglycemia Correlate with Reduced Aldehyde Dehydrogenase-2 Activity

Vishal R. Mali, Guodong Pan, Mandar Deshpande, Rajarajan A. Thandavarayan, Jiang Xu, Xiao-Ping Yang, Suresh S. Palaniyandi

PLoS One. 2016; 11(10): e0163158. Published online 2016 Oct 13. doi: 10.1371/journal.pone.0163158

PMCID:: PMC5063328

Abstract Article PDF–2.5M

Select item 489537817.

The longitudinal effect of the aldehyde dehydrogenase 2*2 allele on the risk for nonalcoholic fatty liver disease

K Oniki, K Morita, T Watanabe, A Kajiwara, K Otake, K Nakagawa, Y Sasaki, Y Ogata, J Saruwatari

Nutr Diabetes. 2016 May; 6(5): e210. Published online 2016 May 23. doi: 10.1038/nutd.2016.17

PMCID:: PMC4895378

Abstract Article PDF–284K

Select item 451719718.

ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis

Shengfang Jin, Jiang Chen, Lizao Chen, Gavin Histen, Zhizhong Lin, Stefan Gross, Jeffrey Hixon, Yue Chen, Charles Kung, Yiwei Chen, Yufei Fu, Yuxuan Lu, Hui Lin, Xiujun Cai, Hua Yang, Rob A. Cairns, Marion Dorsch, Shinsan M. Su, Scott Biller, Tak W. Mak, Yong Cang

Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29): 9088–9093. Published online 2015 Jul 6. doi: 10.1073/pnas.1510757112

PMCID:: PMC4517197

Abstract Article PDF–1.1M

Select item 451521219.

ALDH2 Deficiency Promotes Ethanol-Induced Gut Barrier Dysfunction and Fatty Liver in Mice

Kamljit K. Chaudhry, Geetha Samak, Pradeep K. Shukla, Hina Mir, Ruchika Gangwar, Bhargavi Manda, Toyohi Isse, Toshihiro Kawamoto, Mikko Salaspuro, Pertti Kaihovaara, Paula Dietrich, Ioannis Dragatsis, Laura E. Nagy, RadhaKrishna Rao

Alcohol Clin Exp Res. Author manuscript; available in PMC 2016 Aug 1.

Published in final edited form as: Alcohol Clin Exp Res. 2015 Aug; 39(8): 1465–1475. Published online 2015 Jul 14. doi: 10.1111/acer.12777

PMCID:: PMC4515212

Abstract Article PDF–1.5M

Select item 433872620.

Mitochondrial Aldehyde Dehydrogenase Activation by Alda‐1 Inhibits Atherosclerosis and Attenuates Hepatic Steatosis in Apolipoprotein E‐Knockout Mice

Aneta Stachowicz, Rafał Olszanecki, Maciej Suski, Anna Wiśniewska, Justyna Totoń‐Żurańska, Józef Madej, Jacek Jawień, Magdalena Białas, Krzysztof Okoń, Mariusz Gajda, Katarzyna Głombik, Agnieszka Basta‐Kaim, Ryszard Korbut

J Am Heart Assoc. 2014 Dec; 3(6): e001329. Published online 2014 Nov 12. doi: 10.1161/JAHA.114.001329

PMCID:: PMC4338726

Abstract Article PDF–1.4M

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