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Select item 111923841.

Growth deficiency in a mouse model of Kabuki syndrome 2 bears mechanistic similarities to Kabuki syndrome 1

Christine W. Gao, WanYing Lin, Ryan C. Riddle, Sheetal Chopra, Jiyoung Kim, Leandros Boukas, Kasper D. Hansen, Hans T. Björnsson, Jill A. Fahrner

PLoS Genet. 2024 Jun; 20(6): e1011310. Published online 2024 Jun 10. doi: 10.1371/journal.pgen.1011310

PMCID:: PMC11192384

Abstract Article PDF–2.5M

Select item 111550982.

Inactivation of KDM6A promotes the progression of colorectal cancer by enhancing the glycolysis

Dexiang Zhang, Xiaohong Zhao, Yu Gao, Meixing Wang, Mi Xiao, Kaihua Zhu, Wei Niu, Yuedi Dai

Eur J Med Res. 2024; 29: 310. Published online 2024 Jun 6. doi: 10.1186/s40001-024-01828-1

PMCID:: PMC11155098

Abstract Article PDF–7.5M

Select item 109633663.

Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair

Chengjun Li, Tian Qin, Jinyun Zhao, Yuxin Jin, Yiming Qin, Rundong He, Tianding Wu, Chunyue Duan, Liyuan Jiang, Feifei Yuan, Hongbin Lu, Yong Cao, Jianzhong Hu

Bone Res. 2024; 12: 19. Published online 2024 Mar 25. doi: 10.1038/s41413-024-00323-x

PMCID:: PMC10963366

Abstract Article PDF–11M

Select item 109030144.

Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury

Yudong Liu, Zixiang Luo, Yong Xie, Yi Sun, Feifei Yuan, Liyuan Jiang, Hongbin Lu, Jianzhong Hu

Cell Commun Signal. 2024; 22: 155. Published online 2024 Feb 29. doi: 10.1186/s12964-023-01434-4

PMCID:: PMC10903014

Abstract Article PDF–4.0M

Select item 106387855.

Inhibition of UTX/KDM6A improves recovery of spinal cord injury by attenuating BSCB permeability and macrophage infiltration through the MLCK/p-MLC pathway

Yong Xie, Zixiang Luo, Wei Peng, Yudong Liu, Feifei Yuan, Jiaqi Xu, Yi Sun, Hongbin Lu, Tianding Wu, Liyuan Jiang, Jianzhong Hu

J Neuroinflammation. 2023; 20: 259. Published online 2023 Nov 11. doi: 10.1186/s12974-023-02936-1

PMCID:: PMC10638785

Abstract Article PDF–21M

Select item 104820126.

Altered expression, but small contribution, of the histone demethylase KDM6A in obstructive uropathy in mice

Lisa Y. Q. Hong, Emily S. H. Yeung, Duc Tin Tran, Veera Ganesh Yerra, Harmandeep Kaur, M. D. Golam Kabir, Suzanne L. Advani, Youan Liu, Sri Nagarjun Batchu, Andrew Advani

Dis Model Mech. 2023 Sep 1; 16(9): dmm049991. Published online 2023 Sep 1. doi: 10.1242/dmm.049991

PMCID:: PMC10482012

Abstract Article

Select item 104571987.

UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease

Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuji Momose, Naoya Takayama, Naoki Itokawa, Shuhei Koide, Asuka Shibamiya, Yurie Miyamoto-Nagai, Mohamed Rizk, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Changshan Wang, Atsunori Saraya, Ryoji Ito, Masanori Seimiya, Mariko Watanabe, Satoshi Yamasaki, Tatsuhiro Shibata, Kiyoshi Yamaguchi, Yoichi Furukawa, Tetsuhiro Chiba, Emiko Sakaida, Chiaki Nakaseko, Jun-ichi Tamaru, Yu-Tzu Tai, Kenneth C. Anderson, Hiroaki Honda, Atsushi Iwama

Leukemia. 2023; 37(9): 1895–1907. Published online 2023 May 17. doi: 10.1038/s41375-023-01928-7

Correction in:: Leukemia. 2023; 37(9): 1952.

PMCID:: PMC10457198

Abstract Article PDF–4.0M

Select item 103391438.

Silencing of UTX Mitigates Aging-Associated Cardiac Fibrosis via Blocking Cardiac Fibroblasts-to-Myofibroblasts Trans-Differentiation

Chao Li, Tiantian Lin, Delin Li, Daoyuan Si, Huan Sun, Sibao Yang, Zhongfan Zhang, Qian Zhang, Kaiyao Shi

Anatol J Cardiol. 2023 Jul; 27(7): 398–407. Published online 2023 Jul 1. doi: 10.14744/AnatolJCardiol.2023.2777

PMCID:: PMC10339143

Abstract Article PDF–9.1M

Select item 103343029.

Combined Kdm6a and Trp53 deficiency drives the development of squamous cell skin cancer in mice

Lauren K. Shea, Neal S. Akhave, Leslie A. Sutton, Leigh A. Compton, Conner York, Sai Mukund Ramakrishnan, Christopher A. Miller, Lukas D. Wartman, David Y. Chen

J Invest Dermatol. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: J Invest Dermatol. 2023 Feb; 143(2): 232–241.e6. Published online 2022 Aug 31. doi: 10.1016/j.jid.2022.08.037

PMCID:: PMC10334302

Abstract Article PDF–2.6M

Select item 1032308710.

The histone demethylase Utx controls CD8⁺ T‐cell‐dependent antitumor immunity via epigenetic regulation of the effector function

Haruna Noda, Junpei Suzuki, Yuko Matsuoka, Akira Matsumoto, Makoto Kuwahara, Yoshiaki Kamei, Yasutsugu Takada, Masakatsu Yamashita

Cancer Sci. 2023 Jul; 114(7): 2787–2797. Published online 2023 Apr 17. doi: 10.1111/cas.15814

PMCID:: PMC10323087

Abstract Article PDF–6.8M

Select item 1023519511.

X Chromosome Factor Kdm6a Enhances Cognition Independent of Its Demethylase Function in the Aging XY Male Brain

Cayce K Shaw, Samira Abdulai-Saiku, Francesca Marino, Dan Wang, Emily J Davis, Barbara Panning, Dena B Dubal

J Gerontol A Biol Sci Med Sci. 2023 Jun; 78(6): 938–943. Published online 2023 Jan 9. doi: 10.1093/gerona/glad007

PMCID:: PMC10235195

Abstract Article PDF–317K

Select item 1019742512.

Inhibition of H3K27me3 demethylases promotes plasmablast formation

Anna K. Kania, Muyao Guo, Christopher D. Scharer, Jeremy M. Boss

Immunohorizons. Author manuscript; available in PMC 2023 May 19.

Published in final edited form as: Immunohorizons. 2021 Dec 8; 5(12): 918–930. Published online 2021 Dec 8. doi: 10.4049/immunohorizons.2000087

PMCID:: PMC10197425

Abstract Article PDF–1.7M

Select item 985125213.

UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation

Mingyu Pan, Yue Yin, Tongyu Hu, Xinxia Wang, Tian Jia, Jing Sun, Quanyi Wang, Wei Meng, Juanjuan Zhu, Chunsun Dai, Haiyang Hu, Chen Wang

Autophagy. 2023; 19(2): 440–456. Published online 2022 May 30. doi: 10.1080/15548627.2022.2076192

PMCID:: PMC9851252

Abstract Article PDF–3.3M

Select item 981240014.

Loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis and promotes breast cancer

Ellen Langille, Khalid N. Al-Zahrani, Zhibo Ma, Minggao Liang, Liis Uuskula-Reimand, Roderic Espin, Katie Teng, Ahmad Malik, Helga Bergholtz, Samah El Ghamrasni, Somaieh Afiuni-Zadeh, Ricky Tsai, Sana Alvi, Andrew Elia, YiQing Lü, Robin H. Oh, Katelyn J. Kozma, Daniel Trcka, Masahiro Narimatsu, Jeff C. Liu, Thomas Nguyen, Seda Barutcu, Sampath K. Loganathan, Rod Bremner, Gary D. Bader, Sean E. Egan, David W. Cescon, Therese Sørlie, Jeffrey L. Wrana, Hartland W. Jackson, Michael D. Wilson, Agnieszka K. Witkiewicz, Erik S. Knudsen, Miguel Angel Pujana, Geoffrey M. Wahl, Daniel Schramek

Cancer Discov. Author manuscript; available in PMC 2023 Jun 2.

Published in final edited form as: Cancer Discov. 2022 Dec 2; 12(12): 2930–2953. doi: 10.1158/2159-8290.CD-21-0865

PMCID:: PMC9812400

Abstract Article PDF–4.5M

Select item 930834315.

Sex-biased and parental allele-specific gene regulation by KDM6A

Wenxiu Ma, He Fang, Nicolas Pease, Galina N. Filippova, Christine M. Disteche, Joel B. Berletch

Biol Sex Differ. 2022; 13: 40. Published online 2022 Jul 23. doi: 10.1186/s13293-022-00452-0

PMCID:: PMC9308343

Abstract Article PDF–3.2M

Select item 927984916.

Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer

Steffie Revia, Agnieszka Seretny, Lena Wendler, Ana Banito, Christoph Eckert, Kersten Breuer, Anand Mayakonda, Pavlo Lutsik, Matthias Evert, Silvia Ribback, Suchira Gallage, Ismaiel Chikh Bakri, Kai Breuhahn, Peter Schirmacher, Stefan Heinrich, Matthias M Gaida, Mathias Heikenwälder, Diego F Calvisi, Christoph Plass, Scott W Lowe, Darjus F Tschaharganeh

Gut. 2022 Aug; 71(8): 1613–1628. Published online 2021 Sep 11. doi: 10.1136/gutjnl-2021-325405