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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 111094832.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 109944123.

Megalosplenia as an initial manifestation of multiple myeloma with a novel CYLD gene mutation: A case report and literature review

Jinjing Zhang, Rui Zhang

Medicine (Baltimore) 2024 Apr 5; 103(14): e37624. Published online 2024 Apr 5. doi: 10.1097/MD.0000000000037624

PMCID:: PMC10994412

Abstract Article PDF–667K

Select item 108473354.

TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression

Buhao Deng, Jingyi Wang, Tingyun Yang, Zhao Deng, Jiafan Yuan, Bohan Zhang, Zhen Zhou, Fang Chen, Lu Fang, Chengzhi Liang, Bo Yan, Youwei Ai

J Cell Biol. 2024 Mar 4; 223(3): e202305026. Published online 2024 Feb 6. doi: 10.1083/jcb.202305026

PMCID:: PMC10847335

Abstract Article PDF–8.1M

Select item 108247115.

CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma

Yueshuo Li, Chenxing Yang, Longlong Xie, Feng Shi, Min Tang, Xiangjian Luo, Na Liu, Xudong Hu, Yongwei Zhu, Ann M. Bode, Qiang Gao, Jian Zhou, Jia Fan, Xuejun Li, Ya Cao

Cell Death Dis. 2024 Jan; 15(1): 95. Published online 2024 Jan 29. doi: 10.1038/s41419-024-06419-w

PMCID:: PMC10824711

Abstract Article PDF–6.4M

Select item 108003456.

CYLD regulates cell ferroptosis through Hippo/YAP signaling in prostate cancer progression

Yanan Gu, Shiqi Wu, Junjie Fan, Zeji Meng, Guoqiang Gao, Tianjie Liu, Qi Wang, Huayu Xia, Xinyang Wang, Kaijie Wu

Cell Death Dis. 2024 Jan; 15(1): 79. Published online 2024 Jan 22. doi: 10.1038/s41419-024-06464-5

PMCID:: PMC10800345

Abstract Article PDF–11M

Select item 106946017.

An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses

Norton Cheng, JoAnn Trejo

J Biol Chem. 2023 Dec; 299(12): 105370. Published online 2023 Oct 20. doi: 10.1016/j.jbc.2023.105370

PMCID:: PMC10694601

Abstract Article PDF–5.0M

Select item 104061888.

CYLD stimulates macrophage phagocytosis of leukemic cells through STAT1 signalling in acute myeloid leukemia

Nguyen Thanh Huyen, Nguyen Thy Ngoc, Nguyen Hoang Giang, Do Thi Trang, Ha Hong Hanh, Vu Duc Binh, Nguyen Van Giang, Nguyen Xuan Canh, Nguyen Thi Xuan

PLoS One. 2023; 18(8): e0283586. Published online 2023 Aug 7. doi: 10.1371/journal.pone.0283586

PMCID:: PMC10406188

Abstract Article PDF–1.8M

Select item 102374229.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1017918410.

The Potential of Cylindromatosis (CYLD) as a Therapeutic Target in Oxidative Stress-Associated Pathologies: A Comprehensive Evaluation

Zhenzhou Huang, Yanjie Tan

Int J Mol Sci. 2023 May; 24(9): 8368. Published online 2023 May 6. doi: 10.3390/ijms24098368

PMCID:: PMC10179184

Abstract Article PDF–1.3M

Select item 1012000511.

Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease

Ketu Mishra-Gorur, Tanyeri Barak, Leon D. Kaulen, Octavian Henegariu, Sheng Chih Jin, Stephanie Marie Aguilera, Ezgi Yalbir, Gizem Goles, Sayoko Nishimura, Danielle Miyagishima, Lydia Djenoune, Selin Altinok, Devendra K. Rai, Stephen Viviano, Andrew Prendergast, Cynthia Zerillo, Kent Ozcan, Burcin Baran, Leman Sencar, Nukte Goc, Yanki Yarman, A. Gulhan Ercan-Sencicek, Kaya Bilguvar, Richard P. Lifton, Jennifer Moliterno, Angeliki Louvi, Shiaulou Yuan, Engin Deniz, Martina Brueckner, Murat Gunel

Proc Natl Acad Sci U S A. 2023 Apr 18; 120(16): e2214997120. Published online 2023 Apr 12. doi: 10.1073/pnas.2214997120

PMCID:: PMC10120005

Abstract Article PDF–9.8M

Select item 1001779212.

MALT1-dependent cleavage of CYLD promotes NF-κB signaling and growth of aggressive B-cell receptor-dependent lymphomas

Marthe Minderman, Hildo C. Lantermans, Leonie J. Grüneberg, Saskia A. G. M. Cillessen, Richard J. Bende, Carel J. M. van Noesel, Marie José Kersten, Steven T. Pals, Marcel Spaargaren

Blood Cancer J. 2023 Dec; 13(1): 37. Published online 2023 Mar 15. doi: 10.1038/s41408-023-00809-7

PMCID:: PMC10017792

Abstract Article PDF–3.7M

Select item 999012013.

Interactomes of Glycogen Synthase Kinase-3 Isoforms

Kevin W. Cormier, Brett Larsen, Anne-Claude Gingras, James R. Woodgett

J Proteome Res. 2023 Mar 3; 22(3): 977–989. Published online 2023 Feb 13. doi: 10.1021/acs.jproteome.2c00825

PMCID:: PMC9990120

Abstract Article PDF–3.7M

Select item 994554214.

Neural mechanism underlies CYLD modulation of morphology and synaptic function of medium spiny neurons in dorsolateral striatum

Shu-yi Tan, Jin-xiang Jiang, Hui-xian Huang, Xiu-ping Mo, Jing-ru Feng, Yu Chen, Li Yang, Cheng Long

Front Mol Neurosci. 2023; 16: 1107355. Published online 2023 Feb 8. doi: 10.3389/fnmol.2023.1107355

Correction in:: Front Mol Neurosci. 2023; 16: 1162275.

PMCID:: PMC9945542

Abstract Article PDF–12M

Select item 972467115.

Human ZBP1 induces cell death‐independent inflammatory signaling via RIPK3 and RIPK1

Ruoshi Peng, Chris Kedong Wang, Xuan Wang‐Kan, Manja Idorn, Majken Kjær, Felix Y Zhou, Berthe Katrine Fiil, Frederik Timmermann, Susana L Orozco, Julia McCarthy, Carol S Leung, Xin Lu, Katrin Bagola, Jan Rehwinkel, Andrew Oberst, Jonathan Maelfait, Søren R Paludan, Mads Gyrd‐Hansen

EMBO Rep. 2022 Dec; 23(12): e55839. Published online 2022 Oct 21. doi: 10.15252/embr.202255839

PMCID:: PMC9724671

Abstract Article PDF–1.8M

Select item 956995516.

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation

Yulemi Gonzalez Quesada, Luc DesGroseillers

Int J Mol Sci. 2022 Oct; 23(19): 11588. Published online 2022 Sep 30. doi: 10.3390/ijms231911588

PMCID:: PMC9569955

Abstract Article PDF–2.1M

Select item 953937217.

CYLD variants identified in Alzheimer's disease and frontotemporal dementia patients

Xuewen Xiao, Tianyan Xu, Hui Liu, Xixi Liu, Xinxin Liao, Yafang Zhou, Lu Zhou, Xin Wang, Yuan Zhu, Qijie Yang, Xiaoli Hao, Yingzi Liu, Hong Jiang, Jifeng Guo, Junling Wang, Beisha Tang, Jinchen Li, Lu Shen, Bin Jiao

Ann Clin Transl Neurol. 2022 Oct; 9(10): 1596–1601. Published online 2022 Aug 24. doi: 10.1002/acn3.51655

PMCID:: PMC9539372

Abstract Article PDF–406K

Select item 943393818.

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB

Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan

EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698

PMCID:: PMC9433938

Abstract Article PDF–9.3M

Select item 934857619.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 917769420.

Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1

Yiming Hu, Haohao Zhang, Ningxia Xie, Dandan Liu, Yuhang Jiang, Zhi Liu, Deji Ye, Sanhong Liu, Xi Chen, Cuifeng Li, Qi Wang, Xingxu Huang, Yongzhong Liu, Yufang Shi, Xiaoren Zhang

Cell Death Differ. 2022 Jun; 29(6): 1176–1186. Published online 2021 Dec 1. doi: 10.1038/s41418-021-00908-7

PMCID:: PMC9177694

Abstract Article PDF–3.7M

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