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Items: 1 to 20 of 29

1.
Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function
E. Sandra Chocron, Kennedy Mdaki, Nisi Jiang, Jodie Cropper, Andrew M. Pickering
Commun Biol. 2022; 5: 467. Published online 2022 May 16. doi: 10.1038/s42003-022-03405-w
PMCID:
PMC9110405
AbstractArticlePDF–2.3M
2.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
3.
The mitochondrial thioredoxin reductase system (TrxR2) in vascular endothelium controls peroxynitrite levels and tissue integrity
Petra Kameritsch, Miriam Singer, Christoph Nuernbergk, Natalia Rios, Aníbal M. Reyes, Kjestine Schmidt, Julian Kirsch, Holger Schneider, Susanna Müller, Kristin Pogoda, Ruicen Cui, Thomas Kirchner, Cor de Wit, Bärbel Lange-Sperandio, Ulrich Pohl, Marcus Conrad, Rafael Radi, Heike Beck
Proc Natl Acad Sci U S A. 2021 Feb 16; 118(7): e1921828118. Published online 2021 Feb 12. doi: 10.1073/pnas.1921828118
PMCID:
PMC7896346
AbstractArticlePDF–1.7M
4.
Mitochondrial Dysfunction Leads to Cortical Under-connectivity and Cognitive Impairment
Alejandra Fernandez, Daniel W. Meechan, Beverly A. Karpinski, Elizabeth M. Paronett, Corey A. Bryan, Hanna L. Rutz, Eric A. Radin, Noah Lubin, Erin R. Bonner, Anastas Popratiloff, Lawrence A. Rothblat, Thomas M. Maynard, Anthony-Samuel LaMantia
Neuron. Author manuscript; available in PMC 2020 Jun 19.
Published in final edited form as: Neuron. 2019 Jun 19; 102(6): 1127–1142.e3. Published online 2019 May 9. doi: 10.1016/j.neuron.2019.04.013
PMCID:
PMC6668992
AbstractArticlePDF–4.9M
5.
Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice
Karessa White, Mi-Jung Kim, Chul Han, Hyo-Jin Park, Dalian Ding, Kevin Boyd, Logan Walker, Paul Linser, Zaimary Meneses, Cole Slade, Jonathan Hirst, Katherine Santostefano, Naohiro Terada, Takuya Miyakawa, Masaru Tanokura, Richard Salvi, Shinichi Someya
Sci Rep. 2018; 8: 5039. Published online 2018 Mar 22. doi: 10.1038/s41598-018-23436-w
PMCID:
PMC5864918
AbstractArticlePDF–6.9M
6.
Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium
Claudia Kiermayer, Emily Northrup, Anja Schrewe, Axel Walch, Martin Hrabe de Angelis, Frank Schoensiegel, Hans Zischka, Cornelia Prehn, Jerzy Adamski, Raffi Bekeredjian, Boris Ivandic, Christian Kupatt, Markus Brielmeier
J Am Heart Assoc. 2015 Jul; 4(7): e002153. Published online 2015 Jul 21. doi: 10.1161/JAHA.115.002153
PMCID:
PMC4608093
AbstractArticlePDF–4.3M
7.
Knockout of Mitochondrial Thioredoxin Reductase Stabilizes Prolyl Hydroxylase 2 and Inhibits Tumor Growth and Tumor-Derived Angiogenesis
Juliane Hellfritsch, Julian Kirsch, Manuela Schneider, Tamara Fluege, Markus Wortmann, Jeroen Frijhoff, Markus Dagnell, Theres Fey, Irene Esposito, Pirkko Kölle, Kristin Pogoda, José Pedro Friedmann Angeli, Irina Ingold, Peter Kuhlencordt, Arne Östman, Ulrich Pohl, Marcus Conrad, Heike Beck
Antioxid Redox Signal. 2015 Apr 10; 22(11): 938–950. doi: 10.1089/ars.2014.5889
PMCID:
PMC4376289
AbstractArticlePDF–668K
8.
Resolution of oxidative stress by thioredoxin reductase: Cysteine versus selenocysteine
Brian Cunniff, Gregg W. Snider, Nicholas Fredette, Jason Stumpff, Robert J. Hondal, Nicholas H. Heintz
Redox Biol. 2014; 2: 475–484. Published online 2014 Feb 19. doi: 10.1016/j.redox.2014.01.021
PMCID:
PMC3949094
AbstractArticlePDF–1.9M
9.
Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome
Beverly A. Karpinski, Thomas M. Maynard, Matthew S. Fralish, Samer Nuwayhid, Irene E. Zohn, Sally A. Moody, Anthony-S. LaMantia
Dis Model Mech. 2014 Feb; 7(2): 245–257. Published online 2013 Dec 19. doi: 10.1242/dmm.012484
PMCID:
PMC3917245
AbstractArticle
10.
SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex
Yolanda Olmos, Francisco J. Sánchez-Gómez, Brigitte Wild, Nieves García-Quintans, Sofía Cabezudo, Santiago Lamas, María Monsalve
Antioxid Redox Signal. 2013 Nov 1; 19(13): 1507–1521. doi: 10.1089/ars.2012.4713
PMCID:
PMC3797451
AbstractArticlePDF–1.0M
11.
Selective Metabolism of Hypothiocyanous Acid by Mammalian Thioredoxin Reductase Promotes Lung Innate Immunity and Antioxidant Defense
Joshua D. Chandler, David P. Nichols, Jerry A. Nick, Robert J. Hondal, Brian J. Day
J Biol Chem. 2013 Jun 21; 288(25): 18421–18428. Published online 2013 Apr 29. doi: 10.1074/jbc.M113.468090
PMCID:
PMC3689984
AbstractArticlePDF–1.0M
12.
Structural and Biochemical Studies Reveal Differences in the Catalytic Mechanisms of Mammalian and Drosophila melanogaster Thioredoxin Reductases
Brian E. Eckenroth, Mark A. Rould, Robert J. Hondal, Stephen J. Everse
Biochemistry. Author manuscript; available in PMC 2013 Jun 20.
Published in final edited form as: Biochemistry. 2007 Apr 24; 46(16): 4694–4705. Published online 2007 Mar 27. doi: 10.1021/bi602394p
PMCID:
PMC3687216
AbstractArticlePDF–2.4M
13.
Thioredoxin Reductase-2 Is Essential for Keeping Low Levels of H2O2 Emission from Isolated Heart Mitochondria
Brian A. Stanley, Vidhya Sivakumaran, Sa Shi, Iain McDonald, David Lloyd, Walter H. Watson, Miguel A. Aon, Nazareno Paolocci
J Biol Chem. 2011 Sep 23; 286(38): 33669–33677. Published online 2011 Aug 5. doi: 10.1074/jbc.M111.284612
PMCID:
PMC3190932
AbstractArticlePDF–2.2M
14.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
15.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M
16.
System xc− and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency
Pankaj Kumar Mandal, Alexander Seiler, Tamara Perisic, Pirkko Kölle, Ana Banjac Canak, Heidi Förster, Norbert Weiss, Elisabeth Kremmer, Michael W. Lieberman, Shiro Bannai, Peter Kuhlencordt, Hideyo Sato, Georg W. Bornkamm, Marcus Conrad
J Biol Chem. 2010 Jul 16; 285(29): 22244–22253. Published online 2010 May 12. doi: 10.1074/jbc.M110.121327
PMCID:
PMC2903358
AbstractArticlePDF–3.8M
17.
A mitochondrial protein compendium elucidates complex I disease biology
David J. Pagliarini, Sarah E. Calvo, Betty Chang, Sunil A. Sheth, Scott B. Vafai, Shao-En Ong, Geoffrey A. Walford, Canny Sugiana, Avihu Boneh, William K. Chen, David E. Hill, Marc Vidal, James G. Evans, David R. Thorburn, Steven A. Carr, Vamsi K. Mootha
Cell. Author manuscript; available in PMC 2009 Nov 18.
Published in final edited form as: Cell. 2008 Jul 11; 134(1): 112–123. doi: 10.1016/j.cell.2008.06.016
PMCID:
PMC2778844
AbstractArticlePDF–1.2M
18.
No Selenium Required: Reactions Catalyzed By Mammalian Thioredoxin Reductase That Are Independent of a Selenocysteine Residue.
Adam P. Lothrop, Erik L. Ruggles, Robert J. Hondal
Biochemistry. Author manuscript; available in PMC 2010 Jul 7.
Published in final edited form as: Biochemistry. 2009 Jul 7; 48(26): 6213–6223. doi: 10.1021/bi802146w
PMCID:
PMC2754045
AbstractArticlePDF–1.8M
19.
The Role of Thioredoxin Reductases in Brain Development
Jonna Soerensen, Cemile Jakupoglu, Heike Beck, Heidi Förster, Jörg Schmidt, Wolfgang Schmahl, Ulrich Schweizer, Marcus Conrad, Markus Brielmeier
PLoS One. 2008; 3(3): e1813. Published online 2008 Mar 19. doi: 10.1371/journal.pone.0001813
PMCID:
PMC2263137
AbstractArticlePDF–2.7M
20.
BGEM: An In Situ Hybridization Database of Gene Expression in the Embryonic and Adult Mouse Nervous System
Susan Magdaleno, Patricia Jensen, Craig L Brumwell, Anna Seal, Karen Lehman, Andrew Asbury, Tony Cheung, Tommie Cornelius, Diana M Batten, Christopher Eden, Shannon M Norland, Dennis S Rice, Nilesh Dosooye, Sundeep Shakya, Perdeep Mehta, Tom Curran
PLoS Biol. 2006 Apr; 4(4): e86. Published online 2006 Mar 28. doi: 10.1371/journal.pbio.0040086
PMCID:
PMC1413568
ArticlePDF–99K

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